LOCUS       NM_130783               4557 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tetraspanin 18 (TSPAN18), mRNA.
ACCESSION   NM_130783
VERSION     NM_130783.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4557)
  AUTHORS   Li,G.X., Zhang,S., Liu,R., Singh,B., Singh,S., Quinn,D.I., Crump,G.
            and Gill,P.S.
  TITLE     Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch
            pathways
  JOURNAL   Biol Open 10 (2) (2021)
   PUBMED   32694189
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4557)
  AUTHORS   Gavin,R.L., Koo,C.Z. and Tomlinson,M.G.
  TITLE     Tspan18 is a novel regulator of thrombo-inflammation
  JOURNAL   Med Microbiol Immunol 209 (4), 553-564 (2020)
   PUBMED   32447449
  REMARK    GeneRIF: Tspan18 is a novel regulator of thrombo-inflammation.
            Review article
REFERENCE   4  (bases 1 to 4557)
  AUTHORS   Noy,P.J., Gavin,R.L., Colombo,D., Haining,E.J., Reyat,J.S.,
            Payne,H., Thielmann,I., Lokman,A.B., Neag,G., Yang,J., Lloyd,T.,
            Harrison,N., Heath,V.L., Gardiner,C., Whitworth,K.M., Robinson,J.,
            Koo,C.Z., Di Maio,A., Harrison,P., Lee,S.P., Michelangeli,F.,
            Kalia,N., Rainger,G.E., Nieswandt,B., Brill,A., Watson,S.P. and
            Tomlinson,M.G.
  TITLE     Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von
            Willebrand factor release in endothelial cells
  JOURNAL   Haematologica 104 (9), 1892-1905 (2019)
   PUBMED   30573509
  REMARK    GeneRIF: The findings identify Tspan18 as a novel regulator of
            endothelial cell Orai1/Ca2+ signaling and von Willebrand factor
            release in response to inflammatory stimuli.
REFERENCE   5  (bases 1 to 4557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4557)
  AUTHORS   Zhang,B., Li,D.X., Lu,N., Fan,Q.R., Li,W.H. and Feng,Z.F.
  TITLE     Lack of Association between the TSPAN18 Gene and Schizophrenia
            Based on New Data from Han Chinese and a Meta-Analysis
  JOURNAL   Int J Mol Sci 16 (6), 11864-11872 (2015)
   PUBMED   26016498
  REMARK    GeneRIF: Meta-analysis results show no significant association
            between TSPAN18 gene and schizophrenia in the Han Chinese
            population indicating the gene is unlikely to be a major
            susceptibility gene for schizophrenia in this population.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4557)
  AUTHORS   Yuan,J., Jin,C., Qin,H.D., Wang,J., Sha,W., Wang,M., Zhang,Y.,
            Zhang,F., Li,J., Li,J., Yu,S., Qi,S. and Shugart,Y.Y.
  TITLE     Replication study confirms link between TSPAN18 mutation and
            schizophrenia in Han Chinese
  JOURNAL   PLoS One 8 (3), e58785 (2013)
   PUBMED   23505562
  REMARK    GeneRIF: These results confirm the significant association, in Han
            Chinese populations, of increased SCZ risk and the variant of the
            TSPAN18 gene containing the 'A' allele of SNP rs835784.
REFERENCE   8  (bases 1 to 4557)
  AUTHORS   Yue,W.H., Wang,H.F., Sun,L.D., Tang,F.L., Liu,Z.H., Zhang,H.X.,
            Li,W.Q., Zhang,Y.L., Zhang,Y., Ma,C.C., Du,B., Wang,L.F., Ren,Y.Q.,
            Yang,Y.F., Hu,X.F., Wang,Y., Deng,W., Tan,L.W., Tan,Y.L., Chen,Q.,
            Xu,G.M., Yang,G.G., Zuo,X.B., Yan,H., Ruan,Y.Y., Lu,T.L., Han,X.,
            Ma,X.H., Wang,Y., Cai,L.W., Jin,C., Zhang,H.Y., Yan,J., Mi,W.F.,
            Yin,X.Y., Ma,W.B., Liu,Q., Kang,L., Sun,W., Pan,C.Y., Shuang,M.,
            Yang,F.D., Wang,C.Y., Yang,J.L., Li,K.Q., Ma,X., Li,L.J., Yu,X.,
            Li,Q.Z., Huang,X., Lv,L.X., Li,T., Zhao,G.P., Huang,W., Zhang,X.J.
            and Zhang,D.
