LOCUS       NM_001370302            5506 bp    mRNA    linear   PRI 19-NOV-2024
DEFINITION  Homo sapiens tetraspanin 11 (TSPAN11), transcript variant 3, mRNA.
ACCESSION   NM_001370302 XM_011520680
VERSION     NM_001370302.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5506)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008150.8 and AC008013.8.
            
            On May 4, 2019 this sequence version replaced XM_011520680.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.62477.1, AK293947.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546076.6/ ENSP00000437403.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC008150.8         27626-27674         c
            50-144              AC008150.8         347-441             c
            145-336             AC008013.8         9619-9810
            337-411             AC008013.8         24354-24428
            412-516             AC008013.8         25359-25463
            517-675             AC008013.8         28325-28483
            676-762             AC008013.8         28857-28943
            763-5506            AC008013.8         37649-42392
FEATURES             Location/Qualifiers
     source          1..5506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..5506
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /note="tetraspanin 11"
                     /db_xref="GeneID:441631"
                     /db_xref="HGNC:HGNC:30795"
                     /db_xref="MIM:621013"
     exon            1..49
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /inference="alignment:Splign:2.1.0"
     exon            50..144
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..822
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /note="isoform 1 is encoded by transcript variant 3;
                     tspan-11"
                     /codon_start=1
                     /product="tetraspanin-11 isoform 1"
                     /protein_id="NP_001357231.1"
                     /db_xref="CCDS:CCDS31765.1"
                     /db_xref="GeneID:441631"
                     /db_xref="HGNC:HGNC:30795"
                     /db_xref="MIM:621013"
                     /translation="MAHYKTEQDDWLIIYLKYLLFVFNFFFWVGGAAVLAVGIWTLVE
                     KSGYLSVLASSTFAASAYILIFAGVLVMVTGFLGFGAILWERKGCLSTYFCLLLVIFL
                     VELVAGVLAHVYYQRLSDELKQHLNRTLAENYGQPGATQITASVDRLQQDFKCCGSNS
                     SADWQHSTYILLREAEGRQVPDSCCKTVVVRCGQRAHPSNIYKVEGGCLTKLEQFLAD
                     HLLLMGAVGIGVACLQICGMVLTCCLHQRLQRHFY"
     exon            145..336
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /inference="alignment:Splign:2.1.0"
     exon            337..411
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /inference="alignment:Splign:2.1.0"
     exon            412..516
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /inference="alignment:Splign:2.1.0"
     exon            517..675
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /inference="alignment:Splign:2.1.0"
     exon            676..762
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /inference="alignment:Splign:2.1.0"
     exon            763..5506
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5485..5490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /note="hexamer: AATAAA"
     polyA_site      5506
                     /gene="TSPAN11"
                     /gene_synonym="VSSW1971"
                     /note="major polyA site"
ORIGIN      
