LOCUS       NM_014399               1873 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tetraspanin 13 (TSPAN13), mRNA.
ACCESSION   NM_014399
VERSION     NM_014399.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Jiang,L., Zhang,X., Geradts,J., Wei,Q., Hochwald,S., Xu,H. and
            Huang,H.
  TITLE     Expression of tetraspanins NET-6 and CD151 in breast cancer as a
            potential tumor biomarker
  JOURNAL   Clin Exp Med 19 (3), 377-384 (2019)
   PUBMED   31004251
  REMARK    GeneRIF: The expression of tetraspanins NET-6 and CD151 may
            indicate an alteration of their biological function during
            neoplastic transformation.
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Li,P., Dong,M. and Wang,Z.
  TITLE     Downregulation of TSPAN13 by miR-369-3p inhibits cell proliferation
            in papillary thyroid cancer (PTC)
  JOURNAL   Bosn J Basic Med Sci 19 (2), 146-154 (2019)
   PUBMED   30114378
  REMARK    GeneRIF: downregulation of miR-369-3p and consequent upregulation
            of its target TSPAN13 appear to be involved in pathophysiology of
            papillary thyroid cancer
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Wang,Y.W., Zhao,S., Yuan,X.Y., Liu,Y., Zhang,K., Wang,J., Zhu,J.
            and Ma,R.
  TITLE     miR-4732-5p promotes breast cancer progression by targeting TSPAN13
  JOURNAL   J Cell Mol Med 23 (4), 2549-2557 (2019)
   PUBMED   30701690
  REMARK    GeneRIF: The results suggested that miR-4732-5p may serve as a
            tumor suppressor in the initiation of breast cancer, but as a tumor
            promoter in breast cancer progression by targeting TSPAN13.
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   Jaiswal,R.K., Kumar,P., Kumar,M. and Yadava,P.K.
  TITLE     hTERT promotes tumor progression by enhancing TSPAN13 expression in
            osteosarcoma cells
  JOURNAL   Mol Carcinog 57 (8), 1038-1054 (2018)
   PUBMED   29722072
  REMARK    GeneRIF: Knocking down of TSAPN13 in human TERT overexpressing
            osteosarcoma cells enhanced the apoptosis of the cells. TSPAN13
            knockdown in these cells suppressed mesenchymal properties and
            enhanced epithelial character.
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   Minchenko,D.O., Novik,Y.E., Maslak,H.S., Tiazhka,O.V. and
            Minchenko,O.H.
  TITLE     [EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN
            PEDIATRIC GLIOMA]
  JOURNAL   Lik Sprava (7-8), 43-48 (2015)
   PUBMED   27491149
  REMARK    GeneRIF: The expression of PFKFB3, PFKFB4, NAMPT, and TSPAN13 is
            strongly up-regulated in pediatric glioma.
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 1873)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   8  (bases 1 to 1873)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   9  (bases 1 to 1873)
  AUTHORS   Serru,V., Dessen,P., Boucheix,C. and Rubinstein,E.
  TITLE     Sequence and expression of seven new tetraspans
  JOURNAL   Biochim Biophys Acta 1478 (1), 159-163 (2000)
   PUBMED   10719184
REFERENCE   10 (bases 1 to 1873)
  AUTHORS   Bohme,E., Graf,H. and Schultz,G.
