LOCUS       NM_139022               1380 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens tetraspanin 32 (TSPAN32), mRNA.
ACCESSION   NM_139022 NM_139023
VERSION     NM_139022.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Fagone,P., Mangano,K., Di Marco,R., Reyes-Castillo,Z.,
            Munoz-Valle,J.F. and Nicoletti,F.
  TITLE     Altered Expression of TSPAN32 during B Cell Activation and Systemic
            Lupus Erythematosus
  JOURNAL   Genes (Basel) 12 (6), 931 (2021)
   PUBMED   34207245
  REMARK    GeneRIF: Altered Expression of TSPAN32 during B Cell Activation and
            Systemic Lupus Erythematosus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Lombardo,S.D., Mazzon,E., Basile,M.S., Campo,G., Corsico,F.,
            Presti,M., Bramanti,P., Mangano,K., Petralia,M.C., Nicoletti,F. and
            Fagone,P.
  TITLE     Modulation of Tetraspanin 32 (TSPAN32) Expression in T
            Cell-Mediated Immune Responses and in Multiple Sclerosis
  JOURNAL   Int J Mol Sci 20 (18), 4323 (2019)
   PUBMED   31487788
  REMARK    GeneRIF: TSPAN32 mRNA level is significantly reduced in CD4 T cells
            of multiple sclerosis patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Speedy,H.E., Di Bernardo,M.C., Sava,G.P., Dyer,M.J., Holroyd,A.,
            Wang,Y., Sunter,N.J., Mansouri,L., Juliusson,G., Smedby,K.E.,
            Roos,G., Jayne,S., Majid,A., Dearden,C., Hall,A.G.,
            Mainou-Fowler,T., Jackson,G.H., Summerfield,G., Harris,R.J.,
            Pettitt,A.R., Allsup,D.J., Bailey,J.R., Pratt,G., Pepper,C.,
            Fegan,C., Rosenquist,R., Catovsky,D., Allan,J.M. and Houlston,R.S.
  TITLE     A genome-wide association study identifies multiple susceptibility
            loci for chronic lymphocytic leukemia
  JOURNAL   Nat Genet 46 (1), 56-60 (2014)
   PUBMED   24292274
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Berndt,S.I., Skibola,C.F., Joseph,V., Camp,N.J., Nieters,A.,
            Wang,Z., Cozen,W., Monnereau,A., Wang,S.S., Kelly,R.S., Lan,Q.,
            Teras,L.R., Chatterjee,N., Chung,C.C., Yeager,M.,
            Brooks-Wilson,A.R., Hartge,P., Purdue,M.P., Birmann,B.M.,
            Armstrong,B.K., Cocco,P., Zhang,Y., Severi,G.,
            Zeleniuch-Jacquotte,A., Lawrence,C., Burdette,L., Yuenger,J.,
            Hutchinson,A., Jacobs,K.B., Call,T.G., Shanafelt,T.D., Novak,A.J.,
            Kay,N.E., Liebow,M., Wang,A.H., Smedby,K.E., Adami,H.O., Melbye,M.,
            Glimelius,B., Chang,E.T., Glenn,M., Curtin,K.,
            Cannon-Albright,L.A., Jones,B., Diver,W.R., Link,B.K., Weiner,G.J.,
            Conde,L., Bracci,P.M., Riby,J., Holly,E.A., Smith,M.T.,
            Jackson,R.D., Tinker,L.F., Benavente,Y., Becker,N., Boffetta,P.,
            Brennan,P., Foretova,L., Maynadie,M., McKay,J., Staines,A.,
            Rabe,K.G., Achenbach,S.J., Vachon,C.M., Goldin,L.R., Strom,S.S.,
            Lanasa,M.C., Spector,L.G., Leis,J.F., Cunningham,J.M.,
            Weinberg,J.B., Morrison,V.A., Caporaso,N.E., Norman,A.D.,
            Linet,M.S., De Roos,A.J., Morton,L.M., Severson,R.K., Riboli,E.,
            Vineis,P., Kaaks,R., Trichopoulos,D., Masala,G., Weiderpass,E.,
            Chirlaque,M.D., Vermeulen,R.C., Travis,R.C., Giles,G.G.,
            Albanes,D., Virtamo,J., Weinstein,S., Clavel,J., Zheng,T.,
            Holford,T.R., Offit,K., Zelenetz,A., Klein,R.J., Spinelli,J.J.,
            Bertrand,K.A., Laden,F., Giovannucci,E., Kraft,P., Kricker,A.,
            Turner,J., Vajdic,C.M., Ennas,M.G., Ferri,G.M., Miligi,L.,
            Liang,L., Sampson,J., Crouch,S., Park,J.H., North,K.E., Cox,A.,
            Snowden,J.A., Wright,J., Carracedo,A., Lopez-Otin,C., Bea,S.,
            Salaverria,I., Martin-Garcia,D., Campo,E., Fraumeni,J.F. Jr., de
            Sanjose,S., Hjalgrim,H., Cerhan,J.R., Chanock,S.J., Rothman,N. and
            Slager,S.L.
