LOCUS       NM_001290212            1840 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens tetraspanin 10 (TSPAN10), transcript variant 1, mRNA.
ACCESSION   NM_001290212
VERSION     NM_001290212.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Plotnikov,D., Shah,R.L., Rodrigues,J.N., Cumberland,P.M.,
            Rahi,J.S., Hysi,P.G., Atan,D., Williams,C. and Guggenheim,J.A.
  CONSRTM   UK Biobank Eye and Vision Consortium
  TITLE     A commonly occurring genetic variant within the
            NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of
            strabismus
  JOURNAL   Hum Genet 138 (7), 723-737 (2019)
   PUBMED   31073882
  REMARK    GeneRIF: Genetic variant within the TSPAN10 gene is associated with
            strabismus.
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Dornier,E., Coumailleau,F., Ottavi,J.F., Moretti,J., Boucheix,C.,
            Mauduit,P., Schweisguth,F. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and
            promote Notch activation in flies and mammals
  JOURNAL   J Cell Biol 199 (3), 481-496 (2012)
   PUBMED   23091066
  REMARK    Erratum:[J Cell Biol. 2016 May 23;213(4):495-6. doi:
            10.1083/jcb.20120113304262016c.. PMID: 27185832]
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA626003.1, AB593081.1, BC021923.1, AB593082.1 and AC139530.3.
            
            On Jul 8, 2020 this sequence version replaced NM_001290212.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB593081.1, SRR14038193.3890513.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000611590.2/
                                                ENSP00000484664.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA626003.1         26-27
            3-288               AB593081.1         1-286
            289-779             BC021923.1         49-539
            780-1285            AB593082.1         566-1071
            1286-1286           AC139530.3         81493-81493         c
            1287-1840           BC021923.1         1319-1872
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1840
                     /gene="TSPAN10"
                     /gene_synonym="OCSP"
                     /note="tetraspanin 10"
                     /db_xref="GeneID:83882"
                     /db_xref="HGNC:HGNC:29942"
     exon            1..211
                     /gene="TSPAN10"
                     /gene_synonym="OCSP"
                     /inference="alignment:Splign:2.1.0"
     exon            212..353
                     /gene="TSPAN10"
                     /gene_synonym="OCSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1385
                     /gene="TSPAN10"
                     /gene_synonym="OCSP"
                     /note="isoform a is encoded by transcript variant 1;
                     oculospanin; tspan-10"
                     /codon_start=1
                     /product="tetraspanin-10 isoform a"
                     /protein_id="NP_001277141.2"
                     /db_xref="CCDS:CCDS58608.1"
                     /db_xref="GeneID:83882"
                     /db_xref="HGNC:HGNC:29942"
                     /translation="MEEGERSPLLSQETAGQKPLSVHRPPTSGCLGPVPREDQAEAWG
                     CSCCPPETKHQALSGTPKKGPAPSLSPGSSCVKYLIFLSNFPFSLLGLLALAIGLWGL
                     AVKGSLGSDLGGPLPADPMLGLALGGLVVSAVSLAGYLGALCENTCLLRGFSGGILAF
                     LVLEAVAGALVVALWGPLQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASY
                     QDWQQNLYFNCSSPGVQACSLPASCCIDPREDGASVNDQCGFGVLRLDADAAQRVVYL
                     EGCGPPLRRWLRANLAASGGYAIAVVLLQGAELLLAARLLGALAARRGAAYGPGARGE
                     DRAGPQSPSPGAPPAAKPARG"
     exon            354..991
                     /gene="TSPAN10"
                     /gene_synonym="OCSP"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1840
                     /gene="TSPAN10"
                     /gene_synonym="OCSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN10"
                     /gene_synonym="OCSP"
                     /note="hexamer: AGTAAA"
     polyA_site      1840
                     /gene="TSPAN10"
                     /gene_synonym="OCSP"
                     /note="major polyA site"
ORIGIN      
        1 gcccccgcca tccctgcaac tggaggaggg gattttggaa agttgcgtct gagattactt
       61 ctgctcgtcc tcggaaaccc aagcggcaca ggaaagtcca aaaaggaagc aaagacgagc
      121 atccgaagtc tcacccaaaa ataactactg ctgcgtatta tagcgtatta taattgggga
      181 aacagcattc caaacttctc tccatgcaca gactagccca gggccgcagt caggaccagc
      241 ccagcagccc agccacagag gagccagcga acctctcccg gcgcctgtgc tgggggcttt
      301 ctgttccagc gtcaaggatg gaggaggggg agaggagccc cttactgtcc caggaaactg
      361 caggccagaa gcccctctct gtgcacaggc cacccacctc aggctgccta ggtccagtgc
      421 ccagggagga ccaggcggag gcctggggct gcagctgctg tcccccggag accaagcacc
      481 aggccttgag tggcaccccc aagaaaggac cagccccttc cctctcccca gggagcagct
      541 gcgtcaagta tctgatcttc ctctccaact tccccttctc cctgctgggg ctgctggccc
      601 tggccatcgg gctctggggc ctggctgtca aggggtctct gggaagtgat ctgggggggc
      661 ccctgcccgc agaccccatg ctggggctgg cactgggagg gctggtggtc agcgcagtga
      721 gcctggctgg ctacctgggc gccctctgtg agaacacctg cctgttacgt ggcttctctg
      781 ggggcatcct tgccttcctg gtgcttgagg ccgtggcggg ggccctggtg gtggccctct
      841 ggggcccgct gcaagacagc ctggagcaca ccctgcgtgt ggccatcgcc cactaccagg
      901 acgacccaga cctgcgcttc ctcctcgacc aagtccagct cgggctgagg tgctgcggag
      961 ctgcctccta ccaggactgg cagcagaacc tgtactttaa ctgcagctcc cccggggtgc
     1021 aggcctgcag ccttcccgcc tcctgctgca tcgacccccg cgaagatgga gcctctgtca
     1081 acgaccagtg cggcttcggg gtcctgcgcc tggatgcgga cgcagctcag agagtggtgt
     1141 acctggaggg ctgcggcccg ccgctccggc ggtggctgcg cgcgaacctg gctgcctcgg
     1201 gcggctacgc aatcgcggtg gtgctgctgc agggcgcgga gctcctgctg gccgcccggc
     1261 tactcggggc cctcgctgcc cgcagggggg cggcgtacgg ccccggagcg cgcggggagg
     1321 accgcgctgg cccccagagc cccagccccg gcgccccgcc cgctgccaag cccgcccggg
     1381 gctgagcgca cgccccgagg tccgagaccg ccacgcacag ggatacaggg ggcgcctccg
     1441 cccggctaaa aagcgcggcc tgcgccgccg ccgccgcctg atttcgctcg ggcttcgggt
     1501 gacttcgccg caggacctac ccagctcgct cacttcgctc gctccgcgtc ccccatgcca
     1561 gcccccaacg cagggcgccc ggcgaagcca cgggactggc gggaggagca cgcggggccg
     1621 gaggaaatcc tgaagctgac cctcacctcc gagcccccac tcccacccca gccgcacagt
     1681 tcccacctcc tggcacctcc ctcccctggg gccgccaccc cttctgggct cgtgatggtg
     1741 gagctaaggt ccaggcctct ccctcccgag tgcatttttg gggagatagt aaatgtttta
     1801 ttcgggtgta tcattcatac agtaaagaca ccaatcttca
//
