LOCUS       NM_030927               5547 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens tetraspanin 14 (TSPAN14), transcript variant 1, mRNA.
ACCESSION   NM_030927
VERSION     NM_030927.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5547)
  AUTHORS   Jouannet,S., Saint-Pol,J., Fernandez,L., Nguyen,V., Charrin,S.,
            Boucheix,C., Brou,C., Milhiet,P.E. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins differentially regulate the cleavage of ADAM10
            substrates, Notch activation and ADAM10 membrane
            compartmentalization
  JOURNAL   Cell Mol Life Sci 73 (9), 1895-1915 (2016)
   PUBMED   26686862
REFERENCE   2  (bases 1 to 5547)
  AUTHORS   Noy,P.J., Yang,J., Reyat,J.S., Matthews,A.L., Charlton,A.E.,
            Furmston,J., Rogers,D.A., Rainger,G.E. and Tomlinson,M.G.
  TITLE     TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10
            (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR
            DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS
  JOURNAL   J Biol Chem 291 (7), 3145-3157 (2016)
   PUBMED   26668317
  REMARK    GeneRIF: Data suggest that large extracellular loop of Tspan14
            mediates interaction with ADAM10, promotes ADAM10
            maturation/trafficking to cell surface, and affects ADAM10
            substrate specificity; ADAM10/Tspan14 interact in
            platelets/vascular endothelial cells.
REFERENCE   3  (bases 1 to 5547)
  AUTHORS   Haining,E.J., Yang,J., Bailey,R.L., Khan,K., Collier,R., Tsai,S.,
            Watson,S.P., Frampton,J., Garcia,P. and Tomlinson,M.G.
  TITLE     The TspanC8 subgroup of tetraspanins interacts with A disintegrin
            and metalloprotease 10 (ADAM10) and regulates its maturation and
            cell surface expression
  JOURNAL   J Biol Chem 287 (47), 39753-39765 (2012)
   PUBMED   23035126
REFERENCE   4  (bases 1 to 5547)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 5547)
  AUTHORS   Dornier,E., Coumailleau,F., Ottavi,J.F., Moretti,J., Boucheix,C.,
            Mauduit,P., Schweisguth,F. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and
            promote Notch activation in flies and mammals
  JOURNAL   J Cell Biol 199 (3), 481-496 (2012)
   PUBMED   23091066
  REMARK    Erratum:[J Cell Biol. 2016 May 23;213(4):495-6. doi:
            10.1083/jcb.20120113304262016c.. PMID: 27185832]
REFERENCE   6  (bases 1 to 5547)
  AUTHORS   Bankovic,J., Stojsic,J., Jovanovic,D., Andjelkovic,T.,
            Milinkovic,V., Ruzdijic,S. and Tanic,N.
  TITLE     Identification of genes associated with non-small-cell lung cancer
            promotion and progression
  JOURNAL   Lung Cancer 67 (2), 151-159 (2010)
   PUBMED   19473719
  REMARK    GeneRIF: genetic alterations of TSPAN14, SLC2A13 and PHF20 could
            play a role in non-small-cell lung cancer promotion
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ923322.1, AL136638.1, BC002920.2, AC021028.12 and BM991301.1.
            
            On May 20, 2020 this sequence version replaced NM_030927.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The extent of this transcript is supported by
            transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1680402.1, AL136638.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429989.8/ ENSP00000396270.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BQ923322.1         145-145
            2-505               AL136638.1         1-504
            506-2443            BC002920.2         429-2366
            2444-5138           AC021028.12        112539-115233
            5139-5547           BM991301.1         16-424              c
FEATURES             Location/Qualifiers
     source          1..5547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..5547
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="tetraspanin 14"
                     /db_xref="GeneID:81619"
                     /db_xref="HGNC:HGNC:23303"
     exon            1..62
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            63..160
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..892
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane 4 superfamily member 14; tetraspanin similar
                     to TM4SF9"
                     /codon_start=1
