LOCUS       NM_001278743            3811 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tetraspanin 6 (TSPAN6), transcript variant 5, mRNA.
ACCESSION   NM_001278743
VERSION     NM_001278743.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3811)
  AUTHORS   Mrozowska,M., Gornicki,T., Olbromski,M., Partynska,A.I.,
            Dziegiel,P. and Rusak,A.
  TITLE     New insights into the role of tetraspanin 6, 7, and 8 in physiology
            and pathology
  JOURNAL   Cancer Med 13 (14), e7390 (2024)
   PUBMED   39031113
  REMARK    GeneRIF: New insights into the role of tetraspanin 6, 7, and 8 in
            physiology and pathology.
            Review article
REFERENCE   2  (bases 1 to 3811)
  AUTHORS   Zhang,C., Du,F.H., Wang,R.X., Han,W.B., Lv,X., Zeng,L.H. and
            Chen,G.Q.
  TITLE     TSPAN6 reinforces the malignant progression of glioblastoma via
            interacting with CDK5RAP3 and regulating STAT3 signaling pathway
  JOURNAL   Int J Biol Sci 20 (7), 2440-2453 (2024)
   PUBMED   38725860
  REMARK    GeneRIF: TSPAN6 reinforces the malignant progression of
            glioblastoma via interacting with CDK5RAP3 and regulating STAT3
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3811)
  AUTHORS   Humbert,P.O., Pryjda,T.Z., Pranjic,B., Farrell,A., Fujikura,K., de
            Matos Simoes,R., Karim,R., Kozieradzki,I., Cronin,S.J.F.,
            Neely,G.G., Meyer,T.F., Hagelkruys,A., Richardson,H.E. and
            Penninger,J.M.
  TITLE     TSPAN6 is a suppressor of Ras-driven cancer
  JOURNAL   Oncogene 41 (14), 2095-2105 (2022)
   PUBMED   35184157
  REMARK    GeneRIF: TSPAN6 is a suppressor of Ras-driven cancer.
            Erratum:[Oncogene. 2022 Apr;41(14):2138. doi:
            10.1038/s41388-022-02265-2.. PMID: 35292775]
REFERENCE   4  (bases 1 to 3811)
  AUTHORS   Andrijes,R., Hejmadi,R.K., Pugh,M., Rajesh,S., Novitskaya,V.,
            Ibrahim,M., Overduin,M., Tselepis,C., Middleton,G.W., Gyorffy,B.,
            Beggs,A.D. and Berditchevski,F.
  TITLE     Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer
  JOURNAL   Proc Natl Acad Sci U S A 118 (39) (2021)
   PUBMED   34521767
  REMARK    GeneRIF: Tetraspanin 6 is a regulator of carcinogenesis in
            colorectal cancer.
REFERENCE   5  (bases 1 to 3811)
  AUTHORS   Wang,Y., Tong,X., Omoregie,E.S., Liu,W., Meng,S. and Ye,X.
  TITLE     Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible
            gene I-like receptor-mediated immune signaling in a
            ubiquitination-dependent manner
  JOURNAL   J Biol Chem 287 (41), 34626-34634 (2012)
   PUBMED   22908223
  REMARK    GeneRIF: TSPAN6 functions as a negative regulator of the RLR
            pathway by interacting with MAVS in a ubiquitination-dependent
            manner.
REFERENCE   6  (bases 1 to 3811)
  AUTHORS   Yunta,M. and Lazo,P.A.
  TITLE     Tetraspanin proteins as organisers of membrane microdomains and
            signalling complexes
  JOURNAL   Cell Signal 15 (6), 559-564 (2003)
   PUBMED   12681443
  REMARK    Review article
REFERENCE   7  (bases 1 to 3811)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   8  (bases 1 to 3811)
  AUTHORS   Maeda,K., Matsuhashi,S., Hori,K., Xin,Z., Mukai,T., Tabuchi,K.,
            Egashira,M. and Niikawa,N.
  TITLE     Cloning and characterization of a novel human gene, TM4SF6,
            encoding a protein belonging to the transmembrane 4 superfamily,
            and mapped to Xq22
  JOURNAL   Genomics 52 (2), 240-242 (1998)
   PUBMED   9782095
REFERENCE   9  (bases 1 to 3811)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
REFERENCE   10 (bases 1 to 3811)
  AUTHORS   Maecker,H.T., Todd,S.C. and Levy,S.
