LOCUS       NM_005723               3347 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tetraspanin 5 (TSPAN5), mRNA.
ACCESSION   NM_005723
VERSION     NM_005723.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3347)
  AUTHORS   Wei,S., Gao,T., Wu,Y., Wang,G., Chen,Y., Tao,X., Liang,Y., Zhou,Z.,
            Sun,L., Liu,M., Li,H. and Bao,Y.
  TITLE     The relationship between expression of Tspan5 mRNA in
            maternal-fetal interface and tubal pregnancy
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 296, 91-98 (2024)
   PUBMED   38422804
  REMARK    GeneRIF: The relationship between expression of Tspan5 mRNA in
            maternal-fetal interface and tubal pregnancy.
REFERENCE   2  (bases 1 to 3347)
  AUTHORS   Xie,Q., Guo,H., He,P., Deng,H., Gao,Y., Dong,N., Niu,W., Liu,T.,
            Li,M., Wang,S., Wu,Y. and Li,J.L.
  TITLE     Tspan5 promotes epithelial-mesenchymal transition and tumour
            metastasis of hepatocellular carcinoma by activating Notch
            signalling
  JOURNAL   Mol Oncol 15 (11), 3184-3202 (2021)
   PUBMED   33955149
  REMARK    GeneRIF: Tspan5 promotes epithelial-mesenchymal transition and
            tumour metastasis of hepatocellular carcinoma by activating Notch
            signalling.
REFERENCE   3  (bases 1 to 3347)
  AUTHORS   Ho,M.F., Zhang,C., Zhang,L., Wei,L., Zhou,Y., Moon,I., Geske,J.R.,
            Choi,D.S., Biernacka,J., Frye,M., Wen,Z., Karpyak,V.M., Li,H. and
            Weinshilboum,R.
  TITLE     TSPAN5 influences serotonin and kynurenine: pharmacogenomic
            mechanisms related to alcohol use disorder and acamprosate
            treatment response
  JOURNAL   Mol Psychiatry 26 (7), 3122-3133 (2021)
   PUBMED   32753686
  REMARK    GeneRIF: TSPAN5 influences serotonin and kynurenine:
            pharmacogenomic mechanisms related to alcohol use disorder and
            acamprosate treatment response.
REFERENCE   4  (bases 1 to 3347)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3347)
  AUTHORS   Yang,L.W., Wu,X.J., Liang,Y., Ye,G.Q., Che,Y.C., Wu,X.Z., Zhu,X.J.,
            Fan,H.L., Fan,X.P. and Xu,J.F.
  TITLE     miR-155 increases stemness and decitabine resistance in
            triple-negative breast cancer cells by inhibiting TSPAN5
  JOURNAL   Mol Carcinog 59 (4), 447-461 (2020)
   PUBMED   32096299
  REMARK    GeneRIF: Data show that gene tetraspanin-5 (TSPAN5) is the target
            of miR-155 in breast cancer (BC).
REFERENCE   6  (bases 1 to 3347)
  AUTHORS   Jouannet,S., Saint-Pol,J., Fernandez,L., Nguyen,V., Charrin,S.,
            Boucheix,C., Brou,C., Milhiet,P.E. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins differentially regulate the cleavage of ADAM10
            substrates, Notch activation and ADAM10 membrane
            compartmentalization
  JOURNAL   Cell Mol Life Sci 73 (9), 1895-1915 (2016)
   PUBMED   26686862
REFERENCE   7  (bases 1 to 3347)
  AUTHORS   Dornier,E., Coumailleau,F., Ottavi,J.F., Moretti,J., Boucheix,C.,
            Mauduit,P., Schweisguth,F. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and
            promote Notch activation in flies and mammals
  JOURNAL   J Cell Biol 199 (3), 481-496 (2012)
   PUBMED   23091066
  REMARK    Erratum:[J Cell Biol. 2016 May 23;213(4):495-6. doi:
            10.1083/jcb.20120113304262016c.. PMID: 27185832]
REFERENCE   8  (bases 1 to 3347)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   9  (bases 1 to 3347)
  AUTHORS   Serru,V., Dessen,P., Boucheix,C. and Rubinstein,E.
