LOCUS       NM_178562               2951 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tetraspanin 33 (TSPAN33), mRNA.
ACCESSION   NM_178562
VERSION     NM_178562.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2951)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2951)
  AUTHORS   Navarro-Hernandez,I.C., Lopez-Ortega,O., Acevedo-Ochoa,E.,
            Cervantes-Diaz,R., Romero-Ramirez,S., Sosa-Hernandez,V.A.,
            Meza-Sanchez,D.E., Juarez-Vega,G., Perez-Martinez,C.A.,
            Chavez-Munguia,B., Galvan-Hernandez,A., Antillon,A.,
            Ortega-Blake,I., Santos-Argumedo,L., Hernandez-Hernandez,J.M. and
            Maravillas-Montero,J.L.
  TITLE     Tetraspanin 33 (TSPAN33) regulates endocytosis and migration of
            human B lymphocytes by affecting the tension of the plasma membrane
  JOURNAL   FEBS J 287 (16), 3449-3471 (2020)
   PUBMED   31958362
  REMARK    GeneRIF: Tetraspanin 33 (TSPAN33) regulates endocytosis and
            migration of human B lymphocytes by affecting the tension of the
            plasma membrane.
REFERENCE   3  (bases 1 to 2951)
  AUTHORS   Rouaud,F., Tessaro,F., Aimaretti,L., Scapozza,L. and Citi,S.
  TITLE     Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11
            promotes conformation-dependent interaction with tetraspanin 33
  JOURNAL   J Biol Chem 295 (28), 9299-9312 (2020)
   PUBMED   32371390
  REMARK    GeneRIF: Cooperative binding of the tandem WW domains of PLEKHA7 to
            PDZD11 promotes conformation-dependent interaction with tetraspanin
            33.
REFERENCE   4  (bases 1 to 2951)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2951)
  AUTHORS   Shah,J., Rouaud,F., Guerrera,D., Vasileva,E., Popov,L.M.,
            Kelley,W.L., Rubinstein,E., Carette,J.E., Amieva,M.R. and Citi,S.
  TITLE     A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to
            Promote alpha-Toxin Cytotoxicity
  JOURNAL   Cell Rep 25 (8), 2132-2147 (2018)
   PUBMED   30463011
REFERENCE   6  (bases 1 to 2951)
  AUTHORS   Luu,V.P., Hevezi,P., Vences-Catalan,F., Maravillas-Montero,J.L.,
            White,C.A., Casali,P., Llorente,L., Jakez-Ocampo,J., Lima,G.,
            Vilches-Cisneros,N., Flores-Gutierrez,J.P., Santos-Argumedo,L. and
            Zlotnik,A.
  TITLE     TSPAN33 is a novel marker of activated and malignant B cells
  JOURNAL   Clin Immunol 149 (3), 388-399 (2013)
   PUBMED   24211713
  REMARK    GeneRIF: TSPAN33 is overexpressed in activated and malignant B
            cells.
REFERENCE   7  (bases 1 to 2951)
  AUTHORS   Dornier,E., Coumailleau,F., Ottavi,J.F., Moretti,J., Boucheix,C.,
            Mauduit,P., Schweisguth,F. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and
            promote Notch activation in flies and mammals
  JOURNAL   J Cell Biol 199 (3), 481-496 (2012)
   PUBMED   23091066
  REMARK    Erratum:[J Cell Biol. 2016 May 23;213(4):495-6. doi:
            10.1083/jcb.20120113304262016c.. PMID: 27185832]
REFERENCE   8  (bases 1 to 2951)
  AUTHORS   Heikens,M.J., Cao,T.M., Morita,C., Dehart,S.L. and Tsai,S.
  TITLE     Penumbra encodes a novel tetraspanin that is highly expressed in
            erythroid progenitors and promotes effective erythropoiesis
  JOURNAL   Blood 109 (8), 3244-3252 (2007)
   PUBMED   17158226
REFERENCE   9  (bases 1 to 2951)
  AUTHORS   Huang,S., Yuan,S., Dong,M., Su,J., Yu,C., Shen,Y., Xie,X., Yu,Y.,
            Yu,X., Chen,S., Zhang,S., Pontarotti,P. and Xu,A.