  TITLE     Genome-wide association study identifies a susceptibility locus for
            schizophrenia in Han Chinese at 11p11.2
  JOURNAL   Nat Genet 43 (12), 1228-1231 (2011)
   PUBMED   22037552
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4557)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   10 (bases 1 to 4557)
  AUTHORS   Hemler,M.E.
  TITLE     Specific tetraspanin functions
  JOURNAL   J Cell Biol 155 (7), 1103-1107 (2001)
   PUBMED   11756464
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104241.7 and AC092733.18.
            
            On Apr 10, 2019 this sequence version replaced NM_130783.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.220160.1,
                                           SRR1163658.178032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520358.7/ ENSP00000429993.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               AC104241.7         52252-52577
            327-413             AC092733.18        11681-11767
            414-555             AC092733.18        107584-107725
            556-628             AC092733.18        153663-153735
            629-823             AC092733.18        156961-157155
            824-898             AC092733.18        165228-165302
            899-997             AC092733.18        166470-166568
            998-1180            AC092733.18        167073-167255
            1181-1264           AC092733.18        173930-174013
            1265-4557           AC092733.18        176387-179679
FEATURES             Location/Qualifiers
     source          1..4557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..4557
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /note="tetraspanin 18"
                     /db_xref="GeneID:90139"
                     /db_xref="HGNC:HGNC:20660"
                     /db_xref="MIM:619399"
     exon            1..326
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     exon            327..413
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     exon            414..555
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     exon            556..628
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..1312
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /note="tspan-18"
                     /codon_start=1
                     /product="tetraspanin-18"
                     /protein_id="NP_570139.3"
                     /db_xref="CCDS:CCDS7910.1"
                     /db_xref="GeneID:90139"
                     /db_xref="HGNC:HGNC:20660"
                     /db_xref="MIM:619399"
                     /translation="MEGDCLSCMKYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFREI
                     VAANPLLLTGAYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAA
                     ILAFIFRENLTREFFTKELTKHYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFKFAS
                     VFRLLTLDSEEVPEACCRREPQSRDGVLLSREECLLGRSLFLNKQGCYTVILNTFETY
                     VYLAGALAIGVLAIELFAMIFAMCLFRGIQ"
     exon            629..823
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     exon            824..898