  TITLE     Genome-wide association study identifies multiple risk loci for
            chronic lymphocytic leukemia
  JOURNAL   Nat Genet 45 (8), 868-876 (2013)
   PUBMED   23770605
REFERENCE   5  (bases 1 to 1380)
  AUTHORS   Gartlan,K.H., Belz,G.T., Tarrant,J.M., Minigo,G., Katsara,M.,
            Sheng,K.C., Sofi,M., van Spriel,A.B., Apostolopoulos,V.,
            Plebanski,M., Robb,L. and Wright,M.D.
  TITLE     A complementary role for the tetraspanins CD37 and Tssc6 in
            cellular immunity
  JOURNAL   J Immunol 185 (6), 3158-3166 (2010)
   PUBMED   20709950
  REMARK    GeneRIF: In the absence of both CD37 and Tssc6, immune function is
            further altered when compared with CD37- or Tssc6-deficient
            transgenic mice, demonstrating a complementary role for these two
            molecules in cellular immunity.
REFERENCE   6  (bases 1 to 1380)
  AUTHORS   Nicholson,R.H., Pantano,S., Eliason,J.F., Galy,A., Weiler,S.,
            Kaplan,J., Hughes,M.R. and Ko,M.S.
  TITLE     Phemx, a novel mouse gene expressed in hematopoietic cells maps to
            the imprinted cluster on distal chromosome 7
  JOURNAL   Genomics 68 (1), 13-21 (2000)
   PUBMED   10950922
REFERENCE   7  (bases 1 to 1380)
  AUTHORS   Paulsen,M., El-Maarri,O., Engemann,S., Strodicke,M., Franck,O.,
            Davies,K., Reinhardt,R., Reik,W. and Walter,J.
  TITLE     Sequence conservation and variability of imprinting in the
            Beckwith-Wiedemann syndrome gene cluster in human and mouse
  JOURNAL   Hum Mol Genet 9 (12), 1829-1841 (2000)
   PUBMED   10915772
REFERENCE   8  (bases 1 to 1380)
  AUTHORS   Lee,M.P., Brandenburg,S., Landes,G.M., Adams,M., Miller,G. and
            Feinberg,A.P.
  TITLE     Two novel genes in the center of the 11p15 imprinted domain escape
            genomic imprinting
  JOURNAL   Hum Mol Genet 8 (4), 683-690 (1999)
   PUBMED   10072438
REFERENCE   9  (bases 1 to 1380)
  AUTHORS   Hu,R.J., Lee,M.P., Connors,T.D., Johnson,L.A., Burn,T.C., Su,K.,
            Landes,G.M. and Feinberg,A.P.
  TITLE     A 2.5-Mb transcript map of a tumor-suppressing subchromosomal
            transferable fragment from 11p15.5, and isolation and sequence
            analysis of three novel genes
  JOURNAL   Genomics 46 (1), 9-17 (1997)
   PUBMED   9403053
REFERENCE   10 (bases 1 to 1380)
  AUTHORS   Koi,M., Johnson,L.A., Kalikin,L.M., Little,P.F., Nakamura,Y. and
            Feinberg,A.P.
  TITLE     Tumor cell growth arrest caused by subchromosomal transferable DNA
            fragments from chromosome 11
  JOURNAL   Science 260 (5106), 361-364 (1993)
   PUBMED   8469989
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG506933.1, AY039001.1,
            AA701395.1 and AC129929.5.
            
            On Nov 30, 2019 this sequence version replaced NM_139022.2.
            
            Summary: This gene, which is a member of the tetraspanin
            superfamily, is one of several tumor-suppressing subtransferable
            fragments located in the imprinted gene domain of chromosome
            11p15.5, an important tumor-suppressor gene region. Alterations in
            this region have been associated with Beckwith-Wiedemann syndrome,
            Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung,
            ovarian and breast cancers. This gene is located among several
            imprinted genes; however, this gene, as well as the
            tumor-suppressing subchromosomal transferable fragment 4, escapes
            imprinting. This gene may play a role in malignancies and diseases
            that involve this region, and it is also involved in hematopoietic
            cell function. Alternatively spliced transcript variants have been
            described, but their biological validity has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: A downstream start codon is selected for this RefSeq
            based on better conservation with homologs. The use of an
            alternative upstream start codon, which is present in primate
            species, would increase the protein length from 320 aa to 355 aa.
