LOCUS       NM_001351269            5708 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens tetraspanin 14 (TSPAN14), transcript variant 6, mRNA.
ACCESSION   NM_001351269 XM_006717992
VERSION     NM_001351269.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5708)
  AUTHORS   Jouannet,S., Saint-Pol,J., Fernandez,L., Nguyen,V., Charrin,S.,
            Boucheix,C., Brou,C., Milhiet,P.E. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins differentially regulate the cleavage of ADAM10
            substrates, Notch activation and ADAM10 membrane
            compartmentalization
  JOURNAL   Cell Mol Life Sci 73 (9), 1895-1915 (2016)
   PUBMED   26686862
REFERENCE   2  (bases 1 to 5708)
  AUTHORS   Noy,P.J., Yang,J., Reyat,J.S., Matthews,A.L., Charlton,A.E.,
            Furmston,J., Rogers,D.A., Rainger,G.E. and Tomlinson,M.G.
  TITLE     TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10
            (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR
            DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS
  JOURNAL   J Biol Chem 291 (7), 3145-3157 (2016)
   PUBMED   26668317
  REMARK    GeneRIF: Data suggest that large extracellular loop of Tspan14
            mediates interaction with ADAM10, promotes ADAM10
            maturation/trafficking to cell surface, and affects ADAM10
            substrate specificity; ADAM10/Tspan14 interact in
            platelets/vascular endothelial cells.
REFERENCE   3  (bases 1 to 5708)
  AUTHORS   Haining,E.J., Yang,J., Bailey,R.L., Khan,K., Collier,R., Tsai,S.,
            Watson,S.P., Frampton,J., Garcia,P. and Tomlinson,M.G.
  TITLE     The TspanC8 subgroup of tetraspanins interacts with A disintegrin
            and metalloprotease 10 (ADAM10) and regulates its maturation and
            cell surface expression
  JOURNAL   J Biol Chem 287 (47), 39753-39765 (2012)
   PUBMED   23035126
REFERENCE   4  (bases 1 to 5708)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 5708)
  AUTHORS   Dornier,E., Coumailleau,F., Ottavi,J.F., Moretti,J., Boucheix,C.,
            Mauduit,P., Schweisguth,F. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and
            promote Notch activation in flies and mammals
  JOURNAL   J Cell Biol 199 (3), 481-496 (2012)
   PUBMED   23091066
  REMARK    Erratum:[J Cell Biol. 2016 May 23;213(4):495-6. doi:
            10.1083/jcb.20120113304262016c.. PMID: 27185832]
REFERENCE   6  (bases 1 to 5708)
  AUTHORS   Bankovic,J., Stojsic,J., Jovanovic,D., Andjelkovic,T.,
            Milinkovic,V., Ruzdijic,S. and Tanic,N.
  TITLE     Identification of genes associated with non-small-cell lung cancer
            promotion and progression
  JOURNAL   Lung Cancer 67 (2), 151-159 (2010)
   PUBMED   19473719
  REMARK    GeneRIF: genetic alterations of TSPAN14, SLC2A13 and PHF20 could
            play a role in non-small-cell lung cancer promotion
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021028.12, DN998010.1, BC002920.2 and BM991301.1.
