LOCUS       XM_011537119            4038 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens thyroid stimulating hormone receptor
            (TSHR), transcript variant X1, mRNA.
ACCESSION   XM_011537119
VERSION     XM_011537119.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011537119.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     gene            1..4038
                     /gene="TSHR"
                     /gene_synonym="CHNG1; hTSHR-I; LGR3"
                     /note="thyroid stimulating hormone receptor; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 1 EST, 37 long SRA reads, 7 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7253"
                     /db_xref="HGNC:HGNC:12373"
                     /db_xref="MIM:603372"
     CDS             70..2085
                     /gene="TSHR"
                     /gene_synonym="CHNG1; hTSHR-I; LGR3"
                     /codon_start=1
                     /product="thyrotropin receptor isoform X1"
                     /protein_id="XP_011535421.1"
                     /db_xref="GeneID:7253"
                     /db_xref="HGNC:HGNC:12373"
                     /db_xref="MIM:603372"
                     /translation="MHYSDCVPCNLYREIRNTRNLTYIDPDALKELPLLKFLGIFNTG
                     LKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGY
                     AFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELI
                     ARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQ
                     RKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQE
                     LKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLL
                     ALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHA
                     IDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMV
                     GGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCY
                     VKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNS
                     KILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNST
                     DIQVQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL"
ORIGIN      
        1 tgactctgca gcagctggaa tcacactcct tctacaattt gagtaaagtg actcacataa
       61 cagatacgga tgcattatag tgactgtgtt ccttgtaact tatacagaga aattcggaat
      121 accaggaact taacttacat agaccctgat gccctcaaag agctccccct cctaaagttc
      181 cttggcattt tcaacactgg acttaaaatg ttccctgacc tgaccaaagt ttattccact
      241 gatatattct ttatacttga aattacagac aacccttaca tgacgtcaat ccctgtgaat
      301 gcttttcagg gactatgcaa tgaaaccttg acactgaagc tgtacaacaa tggctttact
      361 tcagtccaag gatatgcttt caatgggaca aagctggatg ctgtttacct aaacaagaat
      421 aaatacctga cagttattga caaagatgca tttggaggag tatacagtgg accaagcttg
      481 ctggacgtgt ctcaaaccag tgtcactgcc cttccatcca aaggcctgga gcacctgaag
      541 gaactgatag caagaaacac ctggactctt aagaaacttc cactttcctt gagtttcctt
      601 cacctcacac gggctgacct ttcttaccca agccactgct gtgcttttaa gaatcagaag
      661 aaaatcagag gaatccttga gtccttgatg tgtaatgaga gcagtatgca gagcttgcgc
      721 cagagaaaat ctgtgaatgc cttgaatagc cccctccacc aggaatatga agagaatctg
      781 ggtgacagca ttgttgggta caaggaaaag tccaagttcc aggatactca taacaacgct
      841 cattattacg tcttctttga agaacaagag gatgagatca ttggttttgg ccaggagctc
      901 aaaaaccccc aggaagagac tctacaagct tttgacagcc attatgacta caccatatgt
      961 ggggacagtg aagacatggt gtgtaccccc aagtccgatg agttcaaccc gtgtgaagac
     1021 ataatgggct acaagttcct gagaattgtg gtgtggttcg ttagtctgct ggctctcctg
     1081 ggcaatgtct ttgtcctgct tattctcctc accagccact acaaactgaa cgtcccccgc
     1141 tttctcatgt gcaacctggc ctttgcggat ttctgcatgg ggatgtacct gctcctcatc
