LOCUS       NM_020856               5065 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens teashirt zinc finger homeobox 3 (TSHZ3), transcript
            variant 1, mRNA.
ACCESSION   NM_020856
VERSION     NM_020856.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5065)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 5065)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5065)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5065)
  AUTHORS   Chabbert,D., Caubit,X., Roubertoux,P.L., Carlier,M., Habermann,B.,
            Jacq,B., Salin,P., Metwaly,M., Frahm,C., Fatmi,A., Garratt,A.N.,
            Severac,D., Dubois,E., Kerkerian-Le Goff,L., Fasano,L. and
            Gubellini,P.
  TITLE     Postnatal Tshz3 Deletion Drives Altered Corticostriatal Function
            and Autism Spectrum Disorder-like Behavior
  JOURNAL   Biol Psychiatry 86 (4), 274-285 (2019)
   PUBMED   31060802
  REMARK    GeneRIF: The study reveals a crucial postnatal role of TSHZ3 in the
            development and functioning of the corticostriatal circuitry and
            provides evidence that dysfunction in these circuits might be
            determinant for autism spectrum disorder pathogenesis.
REFERENCE   5  (bases 1 to 5065)
  AUTHORS   Li,Y., Huang,Y., Qi,Z., Sun,T. and Zhou,Y.
  TITLE     MiR-338-5p Promotes Glioma Cell Invasion by Regulating TSHZ3 and
            MMP2
  JOURNAL   Cell Mol Neurobiol 38 (3), 669-677 (2018)
   PUBMED   28780604
  REMARK    GeneRIF: that miR-338-5p has a function in promoting glioma cell
            invasion by targeting TSHZ3 suppression on MMP2
REFERENCE   6  (bases 1 to 5065)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5065)
  AUTHORS   Jenkins,D., Caubit,X., Dimovski,A., Matevska,N., Lye,C.M.,
            Cabuk,F., Gucev,Z., Tasic,V., Fasano,L. and Woolf,A.S.
  TITLE     Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric
            junction obstruction
  JOURNAL   Nephrol Dial Transplant 25 (1), 54-60 (2010)
   PUBMED   19745106
  REMARK    GeneRIF: Mutations in TSHZ2 and TSHZ3 are not a major cause of
            pelvi-ureteric junction obstruction, at least in Albanian and
            Macedonian populations.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5065)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum Mol Genet 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   9  (bases 1 to 5065)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 5065)
  AUTHORS   Kajiwara,Y., Akram,A., Katsel,P., Haroutunian,V., Schmeidler,J.,
            Beecham,G., Haines,J.L., Pericak-Vance,M.A. and Buxbaum,J.D.
  TITLE     FE65 binds Teashirt, inhibiting expression of the primate-specific
            caspase-4
  JOURNAL   PLoS One 4 (4), e5071 (2009)
   PUBMED   19343227
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB460052.1, AC025809.5,
            AI015687.1, BX648745.1, CN256026.1 and AL136805.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_020856.3.