            
            On May 20, 2020 this sequence version replaced NM_001351269.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4542179.1,
                                           SRR11853558.3056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC021028.12        52296-52395
            101-725             DN998010.1         7-631
            726-2604            BC002920.2         488-2366
            2605-5299           AC021028.12        112539-115233
            5300-5708           BM991301.1         16-424              c
FEATURES             Location/Qualifiers
     source          1..5708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..5708
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="tetraspanin 14"
                     /db_xref="GeneID:81619"
                     /db_xref="HGNC:HGNC:23303"
     exon            1..223
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            224..321
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1053
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="isoform 1 is encoded by transcript variant 6;
                     transmembrane 4 superfamily member 14; tetraspanin similar
                     to TM4SF9"
                     /codon_start=1
                     /product="tetraspanin-14 isoform 1"
                     /protein_id="NP_001338198.1"
                     /db_xref="CCDS:CCDS7369.1"
                     /db_xref="GeneID:81619"
                     /db_xref="HGNC:HGNC:23303"
                     /translation="MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEK
                     GVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVLIF
                     FLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPE
                     DWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFT
                     KGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF"
     exon            322..372
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            373..519
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            520..690
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            691..816
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            817..861
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            862..981
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            982..5708
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2690..2695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="hexamer: AATATA"
     polyA_site      2707
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="major polyA site"
     regulatory      5679..5684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
                     /note="hexamer: AATAAA"
     polyA_site      5708
                     /gene="TSPAN14"
                     /gene_synonym="DC-TM4F2; TM4SF14; tspan-14"
ORIGIN      
        1 agagcttaag tgggcctggg caggctgggg ttgaaactct tcaccccttg cggtctgtac
       61 tgcctcccaa ctgagcagcc agggagaagg cctagagcct gtgcctttca gctagatagc
      121 tggaggaact ggctcctccc tccttaggct gtgctggcct gagctgggag cctgagagct
      181 ggggcagttg tctctaaagt ggcttctggg attctggtaa gagattctgc ttctcagaag
      241 atgcactatt atagatactc taacgccaag gtcagctgct ggtacaagta cctccttttc
      301 agctacaaca tcatcttctg gttggctgga gttgtcttcc ttggagtcgg gctgtgggca