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     exon            899..997
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1180
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1264
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..4557
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4539..4544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /note="hexamer: AATAAA"
     polyA_site      4557
                     /gene="TSPAN18"
                     /gene_synonym="TSPAN"
                     /note="major polyA site"
ORIGIN      
        1 agctgccgcc ggcgtcgcgg ggctccaggc tgcggggcgg acgtagcgcc gagcgatcca
       61 ccgcggagcc gcgcgaggcc gcccgagccc cagccccggc cccggcccca gccccggccc
      121 cggccccggc cccggccccg gccccggtcc cggccccgag ccccgagcga gcgccgccgc
      181 ctcgcgctgc gggtccccgg acgcgccgcc accgccggga aggcagccgg cgccgggcaa
      241 gttgcgagcg cgcccctccg accaggaaag tttccccccg gccgccggcg ggatttggcg
      301 cggggtccgg cagccgccgc tggaagagtg tatccagaag ctactgtcag gaggacactg
      361 taagagaacc ttggcacctc tgggcccaaa gggaaagaca ccagtggaaa gaggtgagca
      421 tctcctggac caccctcaag cttcaggtga gctgagcttc taacactacc atcaaagcaa
      481 ctggaacccc ttgaatttga tttctggaga cgcgagcata atccttttgc agacatctca
      541 acgctggctc tccaggtgga gcaccatgga aggcgactgt ctgagctgca tgaagtatct
      601 gatgtttgta ttcaatttct tcatatttct gggcggggcc tgcctgctgg ccatcggcat
      661 ctgggtcatg gtggacccca ccggcttccg ggagatcgtg gctgccaatc ctctgctcct
      721 cacgggcgcc tacatcctcc tggccatggg gggcctgctc tttctgctcg gcttcctggg
      781 ctgctgcggg gccgtccgtg agaacaagtg tctgctgcta tttttcttcc tgttcatcct
      841 gatcatcttc ctggcagagc tctcagcagc catcctggcc ttcatcttca gggaaaatct
      901 cacccgagaa ttcttcacca aggagctcac caagcactac cagggcaata acgacacaga
      961 cgtcttctct gccacctgga actcggtcat gatcacattt ggttgctgcg gggtcaacgg
     1021 gcctgaagac tttaagtttg catctgtgtt tcgactcctg accctggata gtgaagaggt
     1081 gccggaggcc tgctgccgga gggaacccca aagtcgggac ggggtcctgc tgagccggga
     1141 ggagtgcctc ctgggaagga gcctattcct aaacaagcag ggctgttaca cggtgatcct
     1201 caacaccttc gagacctacg tctacttggc cggagccctt gccatcgggg tactggccat
     1261 cgagcttttc gccatgatct ttgccatgtg cctcttccgg ggcatccagt agagggtatg
     1321 gcctgaagcc tgaagactcg ccccacccac cactgcccag cacccagtgt cctcccgtgc
     1381 ccctccccgc tgtcctcttg gccccagggg agaagatgag gccatcagag atggccagga
     1441 gaagggccag gggaatagag ctattttttt aacaaaacaa aatgaagaca aaaatatgga
     1501 ctgatgtatc ctcgcctgga ctcagggcag gtgccgtggg ttctccagag accccagcaa
     1561 ctggcccagg atgcaggctg ctctagagac caaaggaaca ccaggcccag cgccctcttt
     1621 ggtccagcca gaccctgggc cctctctcct cactgcacca ggacctgatg ccaagaaagt
     1681 gaggatttag gcaacaagga ggcaaaagca aatctcagag aagtcatcaa agcccagggg
     1741 ctgcacggag attcagctgc catgtctttg aggactcgga acccacagcg caatccctgg
     1801 tccactggag gatggactgt tccccccttc aggccggggc caagagtgag ctgctaacac
     1861 ggcatccaag aatggcccag ctggtaggat ccttgctttc cccatctgtt ggaccaaata
     1921 atctcaaagg cccagagagg acagtgacca tccacagaca cacagcacag gcgtgacagt
     1981 tctgaaaaga agctgagttg tctccaggct gctgtcactg catccaggac tctgtcagct