  TITLE     Effects of sodium nitroprusside and other smooth muscle relaxants
            on cyclic GMP formation in smooth muscle and platelets
  JOURNAL   Adv Cyclic Nucleotide Res 9, 131-143 (1978)
   PUBMED   27075
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK093487.1, AK026587.1,
            BC033863.1, AC073333.5 and CB852023.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014399.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.295733.1,
                                           SRR1660809.40091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262067.5/ ENSP00000262067.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AK093487.1         53-157
            106-119             AK026587.1         99-112
            120-435             BC033863.1         1-316
            436-444             AC073333.5         80917-80925
            445-525             AC073333.5         81589-81669
            526-639             AC073333.5         82345-82458
            640-753             AC073333.5         83550-83663
            754-1869            AC073333.5         87964-89079
            1870-1873           CB852023.1         521-524
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..1873
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /note="tetraspanin 13"
                     /db_xref="GeneID:27075"
                     /db_xref="HGNC:HGNC:21643"
                     /db_xref="MIM:613139"
     exon            1..276
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..828
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /note="transmembrane 4 superfamily member 13;
                     transmembrane 4 superfamily member tetraspan NET-6;
                     tspan-13"
                     /codon_start=1
                     /product="tetraspanin-13"
                     /protein_id="NP_055214.1"
                     /db_xref="CCDS:CCDS5363.1"
                     /db_xref="GeneID:27075"
                     /db_xref="HGNC:HGNC:21643"
                     /db_xref="MIM:613139"
                     /translation="MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLR
                     VVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQE
                     QQGQLLEVGWNNTASARNDIQRNLNCCGFRSVNPNDTCLASCVKSDHSCSPCAPIIGE
                     YAGEVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL"
     exon            277..444
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /inference="alignment:Splign:2.1.0"
     exon            445..525
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /inference="alignment:Splign:2.1.0"
     exon            526..639
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /inference="alignment:Splign:2.1.0"
     exon            640..753
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1873
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /note="hexamer: ATTAAA"
     polyA_site      1817
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /note="major polyA site"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /note="hexamer: ATTAAA"
     regulatory      1844..1849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
                     /note="hexamer: AAGAAA"
     polyA_site      1858
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
     polyA_site      1873
                     /gene="TSPAN13"
                     /gene_synonym="NET-6; NET6; TM4SF13"
ORIGIN      
        1 ccggctcagc tgcggcggcc gcaggttcca aagcgggtcc gagccgccgc cgcgcgcgcg
       61 ccgcgcactg cagccccagg ccccggcccc ccacccacgt ctgcgttgct gccccgcctg
      121 ggccaggccc caaaggcaag gacaaagcag ctgtcaggga acctccgccg gagtcgaatt
      181 tacgtgcagc tgccggcaac cacaggttcc aagatggttt gcgggggctt cgcgtgttcc
      241 aagaactgcc tgtgcgccct caacctgctt tacaccttgg ttagtctgct gctaattgga
      301 attgctgcgt ggggcattgg cttcgggctg atttccagtc tccgagtggt cggcgtggtc
      361 attgcagtgg gcatcttctt gttcctgatt gctttagtgg gtctgattgg agctgtaaaa
      421 catcatcagg tgttgctatt tttttatatg attattctgt tacttgtatt tattgttcag
      481 ttttctgtat cttgcgcttg tttagccctg aaccaggagc aacagggtca gcttctggag
      541 gttggttgga acaatacggc aagtgctcga aatgacatcc agagaaatct aaactgctgt
      601 gggttccgaa gtgttaaccc aaatgacacc tgtctggcta gctgtgttaa aagtgaccac
      661 tcgtgctcgc catgtgctcc aatcatagga gaatatgctg gagaggtttt gagatttgtt
      721 ggtggcattg gcctgttctt cagttttaca gagatcctgg gtgtttggct gacctacaga
      781 tacaggaacc agaaagaccc ccgcgcgaat cctagtgcat tcctttgatg agaaaacaag
      841 gaagatttcc tttcgtatta tgatcttgtt cactttctgt aattttctgt taagctccat
      901 ttgccagttt aaggaaggaa acactatctg gaaaagtacc ttattgatag tggaattata
      961 tatttttact ctatgtttct ctacatgttt ttttctttcc gttgctgaaa aatatttgaa
     1021 acttgtggtc tctgaagctc ggtggcacct ggaatttact gtattcattg tcgggcactg
     1081 tccactgtgg cctttcttag catttttacc tgcagaaaaa ctttgtatgg taccactgtg
     1141 ttggttatat ggtgaatctg aacgtacatc tcactggtat aattatatgt agcactgtgc
     1201 tgtgtagata gttcctactg gaaaaagagt ggaaatttat taaaatcaga aagtatgaga
     1261 tcctgttatg ttaagggaaa tccaaattcc caattttttt tggtcttttt aggaaagatt
     1321 gttgtggtaa aaagtgttag tataaaaatg ataatttact tgtagtcttt tatgattaca
     1381 ccaatgtatt ctagaaatag ttatgtctta ggaaattgtg gtttaatttt tgacttttac
     1441 aggtaagtgc aaaggagaag tggtttcatg aaatgttcta atgtataata acatttacct
     1501 tcagcctcca tcagaatgga acgagttttg agtaatcagg aagtatatct atatgatctt
     1561 gatattgttt tataataatt tgaagtctaa aagactgcat ttttaaacaa gttagtatta
     1621 atgcgttggc ccacgtagca aaaagatatt tgattatctt aaaaattgtt aaataccgtt
     1681 ttcatgaaat ttctcagtat tgtaacagca acttgtcaaa cctaagcata tttgaatatg
     1741 atctcccata atttgaaatt gaaatcgtat tgtgtggctc tgtatattct gttaaaaaat
     1801 taaaggacag aaacctttct ttgtgtatgc atgtttgaat taaaagaaag taatggaaga
     1861 attgatcgat gaa
//
