LOCUS       NM_001349014            3473 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens testis specific 10 (TSGA10), transcript variant 5,
            mRNA.
ACCESSION   NM_001349014
VERSION     NM_001349014.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3473)
  AUTHORS   Asgari,R., Bakhtiari,M., Rezazadeh,D., Yarani,R., Esmaeili,F. and
            Mansouri,K.
  TITLE     TSGA10 as a Potential Key Factor in the Process of Spermatid
            Differentiation/Maturation: Deciphering Its Association with
            Autophagy Pathway
  JOURNAL   Reprod Sci 28 (11), 3228-3240 (2021)
   PUBMED   34232471
  REMARK    GeneRIF: TSGA10 as a Potential Key Factor in the Process of
            Spermatid Differentiation/Maturation: Deciphering Its Association
            with Autophagy Pathway.
REFERENCE   2  (bases 1 to 3473)
  AUTHORS   Xiang,M., Wang,Y., Xu,W., Zheng,N., Zhang,J., Duan,Z., Zha,X.,
            Shi,X., Wang,F., Cao,Y. and Zhu,F.
  TITLE     Pathogenesis of acephalic spermatozoa syndrome caused by splicing
            mutation and de novo deletion in TSGA10
  JOURNAL   J Assist Reprod Genet 38 (10), 2791-2799 (2021)
   PUBMED   34409526
  REMARK    GeneRIF: Pathogenesis of acephalic spermatozoa syndrome caused by
            splicing mutation and de novo deletion in TSGA10.
REFERENCE   3  (bases 1 to 3473)
  AUTHORS   Liu,G., Wang,N., Zhang,H., Yin,S., Dai,H., Lin,G. and Li,W.
  TITLE     Novel mutations in PMFBP1, TSGA10 and SUN5: Expanding the spectrum
            of mutations that may cause acephalic spermatozoa
  JOURNAL   Clin Genet 97 (6), 938-939 (2020)
   PUBMED   32285443
  REMARK    GeneRIF: Novel mutations in PMFBP1, TSGA10 and SUN5: Expanding the
            spectrum of mutations that may cause acephalic spermatozoa.
REFERENCE   4  (bases 1 to 3473)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3473)
  AUTHORS   Jahani,M., Shahlaei,M., Norooznezhad,F., Miraghaee,S.S.,
            Hosseinzadeh,L., Moasefi,N., Khodarahmi,R., Farokhi,A., Mahnam,A.
            and Mansouri,K.
  TITLE     TSGA10 Over Expression Decreases Metastasic and Metabolic Activity
            by Inhibiting HIF-1 in Breast Cancer Cells
  JOURNAL   Arch Med Res 51 (1), 41-53 (2020)
   PUBMED   32086108
  REMARK    GeneRIF: TSGA10 overexpression could decrease the metastatic and
            metabolic activity of cancer cells through its inhibitory effect on
            HIF-1 activity. Therefore, TSGA10 could be considered in the
            research for therapeutic candidates in cancer.
REFERENCE   6  (bases 1 to 3473)
  AUTHORS   Roghanian,A., Jones,D.C., Pattisapu,J.V., Wolfe,J., Young,N.T. and
            Behnam,B.
  TITLE     Filament-associated TSGA10 protein is expressed in professional
            antigen presenting cells and interacts with vimentin
  JOURNAL   Cell Immunol 265 (2), 120-126 (2010)
   PUBMED   20797700
  REMARK    GeneRIF: TSGA10 could influence the function of antigen presenting
            cells via its interaction with cytoskeletal proteins such as
            vimentin
REFERENCE   7  (bases 1 to 3473)
  AUTHORS   Reimand,K., Perheentupa,J., Link,M., Krohn,K., Peterson,P. and
            Uibo,R.
