LOCUS       NM_025244               3903 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens testis specific 10 (TSGA10), transcript variant 1,
            mRNA.
ACCESSION   NM_025244 XM_005264028
VERSION     NM_025244.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3903)
  AUTHORS   Asgari,R., Bakhtiari,M., Rezazadeh,D., Yarani,R., Esmaeili,F. and
            Mansouri,K.
  TITLE     TSGA10 as a Potential Key Factor in the Process of Spermatid
            Differentiation/Maturation: Deciphering Its Association with
            Autophagy Pathway
  JOURNAL   Reprod Sci 28 (11), 3228-3240 (2021)
   PUBMED   34232471
  REMARK    GeneRIF: TSGA10 as a Potential Key Factor in the Process of
            Spermatid Differentiation/Maturation: Deciphering Its Association
            with Autophagy Pathway.
REFERENCE   2  (bases 1 to 3903)
  AUTHORS   Xiang,M., Wang,Y., Xu,W., Zheng,N., Zhang,J., Duan,Z., Zha,X.,
            Shi,X., Wang,F., Cao,Y. and Zhu,F.
  TITLE     Pathogenesis of acephalic spermatozoa syndrome caused by splicing
            mutation and de novo deletion in TSGA10
  JOURNAL   J Assist Reprod Genet 38 (10), 2791-2799 (2021)
   PUBMED   34409526
  REMARK    GeneRIF: Pathogenesis of acephalic spermatozoa syndrome caused by
            splicing mutation and de novo deletion in TSGA10.
REFERENCE   3  (bases 1 to 3903)
  AUTHORS   Liu,G., Wang,N., Zhang,H., Yin,S., Dai,H., Lin,G. and Li,W.
  TITLE     Novel mutations in PMFBP1, TSGA10 and SUN5: Expanding the spectrum
            of mutations that may cause acephalic spermatozoa
  JOURNAL   Clin Genet 97 (6), 938-939 (2020)
   PUBMED   32285443
  REMARK    GeneRIF: Novel mutations in PMFBP1, TSGA10 and SUN5: Expanding the
            spectrum of mutations that may cause acephalic spermatozoa.
REFERENCE   4  (bases 1 to 3903)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3903)
  AUTHORS   Jahani,M., Shahlaei,M., Norooznezhad,F., Miraghaee,S.S.,
            Hosseinzadeh,L., Moasefi,N., Khodarahmi,R., Farokhi,A., Mahnam,A.
            and Mansouri,K.
  TITLE     TSGA10 Over Expression Decreases Metastasic and Metabolic Activity
            by Inhibiting HIF-1 in Breast Cancer Cells
  JOURNAL   Arch Med Res 51 (1), 41-53 (2020)
   PUBMED   32086108
  REMARK    GeneRIF: TSGA10 overexpression could decrease the metastatic and
            metabolic activity of cancer cells through its inhibitory effect on
            HIF-1 activity. Therefore, TSGA10 could be considered in the
            research for therapeutic candidates in cancer.
REFERENCE   6  (bases 1 to 3903)
  AUTHORS   Roghanian,A., Jones,D.C., Pattisapu,J.V., Wolfe,J., Young,N.T. and
            Behnam,B.
  TITLE     Filament-associated TSGA10 protein is expressed in professional
            antigen presenting cells and interacts with vimentin
  JOURNAL   Cell Immunol 265 (2), 120-126 (2010)
   PUBMED   20797700
  REMARK    GeneRIF: TSGA10 could influence the function of antigen presenting
            cells via its interaction with cytoskeletal proteins such as
            vimentin
REFERENCE   7  (bases 1 to 3903)
  AUTHORS   Reimand,K., Perheentupa,J., Link,M., Krohn,K., Peterson,P. and
            Uibo,R.
  TITLE     Testis-expressed protein TSGA10 an auto-antigen in autoimmune
            polyendocrine syndrome type I
  JOURNAL   Int Immunol 20 (1), 39-44 (2008)
   PUBMED   18000009
  REMARK    GeneRIF: TSGA10 is target of immune reactions in Autoimmune
            polyendocrine syndrome type 1 (APS1).
REFERENCE   8  (bases 1 to 3903)
  AUTHORS   Mobasheri,M.B., Modarressi,M.H., Shabani,M., Asgarian,H.,
            Sharifian,R.A., Vossough,P. and Shokri,F.
  TITLE     Expression of the testis-specific gene, TSGA10, in Iranian patients
            with acute lymphoblastic leukemia (ALL)
  JOURNAL   Leuk Res 30 (7), 883-889 (2006)
   PUBMED   16406020
  REMARK    GeneRIF: The RT-PCR of TSGA10 expression may help in detection of
            residual clonal cells leading to early diagnosis and better
            prognostic qualification of the acute lymphoblastic leukemia.
REFERENCE   9  (bases 1 to 3903)
  AUTHORS   Tanaka,R., Ono,T., Sato,S., Nakada,T., Koizumi,F., Hasegawa,K.,
            Nakagawa,K., Okumura,H., Yamashita,T., Ohtsuka,M., Asagoe,K.,
            Yamasaki,O., Noguchi,Y., Iwatsuki,K. and Nakayama,E.
