LOCUS       NM_012339               1703 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tetraspanin 15 (TSPAN15), transcript variant 1, mRNA.
ACCESSION   NM_012339
VERSION     NM_012339.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1703)
  AUTHORS   Lipper,C.H., Gabriel,K.H., Seegar,T.C.M., Durr,K.L., Tomlinson,M.G.
            and Blacklow,S.C.
  TITLE     Crystal structure of the Tspan15 LEL domain reveals a conserved
            ADAM10 binding site
  JOURNAL   Structure 30 (2), 206-214 (2022)
   PUBMED   34739841
  REMARK    GeneRIF: Crystal structure of the Tspan15 LEL domain reveals a
            conserved ADAM10 binding site.
REFERENCE   2  (bases 1 to 1703)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1703)
  AUTHORS   Koo,C.Z., Harrison,N., Noy,P.J., Szyroka,J., Matthews,A.L.,
            Hsia,H.E., Muller,S.A., Tushaus,J., Goulding,J., Willis,K.,
            Apicella,C., Cragoe,B., Davis,E., Keles,M., Malinova,A.,
            McFarlane,T.A., Morrison,P.R., Nguyen,H.T.H., Sykes,M.C., Ahmed,H.,
            Di Maio,A., Seipold,L., Saftig,P., Cull,E., Pliotas,C.,
            Rubinstein,E., Poulter,N.S., Briddon,S.J., Holliday,N.D.,
            Lichtenthaler,S.F. and Tomlinson,M.G.
  TITLE     The tetraspanin Tspan15 is an essential subunit of an ADAM10
            scissor complex
  JOURNAL   J Biol Chem 295 (36), 12822-12839 (2020)
   PUBMED   32111735
  REMARK    GeneRIF: The tetraspanin Tspan15 is an essential subunit of an
            ADAM10 scissor complex.
REFERENCE   4  (bases 1 to 1703)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1703)
  AUTHORS   Eschenbrenner,E., Jouannet,S., Clay,D., Chaker,J., Boucheix,C.,
            Brou,C., Tomlinson,M.G., Charrin,S. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and
            half-life
  JOURNAL   Life Sci Alliance 3 (1), e201900444 (2019)
   PUBMED   31792032
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1703)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   7  (bases 1 to 1703)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1703)
  AUTHORS   Semplici,F., Meggio,F., Pinna,L.A. and Oliviero,S.
  TITLE     CK2-dependent phosphorylation of the E2 ubiquitin conjugating
            enzyme UBC3B induces its interaction with beta-TrCP and enhances
            beta-catenin degradation
  JOURNAL   Oncogene 21 (25), 3978-3987 (2002)
   PUBMED   12037680
REFERENCE   9  (bases 1 to 1703)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   10 (bases 1 to 1703)
  AUTHORS   Serru,V., Dessen,P., Boucheix,C. and Rubinstein,E.
  TITLE     Sequence and expression of seven new tetraspans
  JOURNAL   Biochim Biophys Acta 1478 (1), 159-163 (2000)
   PUBMED   10719184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016821.9, DR158973.1,
            BC003157.1, CA454790.1, BM972680.1 and AI612860.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012339.4.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            The use of alternate polyadenylation sites has been found for this
            gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.346384.1,
                                           SRR3476690.1138911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373290.7/ ENSP00000362387.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC016821.9         96347-96348
            3-11                DR158973.1         1-9
            12-948              BC003157.1         1-937
            949-1084            CA454790.1         605-740
            1085-1663           BM972680.1         61-639              c
            1664-1703           AI612860.1         4-43                c
FEATURES             Location/Qualifiers
     source          1..1703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..1703
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /note="tetraspanin 15"
                     /db_xref="GeneID:23555"
                     /db_xref="HGNC:HGNC:23298"
                     /db_xref="MIM:613140"
     exon            1..226
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1015