      361 tggagcgaaa agggtgtgct gtccgacctc accaaagtga cccggatgca tggaatcgac
      421 cctgtggtgc tggtcctgat ggtgggcgtg gtgatgttca ccctggggtt cgccggctgc
      481 gtgggggctc tgcgggagaa tatctgcttg ctcaactttt tctgtggcac catcgtgctc
      541 atcttcttcc tggagctggc tgtggccgtg ctggccttcc tgttccagga ctgggtgagg
      601 gaccggttcc gggagttctt cgagagcaac atcaagtcct accgggacga tatcgatctg
      661 caaaacctca tcgactccct tcagaaagct aaccagtgct gtggcgcata tggccctgaa
      721 gactgggacc tcaacgtcta cttcaattgc agcggtgcca gctacagccg agagaagtgc
      781 ggggtcccct tctcctgctg cgtgccagat cctgcgcaaa aagttgtgaa cacacagtgt
      841 ggatatgatg tcaggattca gctgaagagc aagtgggatg agtccatctt cacgaaaggc
      901 tgcatccagg cgctggaaag ctggctcccg cggaacattt acattgtggc tggcgtcttc
      961 atcgccatct cgctgttgca gatatttggc atcttcctgg caaggacgct gatctcagac
     1021 atcgaggcag tgaaggccgg ccatcacttc tgaggagcag agttgaggga gccgagctga
     1081 gccacgctgg gaggccagag cctttctctg ccatcagccc tacgtccaga gggagaggag
     1141 ccgacacccc cagagccagt gccccatctt aagcatcagc gtgacgtgac ctctctgttt
     1201 ctgcttgctg gtgctgaaga ccaagggtcc cccttgttac ctgcccaaac ttgtgactgc
     1261 atccctctgg agtctaccca gagacagaga atgtgtcttt atgtgggagt ggtgactctg
     1321 aaagacagag agggctcctg tggctgccag gagggcttga ctcagacccc ctgcagctca
     1381 agcatgtctg caggacaccc tggtcccctc tccactggca tccagacatc tgctttgggt
     1441 catccacatc tgtgggtggg ccgtgggtag agggacccac aggcgtggac agggcatctc
     1501 tctccatcaa gcaaagcagc atgggggcct gcccgtaacg ggaggcggac gtggccccgc
     1561 tgggcctctg agtgccagcg cagtctgctg ggacatgcac atatcagggg ttgtttgcag
     1621 gatcctcagc catgttcaag tgaagtaagc ctgagccagt gcgtggactg gtgccacggg
     1681 agtgccttgt ccactgtccc cctgtgtcca ccagctattc tcctggcgcc ggaactgcct
     1741 ctggtcttga tagcattaag ccctgatggc gccggtggcg cggtgggcat ggttcttcac
     1801 tgagagccgg ctctcctttt cttaaagtgt gtaaatagtt tatttatagg ggtaagaatg
     1861 ttctcacacc atttcacttc ctcttcctct cctccagcat tctcctctga gcagccttag
     1921 atagtgtcca tggctggagc cgaccctttg agtccccttg agtgtcttaa gaaccagccc
     1981 acaacagcct ctctttctcc tccacatact gcagcctccc tccatgcatc ccacatacaa
     2041 gcactccccc actccccagc gtggcctcac tgtcttctgg tcttggtgct actgaaattg
     2101 tcacccagaa tttgaatcct gaccctcccc actgcaagcc cagggagccc cagcccaaga
     2161 tggccagcct gaaactgttg gccagggctc ctcttgtggc catgtaccca gggctggctg
     2221 gcctgccatt tgcctctccc cggagacagc cgttcttctg caaccacacc ccgtgcctag
     2281 ccacaacccc aggctgcagc tgctcagaag ctccaggcat tttgtttctg gtgaccgccc
     2341 ctaatgggat atcggtgatc actggtccac ccttcctgtc agggcttttc tggggctgct
     2401 cttggaaatg aagtcttaag tactgaataa ctcccctggg gatagctggg gcatttgtct
     2461 agctgggcta ctttctaaca ctttgccata gctcagacca cttctcatcg ttcagggatg
     2521 gactgcaacc ttaatttact tgccggagtg tacattctag tgtggtgtat actggtggct
     2581 gttgatgatg attttttttt ttttacacaa ttctctgtag actaggagaa gaatgcttgt
     2641 gtttttcgga agtgtgatgc ttctctttga ctgccaaact cttttatgga atatatcttt
     2701 atattaatgc tgttttggtc atttttgttt ggggtcacta ttgagatatt gctaagcatc
     2761 tcagtggtaa acgcggctgc cagaggaacc aagggatagg gtatgtagac cttacagaag
     2821 gatggatggt aaaggcagtc catcatcagc acaatctgac ttacatttca ttgagtaatt
     2881 tttttttttt ttaagattct gtatggcagc actttcagtt gcccttgtgt gccggccaca
     2941 gccgcacaag ttggcttgtg gtttatcccc cgctataagt gagagctgga gaaacttcaa
     3001 ctccataggt ctagaggaaa cattgtttta ggttatttct gtccacccct gtgcgatact
