LOCUS       NM_005999               2634 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens translin associated factor X (TSNAX), mRNA.
ACCESSION   NM_005999
VERSION     NM_005999.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2634)
  AUTHORS   Huang,K.Y., Huang,Y.J., Chen,S.J., Lin,C.H. and Lane,H.Y.
  TITLE     The associations between cognitive functions and TSNAX genetic
            variations in patients with schizophrenia
  JOURNAL   Pharmacol Biochem Behav 225, 173554 (2023)
   PUBMED   37030547
  REMARK    GeneRIF: The associations between cognitive functions and TSNAX
            genetic variations in patients with schizophrenia.
REFERENCE   2  (bases 1 to 2634)
  AUTHORS   Wang,S.H., Cheng,J.Y., Tsai,H.H., Lo,T.C., Hung,J.T., Lin,C.C.,
            Lee,C.W., Ho,Y.H., Kuo,H.H., Yu,A.L. and Yu,J.
  TITLE     Conformational alteration in glycan induces phospholipase Cbeta1
            activation and angiogenesis
  JOURNAL   J Biomed Sci 29 (1), 105 (2022)
   PUBMED   36517806
  REMARK    GeneRIF: Conformational alteration in glycan induces phospholipase
            Cbeta1 activation and angiogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2634)
  AUTHORS   Weng,Y.T., Chen,H.M., Chien,T., Chiu,F.L., Kuo,H.C. and Chern,Y.
  TITLE     TRAX Provides Neuroprotection for Huntington's Disease Via
            Modulating a Novel Subset of MicroRNAs
  JOURNAL   Mov Disord 37 (10), 2008-2020 (2022)
   PUBMED   35997316
  REMARK    GeneRIF: TRAX Provides Neuroprotection for Huntington's Disease Via
            Modulating a Novel Subset of MicroRNAs.
REFERENCE   4  (bases 1 to 2634)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2634)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2634)
  AUTHORS   Erdemir,T., Bilican,B., Oncel,D., Goding,C.R. and Yavuzer,U.
  TITLE     DNA damage-dependent interaction of the nuclear matrix protein C1D
            with Translin-associated factor X (TRAX)
  JOURNAL   J Cell Sci 115 (Pt 1), 207-216 (2002)
   PUBMED   11801738
REFERENCE   7  (bases 1 to 2634)
  AUTHORS   Chennathukuzhi,V.M., Kurihara,Y., Bray,J.D. and Hecht,N.B.
  TITLE     Trax (translin-associated factor X), a primarily cytoplasmic
            protein, inhibits the binding of TB-RBP (translin) to RNA
  JOURNAL   J Biol Chem 276 (16), 13256-13263 (2001)
   PUBMED   11278549
REFERENCE   8  (bases 1 to 2634)
  AUTHORS   Millar,J.K., Christie,S., Semple,C.A. and Porteous,D.J.
  TITLE     Chromosomal location and genomic structure of the human
            translin-associated factor X gene (TRAX; TSNAX) revealed by
            intergenic splicing to DISC1, a gene disrupted by a translocation
            segregating with schizophrenia
  JOURNAL   Genomics 67 (1), 69-77 (2000)
   PUBMED   10945471
REFERENCE   9  (bases 1 to 2634)
  AUTHORS   Meng,G., Aoki,K., Tokura,K., Nakahara,K., Inazawa,J. and Kasai,M.
  TITLE     Genomic structure and chromosomal localization of the gene encoding
            TRAX, a Translin-associated factor X
  JOURNAL   J Hum Genet 45 (5), 305-308 (2000)
   PUBMED   11043515
REFERENCE   10 (bases 1 to 2634)
  AUTHORS   Aoki,K., Ishida,R. and Kasai,M.
  TITLE     Isolation and characterization of a cDNA encoding a Translin-like
            protein, TRAX
  JOURNAL   FEBS Lett 401 (2-3), 109-112 (1997)
   PUBMED   9013868
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445524.28 and AL626763.11.
            
            On Nov 26, 2018 this sequence version replaced NM_005999.2.