                     /product="tetraspanin-14 isoform 1"
                     /protein_id="NP_112189.2"
                     /db_xref="CCDS:CCDS7369.1"
                     /db_xref="GeneID:81619"
                     /db_xref="HGNC:HGNC:23303"
                     /translation="MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEK
                     GVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVLIF
                     FLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPE
                     DWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFT
                     KGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF"
     exon            161..211
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            212..358
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            359..529
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            530..655
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            656..700
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            701..820
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            821..5547
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="hexamer: AATATA"
     polyA_site      2546
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="major polyA site"
     regulatory      5518..5523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="hexamer: AATAAA"
     polyA_site      5547
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
ORIGIN      
        1 gaacttgctc taacttcctc ggccgagccg ggccgcgccg ccgctgccgc cgccgcgcgc
       61 ggattctgct tctcagaaga tgcactatta tagatactct aacgccaagg tcagctgctg
      121 gtacaagtac ctccttttca gctacaacat catcttctgg ttggctggag ttgtcttcct
      181 tggagtcggg ctgtgggcat ggagcgaaaa gggtgtgctg tccgacctca ccaaagtgac
      241 ccggatgcat ggaatcgacc ctgtggtgct ggtcctgatg gtgggcgtgg tgatgttcac
      301 cctggggttc gccggctgcg tgggggctct gcgggagaat atctgcttgc tcaacttttt
      361 ctgtggcacc atcgtgctca tcttcttcct ggagctggct gtggccgtgc tggccttcct
      421 gttccaggac tgggtgaggg accggttccg ggagttcttc gagagcaaca tcaagtccta
      481 ccgggacgat atcgatctgc aaaacctcat cgactccctt cagaaagcta accagtgctg
      541 tggcgcatat ggccctgaag actgggacct caacgtctac ttcaattgca gcggtgccag
      601 ctacagccga gagaagtgcg gggtcccctt ctcctgctgc gtgccagatc ctgcgcaaaa
      661 agttgtgaac acacagtgtg gatatgatgt caggattcag ctgaagagca agtgggatga
      721 gtccatcttc acgaaaggct gcatccaggc gctggaaagc tggctcccgc ggaacattta
      781 cattgtggct ggcgtcttca tcgccatctc gctgttgcag atatttggca tcttcctggc
      841 aaggacgctg atctcagaca tcgaggcagt gaaggccggc catcacttct gaggagcaga
      901 gttgagggag ccgagctgag ccacgctggg aggccagagc ctttctctgc catcagccct
      961 acgtccagag ggagaggagc cgacaccccc agagccagtg ccccatctta agcatcagcg
     1021 tgacgtgacc tctctgtttc tgcttgctgg tgctgaagac caagggtccc ccttgttacc
     1081 tgcccaaact tgtgactgca tccctctgga gtctacccag agacagagaa tgtgtcttta
     1141 tgtgggagtg gtgactctga aagacagaga gggctcctgt ggctgccagg agggcttgac
     1201 tcagaccccc tgcagctcaa gcatgtctgc aggacaccct ggtcccctct ccactggcat
     1261 ccagacatct gctttgggtc atccacatct gtgggtgggc cgtgggtaga gggacccaca
     1321 ggcgtggaca gggcatctct ctccatcaag caaagcagca tgggggcctg cccgtaacgg
     1381 gaggcggacg tggccccgct gggcctctga gtgccagcgc agtctgctgg gacatgcaca
     1441 tatcaggggt tgtttgcagg atcctcagcc atgttcaagt gaagtaagcc tgagccagtg
     1501 cgtggactgg tgccacggga gtgccttgtc cactgtcccc ctgtgtccac cagctattct
     1561 cctggcgccg gaactgcctc tggtcttgat agcattaagc cctgatggcg ccggtggcgc
     1621 ggtgggcatg gttcttcact gagagccggc tctccttttc ttaaagtgtg taaatagttt
     1681 atttataggg gtaagaatgt tctcacacca tttcacttcc tcttcctctc ctccagcatt
     1741 ctcctctgag cagccttaga tagtgtccat ggctggagcc gaccctttga gtccccttga
     1801 gtgtcttaag aaccagccca caacagcctc tctttctcct ccacatactg cagcctccct
     1861 ccatgcatcc cacatacaag cactccccca ctccccagcg tggcctcact gtcttctggt
     1921 cttggtgcta ctgaaattgt cacccagaat ttgaatcctg accctcccca ctgcaagccc
     1981 agggagcccc agcccaagat ggccagcctg aaactgttgg ccagggctcc tcttgtggcc
     2041 atgtacccag ggctggctgg cctgccattt gcctctcccc ggagacagcc gttcttctgc
     2101 aaccacaccc cgtgcctagc cacaacccca ggctgcagct gctcagaagc tccaggcatt