     3061 atttattgat ccaagcagaa gagcttgggg acactgagtc gaagtgggga catgggattg
     3121 aagcctgggc actgctgctg catgagctgt gtgtcctggg tgtgccggcc tttctgtgaa
     3181 gggggttggt ggcagtgccc acctcactag atgcctctga cccagcctcc cctgggggag
     3241 tgggtggcca cagaccctcc ctgccagagc tcctggaagg ctcctgcagg cctgacccat
     3301 ctattcctgt agacctggtt taggatgaag tctcggtgcg atttttgcag agttgggttt
     3361 atctttcaac tatagaccct tctggctgtt ctcagccata tcatgtgact ctgaatagtt
     3421 ggatgaggaa tggaaagaaa gcaaggatga gagccggtca cgtggcagtc tccgcccagc
     3481 atcggctgtc cgcacagagg cacagggcag gcctcctgtg cactccccac ctagcactgg
     3541 cctgtcctga atccccgcct tccctggttg gaggccagct gtggcatttg caccctcttc
     3601 tcacctcacc atgcacatgc taactttaaa gccttggggt ctttcctgta ccccctcctc
     3661 aaccctggtc caccccctct caggatcttg tcaacgttat ttttcctgtc ccgtcttcct
     3721 atcgctggcc ttcctttccc atcctaaaaa cttgccgagg ccctatggct ccctcccttt
     3781 ctttcccagg cagcttctta tctgggctgt ctgtacccct tcctttgcac cacccaccat
     3841 gccccacgta gctgaaagct gcttatccca attgtcaact ctggccttct tcagcctctg
     3901 tagcaccaga cactgcacct cctgaatgtc ctctgcttct ctgcttcaga ggcccaggct
     3961 cgccagttct ctgacctctc ccatatgtct gcttaggact ctgctgcagc tgtcctcacc
     4021 agcctccggg gaatcccact acccacaggg cagggctgtg ggctgggctg aaaaaccatc
     4081 tgcatggtcc acaagaagcc tggcactggg tttccccatg aataacaatg aaaattaatg
     4141 gatgcacaac cttcctggaa cgtggaattt ctctgggaga ttccatgcag aggccactgg
     4201 ggaggtggca ggcatgcatg tgactgtagg tggctgcagt gttggaaggc tcccagcaga
     4261 gcagagaggg tgtcagtctc atcagggaac ccacctgatg gcttctcagc cagcagtctc
     4321 agaggaacat agacgactgc tgagaaagga gggaggcagc agtggtccca gcacctgagg
     4381 catcctgctg tcatgggaag gtctccgccc aaatgtcaga tgcatcagcc tgtcacccgc
     4441 tggtccagag ctttcagctg tactggtagg gggtgggtgg tggagtgctg aatgaccttc
     4501 acaggtgggc ctttccagct ctagggtctt acgggtgtcg gtccacagaa ccacggtttt
     4561 taggttgtgt gtccggggct atgggaacct gtcccccatg atggatcttg gtagagacac
     4621 ttccctctgt catcgtgccc aggaggatgc tgcaggtgac tacctgcagc cctgttctca
     4681 ttcatttgga tgccctccag aaatctgggg agccatacac ctttagagcc ttttttgctc
     4741 cttatcaagt tggcaaggct tggccaattc ctgttcaagg ctgcattaaa ggcatgttca
     4801 ccatcctggc taatacggtg aaaccccttc tctactaaaa atacaaaaaa attagccggg
     4861 cttggtggcg ggtgcctgta gtcccagcta ctccggaggc tgaggcaggg gaatggtgtg
     4921 aacccaggag gcggagcttg cagtgagccg agatcacacc actgcactcc agcctgggct
     4981 caaaaaagaa aaaaaaaaaa aaaaaaaggc ccgttcattc tcaaatgctt ttggcgtctc
     5041 cagggtgcct caggaaaaca tgaagtgggc attgtagaac ttggggctac tgtgtaactt
     5101 tggaagaaaa agttaagggt acttttaagt ggatactgtt ttgatgaaat tgccaacttc
     5161 agggagccca gcttggagaa ggaggacgtg agtattcctt acaaggctcc gaaacaattc
     5221 tttcttcact tagttttctt tctgtgctct gcatcttata ttccagcagg gtcttccaat
     5281 gcatggttta ataactacta gaactggcca ggtgcagtgg ctcacgcctg taatcccaga
     5341 actttgggag gctaagacag gcagatcact tgaggccagg agttcgagac cagcctggac
     5401 aacatggtga tacccagttt ctactaaaaa tacaaaaatt agtcgggcat ggtgatgtgc
     5461 acctgtagtc ccagctgctc gggaggctga ggcaggagaa tcgcttgaac ccgggagaca
     5521 gaggttgcaa cgagccaaga tcgagccact gcgctccggc ctgggtgaca ggagactcca
     5581 tctcaaaaaa taaaattaaa aaaaaactac tacaataaat tatcaccttg gactgtataa
     5641 aacaactttt aaactagtct ttttaaaaag tacacttaaa taaaaatcta aacataagag
     5701 aatgtaaa
//
