LOCUS       NM_004622               3302 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens translin (TSN), transcript variant 1, mRNA.
ACCESSION   NM_004622
VERSION     NM_004622.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Pillai,V., Gupta,A., Rao,A. and Chittela,R.K.
  TITLE     Biochemical characterization of clinically relevant mutations of
            human Translin
  JOURNAL   Mol Cell Biochem 478 (4), 821-834 (2023)
   PUBMED   36098897
  REMARK    GeneRIF: Biochemical characterization of clinically relevant
            mutations of human Translin.
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3302)
  AUTHORS   Oyama,K., Baba,T. and Kashiwabara,S.I.
  TITLE     Functional characterization of testis-brain RNA-binding protein,
            TB-RBP/Translin, in translational regulation
  JOURNAL   J Reprod Dev 67 (1), 35-42 (2021)
   PUBMED   33268667
  REMARK    GeneRIF: Functional characterization of testis-brain RNA-binding
            protein, TB-RBP/Translin, in translational regulation.
REFERENCE   4  (bases 1 to 3302)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3302)
  AUTHORS   Gupta,A., Pillai,V.S. and Chittela,R.K.
  TITLE     Role of amino acid residues important for nucleic acid binding in
            human Translin
  JOURNAL   Int J Biochem Cell Biol 115, 105593 (2019)
   PUBMED   31442605
  REMARK    GeneRIF: Role of amino acid residues important for nucleic acid
            binding in human Translin
REFERENCE   6  (bases 1 to 3302)
  AUTHORS   Kasai,M., Matsuzaki,T., Katayanagi,K., Omori,A., Maziarz,R.T.,
            Strominger,J.L., Aoki,K. and Suzuki,K.
  TITLE     The translin ring specifically recognizes DNA ends at recombination
            hot spots in the human genome
  JOURNAL   J Biol Chem 272 (17), 11402-11407 (1997)
   PUBMED   9111049
REFERENCE   7  (bases 1 to 3302)
  AUTHORS   Aoki,K., Ishida,R. and Kasai,M.
  TITLE     Isolation and characterization of a cDNA encoding a Translin-like
            protein, TRAX
  JOURNAL   FEBS Lett 401 (2-3), 109-112 (1997)
   PUBMED   9013868
REFERENCE   8  (bases 1 to 3302)
  AUTHORS   Aoki,K., Suzuki,K., Sugano,T., Tasaka,T., Nakahara,K., Kuge,O.,
            Omori,A. and Kasai,M.
  TITLE     A novel gene, Translin, encodes a recombination hotspot binding
            protein associated with chromosomal translocations
  JOURNAL   Nat Genet 10 (2), 167-174 (1995)
   PUBMED   7663511
REFERENCE   9  (bases 1 to 3302)
  AUTHORS   Kasai,M., Aoki,K., Matsuo,Y., Minowada,J., Maziarz,R.T. and
            Strominger,J.L.
  TITLE     Recombination hotspot associated factors specifically recognize
            novel target sequences at the site of interchromosomal
            rearrangements in T-ALL patients with t(8;14)(q24;q11) and
            t(1;14)(p32;q11)
  JOURNAL   Int Immunol 6 (7), 1017-1025 (1994)
   PUBMED   7947454
REFERENCE   10 (bases 1 to 3302)
  AUTHORS   Aoki,K., Nakahara,K., Ikegawa,C., Seto,M., Takahashi,T.,
            Minowada,J., Strominger,J.L., Maziarz,R.T. and Kasai,M.
  TITLE     Nuclear proteins binding to a novel target sequence within the
            recombination hotspot regions of Bcl-2 and the immunoglobulin DH
            gene family
  JOURNAL   Oncogene 9 (4), 1109-1115 (1994)
   PUBMED   8134113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018737.9.
            
            On Nov 27, 2018 this sequence version replaced NM_004622.2.
            
            Summary: This gene encodes a DNA-binding protein which specifically
            recognizes conserved target sequences at the breakpoint junction of
            chromosomal translocations. Translin polypeptides form a multimeric
            structure that is responsible for its DNA-binding activity.