     2041 ctgctgccca catgcacccc tggcctcagc atcccggttc ccccagacaa gagagggcaa
     2101 gtcagccagg aactgcctcc tccctgctct acagctaaga aaacaccatt ccatgacttc
     2161 ccaccgcgcc ctcgctccta cctccccaca cctctctctg agtccccagg aacacacaga
     2221 ggtgcacatc acattccctt gtccacactg cccgcctctc ccacatgcca cccccttccc
     2281 tgtccttccc caactcccca gctccaagag tggaagaaat ccccaagatc atctgggtct
     2341 ccctctccac acccagaact gaggcttgga tatcttcttc aacatccttg ccaagacttc
     2401 tccaccctct tgcatacctc cagggacaga gagcttacta cctcccaagg cagcctcctg
     2461 cctttggact gctctgactt tagcatcagc ttaatacaca gaagaggttt ctgtttttct
     2521 gtggctctgt ccatggcatc ccacttgccc actctccttc ctggagtgtt gaggtcacac
     2581 attgactccc ctgagccctc ttctctccag gctaaagaat cccgaaggca tcgaggccat
     2641 ttctgctgca acaaggtttc ctgtctcttc actgtccgca catttcttag tattccctcc
     2701 aggcttgggc agggagactc gcagatgcac acccacaagt attcagttct caaactctag
     2761 acgagtgttg gcaactggat tgcaagatgc tcctaccctg atagatcagg ggtggctgct
     2821 ggaggctgtg ctggggatct gaggtttggt ctgggctcag tgggagacgg cagtgcaatc
     2881 ctgatgagtg atgtctgcca ggcaccgtaa gtttgattag tgatgtctgc cacgggcagg
     2941 gatggaagga gcagtgtgat gtctgctctc ttctctcccc tctgtccctc ttcaggaaga
     3001 aagagctcat tctgtctcac aagccaccgg catcctgtat cagcttccag cctcccctca
     3061 ggctttccag tcaccaggga cactcggagc cacagcctag agccccgtgt tccctggcct
     3121 gtgcgtctgc ccccttctga gatgcagcca gaagctctgt gcctgctgca aagattcagg
     3181 tggaccctcc tctaatctcc tcctgctgtg cccgccagtc cttgccctcc caccaggtct
     3241 ctgagctcag tgttaccaaa ttcgcccttt aacagcttgc tctggcaacc ccataaatga
     3301 cacctgaggt ccgtagaagc taagctcctg agacccaggg ggacctgcca ctggtaccgc
     3361 ggcccagcct ggggcctggg ggctgcccct cttgaaccac ccacatgctt agccccagct
     3421 ttttggaaga ggcaaatggc tggtctgagg atgacacaca aaaacaaaaa caaaaaacaa
     3481 aaaacccatg ctgggcagga ctgaggcaaa ttgcacagct ttatggctct aatccagggg
     3541 catcccaggc ttctggggcc cacagaagtc agagggagga cccaagagaa agggctggtc
     3601 atgaagggaa atctggctaa ggtgggttca agggcagaca caagactgcc cctcagcagc
     3661 tttctacaaa tgtgccaagg aaccctcaat cagccctgat tcagctcgcc agccagccac
     3721 tggccaccct cttaggctgg aaagggaaga caggcagttt ctgctcctgt tggcattcgc
     3781 tcaggctggt agctatttgc aagactgcct gaggccattc cttggaggca aggcaaagaa
     3841 agctcagccc aaatcaggct tgagcctccc tccagagcac agggagaaac agggtttagc
     3901 tggcttggtc cagatacaac ccacagcagg ttctggtggt ggctggggtt gtgggggagg
     3961 ggtgggcagg gatacctctt tgtttctttt caccccgaaa tacaacagcc cataacagag
     4021 acttcctcgg accccactaa cagggcaagg aacaagaaga ctacaccgct catcacaaac
     4081 cctgcctgta tcgaaagcca ctttcctgct ctgaagctac tgcctcttag agaaagggaa
     4141 tagctcttta tgggctgggg gtgagggccc ctccccaggg tccctgttaa tttctggcct
     4201 tggtgctcag gcctgtccac agcctccctt gtctatgtct ctatccatgc ttaaggggcc
     4261 cggacaggat ttcccaaacc agccgaggcc ccagcacccg ccgtctcccc agaagccccc
     4321 tcctccttcc cccatgggtc atatgttgaa agtctatttt aaaaactatg ttccttgccg
     4381 tagattgcag agctaattta tcacgtttct ctcctgtgag accccccttt tatatgatat
     4441 atccagagga agttttgtaa tataaaacag gacgcccaca ctgatggttt tgcactggtt
     4501 tttgtgaatg tttcttacaa aaagaaaaag gaacaaagaa taaatagtga ccgtgaa
//
