LOCUS       NM_033035               2610 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens thymic stromal lymphopoietin (TSLP), transcript
            variant 1, mRNA.
ACCESSION   NM_033035
VERSION     NM_033035.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Jafari,A.J., Rivera,M. and Hebert,A.A.
  TITLE     The role of thymic stromal lymphopoietin in cutaneous disorders
  JOURNAL   Arch Dermatol Res 316 (5), 123 (2024)
   PUBMED   38630260
  REMARK    GeneRIF: The role of thymic stromal lymphopoietin in cutaneous
            disorders.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Infante Cruz,A., Coronel,J.V., Saibene Velez,P., Remes Lenicov,F.,
            Iturrizaga,J., Abelleyro,M., Rosato,M., Shiromizu,C.M.,
            Candolfi,M., Vermeulen,M., Jancic,C., Yasuda,E., Berner,S.,
            Villaverde,M.S. and Salamone,G.V.
  TITLE     Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of
            Glioblastoma: Role of the Neutrophil
  JOURNAL   Cell Mol Neurobiol 44 (1), 31 (2024)
   PUBMED   38557942
  REMARK    GeneRIF: Relevance of Thymic Stromal Lymphopoietin on the
            Pathogenesis of Glioblastoma: Role of the Neutrophil.
            Erratum:[Cell Mol Neurobiol. 2024 Apr 22;44(1):37. doi:
            10.1007/s10571-024-01479-0.. PMID: 38647721]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Bjerkan,L., Schreurs,O., Engen,S.A., Jahnsen,F.L., Baekkevold,E.S.,
            Blix,I.J. and Schenck,K.
  TITLE     The short form of TSLP is constitutively translated in human
            keratinocytes and has characteristics of an antimicrobial peptide
  JOURNAL   Mucosal Immunol 8 (1), 49-56 (2015)
   PUBMED   24850429
  REMARK    GeneRIF: The short protein isoform is expressed in keratinocytes of
            oral cavity, skin and salivary glands, and exhibits a markedly
            stronger antimicrobial activity compared to the longer isoform.
            TSLP displays antibacterial and antifungal activity against B.
            cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C.
            albicans.
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Fernandez,M.I., Heuze,M.L., Martinez-Cingolani,C., Volpe,E.,
            Donnadieu,M.H., Piel,M., Homey,B., Lennon-Dumenil,A.M. and
            Soumelis,V.
  TITLE     The human cytokine TSLP triggers a cell-autonomous dendritic cell
            migration in confined environments
  JOURNAL   Blood 118 (14), 3862-3869 (2011)
   PUBMED   21772055
  REMARK    GeneRIF: TSLP induced the polarization of both microtubule and
            actin cytoskeletons and promoted dendritic cells 3-dimensional
            migration in transwell as well as in microfabricated channels that
            mimic the confined environment of peripheral tissues.
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Ziegler,S.F. and Artis,D.
  TITLE     Sensing the outside world: TSLP regulates barrier immunity
  JOURNAL   Nat Immunol 11 (4), 289-293 (2010)
   PUBMED   20300138
  REMARK    Review article
REFERENCE   6  (bases 1 to 2610)
  AUTHORS   He,R. and Geha,R.S.
  TITLE     Thymic stromal lymphopoietin
  JOURNAL   Ann N Y Acad Sci 1183, 13-24 (2010)
   PUBMED   20146705
  REMARK    GeneRIF: Roles of Thymic stromal lymphopoietin in immunity.
            Review article
REFERENCE   7  (bases 1 to 2610)
  AUTHORS   Quentmeier,H., Drexler,H.G., Fleckenstein,D., Zaborski,M.,
            Armstrong,A., Sims,J.E. and Lyman,S.D.
  TITLE     Cloning of human thymic stromal lymphopoietin (TSLP) and signaling
            mechanisms leading to proliferation
  JOURNAL   Leukemia 15 (8), 1286-1292 (2001)
   PUBMED   11480573
REFERENCE   8  (bases 1 to 2610)
  AUTHORS   Reche,P.A., Soumelis,V., Gorman,D.M., Clifford,T., Liu,Mr.,
            Travis,M., Zurawski,S.M., Johnston,J., Liu,Y.J., Spits,H., de Waal
            Malefyt,R., Kastelein,R.A. and Bazan,J.F.