  TITLE     The phylogenetic analysis of tetraspanins projects the evolution of
            cell-cell interactions from unicellular to multicellular organisms
  JOURNAL   Genomics 86 (6), 674-684 (2005)
   PUBMED   16242907
REFERENCE   10 (bases 1 to 2951)
  AUTHORS   Chen,Z., Pasquini,M., Hong,B., DeHart,S., Heikens,M. and Tsai,S.
  TITLE     The human Penumbra gene is mapped to a region on chromosome 7
            frequently deleted in myeloid malignancies
  JOURNAL   Cancer Genet Cytogenet 162 (2), 95-98 (2005)
   PUBMED   16213355
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            ABBA01057643.1, HY012137.1, BC044244.1, AC011005.7 and AW089489.1.
            
            On Nov 23, 2018 this sequence version replaced NM_178562.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.94650.1,
                                           SRR1163657.516374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000486685.3/ ENSP00000483872.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 ABBA01057643.1     27418-27426         c
            10-45               HY012137.1         1-36
            46-1333             BC044244.1         1-1288
            1334-2621           AC011005.7         93598-94885
            2622-2946           AW089489.1         1-325               c
            2947-2951           AC011005.7         95211-95215
FEATURES             Location/Qualifiers
     source          1..2951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..2951
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /note="tetraspanin 33"
                     /db_xref="GeneID:340348"
                     /db_xref="HGNC:HGNC:28743"
                     /db_xref="MIM:610120"
     exon            1..376
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1126
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /note="penumbra; proerythroblast new membrane"
                     /codon_start=1
                     /product="tetraspanin-33"
                     /protein_id="NP_848657.1"
                     /db_xref="CCDS:CCDS5810.1"
                     /db_xref="GeneID:340348"
                     /db_xref="HGNC:HGNC:28743"
                     /db_xref="MIM:610120"
                     /translation="MARRPRAPAASGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVG
                     VYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLT
                     AVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGI
                     SYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKV
                     IYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQILVNQIKDQIKLQLYNQQ
                     HRADPWY"
     exon            377..434
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /inference="alignment:Splign:2.1.0"
     exon            435..562
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /inference="alignment:Splign:2.1.0"
     exon            563..637
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /inference="alignment:Splign:2.1.0"
     exon            638..733
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /inference="alignment:Splign:2.1.0"
     exon            734..862
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1024
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..2951
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /note="hexamer: AATAAA"
     polyA_site      2086
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /note="major polyA site"
     regulatory      2342..2347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /note="hexamer: ATTAAA"
     polyA_site      2366
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
     regulatory      2915..2920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /note="hexamer: AAGAAA"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
                     /note="hexamer: AATAAA"
     polyA_site      2935
