LOCUS       NM_145003               1905 bp    mRNA    linear   PRI 17-OCT-2024
DEFINITION  Homo sapiens t-SNARE domain containing 1 (TSNARE1), transcript
            variant 1, mRNA.
ACCESSION   NM_145003 XM_005250833
VERSION     NM_145003.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1905)
  AUTHORS   Liu,X., Xie,H., Fu,Z., Yao,Q., Han,T., Zhan,D., Lin,Z. and Zhu,H.
  TITLE     MAD1L1 and TSNARE gene polymorphisms are associated with
            schizophrenia susceptibility in the Han Chinese population
  JOURNAL   BMC Med Genomics 14 (1), 218 (2021)
   PUBMED   34481484
  REMARK    GeneRIF: MAD1L1 and TSNARE gene polymorphisms are associated with
            schizophrenia susceptibility in the Han Chinese population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1905)
  AUTHORS   Gu,L.Z., Jiang,T., Cheng,Z.H., Zhang,Y.C., Ou,M.M., Chen,M.C. and
            Ling,W.M.
  TITLE     TSNARE1 polymorphisms are associated with schizophrenia
            susceptibility in Han Chinese
  JOURNAL   J Neural Transm (Vienna) 122 (6), 929-932 (2015)
   PUBMED   25471352
  REMARK    GeneRIF: Study provides the first evidence that the minor allele of
            TSNARE1 rs10098073 is significantly associated with a reduced risk
            of schizophrenia in a Han Chinese population, suggesting TSNARE1
            may represent a susceptibility gene for this disease
REFERENCE   3  (bases 1 to 1905)
  AUTHORS   Sleiman,P., Wang,D., Glessner,J., Hadley,D., Gur,R.E., Cohen,N.,
            Li,Q. and Hakonarson,H.
  CONSRTM   Janssen-CHOP Neuropsychiatric Genomics Working Group
  TITLE     GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia /
            Bipolar susceptibility locus
  JOURNAL   Sci Rep 3, 3075 (2013)
   PUBMED   24166486
  REMARK    GeneRIF: GWAS meta analysis identifies TSNARE1 as a novel
            Schizophrenia / Bipolar susceptibility locus
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1905)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY009343.1, BC113556.1, AC103758.14 and AK055726.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145003.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            CDS exon combination :: BC113556.1, AK055726.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524325.6/ ENSP00000428763.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                HY009343.1         116-198
            84-1787             BC113556.1         5-1708
            1788-1788           AC103758.14        115005-115005       c
            1789-1905           AK055726.1         1785-1901
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1905
                     /gene="TSNARE1"
                     /note="t-SNARE domain containing 1"
                     /db_xref="GeneID:203062"
                     /db_xref="HGNC:HGNC:26437"
                     /db_xref="MIM:620986"
     exon            1..79
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            80..206
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1660
                     /gene="TSNARE1"
                     /note="isoform a is encoded by transcript variant 1;
                     t-SNARE domain-containing protein 1"
                     /codon_start=1
                     /product="t-SNARE domain-containing protein 1 isoform a"
                     /protein_id="NP_659440.2"
                     /db_xref="CCDS:CCDS6384.1"
                     /db_xref="GeneID:203062"
                     /db_xref="HGNC:HGNC:26437"
                     /db_xref="MIM:620986"
                     /translation="MSYGSIARGGGLGSRGPFGGPSRQGCQPLECARCWTEYGIRHFP
                     CPSPESKLQNRCVGKDGEGDLGPAGTPIVPRARKRGPGVAPEGSRMPEPTSSPTIGPR
                     KDSAAGPHGRMAGPSTTRAKKRKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRR
                     YRVWSRILQAVNALGYCRRDVVDLKHKWRDLRAVVRRKLGDLRKAAHGPSPGSGKPQA
                     LALTPVEQVVAKTFSCQALPSEGFSLEPPRATQVDPCNLQELFQEMSANVFRINSSVT
                     SLERSLQSLGTPSDTQELRDSLHTAQQETNKTIAASASSVKQMAELLRSSCPQERLQQ
                     ERPQLDRLKTQLSDAIQCYGVVQKKIAEKSRALLPMAQRGSKQSPQAPFAELADDEKV
                     FNGSDNMWQGQEQALLPDITEEDLEAIRLREEAILQMESNLLDVNQIIKDLASMVSEQ
                     GEAVDSIEASLEAASSHAEAARQLLAGASRHQLQRHKIKCCFLSAGVTALLVIIIIIA
                     TSVRK"
     exon            207..356
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..863
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..941
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1011
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1102
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1192
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1249
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1408
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1481
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1564
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1671
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1905
                     /gene="TSNARE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSNARE1"
                     /note="hexamer: AATAAA"
     polyA_site      1905
                     /gene="TSNARE1"
                     /note="major polyA site"
ORIGIN      
        1 acgtgatgtt tgggtgcccg ccccgcccgc ctcgcccgcc gtgagcgccc ggagcggtcc
       61 gcgagccacc gaggcccagc tcagtgtgga ggctgctggc cctgccatct gtaagaagat
      121 gtcatacgga tccatcgccc gtggaggtgg cctggggagc cgtggccctt tcgggggacc
      181 ttcgagacaa ggctgtcagc ccctagagtg cgctagatgt tggaccgagt atggaatccg
      241 ccatttcccc tgcccgtcgc cagagagcaa gctgcagaac cgctgtgtgg ggaaggacgg
      301 ggaaggtgat ctggggccag caggcacgcc tattgtccca agggccagga agcgagggcc
      361 tggggttgcc cctgaaggca gccggatgcc ggagcccacc tcatcaccca ccattggccc
      421 gaggaaggac tcggctgctg ggccccatgg ccggatggcg gggcccagca ctacccgggc
      481 caagaagagg aagcccaact tctgcccgca ggagaccgag gtgctggtgt ccaaggtgag
      541 caagcaccac cagctgctgt ttggcacggg gctgctgaag gccgagccca ctcgcaggta
      601 ccgcgtgtgg agccgcatcc tgcaggccgt gaatgcgctg ggctactgtc gccgcgacgt
      661 tgtggacctg aagcacaagt ggcgggacct acgagccgtc gtgcggcgca agctgggcga
      721 cctccggaag gcggcccatg gccccagccc tggttccggc aagccccagg ccctggctct
      781 cacgcccgtg gagcaggtgg tggccaagac cttctcttgc caggccctgc cctccgaggg
      841 cttcagtctg gagccgccca gagccaccca ggtcgatccg tgcaacctcc aggagctgtt
      901 ccaggagatg tcggccaacg tcttccgaat caactccagt gtgacctcct tggagcggag
      961 ccttcagtcc ttagggacac cgagtgacac gcaggagctt cgggacagcc tgcacacggc
     1021 acagcaggag accaacaaga ccattgcagc cagcgccagc tccgtgaagc agatggccga
     1081 gctgctgcgc agctcctgcc cgcaggagcg tctgcagcag gagcgtcctc agctggaccg
     1141 gctgaaaacc cagctctcag atgccattca gtgctatgga gtggtgcaga agaaaattgc
     1201 agaaaagtcc agagcgctgc ttcccatggc gcagaggggc agtaaacaga gtccccaggc
     1261 cccgtttgcc gagctggctg atgatgagaa ggtctttaac gggagtgaca acatgtggca
     1321 gggccaggag caggcgctgc tcccggacat cactgaagag gacctggagg ccatccggct
     1381 gcgggaggag gccatcctgc agatggagag caacttgctg gatgtgaatc agatcatcaa
     1441 ggacttggcc tccatggtgt cagagcaagg agaagctgtt gatagtattg aagccagcct
     1501 tgaggctgcg tcctcgcatg cggaggcagc ccgccagctc ctggctggag ccagccggca
     1561 ccaactccag agacacaaga tcaagtgctg cttcctatca gctggagtca ctgccctgct
     1621 tgtcatcatc atcatcatcg ccacctctgt ccgaaagtga tgctacccgt gcatcggccg
     1681 ctgaaccgtc agctggctgt ggtgtgggct ctccagcccc gagcacccct cctggcccgg
     1741 agctgggagc tgatggagtc cgctgcgttg tcagctgatg ccgtcacttg gcctgcaatg
     1801 gacccgagag cttcacagct gcctgctgtc ctcccctgca ctgaccccac tcgcccctgt
     1861 gtcggcccca gctgagcacc cgaataaacc gctgtggctt atcca
//