  TITLE     Human thymic stromal lymphopoietin preferentially stimulates
            myeloid cells
  JOURNAL   J Immunol 167 (1), 336-343 (2001)
   PUBMED   11418668
  REMARK    GeneRIF: This protein is a hemopoietic cytokine that signals
            through a heterodimeric receptor complex consisting of the human
            TSLP receptor and the IL-7R alpha-chain.
REFERENCE   9  (bases 1 to 2610)
  AUTHORS   Pandey,A., Ozaki,K., Baumann,H., Levin,S.D., Puel,A., Farr,A.G.,
            Ziegler,S.F., Leonard,W.J. and Lodish,H.F.
  TITLE     Cloning of a receptor subunit required for signaling by thymic
            stromal lymphopoietin
  JOURNAL   Nat Immunol 1 (1), 59-64 (2000)
   PUBMED   10881176
REFERENCE   10 (bases 1 to 2610)
  AUTHORS   Isaksen,D.E., Baumann,H., Trobridge,P.A., Farr,A.G., Levin,S.D. and
            Ziegler,S.F.
  TITLE     Requirement for stat5 in thymic stromal lymphopoietin-mediated
            signal transduction
  JOURNAL   J Immunol 163 (11), 5971-5977 (1999)
   PUBMED   10570284
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY037115.1, AL833421.1 and
            AC008572.6.
            
            On Nov 22, 2018 this sequence version replaced NM_033035.4.
            
            Summary: This gene encodes a hemopoietic cytokine proposed to
            signal through a heterodimeric receptor complex composed of the
            thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It
            mainly impacts myeloid cells and induces the release of T
            cell-attracting chemokines from monocytes and enhances the
            maturation of CD11c(+) dendritic cells. The protein promotes T
            helper type 2 (TH2) cell responses that are associated with
            immunity in various inflammatory diseases, including asthma,
            allergic inflammation and chronic obstructive pulmonary disease.
            The protein is therefore considered a potential therapeutic target
            for the treatment of such diseases. In addition, the shorter
            (predominant) isoform is an antimicrobial protein, displaying
            antibacterial and antifungal activity against B. cereus, E. coli,
            E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) encodes the longer isoform (1,
            also known as lfTSLP). This isoform is found in much lower
            abundance compared to the shorter isoform sfTSLP (PMID:24850429)
            and is known to stimulate allergic inflammation in diseases such as
            asthma and COPD.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY037115.1, AF338732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344895.4/ ENSP00000339804.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-688               AY037115.1         22-709
            689-2608            AL833421.1         472-2391
            2609-2610           AC008572.6         98976-98977
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..2610
                     /gene="TSLP"
                     /note="thymic stromal lymphopoietin"
                     /db_xref="GeneID:85480"
                     /db_xref="HGNC:HGNC:30743"
                     /db_xref="MIM:607003"
     exon            1..349
                     /gene="TSLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..658
                     /gene="TSLP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="thymic stromal lymphopoietin isoform 1
                     precursor"
                     /protein_id="NP_149024.1"
                     /db_xref="CCDS:CCDS4101.1"
                     /db_xref="GeneID:85480"
                     /db_xref="HGNC:HGNC:30743"
                     /db_xref="MIM:607003"
                     /translation="MFPFALLYVLSVSFRKIFILQLVGLVLTYDFTNCDFEKIKAAYL
                     STISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKT
                     KAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ"
     exon            350..394
                     /gene="TSLP"
                     /inference="alignment:Splign:2.1.0"
     exon            395..529
                     /gene="TSLP"
