LOCUS       NM_001025239            1299 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens tetraspanin 4 (TSPAN4), transcript variant 7, mRNA.
ACCESSION   NM_001025239
VERSION     NM_001025239.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Zheng,Y., Lang,Y., Qi,B. and Li,T.
  TITLE     TSPAN4 and migrasomes in atherosclerosis regression correlated to
            myocardial infarction and pan-cancer progression
  JOURNAL   Cell Adh Migr 17 (1), 14-19 (2023)
   PUBMED   36513632
  REMARK    GeneRIF: TSPAN4 and migrasomes in atherosclerosis regression
            correlated to myocardial infarction and pan-cancer progression.
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Pitsava,G., Feldkamp,M.L., Pankratz,N., Lane,J., Kay,D.M.,
            Conway,K.M., Shaw,G.M., Reefhuis,J., Jenkins,M.M., Almli,L.M.,
            Olshan,A.F., Pangilinan,F., Brody,L.C., Sicko,R.J., Hobbs,C.A.,
            Bamshad,M., McGoldrick,D., Nickerson,D.A., Finnell,R.H.,
            Mullikin,J., Romitti,P.A. and Mills,J.L.
  CONSRTM   University of Washington Center for Mendelian Genomics, NISC
            Comparative Sequencing Program and the National Birth Defects
            Prevention Study
  TITLE     Exome sequencing of child-parent trios with bladder exstrophy:
            Findings in 26 children
  JOURNAL   Am J Med Genet A 185 (10), 3028-3041 (2021)
   PUBMED   34355505
  REMARK    GeneRIF: Exome sequencing of child-parent trios with bladder
            exstrophy: Findings in 26 children.
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Ma,X., Verweij,E.W.E., Siderius,M., Leurs,R. and Vischer,H.F.
  TITLE     Identification of TSPAN4 as Novel Histamine H4 Receptor Interactor
  JOURNAL   Biomolecules 11 (8), 1127 (2021)
   PUBMED   34439793
  REMARK    GeneRIF: Identification of TSPAN4 as Novel Histamine H4 Receptor
            Interactor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Yauch,R.L., Kazarov,A.R., Desai,B., Lee,R.T. and Hemler,M.E.
  TITLE     Direct extracellular contact between integrin alpha(3)beta(1) and
            TM4SF protein CD151
  JOURNAL   J Biol Chem 275 (13), 9230-9238 (2000)
   PUBMED   10734060
REFERENCE   7  (bases 1 to 1299)
  AUTHORS   Lozahic,S., Christiansen,D., Manie,S., Gerlier,D., Billard,M.,
            Boucheix,C. and Rubinstein,E.
  TITLE     CD46 (membrane cofactor protein) associates with multiple beta1
            integrins and tetraspans
  JOURNAL   Eur J Immunol 30 (3), 900-907 (2000)
   PUBMED   10741407
REFERENCE   8  (bases 1 to 1299)
  AUTHORS   Serru,V., Le Naour,F., Billard,M., Azorsa,D.O., Lanza,F.,
            Boucheix,C. and Rubinstein,E.
  TITLE     Selective tetraspan-integrin complexes (CD81/alpha4beta1,
            CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting
            tetraspan interactions
  JOURNAL   Biochem J 340 (Pt 1) (Pt 1), 103-111 (1999)
   PUBMED   10229664
REFERENCE   9  (bases 1 to 1299)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
REFERENCE   10 (bases 1 to 1299)
  AUTHORS   Tachibana,I., Bodorova,J., Berditchevski,F., Zutter,M.M. and
            Hemler,M.E.