  TITLE     Sequence and expression of seven new tetraspans
  JOURNAL   Biochim Biophys Acta 1478 (1), 159-163 (2000)
   PUBMED   10719184
REFERENCE   10 (bases 1 to 3347)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114811.3, BC009704.1,
            AC058823.4 and AI089708.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005723.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.877177.1,
                                           SRR1803617.220334.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305798.8/ ENSP00000307701.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC114811.3         3634-3685           c
            53-1459             BC009704.1         1-1407
            1460-2891           AC058823.4         137964-139395       c
            2892-3347           AI089708.1         10-465              c
FEATURES             Location/Qualifiers
     source          1..3347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..3347
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /note="tetraspanin 5"
                     /db_xref="GeneID:10098"
                     /db_xref="HGNC:HGNC:17753"
                     /db_xref="MIM:613136"
     exon            1..466
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1192
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /note="transmembrane 4 superfamily member 9; tetraspan
                     TM4SF; tetraspan NET-4; transmembrane 4 superfamily,
                     member 8"
                     /codon_start=1
                     /product="tetraspanin-5"
                     /protein_id="NP_005714.2"
                     /db_xref="CCDS:CCDS3646.1"
                     /db_xref="GeneID:10098"
                     /db_xref="HGNC:HGNC:17753"
                     /db_xref="MIM:613136"
                     /translation="MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEK
                     GVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIF
                     FLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGAD
                     DWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYT
                     KGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW"
     exon            467..517
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /inference="alignment:Splign:2.1.0"
     exon            518..664
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /inference="alignment:Splign:2.1.0"
     exon            665..835
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /inference="alignment:Splign:2.1.0"
     exon            836..961
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1009
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1126
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..3347
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3311..3316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /note="hexamer: AATAAA"
     polyA_site      3347
                     /gene="TSPAN5"
                     /gene_synonym="NET-4; NET4; TM4SF9; TSPAN-5"
                     /note="major polyA site"
ORIGIN      
        1 aagcgagcgg cgtctccacc agcatctgcc gcggccgcct ttgcccgaag cccggggacg
       61 aaccgacgga ccgaccgcct ggcgcacgga cgcgggcgct cgctttgtgt tcggggctag
      121 cgtcggcgag gcttgagctt gcagcgcgcg gcttccctgc tttctcgcgg ccaccccggc
      181 tccggcggcc tcggcgcgcg aggggctgga ggtgcgggag ccgctctccg ccggtcggtc
      241 cccgcgcggc tgagcccagg ccgccagcgc cgcggccccg tgcggtgtcc ctgagctcct
      301 gctccccgcc gggctgctcc gagcaacggt gcttcggagc tccaaactcg ggctgccggg
      361 gcaagtgtct tcatgaaccc agaggatgtc cgggaagcac tacaagggtc ctgaagtcag
      421 ttgttgcatc aaatacttca tatttggctt caatgtcata ttttggtttt tgggaataac