  TITLE     Testis-expressed protein TSGA10 an auto-antigen in autoimmune
            polyendocrine syndrome type I
  JOURNAL   Int Immunol 20 (1), 39-44 (2008)
   PUBMED   18000009
  REMARK    GeneRIF: TSGA10 is target of immune reactions in Autoimmune
            polyendocrine syndrome type 1 (APS1).
REFERENCE   8  (bases 1 to 3473)
  AUTHORS   Mobasheri,M.B., Modarressi,M.H., Shabani,M., Asgarian,H.,
            Sharifian,R.A., Vossough,P. and Shokri,F.
  TITLE     Expression of the testis-specific gene, TSGA10, in Iranian patients
            with acute lymphoblastic leukemia (ALL)
  JOURNAL   Leuk Res 30 (7), 883-889 (2006)
   PUBMED   16406020
  REMARK    GeneRIF: The RT-PCR of TSGA10 expression may help in detection of
            residual clonal cells leading to early diagnosis and better
            prognostic qualification of the acute lymphoblastic leukemia.
REFERENCE   9  (bases 1 to 3473)
  AUTHORS   Tanaka,R., Ono,T., Sato,S., Nakada,T., Koizumi,F., Hasegawa,K.,
            Nakagawa,K., Okumura,H., Yamashita,T., Ohtsuka,M., Asagoe,K.,
            Yamasaki,O., Noguchi,Y., Iwatsuki,K. and Nakayama,E.
  TITLE     Over-expression of the testis-specific gene TSGA10 in cancers and
            its immunogenicity
  JOURNAL   Microbiol Immunol 48 (4), 339-345 (2004)
   PUBMED   15107545
  REMARK    GeneRIF: over-expressed in 4 of 20 hepatocellular carcinomas (HCC),
            1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate
            cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers
REFERENCE   10 (bases 1 to 3473)
  AUTHORS   Modarressi,M.H., Cameron,J., Taylor,K.E. and Wolfe,J.
  TITLE     Identification and characterisation of a novel gene, TSGA10,
            expressed in testis
  JOURNAL   Gene 262 (1-2), 249-255 (2001)
   PUBMED   11179690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092587.3 and AC019097.5.
            
            Transcript Variant: This variant (5) differs in the 5' UTR and
            lacks three alternate in-frame exons in the 5' coding region
            compared to variant 1. Both variants 4 and 5 encode the same
            isoform (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.130615.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AC092587.3         12282-12557         c
            277-412             AC019097.5         10467-10602
            413-628             AC019097.5         11394-11609
            629-694             AC019097.5         18238-18303
            695-818             AC019097.5         19641-19764
            819-977             AC019097.5         20162-20320
            978-1148            AC019097.5         23456-23626
            1149-1226           AC019097.5         23717-23794
            1227-1378           AC019097.5         25035-25186
            1379-1547           AC019097.5         57279-57447
            1548-1658           AC019097.5         60155-60265
            1659-1844           AC019097.5         64029-64214
            1845-2054           AC019097.5         93714-93923
            2055-2257           AC019097.5         108671-108873
            2258-2362           AC019097.5         110513-110617
            2363-2512           AC019097.5         110804-110953
            2513-3473           AC019097.5         130932-131892
FEATURES             Location/Qualifiers
     source          1..3473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..3473
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="testis specific 10"
                     /db_xref="GeneID:80705"
                     /db_xref="HGNC:HGNC:14927"
                     /db_xref="MIM:607166"
     exon            1..276
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            277..412
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            413..628
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            629..694
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            695..818
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     CDS             768..2537
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="isoform 2 is encoded by transcript variant 5;
                     cancer/testis antigen 79; testis-specific gene 10 protein;
                     testis development protein NYD-SP7; testis-specific 10
                     protein"
                     /codon_start=1