            
            Summary: This gene encodes a zinc-finger transcription factor that
            regulates smooth muscle cell differentiation in the developing
            urinary tract. Consistent with this role, mice in which this gene
            has been inactivated exhibit abnormal gene expression in urinary
            tract smooth muscle cell precursors and kidney defects including
            hydronephrosis. The encoded transcription factor comprises a gene
            silencing complex that inhibits caspase expression. Reduced
            expression of this gene and consequent caspase upregulation may be
            correlated with progression of Alzheimer's disease in human
            patients. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.146405.1,
                                           SRR1803612.238272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240587.5/ ENSP00000240587.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               DB460052.1         90-240
            152-152             AC025809.5         192538-192538       c
            153-198             AI015687.1         49-94
            199-906             BX648745.1         1-708
            907-1175            CN256026.1         477-745
            1176-5065           AL136805.1         436-4325
FEATURES             Location/Qualifiers
     source          1..5065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q12"
     gene            1..5065
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="teashirt zinc finger homeobox 3"
                     /db_xref="GeneID:57616"
                     /db_xref="HGNC:HGNC:30700"
                     /db_xref="MIM:614119"
     exon            1..257
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..3463
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="teashirt family zinc finger 3; zinc finger protein
                     537"
                     /codon_start=1
                     /product="teashirt homolog 3"
                     /protein_id="NP_065907.2"
                     /db_xref="CCDS:CCDS12421.2"
                     /db_xref="GeneID:57616"
                     /db_xref="HGNC:HGNC:30700"
                     /db_xref="MIM:614119"
                     /translation="MPRRKQQAPRRAAAYVSEELKAAALVDEGLDPEEHTADGEPSAK
                     YMCPEKELARACPSYQNSPAAEFSCHEMDSESHISETSDRMADFESGSIKNEEETKEV
                     TVPLEDTTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSEKNNGSSSSSSSSSSSC
                     GSGSFDWHQSAMAKTLQQVSQSRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKD
                     CSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLK
                     CMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPATRKKASLELELPSSP
                     DSTGGTPKATISDTNDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECG
                     SSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIVETPVTPTITTLLDEKVQSVPLAAT
                     TFTSPSNTPASISPKLNVEVKKEVDKEKAVTDEKPKQKDKPGEEEEKCDISSKYHYLT
                     ENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGS
                     SGKSTPLKPMFGNSEIVSPTKNQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKV
                     EEKMKEPDGKLSPPKRATPSPCSSEVGEPIKMEASSDGGFRSQENSPSPPRDGCKDGS
                     PLAEPVENGKELVKPLASSLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPS
                     LPALDPMSMLFKMSNSLAEKAAVATPPPLQSKKADHLDRYFYHVNNDQPIDLTKGKSD
                     KGCSLGSVLLSPTSTAPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTE
                     SHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASL
                     RQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTG
                     HPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINSQIAQTKSPSEKMVT
                     SSPEEDLGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVSELEKQ"
     exon            258..5065
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5042..5047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="hexamer: ATTAAA"
     polyA_site      5065
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="major polyA site"
ORIGIN      
        1 cttcttccct ccgcacgttc ggggttcgcg gcggagcgcg gcgcgggggg gacgcggaga
       61 gcctgggcgc agcagcatcc tgcgggcggc cgctctccgg gggggaggct gagagcaggc
      121 ccgcctcgcc cccccgcggg cccgccgccc cctccctccc tgtcctcagc ccggcagcgg
      181 cggcggcggc ggcagtggca gtcgccggag aagcatcatg ccgaggagga agcagcaggc
      241 gccccggcgc gcagcagcct atgtttccga agagttaaag gctgctgccc tggtggacga
      301 aggtttagac ccagaggagc atacggcaga tggagagccc tcggccaagt acatgtgccc
      361 ggagaaggag ctcgccaggg cctgccccag ctaccagaac tccccggccg ccgagttttc
      421 ctgccatgaa atggacagcg agtcacacat cagtgagacc agtgaccgaa tggctgactt
      481 tgaaagcggc tccatcaaga acgaagagga gaccaaggag gtcacggtcc cactggaaga
      541 cacgactgtg tcggatagcc tggagcagat gaaggccgtg tacaacaact tcctctccaa
      601 ctcctactgg tccaacctca acctcaacct gcaccagccc tcctcggaga agaacaacgg
      661 cagcagcagc agcagcagta gcagcagcag cagctgtggc agcgggagct tcgactggca
      721 ccagagcgcc atggctaaga cgctgcagca ggtgtcacag agccgcatgc tcccggagcc
      781 cagcctcttc agcaccgtgc agctgtaccg gcagagcagc aagctctatg gctccatctt
      841 cacgggggcc agcaagttcc gctgtaagga ctgcagcgct gcctacgaca ccctggtgga
      901 gttgacggtg cacatgaacg agacggggca ttaccgcgac gacaaccatg agaccgataa
      961 caacaacccc aagcgctggt ccaagcctcg caaacgctcc ttgctggaaa tggaagggaa
     1021 ggaagacgcc cagaaggtgc tgaagtgcat gtactgtggc cactcctttg agtccctgca
     1081 ggatttgagt gtccatatga tcaaaacaaa acactaccaa aaagtgcctc tgaaggaacc
     1141 cgtcactcct gtcgccgcca aaatcatccc tgccactcgg aagaaagctt ccctggagct
     1201 ggagctcccc agctccccag attccacagg tggaaccccc aaagccacca tctcagacac
     1261 caacgatgca cttcagaaga actccaaccc ttacatcacg ccaaataatc ggtacggcca
     1321 ccagaatggg gccagctatg catggcactt tgaggcccgg aagtcgcaga tcctgaagtg
     1381 catggagtgt gggagctcgc atgacaccct gcaggagctc actgcccaca tgatggtcac
     1441 tggccacttc atcaaggtca ccaactctgc tatgaaaaag gggaagccca ttgtggagac
     1501 gcctgtcaca cctaccatca caaccctgct ggatgagaag gtccagtccg tgcccctggc
     1561 agccaccacc ttcacgtccc cctccaatac acctgccagc atctccccaa aactgaatgt
     1621 ggaggtcaag aaggaagtcg acaaggagaa agcggtcact gacgagaaac ctaagcaaaa
     1681 agacaagcct ggcgaagaag aggagaagtg tgacatctct tccaaatacc attacttgac
     1741 tgaaaatgac ttagaagaga gtcccaaggg ggggcttgat atcctcaaat ccttggaaaa
     1801 cacagtgaca tccgcaatca acaaggccca gaacggcact cctagctggg ggggctatcc
     1861 cagcatccat gccgcctacc aacttcccaa catgatgaag ttgtccctgg gctcgtcggg
     1921 gaagagcacg cccctgaaac ccatgtttgg caacagtgag attgtctccc cgacgaaaaa
     1981 ccagaccctg gtctctccac ccagcagcca gacgtccccc atgcccaaga caaactttca
     2041 tgccatggag gagctggtga aaaaggtcac tgagaaagtt gccaaagtgg aggagaagat
     2101 gaaggagccg gatgggaagc tttccccgcc caagcgggcc actccctccc catgtagcag
     2161 cgaagtcggg gaacccatca agatggaggc atccagcgat gggggcttcc gcagccagga
     2221 gaacagcccc agccccccgc gggatgggtg caaggatggg agccccctcg ctgagccggt