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
     polyA_site      2951
                     /gene="TSPAN33"
                     /gene_synonym="PEN; PEN.; TSPAN-33"
ORIGIN      
        1 ctgggcgcct ggctggccgg gctggtcctg cggccgcggg tgagtctcgt ccgctcgcgc
       61 tgcccaccgc ggctccagca gctccaggcg cggttccccg gcccgcgccg ctcccggccc
      121 cccggctcgg gcgcctcccg ccgcagcgca ggctcccccg ccggccgggc tcctgcgcgg
      181 cgcggctcgg ctcatgcccc cgggcgcggg gcacacaggc cggccggcag ccgctgggaa
      241 ataggccccc gggggcggtg gcggcggcgg ggccatggcg cggagacccc gggcgccggc
      301 cgcctccggg gaggagttct ccttcgtcag cccgctggtg aaatacctgc tcttcttctt
      361 caacatgctc ttctgggtga tttccatggt gatggtggct gtgggtgtct acgctcggct
      421 aatgaagcat gcagaagcag ccctagcctg cctggcagtg gaccctgcca tcctgctgat
      481 cgtggtgggt gtcctcatgt tcctgctcac cttctgtggc tgcattgggt ccctccgcga
      541 gaacatctgc ctcctgcaga cgttctccct ctgcctcacc gctgtgttcc tgctgcagct
      601 ggccgctggg atcctgggct tcgtcttctc agacaaggct cgagggaaag tgagtgagat
      661 catcaacaat gccattgtgc actaccgaga tgacttggat ctgcagaacc tcattgattt
      721 tggccagaaa aagtttagct gctgtggagg gatttcctac aaggactggt ctcagaacat
      781 gtatttcaac tgctcagaag acaaccccag tcgagagcgc tgctctgtgc cttactcctg
      841 ttgcttgcct actcctgacc aggcagtgat caacactatg tgtggccaag gtatgcaggc
      901 ctttgactac ttggaagcta gcaaagtcat ctacaccaat ggctgtattg acaagttggt
      961 caactggata cacagcaacc tattcttact tggtggtgtg gctctaggcc tggccatccc
     1021 ccagctggtg ggaattctgc tgtcccagat cctagtgaat cagatcaaag atcagatcaa
     1081 gctacagctc tacaaccagc agcaccgggc tgacccatgg tactgagaat ccatcctgca
     1141 cctcctcacc atggaaactg gcaagcctca taaacgaaca gcagtgggtg ctgaaagcag
     1201 caccaaatgg agatttggat tccagccccc cagtgacagc ccagtgggaa gaagcaaact
     1261 ccagatgggc agaaggcagg gtgcacaggt ggctccagtc tcaggaggat gcgcctcctc
     1321 tcccccatcc cagccctcag cattgtgcca gagtgatacc cttaagtgtt tgggtttatg
     1381 ttttcagttt tgtttgggaa acagcagttg cacagagagt tgggggtact gctgctgcct
     1441 tttcaccgag gcactgccac caccagctct agcagggatg ctcctgagct tggcggacat
     1501 acttagatcc taacgtgcca gtgagacctg gctgtggaga gtagcactgg cagccctgcc
     1561 tggactccac ttggcatgat accagctcca gaagggaagg gagtggagca ggcagtgagg
     1621 agagagcctg ggggtcggct ggggacagcc gtatgtgcta ggtaggagtg gagggagata
     1681 tgtttaccaa atgcctgtcc tgccatcctc ccaggtagtc agagtgagct acatcctgcc
     1741 ccgccttcat ttccatggaa acatggcagc taggacacgg ggtacaacag cagccaaatt
     1801 cttccccacc tcccttactt cgaaaaaaag tttggaaccc tggtccctat actctgcagt
     1861 cagaagtggg actgagccat acatgccctt gaattcctcc ctgtctggcc ctccctctcc
     1921 agcaagcagg gttttcttta acttggcagt gtgcagagga gaagtggtaa cacccccacc
     1981 ccattcccct gcatcggagc tcagtattcc tacagggtaa gaggtaggaa tcttgctggg
     2041 acgaggggag ccagaagtgg caataaaagc gtgttgacct gggctacgcg ggactccatg
     2101 aattttccat tctggcaact ggaaggggag gtgtagaagg gccctgcaga ggacggcact
     2161 ggagactctc ctaaacgcca cacacctccc ccttgctgcc cgccacacgc gcgtctcctt
     2221 caaccgatgc attgccaccc tcccacagcc tcgccctctg ctctaaatta ggtcgaaaga
     2281 gtcccagttc caatctagga acagcataat tttgttccaa aacctgatct gtgtttttct
     2341 aattaaaatt aatttgtcac ccaaaacagg agggggatgg ggaggaggga catgagcact
     2401 ccgctggggc cgggacgggg aatgaggagg aagaaggccc tctcttcccc tacccgggcc
     2461 ctccaggacc ttctccctga gtcggctgta gggaggactc cgaggaagct cggcgcggtg
     2521 cgctgggcct cctggcgccg ggaggagcgc gcgaggcagg cggggcgggc gcgtccgggg
     2581 cggggcgctg gacttcgtgg gtggtccccg cccccgcggc ggcctaggcc cgcgcctgcg
     2641 tcccccaacc cggaggagat ggggggctgt gctagctgct tgcccagcga gtgttcccgg
     2701 agtctcctcg ccgcaccccg ctatcgggcg ctcagaccag gggctcggcc tggcgggaaa
     2761 tagcctcgac cgaactgctg cggggacaaa gagccgcgag ttcgctccct gcccccagtg
     2821 tctcctaagc gagccttctg ctcctaggaa ggcgcctttc cagcagccgc tgggaccctg
     2881 gccagtgttt agctcccaac tagtaacaga cggaaagaaa aaataaaatt atccagaatc
     2941 tagaataaaa a
//