            Recombination-associated motifs and translin-binding sites are
            present at recombination hotspots and may serve as indicators of
            breakpoints in genes which are fused by translocations. These
            binding activities may play a crucial role in chromosomal
            translocation in lymphoid neoplasms. This protein encoded by this
            gene, when complexed with translin-associated protein X, also forms
            a Mg ion-dependent endoribonuclease that promotes RNA-induced
            silencing complex (RISC) activation. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.220308.1,
                                           SRR1803611.152473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389682.8/ ENSP00000374332.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC018737.9         149752-149946
            196-289             AC018737.9         151341-151434
            290-386             AC018737.9         152811-152907
            387-502             AC018737.9         155510-155625
            503-582             AC018737.9         157106-157185
            583-3302            AC018737.9         159235-161954
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..3302
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /note="translin"
                     /db_xref="GeneID:7247"
                     /db_xref="HGNC:HGNC:12379"
                     /db_xref="MIM:600575"
     exon            1..195
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..816
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     recombination hotspot associated factor; recombination
                     hotspot-binding protein; testis brain-RNA binding protein;
                     component 3 of promoter of RISC"
                     /codon_start=1
                     /product="translin isoform 1"
                     /protein_id="NP_004613.1"
                     /db_xref="CCDS:CCDS33284.1"
                     /db_xref="GeneID:7247"
                     /db_xref="HGNC:HGNC:12379"
                     /db_xref="MIM:600575"
                     /translation="MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQG
                     VHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLA
                     AFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVT
                     AGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFN
                     KETAAACVEK"
     exon            196..289
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /inference="alignment:Splign:2.1.0"
     exon            290..386
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /inference="alignment:Splign:2.1.0"
     exon            387..502
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /inference="alignment:Splign:2.1.0"
     exon            503..582
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /inference="alignment:Splign:2.1.0"
     exon            583..3302
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /note="hexamer: AATAAA"
     polyA_site      2742
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /note="major polyA site"
     regulatory      2932..2937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /note="hexamer: ATTAAA"
     polyA_site      2952
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
     regulatory      3269..3274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
                     /note="hexamer: ATTAAA"
     polyA_site      3302
                     /gene="TSN"
                     /gene_synonym="BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN"
ORIGIN      
        1 ggtcgtggcg taagaccggg gggacgcggc ggtagcggcg gccgttgcga ttgattgcgc
       61 tggttgcctg cggcgtccac ttccttggcc gcccttgcta cactggctga ttgttgtgca
      121 gccggcgcca tgtctgtgag cgagatcttc gtggagctgc agggcttttt ggctgccgag
      181 caggacatcc gagaggaaat cagaaaagtt gtacagagtt tagaacaaac agctcgagag