        1 agtctctcta ggcgcagctc ccttcgccgc ttccggagcc cctggcaggg cccagaagcc
       61 atggcccact ataagactga gcaggacgac tggctgatca tctacttgaa gtatttactc
      121 tttgtcttca acttcttctt ctgggtcggg ggagcagccg tcctggctgt gggcatctgg
      181 accctggtgg agaagagtgg ctacctcagc gtcctggcct ccagcacctt tgccgcctcc
      241 gcctacatcc tcatctttgc gggcgtactt gtcatggtga ccggcttcct gggcttcggt
      301 gccatcctct gggagcggaa gggctgcctc tccacgtatt tctgcctgtt gctcgtcatc
      361 ttcctggttg agctggtggc gggagtcctg gcccatgtgt attaccagag gctgagtgat
      421 gaactgaagc agcacttgaa ccggactctg gctgagaact acgggcagcc cggagccacg
      481 cagatcaccg cctcagtgga ccgactccag caggatttca agtgctgtgg aagcaacagc
      541 tcagccgact ggcagcacag cacgtacatc ctgttgcggg aggccgaggg ccgccaggtg
      601 cccgacagct gctgcaagac agtggtggtg cgctgcggcc agcgggccca cccctccaac
      661 atctataagg tggagggagg ctgcctcacc aagctggagc agttcctggc cgaccacctg
      721 ctgcttatgg gggcagtggg catcggggtg gcctgcctgc agatctgcgg gatggttctc
      781 acctgctgct tgcaccagag gctccagcgg catttttact aatggccaac cacctcctct
      841 tccaactgcc cctcaagaca acatgtggcc acatgccatc tgcaaggcct gcagagttag
      901 caccagctcc actagggcca tagatgcccc ctcctttgtg cctagctcct gcgaatccac
      961 cgagtgcctg agaccatagc ttctgtgccc acccaggcag agaccctcgg ccccctctcc
     1021 tccatttctg agcccccatg gccagatcct gggcagggaa atgatccttt caggagacaa
     1081 ccagagcccc tcaccaggaa cgggggcacc cgtggactac gggagggtgg cggttgggtt
     1141 ctctgctccc tcccagctcc tgaacctgga acaatcggca gaaaacccag gaaccccggc
     1201 actcctgcat tcagcacggg attcccccac ccatgcccag aagccctgac cttgctgttt
     1261 ctggaaaaag catggggtgg ggcagggagg gctggcattt cccccagaag accttgccct
     1321 ttgacctgcc cactctccac actgcctcac ctggaaagcc atgtcctgct ggcctcattc
     1381 cttcctgaag ggcctaggag tggggaggcc tgggtagggc agccacaggc tgggtagagc
     1441 cgccctggca ggaagcaggg ggtaaggtgg ccataccagc acatgctgca ctaggagcag
     1501 agccctgcac ctgcctagct gccttcctgg gagaaacctc cctgggagac catggcccca
     1561 agccctggcc tctagtgata cgcccctcgg gaatctcctg ttccggggcc tgattctcag
     1621 gaacaccagg tttcagacca tcttcagcac ctaatgttga tgggtgtcaa acatctcctg
     1681 gagtggacca actcgcaacc ctgcaaagtc ggagctgctg agaaggggca gctctgaata
     1741 gaggggcatc tgcctgaacc tcacttttcc tggggccctc tccttgaccc cgtagccacc
     1801 accacactgc ttccaggggg tccagctctg cttcccttcc cacctgtcct agagtggaca
     1861 gagctttttc cttgggttct ctcttgcatc actaagttca gcagggaatt tgcggaattt
     1921 tcaggaagaa ctttccccag taataaggga gaacagaaag aaaatcctag aaaatacaga
     1981 gtatccatgc tggcagcttt ttgtacaaca cccataggga cccccccaaa tggctattac
     2041 aaaggggcag cccattcact acacaagaac cccacacctg gcttccaccc tccccagctc
     2101 ctgcacttct ccccagagcg ggaccctctt acttcccccc atgaaggggg gcaccttgtg
     2161 ctaaggccaa ggctgagcga ggtcccagct cacctccctg cttgatccag attgcactgt
     2221 gatgagcaca ttgctgacct aggccagtcc tggggcaggc gtgctctctc tcccatacat
     2281 aggagtggcc tcaaggccac ccagtgctga ccccaacaga gccctgaact gtccagaaac
     2341 tgcatcctca gcacaggaag tacccacatg gacagaggga agcccagcct cggggccggt
     2401 tgcctcctct tctctgggtg ttctccagtg gcttcttgga gcctaggctg gtttatctcc
     2461 cctgcctaaa aggccctggg gttgccaatg caaattcatt aaaacgaaga ccagatatcc
     2521 cagactgcac agaggccgag agaaatggta tagtgcgtga ttagcattgc tgccctccaa
     2581 cctcctggga ttcatgcaga taatcaaaaa ctgactatga ctcccaagtt ctctgaagga
     2641 tgagatcaca actgacaact cttacgacag agggagagtg gtgagagaga gaaagagggt
     2701 actgggctag agccatgttc ttcctgccga ggtgccaggg ggaggcggca gtgggcaggg