  TITLE     NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that
            complexes with integrins and other TM4SF proteins
  JOURNAL   J Biol Chem 272 (46), 29181-29189 (1997)
   PUBMED   9360996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM755435.1, BC000389.2 and
            BM555783.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001025239.1.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface glycoprotein and is similar
            in sequence to its family member CD53 antigen. It is known to
            complex with integrins and other transmembrane 4 superfamily
            proteins. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (7) lacks an in-frame portion of
            the 5' coding region, compared to variant 1. The resulting isoform
            (b) has a shorter N-terminus when compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2003160.1,
                                           SRR14038192.4206182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               BM755435.1         29-192
            165-258             BM755435.1         273-366
            259-266             BC000389.2         293-300
            267-297             BM555783.1         385-415
            298-1299            BC000389.2         332-1333
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1299
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /note="tetraspanin 4"
                     /db_xref="GeneID:7106"
                     /db_xref="HGNC:HGNC:11859"
                     /db_xref="MIM:602644"
     exon            1..64
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            65..164
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            165..356
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..818
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /note="isoform b is encoded by transcript variant 7;
                     transmembrane 4 superfamily member 7; tetraspan TM4SF;
                     novel antigen 2"
                     /codon_start=1
                     /product="tetraspanin-4 isoform b"
                     /protein_id="NP_001020410.1"
                     /db_xref="CCDS:CCDS41589.1"
                     /db_xref="GeneID:7106"
                     /db_xref="HGNC:HGNC:11859"
                     /db_xref="MIM:602644"
                     /translation="MAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYT
                     DKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVP
                     DSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAM
                     TMYCQVVKADTYCA"
     exon            357..431
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            432..533
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            534..665
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..749
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1299
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1281..1286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /note="hexamer: AATAAA"
     polyA_site      1299
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /note="major polyA site"
ORIGIN      
        1 gtgtccgctt gactgacagc tgcgcggcgg gagcgggcgg cgcgagcggg aggcggcggc
       61 gcagagcttg gggcttcctt ggtcgcaccc accacctgcc tgcccactgg tcagccttca
      121 gggaccctga gcaccgcctg gtctctttcc tgtggccagc ccagctggga ggctgtggcg
      181 tgctgggtgt cggcatctgg ctggccgcca cacaggggag cttcgccacg ctgtcctctt
      241 ccttcccgtc cctgtcggct gccaacttgc tcatcatcac cggcgccttt gtcatggcca
      301 tcggcttcgt gggctgcctg ggtgccatca aggagaacaa gtgcctcctg ctcactttct
      361 tcctgctgct gctgctggtg ttcctgctgg aggccaccat cgccatcctc ttcttcgcct
      421 acacggacaa gattgacagg tatgcccagc aagacctgaa gaaaggcttg cacctgtacg
      481 gcacgcaggg caacgtgggc ctcaccaacg cctggagcat catccagacc gacttccgct
      541 gctgtggcgt ctccaactac actgactggt tcgaggtgta caacgccacg cgggtacctg
      601 actcctgctg cttggagttc agtgagagct gtgggctgca cgcccccggc acctggtgga
      661 aggcgccgtg ctacgagacg gtgaaggtgt ggcttcagga gaacctgctg gctgtgggca
      721 tctttgggct gtgcacggcg ctggtgcaga tcctgggcct gaccttcgcc atgaccatgt
      781 actgccaagt ggtcaaggca gacacctact gcgcgtaggc cgcccaccgc ccgcttctct
      841 gccaaaagga cgcccacggg gagatggccg cacccacagc tgcctttccc accaccagcc
      901 tcggtgctct gccccatgct gggaggaggg agggagggac aggtgcctgg agcccccgga
      961 accctgtttc tggaaggccc tagctcaggt ggcttcaggg cctccggacc ccccctggga
     1021 ggggtggcca cgtgctggct gcggaaccca gggcaggggt gggaggggcc tccagcactt
     1081 tttatattta cgtattctcc aaagcagtgt tcacacggga gccagcctgt ggcccccagc
     1141 ctcctggaaa acaggttggc gctggaggag ccgggtcttg gcatcctgga ggtggcccca
     1201 ctggtcctgg tgctccaggc ggggccgtgg acccctcacc tacattccat agtgggcccg
     1261 tggggctcct ggtgcatctt aataaagtgt gagcagcaa
//
