LOCUS       NM_005727               1619 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens tetraspanin 1 (TSPAN1), mRNA.
ACCESSION   NM_005727
VERSION     NM_005727.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Wang,M.D., Li,H.T., Peng,L.X., Mei,Y., Zheng,L.S., Li,C.Z.,
            Meng,D.F., Lang,Y.H., Xu,L., Peng,X.S., Liu,Z.J., Xie,D.H.,
            Guo,L.L., Ma,M.G., Ding,L.Y., Huang,B.J., Cao,Y. and Qian,C.N.
  TITLE     TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via
            suppressing NF-kB signaling
  JOURNAL   Cancer Gene Ther 31 (3), 454-463 (2024)
   PUBMED   38135697
  REMARK    GeneRIF: TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via
            suppressing NF-kB signaling.
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Zhao,X., Zhao,Z., Xie,H., Gao,W. and Ye,C.
  TITLE     ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via Inhibiting
            m6A-Modification of TSPAN1 mRNA
  JOURNAL   Discov Med 36 (180), 61-70 (2024)
   PUBMED   38273746
  REMARK    GeneRIF: ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via
            Inhibiting m6A-Modification of TSPAN1 mRNA.
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Ou,Y., Chen,R., Qian,Q., Cui,N., Miao,Q., Tang,R., You,Z., Ma,X.
            and Wang,Q.
  TITLE     The immunological characteristics of TSPAN1 expressing B cells in
            autoimmune hepatitis
  JOURNAL   Front Immunol 13, 1076594 (2022)
   PUBMED   36591302
  REMARK    GeneRIF: The immunological characteristics of TSPAN1 expressing B
            cells in autoimmune hepatitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1619)
  AUTHORS   Wu,Y., Chen,W., Gong,Y., Liu,H. and Zhang,B.
  TITLE     Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast
            cancer cells via mediating PI3K/Akt pathway
  JOURNAL   Bioengineered 12 (2), 10761-10770 (2021)
   PUBMED   34852709
  REMARK    GeneRIF: Tetraspanin 1 (TSPAN1) promotes growth and transferation
            of breast cancer cells via mediating PI3K/Akt pathway.
REFERENCE   5  (bases 1 to 1619)
  AUTHORS   Stinnesbeck,M., Kristiansen,A., Ellinger,J., Hauser,S., Egevad,L.,
            Tolkach,Y. and Kristiansen,G.
  TITLE     Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer
  JOURNAL   APMIS 129 (4), 204-212 (2021)
   PUBMED   33455017
  REMARK    GeneRIF: Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate
            cancer.
REFERENCE   6  (bases 1 to 1619)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1619)
  AUTHORS   Wollscheid,V., Kuhne-Heid,R., Stein,I., Jansen,L., Kollner,S.,
            Schneider,A. and Durst,M.
  TITLE     Identification of a new proliferation-associated protein NET-1/C4.8
            characteristic for a subset of high-grade cervical intraepithelial
            neoplasia and cervical carcinomas
  JOURNAL   Int J Cancer 99 (6), 771-775 (2002)
   PUBMED   12115476
  REMARK    GeneRIF: Overexpression of NET-1 is associated with
            undifferentiated squamous cell carcinoma of cervical neoplasms
REFERENCE   8  (bases 1 to 1619)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   9  (bases 1 to 1619)
  AUTHORS   Serru,V., Dessen,P., Boucheix,C. and Rubinstein,E.
  TITLE     Sequence and expression of seven new tetraspans
  JOURNAL   Biochim Biophys Acta 1478 (1), 159-163 (2000)
   PUBMED   10719184
REFERENCE   10 (bases 1 to 1619)
  AUTHORS   Todd,S.C., Doctor,V.S. and Levy,S.
