LOCUS       NM_130465               2475 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tetraspanin 17 (TSPAN17), transcript variant 2, mRNA.
ACCESSION   NM_130465 XM_030295
VERSION     NM_130465.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Guo,X.B., Zhang,X.C., Chen,P., Ma,L.M. and Shen,Z.Q.
  TITLE     miR-378a-3p inhibits cellular proliferation and migration in
            glioblastoma multiforme by targeting tetraspanin 17
  JOURNAL   Oncol Rep 42 (5), 1957-1971 (2019)
   PUBMED   31432186
  REMARK    GeneRIF: Data suggested that increased miR378a3p and decreased
            TSPAN17 levels were associated with improved survival in
            glioblastoma multiforme (GBM). Additionally, high levels of TSPAN17
            were linked to the poor prognosis of patients with GBM aged 5060,
            larger tumor sizes and an advanced World Health Organization stage.
            TSPAN17 was identified and confirmed as a direct target of miR378a.
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Reyat,J.S., Chimen,M., Noy,P.J., Szyroka,J., Rainger,G.E. and
            Tomlinson,M.G.
  TITLE     ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate
            VE-Cadherin Expression and Promote T Lymphocyte Transmigration
  JOURNAL   J Immunol 199 (2), 666-676 (2017)
   PUBMED   28600292
  REMARK    GeneRIF: Endothelial Tspan5- and Tspan17-ADAM10 complexes may
            regulate inflammation by maintaining normal VE-cadherin expression
            and promoting T lymphocyte transmigration.
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Dornier,E., Coumailleau,F., Ottavi,J.F., Moretti,J., Boucheix,C.,
            Mauduit,P., Schweisguth,F. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and
            promote Notch activation in flies and mammals
  JOURNAL   J Cell Biol 199 (3), 481-496 (2012)
   PUBMED   23091066
  REMARK    Erratum:[J Cell Biol. 2016 May 23;213(4):495-6. doi:
            10.1083/jcb.20120113304262016c.. PMID: 27185832]
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091934.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_130465.4.
            
            Summary: This gene encodes a member of the transmembrane 4
            superfamily. It is characterized by four tetraspanin transmembrane
            segments. The function of this gene has not yet been determined.
            [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067105.1, SRR3476690.251237.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508164.6/ ENSP00000422053.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC091934.2         15466-15684         c
            220-270             AC091934.2         11502-11552         c
            271-417             AC091934.2         11268-11414         c
            418-588             AC091934.2         10255-10425         c
            589-714             AC091934.2         8148-8273           c
            715-762             AC091934.2         7043-7090           c
            763-879             AC091934.2         6352-6468           c
            880-941             AC091934.2         6212-6273           c
            942-2475            AC091934.2         4117-5650           c
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..2475
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /note="tetraspanin 17"
                     /db_xref="GeneID:26262"
                     /db_xref="HGNC:HGNC:13594"
                     /db_xref="MIM:620446"
     exon            1..219
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1122
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /EC_number="3.6.5.3"
                     /note="isoform b is encoded by transcript variant 2; F-box
                     only protein 23, transmembrane 4 superfamily member 17;
                     tetraspan protein SB134"
                     /codon_start=1
                     /product="tetraspanin-17 isoform b"
                     /protein_id="NP_569732.2"
                     /db_xref="CCDS:CCDS54952.1"
                     /db_xref="GeneID:26262"
                     /db_xref="HGNC:HGNC:13594"
                     /db_xref="MIM:620446"
                     /translation="MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWG
                     EKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGL
                     IFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARG
                     PNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFI
                     HTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKAVKANWSKWNDD
                     FENHWLTPTISEVLSTAGPQQNSLTGAPGPAPPSRHVFFGLGGLYPEPTFKNW"
     exon            220..270
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     exon            271..417
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     exon            418..588
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     exon            589..714
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     exon            715..762
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     exon            763..879
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     exon            880..941
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     exon            942..2475
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /note="hexamer: AATAAA"
     polyA_site      2475
                     /gene="TSPAN17"
                     /gene_synonym="FBX23; FBXO23; TM4SF17"
                     /note="major polyA site"
ORIGIN      
        1 gctctgtgtg gccgaggcca tgaagccgca gccgcccggc taggccccgg gcggctctag
       61 cccagggcgg cccgcggggc gctgggcctg gctcccggct ccggtttccg ggccggcggg
      121 tggccgctca ccatgcccgg caagcaccag catttccagg aacctgaggt cggctgctgc
      181 gggaaatact tcctgtttgg cttcaacatt gtcttctggg tgctgggagc cctgttcctg
      241 gctatcggcc tctgggcctg gggtgagaag ggcgttctct cgaacatctc agcgctgaca
      301 gatctgggag gccttgaccc cgtgtggctg tttgtggtag ttggaggcgt catgtcggtg
      361 ctgggctttg ctggctgcat tggggccctc cgggagaaca ccttcctgct caagtttttc
      421 tccgtgttcc tcggtctcat cttcttcctg gagctggcaa cagggatcct ggcctttgtc
      481 ttcaaggact ggattcgaga ccagctcaac ctcttcatca acaacaacgt caaggcctac
      541 cgggacgaca ttgacctcca gaacctcatt gactttgctc aggaatactg gtcttgctgc
      601 ggagcccgag gccccaatga ctggaacctc aatatctact tcaactgcac tgacttgaac
      661 cccagccggg agcgctgcgg ggtgcccttc tcctgctgcg tcagggaccc tgcggaggat
      721 gtcctcaaca cccagtgtgg ctacgacgtc cggctcaaac tggagctgga gcagcagggc
      781 ttcatccaca ccaaaggctg cgtgggccag tttgagaagt ggctgcagga caacctgatt
      841 gtggtggcgg gagtcttcat gggcatcgcc ctcctccaga tctttggcat ctgcctggcc
      901 cagaacctcg tgagtgacat caaggcagtg aaagccaact ggagcaaatg gaatgatgac
      961 tttgaaaacc actggcttac gcccaccatt tccgaggtcc tgtccacggc ggggcctcag
     1021 cagaactctc tgactggggc ccctggcccg gccccaccca gccgacatgt tttctttggc
     1081 ctgggtggtt tataccctga gccaaccttt aaaaattggt agatttcaca taaaagtcca
     1141 gatccacagc ttctcttgaa gaatgaccac ctggctacgc cggctcttcg gtggcaacac
     1201 tacctgggac actgcctccc cagtcaccaa gggccccagc tggcccgttc tactcaccta
     1261 agtgccgcct gacccttgta cactaggagc tggcctccca cctctgcagg gttattccct
     1321 gcacctcgag gccgctgcgg gccaatctgg agtgaaacac ggggacctga aggatggaga
     1381 ggctggaccc cgctttgaag agggtgcagc ctgggaaggg cggccttgct ggggactgcg
     1441 gtgggagtag agtgcccagg agagggtctg aggggtggga tgggggtcag gacaattttg
     1501 caaaagaagt agctggaagc catgggactg gcgggagcct gtttggggga tctggatggt
     1561 tgactcctag gagtcaagtt cagcatcttc accgtggctg cagagctgcc tgatgggcac
     1621 tagagggcat gccagcccca cactccctgg gtctggcttc ctcccgcaac ctcactctag
     1681 tagagcctgt gcctgcctac tagcgctctg gggttcggag agtttgggaa tttctcagag
     1741 ccaactggct caggcttggg aaggctggct gctgccctca gctccgcctc atcagctatg
     1801 tgaaggggtg tgtgtggagt gatcctgccg ccccctccct gggctcgtcc agagatctca
     1861 aactccgatg cccctggggc cacgtatgtt gtataaatgg atgaaacagg cccttgagtt
     1921 gggagcctgc ttcactttga ctttcccact gttgctggag acaaagacat cgtgatgaga
     1981 gaaagttcgc acaatctagt cggtaacagc cactttcctt gagaccaaga gagtgcggtg
     2041 gggatggggg ggagagcacg ggtccccgtc tgacagtggc cgctgccata ttcaggtgta
     2101 gctaattgct ctggtgtggg aatgcaggcc taatgacaga aatctggaga agccagaaat
     2161 acagatttgt atgtgagatg tcctgatttt ttaagttgtt ggcagaaatt aattcagaaa
     2221 tcaaatctgc aggccaaaca aggtgcagga cccagctttg gccccatgcc cctgtaggtc
     2281 cctctgggac agtcaccgct ggggtcctgg ctgctctgtc attgagggat gctgggcact
     2341 gctgccgggt ggccagggta tggggcatgt gcccagcaat gtggctcctt ggccccgctg
     2401 gccagtgtcc tgggcccctg acaggcgctg gctgtgagtg gtttgtacat gctacaataa
     2461 atgcagctgg cagca
//