  TITLE     The tetraspanin superfamily: molecular facilitators
  JOURNAL   FASEB J 11 (6), 428-442 (1997)
   PUBMED   9194523
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI458635.1, DA038474.1,
            AB097016.1, AL035608.11 and N64145.1.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            The protein encoded by this gene is a cell surface glycoprotein and
            is highly similar in sequence to the transmembrane 4 superfamily
            member 2 protein. It functions as a negative regulator of retinoic
            acid-inducible gene I-like receptor-mediated immune signaling via
            its interaction with the mitochondrial antiviral signaling-centered
            signalosome. This gene uses alternative polyadenylation sites, and
            multiple transcript variants result from alternative splicing.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (5) differs in its 5' UTR, lacks a
            portion of the 5' coding region, uses a downstream in-frame start
            codon, and lacks an alternate in-frame exon in the 3' coding
            region, compared to variant 1. The encoded isoform (d) is shorter
            at the N-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: DA038474.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               BI458635.1         53-315
            264-425             DA038474.1         1-162
            426-819             DA038474.1         164-557
            820-1875            AB097016.1         738-1793
            1876-3631           AL035608.11        72433-74188         c
            3632-3811           N64145.1           1-180               c
FEATURES             Location/Qualifiers
     source          1..3811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..3811
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="tetraspanin 6"
                     /db_xref="GeneID:7105"
                     /db_xref="HGNC:HGNC:11858"
                     /db_xref="MIM:300191"
     exon            1..312
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            313..501
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..879
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="isoform d is encoded by transcript variant 5;
                     transmembrane 4 superfamily member 6; tetraspan TM4SF; A15
                     homolog; tetraspanin TM4-D; putative NF-kappa-B-activating
                     protein 321"
                     /codon_start=1
                     /product="tetraspanin-6 isoform d"
                     /protein_id="NP_001265672.1"
                     /db_xref="CCDS:CCDS76001.1"
                     /db_xref="GeneID:7105"
                     /db_xref="HGNC:HGNC:11858"
                     /db_xref="MIM:300191"
                     /translation="MLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQ
                     YNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDAD
                     KVNNELIGIFLAYCLSRAITNNQYEIV"
     exon            502..576
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            577..675
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            676..810
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            811..918
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     exon            919..3797
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1193..1198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="hexamer: AGTAAA"
     polyA_site      1213
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="hexamer: AATAAA"
     polyA_site      1880
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="major polyA site"
     regulatory      2161..2166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="hexamer: ATTAAA"
     polyA_site      2190
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
     regulatory      3776..3781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
                     /note="hexamer: AATAAA"
     polyA_site      3797
                     /gene="TSPAN6"
                     /gene_synonym="T245; TM4SF6; TSPAN-6"
ORIGIN      
        1 ggcaccaggg gccagggagg cccaatctca gagcgctgcg ggctctgctg gtgatagaaa
       61 caatatggtg aagttataag gagaggggag gggtgggggg cgggaaagat tccttaggat
      121 agaaaaaaaa caatgaagaa agctccactt gaagacctat gaaatttccg acactagaac
      181 ctttgtatat agttttcggt aaccttcggc agggggcgct ctgaaattgt tgccactttc
      241 cggacagcct cccatacttt accctctaca aaattgtaca gtgtttccgg cccttctcag