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane 4 superfamily member tetraspan NET-7;
                     transmembrane 4 superfamily member 15; tspan-15"
                     /codon_start=1
                     /product="tetraspanin-15 isoform 1"
                     /protein_id="NP_036471.1"
                     /db_xref="CCDS:CCDS7294.1"
                     /db_xref="GeneID:23555"
                     /db_xref="HGNC:HGNC:23298"
                     /db_xref="MIM:613140"
                     /translation="MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGALVLSVGIY
                     AEVERQKYKTLESAFLAPAIILILLGVVMFMVSFIGVLASLRDNLYLLQAFMYILGIC
                     LIMELIGGVVALTFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDY
                     RDWSKNQYHDCSAPGPLACGVPYTCCIRNTTEVVNTMCGYKTIDKERFSVQDVIYVRG
                     CTNAVIIWFMDNYTIMAGILLGILLPQFLGVLLTLLYITRVEDIIMEHSVTDGLLGPG
                     AKPSVEAAGTGCCLCYPN"
     exon            227..412
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /inference="alignment:Splign:2.1.0"
     exon            413..487
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /inference="alignment:Splign:2.1.0"
     exon            488..583
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /inference="alignment:Splign:2.1.0"
     exon            584..700
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /inference="alignment:Splign:2.1.0"
     exon            701..748
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /inference="alignment:Splign:2.1.0"
     exon            749..865
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1703
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /note="hexamer: AATAAA"
     polyA_site      1703
                     /gene="TSPAN15"
                     /gene_synonym="2700063A19Rik; NET-7; NET7; TM4SF15"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtcccg gagagaacgc cggtggcggg gctggtagcc cggcagccgc aggtggggcc
       61 acgagcgctg gctgagggac cgagccggag agccccggag cccccgtaac ccgcgcgggg
      121 agcgcccagg atgccgcgcg gggactcgga gcaggtgcgc tactgcgcgc gcttctccta
      181 cctctggctc aagttttcac ttatcatcta ttccaccgtg ttctggctga ttggggccct
      241 ggtcctgtct gtgggcatct atgcagaggt tgagcggcag aaatataaaa cccttgaaag
      301 tgccttcctg gctccagcca tcatcctcat cctcctgggc gtcgtcatgt tcatggtctc
      361 cttcattggt gtgctggcgt ccctccgtga caacctgtac cttctccaag cattcatgta
      421 catccttggg atctgcctca tcatggagct cattggtggc gtggtggcct tgaccttccg
      481 gaaccagacc attgacttcc tgaacgacaa cattcgaaga ggaattgaga actactatga
      541 tgatctggac ttcaaaaaca tcatggactt tgttcagaaa aagttcaagt gctgtggcgg
      601 ggaggactac cgagattgga gcaagaatca gtaccacgac tgcagtgccc ctggacccct
      661 ggcctgtggg gtgccctaca cctgctgcat caggaacacg acagaagttg tcaacaccat
      721 gtgtggctac aaaactatcg acaaggagcg tttcagtgtg caggatgtca tctacgtgcg
      781 gggctgcacc aacgccgtga tcatctggtt catggacaac tacaccatca tggcgggcat
      841 cctcctgggc atcctgcttc cccagttcct gggggtgctg ctgacgctgc tgtacatcac
      901 ccgggtggag gacatcatca tggagcactc tgtcactgat gggctcctgg ggcccggtgc
      961 caagcccagc gtggaggcgg caggcacggg atgctgcttg tgctacccca attagggccc
     1021 agcctgccat ggcagctcca acaaggaccg tctgggatag cacctctcag tcaacatcgt
     1081 ggggctggac agggctgcgg cccctctgcc cacactcagt actgaccaaa gccagggctg
     1141 tgtgtgcctg tgtgtaggtc ccacggcctc tgcctcccca gggagcagag cctgggcctc
     1201 ccctaagagg ctttccccga ggcagctctg gaatctgtgc ccacctgggg cctggggaac
     1261 aaggccctcc tttctccagg cctgggctac gggggaggga gagcctgagg ctctgctcag
     1321 ggcccatttc atctctggca gtgccttggc ggtggtattc aaggcagttt tgtagcacct
     1381 gtaattgggg agagggagtg tgcccctcgg ggcaggaggg aagggcatct ggggaagggc
     1441 aggagggaag agctgtccat gcagccacgc ccatggccag gttggcctct tctcagcctc
     1501 ccaggtgcct tgagccctct tgcaagggcg gctgcttcct tgagcctagt ttttttacgt
     1561 gatttttgta acattcattt ttttgtacag ataacaggag tttctgacta atcaaagctg
     1621 gtatttcccc gcatgtctta ttcttgccct tcccccaacc agtttgttaa tcaaacaata
     1681 aaaacatgtt tttttttttt ttt
//