      481 atttcttgga attggactgt gggcatggaa tgaaaaagga gttctgtcca acatctcttc
      541 catcaccgat ctcggcggct ttgacccagt ttggctcttc cttgtggtgg gaggagtgat
      601 gttcattttg ggatttgcag ggtgcattgg agcgctacgg gaaaacactt tccttctcaa
      661 gtttttttct gtgttcctgg gaattatttt cttcctggag ctcactgccg gagttctagc
      721 atttgttttc aaagactgga tcaaagacca gctgtatttc tttataaaca acaacatcag
      781 agcatatcgg gatgacattg atttgcaaaa cctcatagac ttcacccagg aatattggca
      841 gtgctgtggg gcttttggag ctgatgattg gaacctaaat atttacttca attgcacaga
      901 ttccaatgca agtcgagagc gatgtggcgt tccattctcc tgctgcacta aagatcccgc
      961 agaagatgtc atcaacactc agtgtggcta tgatgccagg caaaaaccag aagttgacca
     1021 gcagattgta atctacacga aaggctgtgt gccccagttt gagaagtggt tgcaggacaa
     1081 tttaaccatc gttgctggta ttttcatagg cattgcattg ctgcagatat ttgggatatg
     1141 cctggcccag aatttggtta gcgatatcga agctgtcagg gcgagctggt agaccccctg
     1201 caaccgctgc tgcaagacac tggacagacc cagctttcgg gaccctcccg cgtgccgaac
     1261 tgatcttcga gctgcatgga cctaatcaca gatgcagcct gcagtctcgc ctaatggagc
     1321 tgccattagg ggagtgtaaa actgggaaat gctgctcact gacagaatta aaaaaaaaaa
     1381 taaccagtat gaaagtcgtt gcgccgtgaa tctctactgt agccatgaat ttatggacag
     1441 ttagatgctt accaaaaaag aaaaaaaggg agggtagggg acccagatgt acttgaatgt
     1501 gcagaaaata cattcttgtc ctcatcttcc gtaattggag ggctgggaga ggcagctttg
     1561 ctcttcacca caccttggac ggaccacctt ctttctgttc catggcctga aggagtgcat
     1621 ctcctcaaag actcagcccc tcacctggga gggcagtggt ttgtgggcat ccctccatgt
     1681 acattttagg aaacacttgc aactctcatc tgaagaagaa aacaactcat ctttgggttc
     1741 agattttgtg atggtattca gcaagtcact tgggcgagca cacttggtct atcctggaaa
     1801 gtctccttat aagagaagtt gtgtatttca tgtgcaccga gcaagggcat tggaagacgt
     1861 catgaggctg tattttagca ggactgatcg tttttctaag tagacctgag ctttgtttat
     1921 cagtgaaatt caaggagaaa atgaggttaa tgaagaggta tcagttaaat atccccttct
     1981 tctcaccctg ccaaaattag cagttggatt tttggaaact ctggaatatt ctgggtcatt
     2041 ttgttttgta tgtttgttgt ttttcgtctt ccaaaggtga aagctatgat acagttccac
     2101 ttaaatttta gtgttttctt actcagctca agcattaatt tttgattaag tcttaatctg
     2161 catgacctgt gaatctgaat ccatcatctc cctttcctgc cagcttttct acaaacattg
     2221 aaatatgtta tttggtcagc acttatttcc taggttcaca gccttgggag gttgtggcat
     2281 gtcctcccag tctggctggg aagagaccag ctgtaccatc caaatgcttc cctggtcttg
     2341 atgatctctt ccagagtcga tctgagtggc cttttctgca ccctcccctt ctttctcttt
     2401 gaatggaatt aaacccaatt tggaaacaac attgacccag tcaaaagctt ctaatggttt
     2461 ctttttcttc ctccagtttt agtttgcttt tattaaaaaa agaaaatagt gcatggccat
     2521 agctccttca gttctcttat tgcagactaa ccatcaggat ggtatcaaag cacaaatact
     2581 ttggagggga atgcgttgaa ctggggcaag tactctgtaa cacaaagtgg gaaaccactt
     2641 cctggtgctg ccgctcctgc ccccacttta ggtgggaggg acgagttttg ccctctagat
     2701 tttaatccag ctggtgtcca ccggatgttg ccctcctggg gagcagatat cagtctgtgg
     2761 aactctggga aaaccacagg cacatttttc ggtgcggaca gatttgccag cacataactg
     2821 ggcagccagc tagaatactt tgtggaaatt aagcgaggtt ttccatttca gccccatggt
     2881 gcatggtggt ggccgatgaa tgtgtcagtc tgctcagaga aaggacaaaa aggaaattat
     2941 tttcaaaact gtgttcactg tttgggtgtg tgtatggctc tgcatgtgtg tgtttttgtc
     3001 tctgtatagg tagaggtatt cacatcttac tccgactgta aggttgtctt acttcatctc
     3061 tgcccccacc acagttgcca ttttgtaatg tccttccaac atggagaaga cacgagctct
     3121 ctccagttgg catcatttgt cttttttgtt gattgcctca ttctccagtg aactccatct
     3181 ggccaattga ttcagaatca ggcaagatcc ctgccctttg gcacatccac tgaaaggcca
     3241 aacagcaagt ccgagtgagt tttaaatatt aattaatcac cctttatttt ttacacttga
     3301 gagtgattgt aataaaggct gtcattaata aacttggttc tacctta
//