     1201 gcctctgtag acctctacac tcactctgag tactacaacc atgccatcga ctggcagaca
     1261 ggccctgggt gcaacacggc tggtttcttc actgtctttg caagcgagtt atcggtgtat
     1321 acgctgacgg tcatcaccct ggagcgctgg tatgccatca ccttcgccat gcgcctggac
     1381 cggaagatcc gcctcaggca cgcatgtgcc atcatggttg ggggctgggt ttgctgcttc
     1441 cttctcgccc tgcttccttt ggtgggaata agtagctatg ccaaagtcag tatctgcctg
     1501 cccatggaca ccgagacccc tcttgctctg gcatatattg tttttgttct gacgctcaac
     1561 atagttgcct tcgtcatcgt ctgctgctgt tatgtgaaga tctacatcac agtccgaaat
     1621 ccgcagtaca acccagggga caaagatacc aaaattgcca agaggatggc tgtgttgatc
     1681 ttcaccgact tcatatgcat ggccccaatc tcattctatg ctctgtcagc aattctgaac
     1741 aagcctctca tcactgttag caactccaaa atcttgctgg tactcttcta tccacttaac
     1801 tcctgtgcca atccattcct ctatgctatt ttcaccaagg ccttccagag ggatgtgttc
     1861 atcctactca gcaagtttgg catctgtaaa cgccaggctc aggcataccg ggggcagagg
     1921 gttcctccaa agaacagcac tgatattcag gttcaaaagg ttacccacga gatgaggcag
     1981 ggtctccaca acatggaaga tgtctatgaa ctgattgaaa actcccatct aaccccaaag
     2041 aagcaaggcc aaatctcaga agagtatatg caaacggttt tgtaagttaa cactacacta
     2101 ctcacaatgg taggggaact tacaaaataa tagtttcttg aatatgcatt ccaatcccat
     2161 gacaccccca acacatagct gccctcactc ttgtgcaggc gatgtttcaa tgtttcatgg
     2221 ggcaagagtt tatctctgga gagtgattag tattaaccta atcattgccc ccaagaagga
     2281 agttaggcta ccagcatatt tgaatgccag gtgaaatcaa aataatctac actatctaga
     2341 agactttctt gatgccaagt ccagagatgt cattgtgtag gatgttcagt aaatattaac
     2401 tgagctatgt caatatagag cttctcagtt ttgtataaca tttcatacta aagattcagc
     2461 aaatggaaaa tgctattaat ttggttggtg accacaagat aaaatcagtc ccacgttggc
     2521 tcagttcaac tagatgttcc ctgatacaaa gagaacttga tttccttaaa actgaaaagc
     2581 caaacacagc tagctgtcat acaagaaaca gctattatga gacatgaagg agggtaagaa
     2641 ttagctttaa gttttgtttt gctttgtttt gttttttaac tcaacctatt aatcatctct
     2701 tcacaagaat ccacctgatg tgaccaagct attatgtgtt gcctggaaaa actggcaaga
     2761 tttcagctta tgtggcctag caaactaaga attgctcttc ttggccagcc tcatagcata
     2821 aaagatgtga actctaggaa gtctttctga gtagcaataa gtgggaatta tgggcagagc
     2881 acactcaatc ccctgttgat taataaaaca ggctggacac taattaacta tgggacttaa
     2941 atctgtagaa atgaaggagt ccaatagctt cttccaattt taaaactcta gtacatccct
     3001 ttccctcaaa tatatatttc taagataaag agaaagaaga gcactaagta agtagaatct
     3061 gtttttccta ttttgtaggg ctgctgactc ctagtccttg aagcctagac acatgaccca
     3121 ggaaattttt cctttgtttc acttttgatt atgatgtctg agccaaaaat tcaattaagt
     3181 aaacatactc gcctggatct gaatcattca tttaattact agatctaccc agctgttata
     3241 tcaggccaaa aacagattcg tgtttatata aaagagtaaa cgatggttgc aaattttggc
     3301 tatttagagt tgctacttca ctatgaagag tcacttcaaa acacttcgct tgtctttagg
     3361 gatgattttt gccatttcca gtccacggta tgatactaaa gctgtcaaga gaggtttctt
     3421 cttttctgaa actgccagct ctttccagcc ctgttgatca ctggacataa agcttctttt
     3481 ccccaataat tcttctttac ttaaaatagt caggatcttt atctacagat gtactctcca
     3541 ggttacctgt gatgatagcc ccctaatgtc ctgctagaaa agtctccaag cagagatgac
     3601 attacttctg aatgctcata aaccacacca tgaaataaaa gctctttgtt gttttaagat
     3661 tgtgaagtgt cgttaatggg tccccacaga tggtccctgc tggactcacc tggaatctct
     3721 ccacagccat acccactcat cactatcatt gagacctgca catcttaata gaaatattat
     3781 aaacatcgaa aatcatgact tacctagaag ttcgcttgta actaatgaaa ttaaacaaat
     3841 gtgttgcctt ttgtcatgtg tttctctcct gtgacatttc aaaatatcac atcttgataa
     3901 ataatgtgtt tcatcttgaa tagctgaact aattgctttg gaaacagagt cctagaaaag
     3961 tgacttcaac agaattgtta ctaaaatttg cactcacaac atgaaataaa ttttcttcct
     4021 atggaataat cgtgccaa
//