      301 ttgtggacgc tcatcactgg cgttatcctt cttgcagttg gcatttgggg caaggtgagc
      361 ctggagaatt acttttctct tttaaatgag aaggccacca atgtcccctt cgtgctcatt
      421 gctactggta ccgtcattat tcttttgggc acctttggtt gttttgctac ctgccgagct
      481 tctgcatgga tgctaaaact gtatgcaatg tttctgactc tcgttttttt ggtcgaactg
      541 gtcgctgcca tcgtaggatt tgttttcaga catgagatta agaacagctt taagaataat
      601 tatgagaagg ctttgaagca gtataactct acaggagatt atagaagcca tgcagtagac
      661 aagatccaaa atacgttgca ttgttgtggt gtcaccgatt atagagattg gacagatact
      721 aattattact cagaaaaagg atttcctaag agttgctgta aacttgaaga ttgtactcca
      781 cagagagatg cagacaaagt aaacaatgaa ctgattggaa tctttctcgc ctactgcctc
      841 tctcgtgcca taacaaataa ccagtatgag atagtgtaac ccaatgtatc tgtgggccta
      901 ttcctctcta cctttaagga catttagggt cccccctgtg aattagaaag ttgcttggct
      961 ggagaactga caacactact tactgataga ccaaaaaact acaccagtag gttgattcaa
     1021 tcaagatgta tgtagaccta aaactacacc aataggctga ttcaatcaag atccgtgctc
     1081 gcagtgggct gattcaatca agatgtatgt ttgctatgtt ctaagtccac cttctatccc
     1141 attcatgtta gatcgttgaa accctgtatc cctctgaaac actggaagag ctagtaaatt
     1201 gtaaatgaag taatactgtg ttcctcttga ctgttatttt tcttagtagg gggcctttgg
     1261 aaggcactgt gaatttgcta ttttgatgta gtgttacaag atggaaaatt gattcctctg
     1321 actttgctat tgatgtagtg tgatagaaaa ttcacccctc tgaactggct ccttcccagt
     1381 caaggttatc tggtttgatt gtataatttg caccaagaag ttaaaatgtt ttatgactct
     1441 ctgttctgct gacaggcaga gagtcacatt gtgtaattta atttcagtca gtcaatagat
     1501 ggcatccctc atcagggttg ccagatggtg ataacagtgt aaggccttgg gtctaaggca
     1561 tccacgactg gaagggacta ctgatgttct gtgatacatc aggtttcagc acacaactta
     1621 catttctttg cctccaaatt gaggcattta ttatgatgtt catactttcc ctcttgtttg
     1681 aaagtttcta attattaaat ggtgtcggaa ttgttgtatt ttccttagga attcagtgga
     1741 acttatcttc attaaattta gctggtacca ggttgatatg acttgtcaat attatggtca
     1801 actttaagtc ttagttttcg tttgtgcctt tgattaataa gtataactct tatacaataa
     1861 atactgcttt cctctaaaaa gatcgtgttt aaattaactt gtagaaaatc tgctggaatg
     1921 gttgttgttt tccactgaga aagctaagcc ctacatttct attcagagta ctgtttttag
     1981 atgtgaaata taagcctgcg gccttaactc tgtattaaaa aaaatgtttt tgtttaaaaa
     2041 aaactgttcc cataggtgca gcaaaccacc atggcacatg tatacctatg taacaaacct
     2101 gcacattctg cacatgtatc ccagaactta atgtaaacaa aaaaatctta aagtgcaaat
     2161 attaaaaaaa actgttctct gtgaaaaaaa ttatattcca tgttataaag tagcatatga
     2221 ctagtgttct cctagagatc agactttttt gattgtatag tttgcattaa aaagttgtac
     2281 agggagggat gtaacctgta tcttcaggat aatagggaaa ttaataagga aaataataat
     2341 tactaaaatt tgagttgaag tcagggaatt atttctttgg ttttgagtct ctttatacat
     2401 ccattagtag aacctgtcta gtctgattgc cacagtcctt gaattgatgg taagggggag
     2461 tcagttacag ttagaaaaaa acctgggcaa aaactactag ttaaatgatc atgaattttg
     2521 agtatgtgtt ttaaaatgct tggagttatt gcagaaaaat gatattctcc attagaacat
     2581 ttgatgtgtg acttttgaca taggataagg tgataagaaa attaagttga aaaatagtga
     2641 ctcaagtaca gcaaatcaga tttttggcta ctgagattaa agaagcaaat atttaaagga
     2701 ttatcagcaa ttttcaaata catatttttc actgcagtgg ttttgaagaa tgttttaagg
     2761 ttatatttag agtttttaaa aaagttttcc ctcagccagc catggtggct cacatctgta
     2821 atcccagcac tttgagaggc tgaggcgggc ggatcacctg aggtcaggag ttctagacca
     2881 gcctggccaa catggtaaaa caccgtctct aataaaaatg caaaaattag ctgggtgtgg
     2941 tggcaagcac ctgtaatccc agctacttgg gagactgagg caggagaatc acttgaatcc
     3001 aggagtcaga ggttgcagtg agccgagatc acaccactgc actccagcct gggcgataag
     3061 agtgaacctg catctcagaa aaaaaaaaaa agttttccct cattattaaa aaggaaaaat
     3121 tatagaaaat taaaatatag aatgtagaaa gaggaaaaac accacacatc actcgtcagg
     3181 tggattggtt tgtttatttt taagatgggt ttattttgga tagccagtta gaaaacgccc
     3241 ttatagctga tgtgtgcttg tgcatactga attgtatact taattctgaa agtaatgagg
     3301 aaacatttca cctaatgata actggtacaa aggaaagttc acgtgtcttt aatagtttgc
     3361 taattagact agctggttag aaagagggat cactagattg gagagagaga tccagtttcc
     3421 actggaggca gtaggtctgc tcatttccat ggtgacaatc ctaatggcag agggagtgag
     3481 tttcccttag tggcacaggc tgggggtttt gagcttttaa gttttgtttt atagaaatct
     3541 ggagaatttt acattttact tcactatata tctatgttta aaataattca tttttgatgt
     3601 cccaaaattg atgtgggttg ccttatttcc aggcaccagg ttgctcactg caaggtgaca
     3661 ttttgagaag cagaaatctc taggtatatc ttaagtgtga aaagcttgtt agatttccat
     3721 ggcctattcc aggtgggttg ttgggtttat gttgtaagca tcaaactttt gtggaaataa
     3781 atacctaata caaggtaaaa aaaaaaaaaa a
//