  TITLE     Over-expression of the testis-specific gene TSGA10 in cancers and
            its immunogenicity
  JOURNAL   Microbiol Immunol 48 (4), 339-345 (2004)
   PUBMED   15107545
  REMARK    GeneRIF: over-expressed in 4 of 20 hepatocellular carcinomas (HCC),
            1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate
            cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers
REFERENCE   10 (bases 1 to 3903)
  AUTHORS   Modarressi,M.H., Cameron,J., Taylor,K.E. and Wolfe,J.
  TITLE     Identification and characterisation of a novel gene, TSGA10,
            expressed in testis
  JOURNAL   Gene 262 (1-2), 249-255 (2001)
   PUBMED   11179690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092587.3, BX647157.1, DB085678.1, DC396566.1, AF254756.1 and
            AC019097.5.
            
            On Nov 22, 2018 this sequence version replaced NM_025244.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1-3 encode
            the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KY607424.1, BX647157.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393483.8/ ENSP00000377123.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC092587.3         25579-25796         c
            219-476             BX647157.1         194-451
            477-750             DB085678.1         282-555
            751-911             DC396566.1         411-571
            912-3031            AF254756.1         669-2788
            3032-3903           AC019097.5         131021-131892
FEATURES             Location/Qualifiers
     source          1..3903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..3903
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="testis specific 10"
                     /db_xref="GeneID:80705"
                     /db_xref="HGNC:HGNC:14927"
                     /db_xref="MIM:607166"
     exon            1..250
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            251..379
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            380..515
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            516..731
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            732..797
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            798..921
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     CDS             871..2967
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 79; testis-specific gene 10 protein;
                     testis development protein NYD-SP7; testis-specific 10
                     protein"
                     /codon_start=1
                     /product="testis-specific gene 10 protein isoform 1"
                     /protein_id="NP_079520.1"
                     /db_xref="CCDS:CCDS2037.1"
                     /db_xref="GeneID:80705"
                     /db_xref="HGNC:HGNC:14927"
                     /db_xref="MIM:607166"
                     /translation="MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYE
                     RHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVE
                     TERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERME
                     QMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQ
                     RHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQAC
                     LDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLD
                     ETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDT
                     NLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEA
                     EGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADL
                     SSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQN
                     LEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLE
                     ADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTKCHSPERAHHRSPD
                     RGLDRSLEENLCYRDF"
     exon            922..1080
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1251
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1329
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1481
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1597
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1752
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1808
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1977
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2088
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2274
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2484
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2687
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2792
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2942
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3903
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3250..3255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="hexamer: AATAAA"
     polyA_site      3278
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
     regulatory      3876..3881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="hexamer: AATAAA"