            The presence of a predicted signal anchor for the shorter, but not
            the longer, protein suggests that the downstream start codon may be
            preferentially used. The shorter protein is described in PMID
            11718897.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY039001.1, DRR138524.801838.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000182290.9/
                                                ENSP00000182290.5
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               BG506933.1         2-132
            132-1318            AY039001.1         1-1187
            1319-1376           AA701395.1         1-58                c
            1377-1380           AC129929.5         68893-68896         c
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1380
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /note="tetraspanin 32"
                     /db_xref="GeneID:10077"
                     /db_xref="HGNC:HGNC:13410"
                     /db_xref="MIM:603853"
     exon            1..203
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1100
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /note="tumor-suppressing subchromosomal transferable
                     fragment cDNA 6; tumor-suppressing subtransferable
                     candidate 6; tumor-suppressing STF cDNA 6;
                     pan-hematopoietic expression protein; protein Phemx"
                     /codon_start=1
                     /product="tetraspanin-32"
                     /protein_id="NP_620591.3"
                     /db_xref="CCDS:CCDS7733.1"
                     /db_xref="GeneID:10077"
                     /db_xref="HGNC:HGNC:13410"
                     /db_xref="MIM:603853"
                     /translation="MGPWSRVRVAKCQMLVTCFFILLLGLSVATMVTLTYFGAHFAVI
                     RRASLEKNPYQAVHQWAFSAGLSLVGLLTLGAVLSAAATVREAQGLMAGGFLCFSLAF
                     CAQVQVVFWRLHSPTQVEDAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKS
                     PFSRLGSTEADLCQGEEAAREDCLQGIRSFLRTHQQVASSLTSIGLALTVSALLFSSF
                     LWFAIRCGCSLDRKGKYTLTPRACGRQPQEPSLLRCSQGGPTHCLHSEAVAIGPRGCS
                     GSLRWLQESDAAPLPLSCHLAAHRALQGRSRGGLSGCPERGLSD"
     exon            204..318
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     exon            319..416
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     exon            417..491
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     exon            492..593
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     exon            594..680
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     exon            681..764
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     exon            765..856
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1038
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1380
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /note="hexamer: AATATA"
     polyA_site      1318
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /note="major polyA site"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
                     /note="hexamer: AATACA"
     polyA_site      1380
                     /gene="TSPAN32"
                     /gene_synonym="ART1; PHEMX; PHMX; TSSC6"
ORIGIN      
        1 agggcgatgt tgacagacag acagaggggc ggatgcagcc tacctcctgg gcagtgagct
       61 gcggtctgag gcccctgccc agctggaaac cacagggagg ggaagggagg ggaggagagg
      121 agaggagagg aaccgtcatg gggccttgga gtcgagtcag ggttgccaaa tgccagatgc
      181 tggtcacctg cttctttatc ttgctgctgg gcctctctgt ggccaccatg gtgactctta
      241 cctacttcgg ggcccacttt gctgtcatcc gccgagcgtc cctggagaag aacccgtacc
      301 aggctgtgca ccaatgggcc ttctctgcgg ggttgagcct ggtgggcctc ctgactctgg
      361 gagccgtgct gagcgctgca gccaccgtga gggaggccca gggcctcatg gcagggggct
      421 tcctgtgctt ctccctggcg ttctgcgcac aggtgcaggt ggtgttctgg agactccaca
      481 gccccaccca ggtggaggac gccatgctgg acacctacga cctggtatat gagcaggcga
      541 tgaaaggtac gtcccacgtc cggcggcagg agctggcggc catccaggac gtgtttctgt
      601 gctgtgggaa gaagtctcct ttcagccgtc tggggagcac agaggctgac ctgtgtcagg
      661 gagaggaggc ggcgagagag gactgccttc agggcatccg gagcttcctg aggacacacc
      721 agcaggtcgc ctccagcctg accagcatcg gcctggccct cacggtgtcc gccttgctct
      781 tcagctcctt cctgtggttt gccatccgct gtggctgcag cttggaccgc aagggcaaat
      841 acaccctgac cccacgagca tgtggccgcc agccccagga gcccagcctc ttgagatgct
      901 cccagggtgg acccacacat tgtctccact ccgaagcagt tgctattggt ccaagaggat
      961 gctcgggtag tcttcggtgg ctgcaggaga gcgatgctgc gcctctgccc ctctcctgcc
     1021 acctggctgc ccacagagct ctccagggca gaagtcgcgg tgggctcagt gggtgccctg
     1081 agcggggtct ctcagactga cgtcaggcct tggtgggctg cactctcacc tggaggctcc
     1141 ggggaagcat ctgcctccag gaccattcag gctgttgaca agtcaactcc tcatggctgt
     1201 aggactgagg ttcccaagtc cttgtccctg gtcctgtggt ccctccacct tcaaaccagc
     1261 aatggtgcat tgagcaaatt gtggtcaaat atacatcaca tcaaatttac catcttaacc
     1321 attgttaagt gtatggtttg tggcattaaa tacattcaca ttgttgtgca accatcacca
//