     2161 ttgtttctgg tgaccgcccc taatgggata tcggtgatca ctggtccacc cttcctgtca
     2221 gggcttttct ggggctgctc ttggaaatga agtcttaagt actgaataac tcccctgggg
     2281 atagctgggg catttgtcta gctgggctac tttctaacac tttgccatag ctcagaccac
     2341 ttctcatcgt tcagggatgg actgcaacct taatttactt gccggagtgt acattctagt
     2401 gtggtgtata ctggtggctg ttgatgatga tttttttttt tttacacaat tctctgtaga
     2461 ctaggagaag aatgcttgtg tttttcggaa gtgtgatgct tctctttgac tgccaaactc
     2521 ttttatggaa tatatcttta tattaatgct gttttggtca tttttgtttg gggtcactat
     2581 tgagatattg ctaagcatct cagtggtaaa cgcggctgcc agaggaacca agggataggg
     2641 tatgtagacc ttacagaagg atggatggta aaggcagtcc atcatcagca caatctgact
     2701 tacatttcat tgagtaattt tttttttttt taagattctg tatggcagca ctttcagttg
     2761 cccttgtgtg ccggccacag ccgcacaagt tggcttgtgg tttatccccc gctataagtg
     2821 agagctggag aaacttcaac tccataggtc tagaggaaac attgttttag gttatttctg
     2881 tccacccctg tgcgatacta tttattgatc caagcagaag agcttgggga cactgagtcg
     2941 aagtggggac atgggattga agcctgggca ctgctgctgc atgagctgtg tgtcctgggt
     3001 gtgccggcct ttctgtgaag ggggttggtg gcagtgccca cctcactaga tgcctctgac
     3061 ccagcctccc ctgggggagt gggtggccac agaccctccc tgccagagct cctggaaggc
     3121 tcctgcaggc ctgacccatc tattcctgta gacctggttt aggatgaagt ctcggtgcga
     3181 tttttgcaga gttgggttta tctttcaact atagaccctt ctggctgttc tcagccatat
     3241 catgtgactc tgaatagttg gatgaggaat ggaaagaaag caaggatgag agccggtcac
     3301 gtggcagtct ccgcccagca tcggctgtcc gcacagaggc acagggcagg cctcctgtgc
     3361 actccccacc tagcactggc ctgtcctgaa tccccgcctt ccctggttgg aggccagctg
     3421 tggcatttgc accctcttct cacctcacca tgcacatgct aactttaaag ccttggggtc
     3481 tttcctgtac cccctcctca accctggtcc accccctctc aggatcttgt caacgttatt
     3541 tttcctgtcc cgtcttccta tcgctggcct tcctttccca tcctaaaaac ttgccgaggc
     3601 cctatggctc cctccctttc tttcccaggc agcttcttat ctgggctgtc tgtacccctt
     3661 cctttgcacc acccaccatg ccccacgtag ctgaaagctg cttatcccaa ttgtcaactc
     3721 tggccttctt cagcctctgt agcaccagac actgcacctc ctgaatgtcc tctgcttctc
     3781 tgcttcagag gcccaggctc gccagttctc tgacctctcc catatgtctg cttaggactc
     3841 tgctgcagct gtcctcacca gcctccgggg aatcccacta cccacagggc agggctgtgg
     3901 gctgggctga aaaaccatct gcatggtcca caagaagcct ggcactgggt ttccccatga
     3961 ataacaatga aaattaatgg atgcacaacc ttcctggaac gtggaatttc tctgggagat
     4021 tccatgcaga ggccactggg gaggtggcag gcatgcatgt gactgtaggt ggctgcagtg
     4081 ttggaaggct cccagcagag cagagagggt gtcagtctca tcagggaacc cacctgatgg
     4141 cttctcagcc agcagtctca gaggaacata gacgactgct gagaaaggag ggaggcagca
     4201 gtggtcccag cacctgaggc atcctgctgt catgggaagg tctccgccca aatgtcagat
     4261 gcatcagcct gtcacccgct ggtccagagc tttcagctgt actggtaggg ggtgggtggt
     4321 ggagtgctga atgaccttca caggtgggcc tttccagctc tagggtctta cgggtgtcgg
     4381 tccacagaac cacggttttt aggttgtgtg tccggggcta tgggaacctg tcccccatga
     4441 tggatcttgg tagagacact tccctctgtc atcgtgccca ggaggatgct gcaggtgact
     4501 acctgcagcc ctgttctcat tcatttggat gccctccaga aatctgggga gccatacacc
     4561 tttagagcct tttttgctcc ttatcaagtt ggcaaggctt ggccaattcc tgttcaaggc
     4621 tgcattaaag gcatgttcac catcctggct aatacggtga aaccccttct ctactaaaaa
     4681 tacaaaaaaa ttagccgggc ttggtggcgg gtgcctgtag tcccagctac tccggaggct
     4741 gaggcagggg aatggtgtga acccaggagg cggagcttgc agtgagccga gatcacacca
     4801 ctgcactcca gcctgggctc aaaaaagaaa aaaaaaaaaa aaaaaaggcc cgttcattct
     4861 caaatgcttt tggcgtctcc agggtgcctc aggaaaacat gaagtgggca ttgtagaact
     4921 tggggctact gtgtaacttt ggaagaaaaa gttaagggta cttttaagtg gatactgttt
     4981 tgatgaaatt gccaacttca gggagcccag cttggagaag gaggacgtga gtattcctta
     5041 caaggctccg aaacaattct ttcttcactt agttttcttt ctgtgctctg catcttatat
     5101 tccagcaggg tcttccaatg catggtttaa taactactag aactggccag gtgcagtggc
     5161 tcacgcctgt aatcccagaa ctttgggagg ctaagacagg cagatcactt gaggccagga
     5221 gttcgagacc agcctggaca acatggtgat acccagtttc tactaaaaat acaaaaatta
     5281 gtcgggcatg gtgatgtgca cctgtagtcc cagctgctcg ggaggctgag gcaggagaat
     5341 cgcttgaacc cgggagacag aggttgcaac gagccaagat cgagccactg cgctccggcc
     5401 tgggtgacag gagactccat ctcaaaaaat aaaattaaaa aaaaactact acaataaatt
     5461 atcaccttgg actgtataaa acaactttta aactagtctt tttaaaaagt acacttaaat
     5521 aaaaatctaa acataagaga atgtaaa
//
