LOCUS       NM_003270               3768 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 1, mRNA.
ACCESSION   NM_003270
VERSION     NM_003270.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3768)
  AUTHORS   Mrozowska,M., Gornicki,T., Olbromski,M., Partynska,A.I.,
            Dziegiel,P. and Rusak,A.
  TITLE     New insights into the role of tetraspanin 6, 7, and 8 in physiology
            and pathology
  JOURNAL   Cancer Med 13 (14), e7390 (2024)
   PUBMED   39031113
  REMARK    GeneRIF: New insights into the role of tetraspanin 6, 7, and 8 in
            physiology and pathology.
            Review article
REFERENCE   2  (bases 1 to 3768)
  AUTHORS   Zhang,C., Du,F.H., Wang,R.X., Han,W.B., Lv,X., Zeng,L.H. and
            Chen,G.Q.
  TITLE     TSPAN6 reinforces the malignant progression of glioblastoma via
            interacting with CDK5RAP3 and regulating STAT3 signaling pathway
  JOURNAL   Int J Biol Sci 20 (7), 2440-2453 (2024)
   PUBMED   38725860
  REMARK    GeneRIF: TSPAN6 reinforces the malignant progression of
            glioblastoma via interacting with CDK5RAP3 and regulating STAT3
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3768)
  AUTHORS   Humbert,P.O., Pryjda,T.Z., Pranjic,B., Farrell,A., Fujikura,K., de
            Matos Simoes,R., Karim,R., Kozieradzki,I., Cronin,S.J.F.,
            Neely,G.G., Meyer,T.F., Hagelkruys,A., Richardson,H.E. and
            Penninger,J.M.
  TITLE     TSPAN6 is a suppressor of Ras-driven cancer
  JOURNAL   Oncogene 41 (14), 2095-2105 (2022)
   PUBMED   35184157
  REMARK    GeneRIF: TSPAN6 is a suppressor of Ras-driven cancer.
            Erratum:[Oncogene. 2022 Apr;41(14):2138. doi:
            10.1038/s41388-022-02265-2.. PMID: 35292775]
REFERENCE   4  (bases 1 to 3768)
  AUTHORS   Andrijes,R., Hejmadi,R.K., Pugh,M., Rajesh,S., Novitskaya,V.,
            Ibrahim,M., Overduin,M., Tselepis,C., Middleton,G.W., Gyorffy,B.,
            Beggs,A.D. and Berditchevski,F.
  TITLE     Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer
  JOURNAL   Proc Natl Acad Sci U S A 118 (39) (2021)
   PUBMED   34521767
  REMARK    GeneRIF: Tetraspanin 6 is a regulator of carcinogenesis in
            colorectal cancer.
REFERENCE   5  (bases 1 to 3768)
  AUTHORS   Wang,Y., Tong,X., Omoregie,E.S., Liu,W., Meng,S. and Ye,X.
  TITLE     Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible
            gene I-like receptor-mediated immune signaling in a
            ubiquitination-dependent manner
  JOURNAL   J Biol Chem 287 (41), 34626-34634 (2012)
   PUBMED   22908223
  REMARK    GeneRIF: TSPAN6 functions as a negative regulator of the RLR
            pathway by interacting with MAVS in a ubiquitination-dependent
            manner.
REFERENCE   6  (bases 1 to 3768)
  AUTHORS   Yunta,M. and Lazo,P.A.
  TITLE     Tetraspanin proteins as organisers of membrane microdomains and
            signalling complexes
  JOURNAL   Cell Signal 15 (6), 559-564 (2003)
   PUBMED   12681443
  REMARK    Review article
REFERENCE   7  (bases 1 to 3768)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   8  (bases 1 to 3768)
  AUTHORS   Maeda,K., Matsuhashi,S., Hori,K., Xin,Z., Mukai,T., Tabuchi,K.,
            Egashira,M. and Niikawa,N.
  TITLE     Cloning and characterization of a novel human gene, TM4SF6,
            encoding a protein belonging to the transmembrane 4 superfamily,
            and mapped to Xq22
  JOURNAL   Genomics 52 (2), 240-242 (1998)
   PUBMED   9782095
REFERENCE   9  (bases 1 to 3768)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
REFERENCE   10 (bases 1 to 3768)
  AUTHORS   Maecker,H.T., Todd,S.C. and Levy,S.
