LOCUS       NM_052933               1633 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens testis specific 13 (TSGA13), transcript variant 2,
            mRNA.
ACCESSION   NM_052933
VERSION     NM_052933.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1633)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1633)
  AUTHORS   Jung,S.M., Namgoong,S., Seo,J.M., Kim,D.Y., Oh,J.T., Kim,H.Y. and
            Kim,J.H.
  TITLE     Potential association between TSGA13 variants and risk of total
            colonic aganglionosis in Hirschsprung disease
  JOURNAL   Gene 710, 240-245 (2019)
   PUBMED   31181311
  REMARK    GeneRIF: Findings provide evidence for genetic association of the
            TSGA13 gene with total colonic aganglionosis, the most severe
            subtype of Hirschsprung disease.
REFERENCE   3  (bases 1 to 1633)
  AUTHORS   Zhao,H., Lai,X., Xu,X., Sui,K., Bu,X., Ma,W., Li,D., Guo,K., Xu,J.,
            Yao,L., Li,W. and Su,J.
  TITLE     Histochemical analysis of testis specific gene 13 in human normal
            and malignant tissues
  JOURNAL   Cell Tissue Res 362 (3), 653-663 (2015)
   PUBMED   26111495
  REMARK    GeneRIF: the data from the current study strongly suggest the
            association between TSGA13 and tumor malignancy.
REFERENCE   4  (bases 1 to 1633)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   5  (bases 1 to 1633)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   6  (bases 1 to 1633)
  AUTHORS   Yamada,T., Mitsuya,K., Kayashima,T., Yamasaki,K., Ohta,T.,
            Yoshiura,K., Matsumoto,N., Yamada,H., Minakami,H., Oshimura,M.,
            Niikawa,N. and Kishino,T.
  TITLE     Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb
            MEST-flanking region at human chromosome 7q32
  JOURNAL   Genomics 83 (3), 402-412 (2004)
   PUBMED   14962666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC038415.1, AK093329.1, AF431815.1 and AC234644.1.
            
            On Jun 2, 2019 this sequence version replaced NM_052933.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038415.1, AF431815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356588.8/ ENSP00000348996.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BC038415.1         24-46
            24-24               AK093329.1         623-623
            25-58               BC038415.1         48-81
            59-59               AF431815.1         82-82
            60-1630             BC038415.1         83-1653
            1631-1633           AC234644.1         78314-78316
FEATURES             Location/Qualifiers
     source          1..1633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..1633
                     /gene="TSGA13"
                     /note="testis specific 13"
                     /db_xref="GeneID:114960"
                     /db_xref="HGNC:HGNC:12369"
     exon            1..284
                     /gene="TSGA13"
                     /inference="alignment:Splign:2.1.0"
     exon            285..457
                     /gene="TSGA13"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..1262
                     /gene="TSGA13"
                     /note="testis-specific A13"
                     /codon_start=1
                     /product="testis-specific gene 13 protein"
                     /protein_id="NP_443165.1"
                     /db_xref="CCDS:CCDS5824.1"
                     /db_xref="GeneID:114960"
                     /db_xref="HGNC:HGNC:12369"
                     /translation="MSQKRQTKFQNGKSKTSENSSAKREKGMVVNSKEISDAVGQSKF
                     VLENLRHYTVHPNLAQYYKPLKATALQKFLAQNRKNTSFMLKVTQYDQDKTLLIMTNN
                     PPPCSITQQDKESASKYFSKELLLKVMESHHQHKPTENLWLPRMPQKKKLRSKLKPIF
                     PLILSDDPTSKREQWFRFSTDNDFKSEGKYSKVYALRTQKKMYPQLTFAPVHERDMRK
                     DASKKSASERPISKVIREPLTLASLLEDMPTRTAPGESAFRNGRAPQWIIKKATVIG"
     exon            458..536
                     /gene="TSGA13"
                     /inference="alignment:Splign:2.1.0"
     exon            537..608
                     /gene="TSGA13"
                     /inference="alignment:Splign:2.1.0"
     exon            609..821
                     /gene="TSGA13"
                     /inference="alignment:Splign:2.1.0"
     exon            822..964
                     /gene="TSGA13"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1092
                     /gene="TSGA13"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1633
                     /gene="TSGA13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1330..1335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSGA13"
                     /note="hexamer: AATAAA"
     polyA_site      1351
                     /gene="TSGA13"
                     /note="major polyA site"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSGA13"
                     /note="hexamer: ATTAAA"
     polyA_site      1633
                     /gene="TSGA13"
ORIGIN      
        1 agaatccaga aaagaataat tacgatattt tcaaaatgga aagttcccat gccaaagact
       61 ttgccttctt caccaaacta tgatttcgtg atgttcttaa aggtagtgta caccaggttt
      121 ttacattctt attttgaatg tagttttagt gtttgtgtga tttgtttttc agcctggcct
      181 gcagactagc aacccaagac ttatactgcc caatttgaca gctcattttt attttagttt
      241 caccatatac atgaattgga cttacaattc cagaaaaatt aaaggctcaa gaatggggca
      301 tgagtacaca ctgtgtgcta aggaaagaat atttggattg aattgaaccc ctgcagaacg
      361 tggactattt agagacctga atttggcctt gggtgaatac ctgccttggg ttggccaact
      421 agcagtcaac agcaatgagc caaaagagac aaaccaagtt tcaaaatggc aaatcaaaga
      481 cttcagaaaa tagctcagct aaacgtgaga aaggaatggt tgtcaatagc aaagagattt
      541 ctgatgcagt cgggcaatca aaatttgttc tagagaacct tcggcattac acagtccatc
      601 caaatttggc ccagtactat aagcctttga aggccactgc cctgcagaaa ttcctggctc
      661 aaaacaggaa aaacaccagc ttcatgttaa aagtaacaca gtatgaccag gataagacgt
      721 tactgattat gaccaacaac ccacctccct gctcaatcac ccagcaagac aaggagagtg
      781 catcaaaata tttttccaag gagttactgc tcaaggtcat ggaaagtcat catcagcaca
      841 aacccactga gaacctctgg ctgccccgca tgcctcagaa aaaaaagtta agatctaagc
      901 tgaaaccaat cttccctttg atactgtcgg atgatcccac atccaagcga gaacaatggt
      961 ttaggttttc cactgacaat gatttcaaga gcgaagggaa gtattcaaaa gtctacgctt
     1021 tgaggacaca gaagaaaatg taccctcagc tcacctttgc tccagtccat gagagagata
     1081 tgaggaaaga tgcttccaag aagtcagcga gtgaaaggcc aatttccaaa gtgattcggg
     1141 aaccactgac actcgcatcg ctcttggaag acatgcccac cagaaccgcg cccggggaga
     1201 gcgccttccg caacgggagg gccccgcagt ggattatcaa aaaggccacg gtcatcgggt
     1261 gaacacagac ccctcagtcc tcccgcctcg ctctcttgag actgaggggt ccgcagaagt
     1321 cgccacccaa ataaaaccac attcctgctg ctgcgggcgt gggctcccgg gtcgcaagcc
     1381 gggagggtcg agccgaagtc tccggcgggc cgcaagagga gaagggggcg tggctgcgtc
     1441 ccgggggccg agggcggccg gggagggcgg gccttggccc cgagtgaagg cgcggcggcc
     1501 caaccggcgt gagagcgcgg ggccggcctt cctgcagcct cttccgctcg ccggctgcgg
     1561 cgcctgggac ggttgcggtg ggtctgggcg ctgggaagtc gtccaagatg attaaaaaat
     1621 tcgacaagaa gga
//
