LOCUS       NM_003271               1379 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tetraspanin 4 (TSPAN4), transcript variant 5, mRNA.
ACCESSION   NM_003271
VERSION     NM_003271.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Zheng,Y., Lang,Y., Qi,B. and Li,T.
  TITLE     TSPAN4 and migrasomes in atherosclerosis regression correlated to
            myocardial infarction and pan-cancer progression
  JOURNAL   Cell Adh Migr 17 (1), 14-19 (2023)
   PUBMED   36513632
  REMARK    GeneRIF: TSPAN4 and migrasomes in atherosclerosis regression
            correlated to myocardial infarction and pan-cancer progression.
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Pitsava,G., Feldkamp,M.L., Pankratz,N., Lane,J., Kay,D.M.,
            Conway,K.M., Shaw,G.M., Reefhuis,J., Jenkins,M.M., Almli,L.M.,
            Olshan,A.F., Pangilinan,F., Brody,L.C., Sicko,R.J., Hobbs,C.A.,
            Bamshad,M., McGoldrick,D., Nickerson,D.A., Finnell,R.H.,
            Mullikin,J., Romitti,P.A. and Mills,J.L.
  CONSRTM   University of Washington Center for Mendelian Genomics, NISC
            Comparative Sequencing Program and the National Birth Defects
            Prevention Study
  TITLE     Exome sequencing of child-parent trios with bladder exstrophy:
            Findings in 26 children
  JOURNAL   Am J Med Genet A 185 (10), 3028-3041 (2021)
   PUBMED   34355505
  REMARK    GeneRIF: Exome sequencing of child-parent trios with bladder
            exstrophy: Findings in 26 children.
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Ma,X., Verweij,E.W.E., Siderius,M., Leurs,R. and Vischer,H.F.
  TITLE     Identification of TSPAN4 as Novel Histamine H4 Receptor Interactor
  JOURNAL   Biomolecules 11 (8), 1127 (2021)
   PUBMED   34439793
  REMARK    GeneRIF: Identification of TSPAN4 as Novel Histamine H4 Receptor
            Interactor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Yauch,R.L., Kazarov,A.R., Desai,B., Lee,R.T. and Hemler,M.E.
  TITLE     Direct extracellular contact between integrin alpha(3)beta(1) and
            TM4SF protein CD151
  JOURNAL   J Biol Chem 275 (13), 9230-9238 (2000)
   PUBMED   10734060
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Lozahic,S., Christiansen,D., Manie,S., Gerlier,D., Billard,M.,
            Boucheix,C. and Rubinstein,E.
  TITLE     CD46 (membrane cofactor protein) associates with multiple beta1
            integrins and tetraspans
  JOURNAL   Eur J Immunol 30 (3), 900-907 (2000)
   PUBMED   10741407
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Serru,V., Le Naour,F., Billard,M., Azorsa,D.O., Lanza,F.,
            Boucheix,C. and Rubinstein,E.
  TITLE     Selective tetraspan-integrin complexes (CD81/alpha4beta1,
            CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting
            tetraspan interactions
  JOURNAL   Biochem J 340 (Pt 1) (Pt 1), 103-111 (1999)
   PUBMED   10229664
REFERENCE   9  (bases 1 to 1379)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
REFERENCE   10 (bases 1 to 1379)
  AUTHORS   Tachibana,I., Bodorova,J., Berditchevski,F., Zutter,M.M. and
            Hemler,M.E.
