LOCUS       NM_001288990            2475 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens translin associated factor X interacting protein 1
            (TSNAXIP1), transcript variant 1, mRNA.
ACCESSION   NM_001288990 XM_005256048
VERSION     NM_001288990.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2475)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Kishi,T., Okochi,T., Kitajima,T., Ujike,H., Inada,T., Yamada,M.,
            Uchimura,N., Sora,I., Iyo,M., Ozaki,N., Correll,C.U. and Iwata,N.
  TITLE     Lack of association between translin-associated factor X gene
            (TSNAX) and methamphetamine dependence in the Japanese population
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 35 (7), 1618-1622 (2011)
   PUBMED   21683752
  REMARK    GeneRIF: rs1630250 was associated in males w/ methamphetamine
            dependence in allele analysis. results not significant after
            Bonferroni correction. findings suggest TSNAX does not play a role
            in methamphetamine dependence in Japanese population
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062628.1, AK301920.1 and BU607826.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001288990.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.250350.1, AK301920.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000561639.6/ ENSP00000457241.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               BC062628.1         12-227
            217-2474            AK301920.1         1-2258
            2475-2475           BU607826.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2475
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /note="translin associated factor X interacting protein 1"
                     /db_xref="GeneID:55815"
                     /db_xref="HGNC:HGNC:18586"
                     /db_xref="MIM:607720"
     exon            1..308
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..2400
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /note="isoform a is encoded by transcript variant 1;
                     trax-interacting protein 1"
                     /codon_start=1
                     /product="translin-associated factor X-interacting protein
                     1 isoform a"
                     /protein_id="NP_001275919.1"
                     /db_xref="CCDS:CCDS73903.1"
                     /db_xref="GeneID:55815"
                     /db_xref="HGNC:HGNC:18586"
                     /db_xref="MIM:607720"
                     /translation="MACQQSRYHSFSSASRLQPRPSGVTIDESFLTEDKSTQNRKLLQ
                     KRRTLTGQFSMGGHLSPWPTYTSGQTILQNRKPCSDDYRKRVGSCQQHPFRTAKPQYL
                     EELENYLRKELLLLDLGTDSTQELRLQPYREIFEFFIEDFKTYKPLLSSIKNAYEGML
                     AHQREKIRALEPLKAKLVTVNEDCNERILAMRAEEKYEISLLKKEKMNLLKLIDKKNE
                     EKISLQSEVTKLRKNLAEEYLHYLSERDACKILIADLNELRYQREDMSLAQSPGIWGE
                     DPVKLTLALKMTRQDLTRTQMELNNMKANFGDVVPRRDFEMQEKTNKDLQEQLDTLRA
                     SYEEVRKEHEILMQLHMSTLKERDQFFSELQEIQRTSTPRPDWTKCKDVVAGGPERWQ
                     MLAEGKNSDQLVDVLLEEIGSGLLREKDFFPGLGYGEAIPAFLRFDGLVENKKPSKKD
                     VVNLLKDAWKERLAEEQKETFPDFFFNFLEHRFGPSDAMAWAYTIFENIKIFHSNEVM
                     SQFYAVLMGKRSENVYVTQKETVAQLLKEMTNADSQNEGLLTMEQFNTVLKSTFPLKT
                     EEQIQELMEAGGWHPSSSNADLLNYRSLFMEDEEGQSEPFVQKLWEQYMDEKDEYLQQ
                     LKQELGIELHEEVTLPKLRGGLMTIDPSLDKQTVNTYMSQAFQLPESEMPEEGDEKEE
                     AVVEILQTALERLQVIDIRRVGPREPEPAS"
     exon            309..408
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..521
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..648
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..742
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..939
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1075
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1245