  TITLE     Sequences and expression of six new members of the
            tetraspanin/TM4SF family
  JOURNAL   Biochim Biophys Acta 1399 (1), 101-104 (1998)
   PUBMED   9714763
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313774.1, AF065388.1 and
            BM856468.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005727.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.211294.1,
                                           SRR5189667.345078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372003.6/ ENSP00000361072.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1190              AK313774.1         1-1190
            1191-1615           AF065388.1         848-1272
            1616-1619           BM856468.1         261-264
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..1619
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /note="tetraspanin 1"
                     /db_xref="GeneID:10103"
                     /db_xref="HGNC:HGNC:20657"
                     /db_xref="MIM:613170"
     exon            1..323
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     exon            324..456
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     exon            457..521
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..1190
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /note="tetraspan 1"
                     /codon_start=1
                     /product="tetraspanin-1"
                     /protein_id="NP_005718.2"
                     /db_xref="CCDS:CCDS530.1"
                     /db_xref="GeneID:10103"
                     /db_xref="HGNC:HGNC:20657"
                     /db_xref="MIM:613170"
                     /translation="MQCFSFIKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLKIFG
                     PLSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCALVTFFFILLLIFIAEVA
                     AAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFED
                     SPYFKENSAFPPFCCNDNVTNTANETCTKQKAHDQKVEGCFNQLLYDIRTNAVTVGGV
                     AAGIGGLELAAMIVSMYLYCNLQ"
     exon            522..728
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     exon            729..803
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     exon            804..902
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1058
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1142
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1619
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /note="hexamer: CATAAA"
     polyA_site      1619
                     /gene="TSPAN1"
                     /gene_synonym="NET1; TM4C; TM4SF"
                     /note="major polyA site"
ORIGIN      
        1 agacacacac accagcagct acacctacac gctgaccatc acaggcacac agaggcacat
       61 ccacctcaca tccacctcat acttgtgtac tctcagggtt cagtctttca tcctatccct
      121 ctctgatctg tgcctcccaa taccttccaa gatgtttaca gagacccttc tccctgtgca
      181 gttaggagtg taaggcaaga gagcccctac ttcatggggc agatcaagag ctgagaccaa
      241 agatggtcta tgttgctgac cttgtcctgt cctcctgctg tcttaaacta tgatccctgc
      301 tgcggtcact gaagcctttc cctgtgagca gtggtgtgtg agagccaggc gtccctctgc
      361 ctgcccactc agtggcaaca cccgggagct gttttgtcct ttgtggagcc tcagcagttc
      421 cctctttcag aactcactgc caagagccct gaacaggagc caccatgcag tgcttcagct
      481 tcattaagac catgatgatc ctcttcaatt tgctcatctt tctgtgtggt gcagccctgt
      541 tggcagtggg catctgggtg tcaatcgatg gggcatcctt tctgaagatc ttcgggccac
      601 tgtcgtccag tgccatgcag tttgtcaacg tgggctactt cctcatcgca gccggcgttg
      661 tggtctttgc tcttggtttc ctgggctgct atggtgctaa gactgagagc aagtgtgccc
      721 tcgtgacgtt cttcttcatc ctcctcctca tcttcattgc tgaggttgca gctgctgtgg
      781 tcgccttggt gtacaccaca atggctgagc acttcctgac gttgctggta gtgcctgcca
      841 tcaagaaaga ttatggttcc caggaagact tcactcaagt gtggaacacc accatgaaag
      901 ggctcaagtg ctgtggcttc accaactata cggattttga ggactcaccc tacttcaaag
      961 agaacagtgc ctttccccca ttctgttgca atgacaacgt caccaacaca gccaatgaaa
     1021 cctgcaccaa gcaaaaggct cacgaccaaa aagtagaggg ttgcttcaat cagcttttgt
     1081 atgacatccg aactaatgca gtcaccgtgg gtggtgtggc agctggaatt gggggcctcg
     1141 agctggctgc catgattgtg tccatgtatc tgtactgcaa tctacaataa gtccacttct
     1201 gcctctgcca ctactgctgc cacatgggaa ctgtgaagag gcaccctggc aagcagcagt
     1261 gattggggga ggggacagga tctaacaatg tcacttgggc cagaatggac ctgccctttc
     1321 tgctccagac ttggggctag atagggacca ctccttttag gcgatgcctg actttccttc
     1381 cattggtggg tggatgggtg gggggcattc cagagcctct aaggtagcca gttctgttgc
     1441 ccattccccc agtctattaa acccttgata tgccccctag gcctagtggt gatcccagtg
     1501 ctctactggg ggatgagaga aaggcatttt atagcctggg cataagtgaa atcagcagag
     1561 cctctgggtg gatgtgtaga aggcacttca aaatgcataa acctgttaca atgttgcca
//