            
            Summary: This gene encodes a protein which specifically interacts
            with translin, a DNA-binding protein that binds consensus sequences
            at breakpoint junctions of chromosomal translocations. The encoded
            protein contains bipartite nuclear targeting sequences that may
            provide nuclear transport for translin, which lacks any nuclear
            targeting motifs. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95073.1, SRR1660805.192954.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366639.9/ ENSP00000355599.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL445524.28        119447-119604
            159-263             AL445524.28        120033-120137
            264-378             AL445524.28        127991-128105
            379-509             AL445524.28        133259-133389
            510-637             AL445524.28        151906-152033
            638-2634            AL626763.11        3235-5231
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..2634
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /note="translin associated factor X"
                     /db_xref="GeneID:7257"
                     /db_xref="HGNC:HGNC:12380"
                     /db_xref="MIM:602964"
     exon            1..158
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1015
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /note="translin-like protein"
                     /codon_start=1
                     /product="translin-associated protein X"
                     /protein_id="NP_005990.1"
                     /db_xref="CCDS:CCDS1596.1"
                     /db_xref="GeneID:7257"
                     /db_xref="HGNC:HGNC:12380"
                     /db_xref="MIM:602964"
                     /translation="MSNKEGSGGFRKRKHDNFPHNQRREGKDVNSSSPVMLAFKSFQQ
                     ELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEDILTESEIKLDGVRQKIF
                     QVAQELSGEDMHQFHRAITTGLQEYVEAVSFQHFIKTRSLISMDEINKQLIFTTEDNG
                     KENKTPSSDAQDKQFGTWRLRVTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVS
                     QFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVF
                     SVKTEMIDQEEGIS"
     exon            159..263
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /inference="alignment:Splign:2.1.0"
     exon            264..378
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /inference="alignment:Splign:2.1.0"
     exon            379..509
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /inference="alignment:Splign:2.1.0"
     exon            510..637
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /inference="alignment:Splign:2.1.0"
     exon            638..2634
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2609..2614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /note="hexamer: AATAAA"
     polyA_site      2634
                     /gene="TSNAX"
                     /gene_synonym="C3PO; TRAX"
                     /note="major polyA site"
ORIGIN      
        1 ccggccactg cgttgtagtc ggcccggctg caaagcgttt ttctgcaggc tgttttccca
       61 ggttccctcg gcctgtacct cgcgcactcc tcttgctcca ggtccttcag tctccgctcg
      121 tctcaccgta ggctgtgacg acatgagcaa caaagaagga tcaggagggt tcaggaaaag
      181 gaagcatgac aatttcccac ataaccaaag aagagaaggg aaggatgtta attcatcttc
      241 acccgtgatg ttggccttta aatcatttca gcaggaactt gatgcaaggc atgacaaata
      301 tgagagactt gtgaaactta gtcgggatat aactgttgaa agtaaaagga caatttttct
      361 cctccatagg attacaagtg ctcctgatat ggaagatata ttgactgaat cagaaattaa
      421 attggatggt gtcagacaaa agatattcca ggtagcccaa gagctatcag gggaagatat
      481 gcatcagttc catcgagcca ttactacagg actacaggaa tatgtggaag ctgtctcttt
      541 tcaacacttc atcaaaacac gatcattaat tagtatggat gaaattaata aacaattgat
      601 atttacgact gaagacaatg ggaaagaaaa taaaactccc tcctctgatg cacaggataa
      661 gcagtttggt acttggagac tgagagtcac acctgtcgat taccttctgg gagtggctga
      721 cttaactgga gaattgatgc ggatgtgtat taacagtgtg gggaatgggg acattgatac
      781 cccctttgaa gtgagccagt ttttacgtca ggtttatgat gggttttcat tcattggcaa
      841 cactggacct tacgaggttt ctaagaagct gtataccttg aaacaaagtt tggccaaagt
      901 ggagaatgct tgttatgcct tgaaagtcag agggtcagaa attccaaaac atatgttggc
      961 agatgtgttt tcagttaaaa cagaaatgat agatcaagaa gagggcattt cttagaatct
     1021 aacgttactc agttactaat tcttttgaga actcctaaga gaccaatttg taagacttat
     1081 ttagtatttc atttaacttt attgtggctt ttacatagaa acatattcag ttgtacttgt
     1141 tttaaattgt atacaagctg tacataaaat tagccaaatg aatcatttct tatatcttat
     1201 tcatgaaagt ttgcatacag atgtttgcat atatgccttt ttgaattttt gctggttaac
     1261 ctttatcatt tatctttgta atgtgaacat gcttcagagt gtaccttttg ccataaccta
     1321 ttttaattta ctttttctga agtttggagt gataattttt agtggaagca atttgtaatt
     1381 taagttggta gttatattat atatagaaaa gattttttag ttaaacttct ggacatgagc
     1441 gtcctgttta aatttcttgt taatatcgtg ccaagcctca aaaataggct tattccatgg
     1501 aacaagaatt aaaaatgaat aagctatcaa tatataattt aagtacaagt ttaggctggg
     1561 cgtggtggct cacgcctgta atcccagcac tttgggaggc cgaggtaggc agatcacgag
     1621 gtcaagagat caagaccagc ctgaccaacg tggcgaaacc tcgtctctac tagaaataca
     1681 aaaattagct ggatatggtg gtatgtgcct gtaatcccag ctacttggga ggctgaggca
     1741 ggagactcgc ttgaacctgg gaggcagagg ttgcagtgag ccgagattgc gccactgcac
     1801 tccagcctgg gtaacagagc aagactccat ctcaaaaaaa gaaagaaaga aaaaagaaag
     1861 tacaagttta taaagtatta tagtgaaaaa ttcgcattct ggctgatttt aagccattta
     1921 aaatttatat aaaacaacct tccataaaaa tttgacaggt gcccagatgt tgctttctcc
     1981 atttattttt tgtttttttt taatcacagt aggtctgata gagaattgga gctaaattat
     2041 aatatttttg ttggtaaagt tgagttatat acttgtacat acaatggaaa tgcttttagt
     2101 agtgattatt tagcaatttt tgtttttgtt atattaggca tgtttggagg ctttcctatt
     2161 ctagcattta aatttaaatt ttattaaaat taaataattt aaatctagca tttaaattta
     2221 aataatttaa gtctagcatt tacttttaaa taattataat gaagttttga aatactaagt
     2281 taatccagac ctttagttgt cccatggtgt taataaagtt gccaaagaag atgtattatg
     2341 aacaattcag caataagaca attgtcaaca cagttgagaa taacaatggt aatcgttagt
     2401 aatatttaga attggaattt gcctactgaa atagttatag atgattactt gtgatgtgaa
     2461 actgaattga gcatgacaac cagacatttc cagttggttt tgtaagtttt gagaatctag
     2521 atactgggtt ttattttttg aaagattagc tctgtttgta agggctgatt ccttgaaaat
     2581 gtaattttcc agaaaaacac ctaaagaaaa taaaacatgg acatgcctag taaa
//