  TITLE     The tetraspanin superfamily: molecular facilitators
  JOURNAL   FASEB J 11 (6), 428-442 (1997)
   PUBMED   9194523
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CX760536.1, AY358825.1,
            AL035608.11 and N64145.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003270.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            The protein encoded by this gene is a cell surface glycoprotein and
            is highly similar in sequence to the transmembrane 4 superfamily
            member 2 protein. It functions as a negative regulator of retinoic
            acid-inducible gene I-like receptor-mediated immune signaling via
            its interaction with the mitochondrial antiviral signaling-centered
            signalosome. This gene uses alternative polyadenylation sites, and
            multiple transcript variants result from alternative splicing.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075072.1, AB209876.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373020.9/ ENSP00000362111.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                CX760536.1         52-123
            73-1182             AY358825.1         1-1110
            1183-3602           AL035608.11        72433-74852         c
            3603-3768           N64145.1           15-180              c
FEATURES             Location/Qualifiers
     source          1..3768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..3768
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="tetraspanin 6"
                     /db_xref="GeneID:7105"
                     /db_xref="HGNC:HGNC:11858"
                     /db_xref="MIM:300191"
     exon            1..199
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..850
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane 4 superfamily member 6; tetraspan TM4SF; A15
                     homolog; tetraspanin TM4-D; putative NF-kappa-B-activating
                     protein 321"
                     /codon_start=1
                     /product="tetraspanin-6 isoform a"
                     /protein_id="NP_003261.1"
                     /db_xref="CCDS:CCDS14470.1"
                     /db_xref="GeneID:7105"
                     /db_xref="HGNC:HGNC:11858"
                     /db_xref="MIM:300191"
                     /translation="MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKV
                     SLENYFSLLNEKATNVPFVLIATGTVIILLGTFGCFATCRASAWMLKLYAMFLTLVFL
                     VELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYR
                     DWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFG
                     VACFQLIGIFLAYCLSRAITNNQYEIV"
     exon            200..388
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            389..463
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            464..562
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            563..697
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            698..781
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            782..889
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            890..3768
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1164..1169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="hexamer: AGTAAA"
     polyA_site      1184
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
     regulatory      1827..1832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="hexamer: AATAAA"
     polyA_site      1851
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="major polyA site"
     regulatory      2132..2137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="hexamer: ATTAAA"
     polyA_site      2161
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
     regulatory      3747..3752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="hexamer: AATAAA"
     polyA_site      3768
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
ORIGIN      
        1 agttgtggac gctcgtaagt tttcggcagt ttccggggag actcggggac tccgcgtctc
       61 gctctctgtg ttccaatcgc ccggtgcggt ggtgcagggt ctcgggctag tcatggcgtc
      121 cccgtctcgg agactgcaga ctaaaccagt cattacttgt ttcaagagcg ttctgctaat
      181 ctacactttt attttctgga tcactggcgt tatccttctt gcagttggca tttggggcaa
      241 ggtgagcctg gagaattact tttctctttt aaatgagaag gccaccaatg tccccttcgt