                     /inference="alignment:Splign:2.1.0"
     exon            530..2610
                     /gene="TSLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1356..1361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSLP"
                     /note="hexamer: AATAAA"
     regulatory      1361..1366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSLP"
                     /note="hexamer: AATAAT"
     polyA_site      1377
                     /gene="TSLP"
                     /note="major polyA site"
     polyA_site      1388
                     /gene="TSLP"
     regulatory      2585..2590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSLP"
                     /note="hexamer: AATAAA"
     polyA_site      2610
                     /gene="TSLP"
ORIGIN      
        1 atcagggaga ctccaactta aggcaacagc atgggtgaat aagggcttcc tgtggactgg
       61 caatgagagg caaaacctgg tgcttgagca ctggccccta aggcaggcct tacagatctc
      121 ttacactcgt ggtgggaaga gtttagtgtg aaactggggt ggaattgggt gtccacgtat
      181 gttccctttt gccttactat atgttctgtc agtttctttc aggaaaatct tcatcttaca
      241 acttgtaggg ctggtgttaa cttacgactt cactaactgt gactttgaga agattaaagc
      301 agcctatctc agtactattt ctaaagacct gattacatat atgagtggga ccaaaagtac
      361 cgagttcaac aacaccgtct cttgtagcaa tcggccacat tgccttactg aaatccagag
      421 cctaaccttc aatcccaccg ccggctgcgc gtcgctcgcc aaagaaatgt tcgccatgaa
      481 aactaaggct gccttagcta tctggtgccc aggctattcg gaaactcaga taaatgctac
      541 tcaggcaatg aagaagagga gaaaaaggaa agtcacaacc aataaatgtc tggaacaagt
      601 gtcacaatta caaggattgt ggcgtcgctt caatcgacct ttactgaaac aacagtaaac
      661 catctttatt atggtcatat ttcacagcac caaaataaat catctttatt aagtagatga
      721 aacattaact ctaactgtga caaagaagac cacaaatagt tatcttttaa ttacagaaga
      781 gtttcttaac ttacttttgt aagtttttat tgtgtaagtt tataatgcag gggaagtact
      841 actcctcaaa tgttgaggga agcttccata acattgatga ctggcttcat ggcagtaatt
      901 ctcggctgta gttgcataag cattgctcaa gaggaaaatc caaaagtgca gcaggagaac
      961 tcttttccct gaaaaaggaa aaatattgaa ctcaatgata gcacctaaac ttacatttaa
     1021 aagacagaca ttccttctac atgtaatgac acttcttgtg ttaaactaaa aatttacaag
     1081 agaagaaagt gaaagcaaat ggggtttcac aaatagttgt aaatatagtg aagcaatttg
     1141 aaataatttt caagcaaagt attgtgaaag tattctaagc caagttttaa atattatcta
     1201 acagacaaga gtggtatata caagtagatc ctgagaagta cctttgttac agctactata
     1261 aatatacata taaattatag aatctacttt aatttatttt gtgaacactt ttgaaaatgt
     1321 acatgttcct ttgtaattga cactatatat ttcttaataa aataattctc aaatttgttt
     1381 cttatgaatc atctctcaaa tctagttaga caatttgcac acatactttt ctaagggaca
     1441 ttatcttcct tcaggttttt acctccactc atccttagag cccactgact gctccccttt
     1501 atacctgttg gccctgccta taggagagaa tatttggaga taggcagctt caggatgcat
     1561 tgcaatcatc cttttcttaa attatgtcac tagtctttta ttttttcccc tcttgaactt
     1621 tcctcacacc tggaagaaac aaagtaggaa aaagtgaaca ggggatgtca aatcgattct
     1681 tgaattcccg ctgcaagcta gagccgcagg caccctctca ctcaatttcc actcagaacc
     1741 ctataaacac cagtgggaag ggcaacccac tgcacgtggg aatgcactga tttttcctag
     1801 gagtagacat gttcctctaa ttactccctg agggttagtt ggggctaaac catgacagaa
     1861 gtggggaagt tcaatgtcct taaatccatc ttacttgcca acaggtaaga ggaagcttac
     1921 attacatgtc cagtccacat ttaaagagca cttactgtgg aacaagcctt cagccaaaca
     1981 atggggatag aaaagtaggt aagactcagc ctttgtccag agaagctcag ggtatagctg
     2041 aataggcagt ttcttttgtc ctgaggaaaa tcaggacatg cctgctttct aaaaatcttc
     2101 ctctgaagac ctgacccaag ctcttaaatg ctattgtaag agaaatttct ttgtctatta
     2161 actccatttt agtagggatt cactgactag attttactga actatgaaaa taaatacaca
     2221 taatttttca caaaattttg ggcccaattc ccctaaaaga attgaggatt agggagaaag
     2281 gagacaactc aaagtcatcc cattaagtgc agtttctttg aatcttctgc tttatcttta
     2341 aaaatttgta taatttatat attttattct atgtgttcca tagatatctt aatgtaaaat
     2401 tagtcattta aattacactg tcaattaaaa gtaatgggca agagattgca tcatactaat
     2461 ttagtaagaa cgttcccaaa tgttgtaaca atgtggatca tacatctctg gttttttaaa
     2521 tgtattgagg ctttcttggt ggactagtat agtatacggt cagttatgtc aatgtttcat
     2581 ggtcaataaa aaggaagttg caaattgtga
//