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1405
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1536
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1662
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1815
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1925
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2052
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2159
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2475
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /note="hexamer: TATAAA"
     polyA_site      2475
                     /gene="TSNAXIP1"
                     /gene_synonym="TXI1"
                     /note="major polyA site"
ORIGIN      
        1 atccccctgc ctcagttctg gtacctgggg tcaaatcggc tgtagtggtt gactctcagg
       61 gcacccgctg ccgggtccca gtccaccttt gctactttgt cctactccca gcccgcgggc
      121 gctaggctcg ggggcgtggc gcatccctga ctccgccccc gccgcggggg ggcctctggg
      181 gcctggtcgc catggcgacc ggctgtacgc taccacagct tcccaggccg cgggtgctga
      241 ttgcccgcct gcccgtgggt catggcctgc cagcagtcgc ggtaccacag cttctcgtcc
      301 gcgtcgagat tacagccacg gccttcagga gtgaccatag acgaatcctt tctcacagaa
      361 gacaagagca cccagaatcg caagcttctt cagaaacgaa ggacgctgac tggtcagttc
      421 tccatgggtg ggcacctgtc cccatggccc acatacacca gtggccagac cattttgcaa
      481 aatcgaaaac cctgttcaga tgactaccgg aagcgagtag ggagctgcca gcagcacccc
      541 tttcgcactg ccaagcccca gtacttggag gaactggaaa actacctacg caaggagctc
      601 ctcctgctgg acctgggcac agattccacc caggaactaa ggctgcagcc ttacagagag
      661 atctttgagt tcttcataga ggacttcaaa acgtacaagc cattactatc ctccatcaag
      721 aatgcgtatg aggggatgct ggcccaccaa agggagaaga ttcgggctct ggagcccctg
      781 aaggccaagc ttgtcactgt gaatgaggac tgcaatgaga ggatcctggc catgagagct
      841 gaggagaaat atgaaatctc cctgctcaag aaagagaaga tgaacttgct aaaactcatc
      901 gacaaaaaga atgaggagaa gatttcattg cagagcgagg tgaccaaact gaggaagaac
      961 ttggctgagg agtacctgca ctacctcagt gagcgagatg cctgtaagat cctcatcgca
     1021 gacctgaatg agctgcggta ccagcgggag gacatgtcat tagcccagtc gccaggcatc
     1081 tggggggagg accctgtgaa gttaaccctg gctcttaaga tgacccggca agacctgacc
     1141 cgcacgcaga tggaactcaa caacatgaag gccaactttg gagatgtggt ccccaggagg
     1201 gactttgaaa tgcaggagaa gaccaacaag gatcttcagg agcagctgga caccctgaga
     1261 gccagctacg aggaggttcg caaggagcat gagatcctca tgcagctgca catgagcacg
     1321 ctgaaggaac gggaccaatt cttctctgag ctgcaggaga tccagcgcac ttccacgccg
     1381 cggcctgact ggaccaagtg caaagatgtg gtggctgggg gcccagagcg ctggcagatg
     1441 ctggctgagg gcaagaacag cgaccagctg gtggacgtgc tcctggaaga gattggttcg
     1501 gggctgctgc gggagaaaga cttcttccct ggtctgggct atggggaagc catccctgct
     1561 tttcttcggt ttgatggcct cgtggagaac aagaagccaa gcaagaagga cgtggtcaac
     1621 ctcctcaagg atgcctggaa ggaacgtctt gctgaggagc agaaagagac gttcccagat
     1681 ttcttcttca atttcctgga gcatcgcttt gggcccagtg atgccatggc ctgggcttat
     1741 actatttttg aaaatatcaa gatcttccac tccaacgagg ttatgagtca gttctatgca
     1801 gtcttgatgg gaaagcggag tgagaatgtg tatgtcaccc agaaggagac agtagcccag
     1861 ctgctgaagg agatgacaaa tgctgacagt cagaacgagg ggctactaac catggagcag
     1921 ttcaacactg tcctcaagag taccttccct ctcaagacag aagagcaaat ccaggagctg
     1981 atggaggcag ggggctggca tcccagcagc agcaatgcag acttgctcaa ctaccgctca
     2041 ctgtttatgg aggatgagga gggccagagt gagccctttg tgcaaaaact ctgggaacaa
     2101 tacatggatg agaaggacga gtacttacag cagctaaagc aggagcttgg catagaactc
     2161 catgaggaag tgactctgcc caagctgcga gggggcctga tgaccatcga ccccagcctg
     2221 gacaagcaga cagtgaacac ctacatgagc caggccttcc agctccctga gtcggaaatg
     2281 ccagaggagg gtgacgagaa ggaagaagcc gtggtggaaa tcctccagac tgccctggag
     2341 cggcttcagg tgattgacat caggcgtgtg ggacctcgag agccagagcc tgcaagctag
     2401 gaacttgtgg gcagcctgcg tactccagtc ctgctaaccc ctagctttta atataaaagt
     2461 gtttgtctga atcca
//