      241 attttaactc tactgcaagg ggtccatcag ggtgctgggt ttcaggacat tccaaagagg
      301 tgtttgaaag ctcgagaaca ttttggtaca gtaaaaacac atctaacatc tttgaagacc
      361 aaatttcctg ctgaacagta ttacagattt catgagcact ggaggtttgt gttgcagcgc
      421 ttggtcttct tggcagcatt tgttgtgtat ttggaaacag aaacactagt gactcgagaa
      481 gcagttacag aaattcttgg cattgagcca gatcgggaga aaggatttca tctggatgta
      541 gaagattatc tctcaggagt tctaattctt gccagtgaac tgtcgaggct gtctgtcaac
      601 agcgtgactg ctggagacta ctcccgaccc ctccacatct ccaccttcat caatgagctg
      661 gattccggtt ttcgccttct caacctgaaa aatgactccc tgaggaagcg ctacgacgga
      721 ttgaaatatg acgtgaagaa agtagaggaa gtggtctatg atctctccat ccggggcttt
      781 aataaggaga cggcagcagc ttgtgttgaa aaataggagg ctctccttgc tcctggcctt
      841 gctgacctca gcggttgcca ggaaggggtg agcacagagt gcctcttacg gtagttagga
      901 tgctcagttg ctaaacactg cgctttattt tcttaaccag ttgtggtgtg agtatcagaa
      961 ttgaaacact tttttggggg taaaaaatat agcctttaca tggacagaat tttttttgtt
     1021 gtttcagtga atatgcctgt aattcagtgt atttcagttc cgtcagaaag tgtaaatgtt
     1081 agtttcttgg taaagtcctt ttcttgctta ccttgactgt tgatgtactg attgagaagt
     1141 tcattgtctc gtttgtgatt cttccagatg tgatgcttga tattttctat atgcgagtta
     1201 gccatccaca cccaggcata gcctggatac agtataaaaa tagataatta aaaagatggt
     1261 tgccaagcaa ggaaaactta ttttatattt tcccttcctt attttaagca ttgtgagtaa
     1321 atcagatgtt gaattctttt gccaagggaa ttatagctgc aggttctctc tcactgccat
     1381 caaactgtaa aagattaaac tgcgaagtca agctcaacag attattttgg aaagtttttg
     1441 tattaaggga tttagtaaca tcattttgtt ttccaccagg cagggagtag ggcttagtgt
     1501 tttaaaacac ctctgctttc tgatgttgcc ttaatattct gctattgcag caattaaaaa
     1561 ttgtcttcat gtacatttgg aactaacacg tgatgtgata tattcctaaa ctatgaaacc
     1621 tttttcctag tagtcagcta gatcatttgt tctgggagta taaagccacc cacgtaagtt
     1681 aataagcaaa atcctgacta ttatgttgtt agagaaaaat gctttgcttt gtctggaaga
     1741 aagataaaat agtgaattat aaataagtca ggccgggcgt ggtggctcac acctgtaatc
     1801 ccagcacact gggaggccga ggcaggggga ctgcttgagc tcaggagttc gagaccagcc
     1861 tgggcaacaa agtgagactc catctctata taaaaacaaa aaccacgaaa gcacacacaa
     1921 aataaatcag tgggatttgg taatgtgttt tagagtaaga aatttcaggt tgttggtgac
     1981 tatcccaaca gtcatgtttt aaatgtacag tttggggcaa gtcatgtaaa tactgttggt
     2041 ggtcttcccc acacgcccca attttcaggt agtactaaga gtatgtgcca ggaaactctt
     2101 gctattgaat tgagatgatt aaaatggtga cttaatccgt agttattttg cacccactga
     2161 aaggaaagtg ctttccagaa taatatgaag tatctaaaag tgtcaccttt tcttgcctga
     2221 tcaacaattt gggcttcctg tttgtacaag gggccatttg gcataccttt cacagctttt
     2281 atcaggccaa gttaaaggct gactacattt tttcatcatg aggaaagcag ttgaaatgag
     2341 gcatgagtta ctgtgcattg ggattttaga acaattttct tgtgacagct ctttttgtga
     2401 agttaggttc ttaaaagtgc ccatgatggt cacttaaaat gtgcagtaat agcactgcca
     2461 ggatcaagca tgaaaggctt ttaaattaga tcatcccaca gacaatacgt ttgataatag
     2521 ttttttcttt taacctcttt aagtattgat tctgcttgag aatattgaag tacttgccag
     2581 aagttgtgga tttcagtttt aacaaatgct attaaagtgg agaagcacac tctggtcttg
     2641 gaattccatt tgaggattta gaagtgtcat gtttataact attcagttgt gtttgttgct
     2701 ggcttgttgt aaagcaataa aatttttttg gtctttttgt aagtgagtgt gctgctgtaa
     2761 gaaatctccc atgtgcataa caaattctga atattttttg aggctaaaga agaccggggt
     2821 gacaagcaga tactgctgtg taatggttac actaaccaaa agacaccagc cactcagagt
     2881 tctatactgt aaagcgcaga taacatttgt gtgttatacc ttgattgggg aattaaaagt
     2941 catttaactg aagatgttga gaaacctggg ctctggtttt agtataccgg aattactttt
     3001 ttccaatttt agaaaatcaa gcaggttaga gaaaatagag atgaattagg ggacactgtc
     3061 ttatggattc atttataaga agagaaccag ccatatacac ttggggagat ttgccacatc
     3121 ttaaacttga ataatagtat gagtaatgct taagggagtt taatagagaa ggaaagcttt
     3181 ggcagtgttt tgagaactta agtggctaaa gagatgagac aaacatgcag gtcgctactg
     3241 gcatagtttc ataattgtgt actcggaaat taaagtttgc ttgtttcttg gtctggatta
     3301 aa
//