     2281 ggagaatggc aaggagctgg tgaagcccct agccagcagt ttgagtggca gcacggccat
     2341 catcaccgac cacccgcctg aacagccttt tgttaaccct ttgagcgccc tgcagtcagt
     2401 catgaacatt cacctgggca aggccgccaa gccctccctg cctgccctgg accccatgag
     2461 catgcttttc aagatgagca acagcctggc ggagaaggct gctgtggcca ccccgccgcc
     2521 cctgcagtcc aagaaggcag accacctcga ccgctatttc taccacgtca acaacgacca
     2581 gcccatagac ttgacaaaag ggaagagtga caaaggctgc tccttgggtt cagtgcttct
     2641 gtcacccacg tccacagccc cggcaacctc ctcatccacg gtgacaacgg caaagacatc
     2701 tgccgtcgta tcattcatgt caaactcgcc gctacgcgag aatgccttgt cagatatatc
     2761 cgatatgctg aagaacttga cagagagcca cacgtcaaaa tcctccactc cttccagcat
     2821 ctccgagaag tctgacattg acggggccac tctggaggag gctgaggagt cgacgcccgc
     2881 ccagaagagg aagggccgcc agtcaaactg gaacccccag cacctcctga tcctccaggc
     2941 ccagtttgcc gccagcctcc ggcagacctc agaagggaag tacatcatgt cagacctgag
     3001 cccccaggag cggatgcata tctccaggtt caccgggctg tccatgacca ccatcagcca
     3061 ctggctggcc aacgtgaaat accagcttcg aaggacaggt ggaacaaagt tcctcaaaaa
     3121 cttggacact ggccaccccg tcttcttttg taacgattgt gcgtcccaaa tcaggactcc
     3181 ttccacgtac atcagtcacc tagagtcaca cttaggcttc cggctacggg acttatccaa
     3241 actgtccacc gaacagatta acagtcagat agcacaaacc aagtcaccgt cagaaaaaat
     3301 ggtgacgtcc tcccccgagg aagacctggg gacttcctat cagtgcaaac tttgcaatcg
     3361 gacctttgcc agcaagcacg ctgttaaact tcaccttagc aaaacacacg ggaaatctcc
     3421 ggaagaccac cttctgtatg tctctgagtt agagaagcag tagcatttgc ttttgataga
     3481 aaggactgca gtttgctttg agggaaactg tggaaggcac cttcaggccc cctctgactt
     3541 gttgttcttg gcacatgttc ttattttaac tgcagagaat cactctgggc tggactgttt
     3601 tgtataactg tacagtgttt aatagaggtg cataatcagc tgttgttact ggtaaaatat
     3661 gaaggttaaa atgcagtggt aagtgtttgg aactttgtgt aaacgggatt tagttgtgag
     3721 catcctcccg atgcttcaag ctgcatgcat taacagacag tttaattaag catttataac
     3781 ggaatcaggc acaccttttc cacgagactc gagtgtgctg gcatttctca ccctttcatc
     3841 tttagccctc tgagtacttt gaagcacttt tgcattaatt tggttaaaaa ataaaataaa
     3901 ataataataa tgtatgaagc tctgtttttt aaactcctta ccagcttagt tataatgaat
     3961 aatatgaacc tccatttatg caggtctgca ggggtataac acgccttgaa atttaaaaga
     4021 atattatttt cacattgaaa catagatgta tatattgtat agatttcaga ctctcttatg
     4081 aaaaaaaatg tgattgtggt taaatgacct ttttcttgca tttatagcaa cagtgtttta
     4141 tgcacctgct atgctctggg cataagctgt gcctatgtat agtgtatatt tctttttttc
     4201 ttttttttaa ggtctatggg ttttgttttt tacatgcaaa cattgtaaat tatacagaag
     4261 ataccacaga tagcatttat aaagtataca gaaacattat ctgaaagcaa agtatgatag
     4321 tttgttttgc tatacagtac atctatattg atagaggttc atgtttaaat tatacatatt
     4381 tattagcatc atattgtcat ttgttttgag cagtctgaat aaacgagacc gggaaagaca
     4441 tccctggcag gcatcagaac tattttgcac atgattttta aaggtattta ttagaaatca
     4501 aagaacactc aaaataaact cagtgctcaa agggttaagt ctatttgaaa aggttaaaaa
     4561 aaagaacaaa aaaaaaaaaa gaacttgtac tgtatttcct aaacattgat aaagccttta
     4621 aaatgtttgt actgtaatac tttgcttaaa agtcatgagg cattctgtga tccaacctct
     4681 ttcacttatt tataagccct cttggttgct attccatatt gtaggatgcc tttctatttc
     4741 aattggtaac tttctgtttt gttcttccta attattctcc caagatccca cactgcagct
     4801 ttatctttag gcttatgaaa ggtaacccgt ggttaccggc tctccaagtg attctgttct
     4861 tctccatttt tggcagttaa tttgcagaag taactgacag ctgacaccat atgagaacct
     4921 ttgtataaaa tattggcatg taaacagcac agacaccgta acacactctg tgccctgttt
     4981 ggttgttgac aatgaagcac cattatgtga ctcttcatat aacccttttt tctacggcag
     5041 cattaaaatt gtctttttgc tataa
//