     2761 ggtgctgggg ccttacctgt ctgccctggt ggggatgaaa gacaggtgac aggcaggtgc
     2821 cctgtgcaca gccttatcat tgaaggcagg cccaggacag cctgccccat ctgccccagc
     2881 cccatgggat ggttggtcca gcctgactgg ggcaggatta gctgcaattc ctgccctgtg
     2941 tgtcgtccag ccagactgcc tcttgaaaga tggcttgtcc aagcggcaga cagtggtaga
     3001 acaacccagg gcttggaaat ctgacctcct tgtccatgcc aacagcctgg gagatgagac
     3061 agggttagag gaaacagagg cccaggatac ggcaggttct gcctgggagt gtacaatggt
     3121 tggagtccag agccaacgat gtggtcccca gcggggtgtg cccctcctgc tgacgagggt
     3181 acagatccat acccaggtca attcctcccg ggcccctgtt tggaggctgc tacagccttg
     3241 agttccttgg agagagagga cacgcctgtg gaatgtcacc ttcagtcccg tgcaggcaaa
     3301 aggcccctgc acaccagggc cctaggaaag cagcatcagg tgctgggatc ccacccagct
     3361 ggcacgggca cgttcttgcc ctgcacactc catgctgccc ttccctgagc tcgcaggggc
     3421 agacaccaag agaagggcgc gtccccgagt cccctgggtg acctgtgtca ggacagcagg
     3481 caagaatgaa acgtggcctt ggctgacggg ttggaatatt tgtgaccgtt cttgtctttc
     3541 tccctcctgc ttccccggca ccctagcccc atctccagga gcccctcagg cagagtaagt
     3601 ggggagtgtg tccagggatt tttttgtgtt taccaaggtc ctgctgtgca cttagaatct
     3661 gtcaccataa atacttatct cgcagttacc ccagcaagag ggtgttattt cccccatttt
     3721 ataaaaggaa attaaggctg ggcaaagtta agacttgctt gtcagtggtc atggctgttg
     3781 tcttgccacc cccagctggg gagaaggaag aaaactgggc cgggaacccc tcccctcagt
     3841 gtcccccagt tctccatctc cataaggagc catcaggctg tcattaagga acagagtgtc
     3901 actcaggggg cactgtcaca aagcagcacc catggcacat gggccggggg tgcagaagcc
     3961 tggcttattt caggctgaca gctggaccct ctgggtgcag gggctcaggc agtggccaag
     4021 agcccaaagg gctaaggccc gtgacgacca cccagcccgt caccccaggt acaaacactg
     4081 accccaaagc aagagcaggg actgtccctc agccctcagg gccttcatgc agggtgcaga
     4141 atctcatgtc cacatggagg tcacccctca ggtcacaccc actcccagag caaccctggg
     4201 cagggagggg caccctgggg ttgtgttgac cacctcccct tcaggtgagg cccttttctg
     4261 ccttctttct agccccctgc atggggcacc tgctattgct ggggctctgg ggtggaccct
     4321 gtgtgatttc tgtcagggag cttgtgctgt gcatggccag aggtgtttac atccagaagg
     4381 gcccagcacg gccctgtggg gtgtgggggg aatatggtag atcattgtga tgtgcctcgg
     4441 ggccctcttg ccttggagcc agctttgttt cagaatctgc tacttgggcc ctcttcaggg
     4501 ttttgaggct ggagaagtga gttgggacag tcactgtcat caccacccac cctgtcaccc
     4561 acctggaaaa cattcttgat atactggcca tgctgggccg ggctcacatc cactgagggt
     4621 atagtgacca agcgtctaaa ccagtcgttc tcaaacttcg gtgagtatca gaatcacctg
     4681 gaagggcttt tacaaacaga ttgctggccc caccccccag aatttctcat caggagtggg
     4741 caagaccaat catttgcatt tctgacaagt tcccaggagc tgcagctgct ggccctggaa
     4801 ccacactttg agaaccactg ctttagacca aacaccaaag gaagatgcag ccaccctcct
     4861 ttacatgtca caacgctcag ggtccatgag tacctcaggc tgtccagctg agctccacct
     4921 gcagcagccg agattcccga ctcgctccac cattgggggc taggagtgaa gcgtgtcacc
     4981 atggtcagct catggccagc caggaaagcc tctctgctgt gcgtctgtgc agttcttgtt
     5041 cttccctgga ggactcttgg atcgcctgtg atcttggcca ggagaccagg tgcctgggtc
     5101 ccttcctgga aggggacaag ttacacaccc cagccccatt ttcccaccaa cttctacatg
     5161 ccttgggaga acctgctaca tgttggctgc ccccttcccc tatttcagca gtgcccagtc
     5221 ctgcttataa acctgaggcc tgctccccat accctgccct gtgcaagtgc cagccgttat
     5281 tccaggcagc ccaatgttgt tgaggccaga tggattcctg gaagcagctg gcccatggat
     5341 gtgagtcatc acagtattct agaaacagag aagaggtctt aacctaatgc gcatagagaa
     5401 attgttctca ttgtaaacat acccctgtcc ttagctgatc taggtggaag cccagcttca
     5461 tgtgctaggg ggcatgataa tgataataaa ggaattgtat ctagga
//