     polyA_site      3903
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="major polyA site"
ORIGIN      
        1 gagggccggc cccctgaagc gcaagagaag gaggggcgcg cagggatcgc gcctagtctc
       61 tccgcctgcg gagccgtggg gtcccggcag cccgcaggag tgctaagtaa gggtccttca
      121 gggcgggaac caggttccag gcagggacgc aggctacgtt cgaataaaag taccgaaggt
      181 cataaggccc cagttcagat gggacttccc cgcgtgacag cacagagata acggccagcc
      241 ctgggcgaag gttaccacca aagaatatga ttttggtcta ggggctccag tttctgaagc
      301 tgaaaactac cagaatactc tccagctaga acaagaagtg agaaaccaag atagattcat
      361 ctcgacactg aaattacagg catttggata cctttgtgat agaaaaggcc cttttcttca
      421 tccattgatg gtttgatagt gggctgggaa ggaaagctgt gttcctccac attaggcagc
      481 aaatacttga ttgatttgat atttagctta gtcaaattga agatctcaaa cagacaaatc
      541 atggcttgga agaatatgtt aggaaactct tggatagtaa ggaggtggta agcagtcaag
      601 tagatgattt aaccagccac aatgagcatc tttgtaaaga attgattaaa attgaccaac
      661 tagcagagca actcgaaaaa gagaaaaatt ttgtggtgga ttccgccaac aaggaacttg
      721 aagaagccaa gattgatctc atttgccagc aaaataatat tatagtattg gaagatacaa
      781 taaaaaggct taaatctact tgattccttt gtcaagactt tggaagcaga caaagatcac
      841 tataagagtg aagctcaaca tttgagaaag atgatgcgaa gtaggtctaa aagtccaaga
      901 cgcccatcac caactgcccg gggtgcaaac tgtgatgtag aacttttgaa gacaacaaca
      961 agagatcgtg aagaacttaa atgcatgctg gaaaaatatg agcgccattt ggcagaaatt
     1021 cagggtaatg tcaaggttct taaatctgag agagacaaga tcttccttct ttatgaacag
     1081 gcacaggaag aaattacccg acttcgacga gaaatgatga aaagctgtaa gagtcctaaa
     1141 tcaacaacgg cacatgctat tctccggcga gtggagactg aaagagatgt agcctttact
     1201 gatttacgaa gaatgaccac agaacgagat agtctaaggg agaggctaaa gattgctcaa
     1261 gagacagcat ttaatgagaa ggctcacctg gaacaaagga tagaggagct ggagtgtaca
     1321 gttcataatc ttgatgatga acgtatggag caaatgtcaa atatgacttt gatgaaggaa
     1381 accataagca ctgtggaaaa agaaatgaaa tcactagcaa gaaaggcaat ggataccgaa
     1441 agtgaacttg gcagacaaaa agcagagaat aattctttga gacttttgta tgaaaacaca
     1501 gaaaaagatc tttctgatac tcagcgacac cttgctaaga aaaaatatga gctacagctt
     1561 actcaggaga aaattatgtg cttggatgaa aaaattgata actttacaag gcaaaatatt
     1621 gcacagcgag aagaaatcag cattcttggt ggaaccctca atgatctggc taaagaaaag
     1681 gaatgcctgc aagcatgttt ggataaaaaa tctgagaata ttgcatccct tggagagagt
     1741 ttggcaatga aagaaaagac catttcaggc atgaagaata tcattgctga gatggaacag
     1801 gcatcaagac agtgtactga ggccctaatt gtgtgtgaac aagacgtttc cagaatgcgt
     1861 cggcaattgg atgagacaaa tgatgagctg gcccagatcg ccagggaaag agatatcttg
     1921 gctcatgaca atgacaatct ccaggaacag tttgctaaag ctaaacaaga aaaccaggca
     1981 ctgtccaaaa aattgaatga cactcataat gaacttaatg acataaaaca gaaggttcaa
     2041 gatactaatt tggaggttaa caagctgaag aatatattaa agtctgaaga atctgagaac
     2101 cggcaaatga tggaacaact tcgaaaagcc aatgaagatg ctgaaaactg ggaaaataaa
     2161 gcccgtcaat cagaggcaga taacaatacc ctcaaactgg aacttatcac tgctgaggca
     2221 gagggtaaca gattaaaaga aaaagtagat tccctcaaca gagaggttga gcaacactta
     2281 aatgcagaaa ggtcttacaa gtcccagatt tctaccttac ataaatctgt tgtaaaaatg
     2341 gaagaggagc ttcagaaggt tcagtttgaa aaagtgtccg ctcttgcaga tttgtcttct
     2401 actagggaac tctgtattaa acttgactca agcaaagaac ttcttaatcg acagctggtt
     2461 gctaaagatc aagaaataga aatgagggag aatgagttag attctgctca ttctgaaatt
     2521 gaactcctga ggagtcagat ggcaaatgag agaatctcca tgcagaatct agaagctttg
     2581 ctggtggcca atcgagacaa agaatatcag tctcagatag cacttcaaga aaaagaatct
     2641 gaaattcagc ttcttaaaga acacctttgt ttggcagaaa ataaaatggc catccagagt
     2701 agagatgtgg cccagttcag aaatgttgtc acacaattgg aagctgattt agacattacc
     2761 aaaagacaac taggaacaga gcgctttgaa agggagaggg ccgtacaaga acttcgccgc
     2821 caaaattatt caagtaatgc ttatcatatg agttctacaa tgaagccaaa tacaaaatgt
     2881 cattcaccag aacgtgctca ccatcgatct cctgaccgag gcctagatcg atcattagaa
     2941 gagaatcttt gctacagaga tttctgacac ctgaaatgat tcttcacatc cctgagaaag
     3001 gtcaaagtta caaactgatt tttttttttt tgctacatga gtgcatttat cttttaaatg
     3061 cttggcaatg ttaaatgtat ttattaactt tgtgtctctg aatctctgtt ctaatgtgcc
     3121 atgttgcagt gatctgagat gacttataaa aacaaaaatg tatatggctc tttctatcca
     3181 tgcagtgata gtgagtgtaa aatctgctta cttcactatt gaacactatt ctgttcacta
     3241 tctggagtaa ataaagaagc ttattaaaac agggaaaagt gtttttacaa aactgctttc
     3301 ctttcctttc ttggtatctc aaataattgg ttggttaatt ttttttcttt gtgatttgtg
     3361 ttttcatggc tggaaaatct gtgccaaaat gggtacaact tactgatact ggtctgggat
     3421 ctgatattcc attttggaac caaccttaca tgaattccat gccataatct gatattgaag
     3481 cagcagaaag taggagtgtt gtcagggttt taaaacctat agtattgtac cactcaaaga
     3541 ctaagtaaca tacatattct acaattgtgt ttactactac tgcttttaga aaggtaggtg
     3601 atggtatatc tgtcaagaat gtaagatttt attaaaaatc tttattttta ataagttttc
     3661 tttcaagtac tgcaatcaac ttaattgcga ttttatttta ttgtctgtgg cagctgtctg
     3721 taatctggag taataagata agtgatgttt ccttcctccc ccaatttcct aaatctctta
     3781 ccttatctat ccataggctt tgatgtaatg ttcatattag agcctgaatg ctactgtatt
     3841 ttactgatat aaactatttg tattcttgcc attttaataa aaaaaggctt gtcattaata
     3901 gta
//