  TITLE     NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that
            complexes with integrins and other TM4SF proteins
  JOURNAL   J Biol Chem 272 (46), 29181-29189 (1997)
   PUBMED   9360996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM755435.1, BC000389.2 and
            BM555783.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003271.4.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface glycoprotein and is similar
            in sequence to its family member CD53 antigen. It is known to
            complex with integrins and other transmembrane 4 superfamily
            proteins. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.838167.1,
                                           SRR3476690.185802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397397.7/ ENSP00000380552.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               BM755435.1         29-366
            339-346             BC000389.2         293-300
            347-377             BM555783.1         385-415
            378-1379            BC000389.2         332-1333
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1379
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /note="tetraspanin 4"
                     /db_xref="GeneID:7106"
                     /db_xref="HGNC:HGNC:11859"
                     /db_xref="MIM:602644"
     exon            1..64
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            65..164
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            165..244
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..898
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /note="isoform a is encoded by transcript variant 5;
                     transmembrane 4 superfamily member 7; tetraspan TM4SF;
                     novel antigen 2"
                     /codon_start=1
                     /product="tetraspanin-4 isoform a"
                     /protein_id="NP_003262.1"
                     /db_xref="CCDS:CCDS7721.1"
                     /db_xref="GeneID:7106"
                     /db_xref="HGNC:HGNC:11859"
                     /db_xref="MIM:602644"
                     /translation="MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATL
                     SSSFPSLSAANLLIITGAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAI
                     LFFAYTDKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVY
                     NATRVPDSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQIL
                     GLTFAMTMYCQVVKADTYCA"
     exon            245..436
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            437..511
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            512..613
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            614..745
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            746..829
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1379
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1361..1366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /note="major polyA site"
ORIGIN      
        1 gtgtccgctt gactgacagc tgcgcggcgg gagcgggcgg cgcgagcggg aggcggcggc
       61 gcagagcttg gggcttcctt ggtcgcaccc accacctgcc tgcccactgg tcagccttca
      121 gggaccctga gcaccgcctg gtctctttcc tgtggccagc ccagaactga agcgctgcgg
      181 catggcgcgc gcctgcctcc aggccgtcaa gtacctcatg ttcgccttca acctgctctt
      241 ctggctggga ggctgtggcg tgctgggtgt cggcatctgg ctggccgcca cacaggggag
      301 cttcgccacg ctgtcctctt ccttcccgtc cctgtcggct gccaacttgc tcatcatcac
      361 cggcgccttt gtcatggcca tcggcttcgt gggctgcctg ggtgccatca aggagaacaa
      421 gtgcctcctg ctcactttct tcctgctgct gctgctggtg ttcctgctgg aggccaccat
      481 cgccatcctc ttcttcgcct acacggacaa gattgacagg tatgcccagc aagacctgaa
      541 gaaaggcttg cacctgtacg gcacgcaggg caacgtgggc ctcaccaacg cctggagcat
      601 catccagacc gacttccgct gctgtggcgt ctccaactac actgactggt tcgaggtgta
      661 caacgccacg cgggtacctg actcctgctg cttggagttc agtgagagct gtgggctgca
      721 cgcccccggc acctggtgga aggcgccgtg ctacgagacg gtgaaggtgt ggcttcagga
      781 gaacctgctg gctgtgggca tctttgggct gtgcacggcg ctggtgcaga tcctgggcct
      841 gaccttcgcc atgaccatgt actgccaagt ggtcaaggca gacacctact gcgcgtaggc
      901 cgcccaccgc ccgcttctct gccaaaagga cgcccacggg gagatggccg cacccacagc
      961 tgcctttccc accaccagcc tcggtgctct gccccatgct gggaggaggg agggagggac
     1021 aggtgcctgg agcccccgga accctgtttc tggaaggccc tagctcaggt ggcttcaggg
     1081 cctccggacc ccccctggga ggggtggcca cgtgctggct gcggaaccca gggcaggggt
     1141 gggaggggcc tccagcactt tttatattta cgtattctcc aaagcagtgt tcacacggga
     1201 gccagcctgt ggcccccagc ctcctggaaa acaggttggc gctggaggag ccgggtcttg
     1261 gcatcctgga ggtggcccca ctggtcctgg tgctccaggc ggggccgtgg acccctcacc
     1321 tacattccat agtgggcccg tggggctcct ggtgcatctt aataaagtgt gagcagcaa
//