      301 gctcattgct actggtaccg tcattattct tttgggcacc tttggttgtt ttgctacctg
      361 ccgagcttct gcatggatgc taaaactgta tgcaatgttt ctgactctcg tttttttggt
      421 cgaactggtc gctgccatcg taggatttgt tttcagacat gagattaaga acagctttaa
      481 gaataattat gagaaggctt tgaagcagta taactctaca ggagattata gaagccatgc
      541 agtagacaag atccaaaata cgttgcattg ttgtggtgtc accgattata gagattggac
      601 agatactaat tattactcag aaaaaggatt tcctaagagt tgctgtaaac ttgaagattg
      661 tactccacag agagatgcag acaaagtaaa caatgaaggt tgttttataa aggtgatgac
      721 cattatagag tcagaaatgg gagtcgttgc aggaatttcc tttggagttg cttgcttcca
      781 actgattgga atctttctcg cctactgcct ctctcgtgcc ataacaaata accagtatga
      841 gatagtgtaa cccaatgtat ctgtgggcct attcctctct acctttaagg acatttaggg
      901 tcccccctgt gaattagaaa gttgcttggc tggagaactg acaacactac ttactgatag
      961 accaaaaaac tacaccagta ggttgattca atcaagatgt atgtagacct aaaactacac
     1021 caataggctg attcaatcaa gatccgtgct cgcagtgggc tgattcaatc aagatgtatg
     1081 tttgctatgt tctaagtcca ccttctatcc cattcatgtt agatcgttga aaccctgtat
     1141 ccctctgaaa cactggaaga gctagtaaat tgtaaatgaa gtaatactgt gttcctcttg
     1201 actgttattt ttcttagtag ggggcctttg gaaggcactg tgaatttgct attttgatgt
     1261 agtgttacaa gatggaaaat tgattcctct gactttgcta ttgatgtagt gtgatagaaa
     1321 attcacccct ctgaactggc tccttcccag tcaaggttat ctggtttgat tgtataattt
     1381 gcaccaagaa gttaaaatgt tttatgactc tctgttctgc tgacaggcag agagtcacat
     1441 tgtgtaattt aatttcagtc agtcaataga tggcatccct catcagggtt gccagatggt
     1501 gataacagtg taaggccttg ggtctaaggc atccacgact ggaagggact actgatgttc
     1561 tgtgatacat caggtttcag cacacaactt acatttcttt gcctccaaat tgaggcattt
     1621 attatgatgt tcatactttc cctcttgttt gaaagtttct aattattaaa tggtgtcgga
     1681 attgttgtat tttccttagg aattcagtgg aacttatctt cattaaattt agctggtacc
     1741 aggttgatat gacttgtcaa tattatggtc aactttaagt cttagttttc gtttgtgcct
     1801 ttgattaata agtataactc ttatacaata aatactgctt tcctctaaaa agatcgtgtt
     1861 taaattaact tgtagaaaat ctgctggaat ggttgttgtt ttccactgag aaagctaagc
     1921 cctacatttc tattcagagt actgttttta gatgtgaaat ataagcctgc ggccttaact
     1981 ctgtattaaa aaaaatgttt ttgtttaaaa aaaactgttc ccataggtgc agcaaaccac
     2041 catggcacat gtatacctat gtaacaaacc tgcacattct gcacatgtat cccagaactt
     2101 aatgtaaaca aaaaaatctt aaagtgcaaa tattaaaaaa aactgttctc tgtgaaaaaa
     2161 attatattcc atgttataaa gtagcatatg actagtgttc tcctagagat cagacttttt
     2221 tgattgtata gtttgcatta aaaagttgta cagggaggga tgtaacctgt atcttcagga
     2281 taatagggaa attaataagg aaaataataa ttactaaaat ttgagttgaa gtcagggaat
     2341 tatttctttg gttttgagtc tctttataca tccattagta gaacctgtct agtctgattg
     2401 ccacagtcct tgaattgatg gtaaggggga gtcagttaca gttagaaaaa aacctgggca
     2461 aaaactacta gttaaatgat catgaatttt gagtatgtgt tttaaaatgc ttggagttat
     2521 tgcagaaaaa tgatattctc cattagaaca tttgatgtgt gacttttgac ataggataag
     2581 gtgataagaa aattaagttg aaaaatagtg actcaagtac agcaaatcag atttttggct
     2641 actgagatta aagaagcaaa tatttaaagg attatcagca attttcaaat acatattttt
     2701 cactgcagtg gttttgaaga atgttttaag gttatattta gagtttttaa aaaagttttc
     2761 cctcagccag ccatggtggc tcacatctgt aatcccagca ctttgagagg ctgaggcggg
     2821 cggatcacct gaggtcagga gttctagacc agcctggcca acatggtaaa acaccgtctc
     2881 taataaaaat gcaaaaatta gctgggtgtg gtggcaagca cctgtaatcc cagctacttg
     2941 ggagactgag gcaggagaat cacttgaatc caggagtcag aggttgcagt gagccgagat
     3001 cacaccactg cactccagcc tgggcgataa gagtgaacct gcatctcaga aaaaaaaaaa
     3061 aagttttccc tcattattaa aaaggaaaaa ttatagaaaa ttaaaatata gaatgtagaa
     3121 agaggaaaaa caccacacat cactcgtcag gtggattggt ttgtttattt ttaagatggg
     3181 tttattttgg atagccagtt agaaaacgcc cttatagctg atgtgtgctt gtgcatactg
     3241 aattgtatac ttaattctga aagtaatgag gaaacatttc acctaatgat aactggtaca
     3301 aaggaaagtt cacgtgtctt taatagtttg ctaattagac tagctggtta gaaagaggga
     3361 tcactagatt ggagagagag atccagtttc cactggaggc agtaggtctg ctcatttcca
     3421 tggtgacaat cctaatggca gagggagtga gtttccctta gtggcacagg ctgggggttt
     3481 tgagctttta agttttgttt tatagaaatc tggagaattt tacattttac ttcactatat
     3541 atctatgttt aaaataattc atttttgatg tcccaaaatt gatgtgggtt gccttatttc
     3601 caggcaccag gttgctcact gcaaggtgac attttgagaa gcagaaatct ctaggtatat
     3661 cttaagtgtg aaaagcttgt tagatttcca tggcctattc caggtgggtt gttgggttta
     3721 tgttgtaagc atcaaacttt tgtggaaata aatacctaat acaaggta
//