                     /product="testis-specific gene 10 protein isoform 2"
                     /protein_id="NP_001335943.1"
                     /db_xref="GeneID:80705"
                     /db_xref="HGNC:HGNC:14927"
                     /db_xref="MIM:607166"
                     /translation="MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYE
                     RHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVE
                     TERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERME
                     QMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRQCTEALIVCEQDVS
                     RMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDI
                     KQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKL
                     ELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEK
                     VSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMAN
                     ERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFR
                     NVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTKCHSPER
                     AHHRSPDRGLDRSLEENLCYRDF"
     exon            819..977
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1148
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1226
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1378
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1547
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1658
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1844
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2054
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2257
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2362
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2512
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..3473
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2820..2825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="hexamer: AATAAA"
     polyA_site      2848
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
     regulatory      3446..3451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="hexamer: AATAAA"
     polyA_site      3473
                     /gene="TSGA10"
                     /gene_synonym="CEP4L; CT79; SPGF26"
                     /note="major polyA site"
ORIGIN      
        1 gccttgcgca tgcgcgttcc atccaggtgc ggcagcctca ggcagagatt aagaaatgag
       61 tcgtggaaaa gggggctagc ggctggttac taggagacgg gacgctcggc tcgggcgtct
      121 aggcgctgcg tgggcgtgcg cctgcgcggc gcggatgggc caggaagggg tccctcctag
      181 gtgccctgta aggcaggcag gtagacgtac gcgtcgctcc gtgcgtagga gcgcgcgcac
      241 ggcttgtaga ccccgcgaga aggaaggtcg agccaggcat ttggatacct ttgtgataga
      301 aaaggccctt ttcttcatcc attgatggtt tgatagtggg ctgggaagga aagctgtgtt
      361 cctccacatt aggcagcaaa tacttgattg atttgatatt tagcttagtc aaattgaaga
      421 tctcaaacag acaaatcatg gcttggaaga atatgttagg aaactcttgg atagtaagga
      481 ggtggtaagc agtcaagtag atgatttaac cagccacaat gagcatcttt gtaaagaatt
      541 gattaaaatt gaccaactag cagagcaact cgaaaaagag aaaaattttg tggtggattc
      601 cgccaacaag gaacttgaag aagccaagat tgatctcatt tgccagcaaa ataatattat
      661 agtattggaa gatacaataa aaaggcttaa atctacttga ttcctttgtc aagactttgg
      721 aagcagacaa agatcactat aagagtgaag ctcaacattt gagaaagatg atgcgaagta
      781 ggtctaaaag tccaagacgc ccatcaccaa ctgcccgggg tgcaaactgt gatgtagaac
      841 ttttgaagac aacaacaaga gatcgtgaag aacttaaatg catgctggaa aaatatgagc
      901 gccatttggc agaaattcag ggtaatgtca aggttcttaa atctgagaga gacaagatct
      961 tccttcttta tgaacaggca caggaagaaa ttacccgact tcgacgagaa atgatgaaaa
     1021 gctgtaagag tcctaaatca acaacggcac atgctattct ccggcgagtg gagactgaaa
     1081 gagatgtagc ctttactgat ttacgaagaa tgaccacaga acgagatagt ctaagggaga
     1141 ggctaaagat tgctcaagag acagcattta atgagaaggc tcacctggaa caaaggatag
     1201 aggagctgga gtgtacagtt cataatcttg atgatgaacg tatggagcaa atgtcaaata
     1261 tgactttgat gaaggaaacc ataagcactg tggaaaaaga aatgaaatca ctagcaagaa
     1321 aggcaatgga taccgaaagt gaacttggca gacaaaaagc agagaataat tctttgagac
     1381 agtgtactga ggccctaatt gtgtgtgaac aagacgtttc cagaatgcgt cggcaattgg
     1441 atgagacaaa tgatgagctg gcccagatcg ccagggaaag agatatcttg gctcatgaca
     1501 atgacaatct ccaggaacag tttgctaaag ctaaacaaga aaaccaggca ctgtccaaaa
     1561 aattgaatga cactcataat gaacttaatg acataaaaca gaaggttcaa gatactaatt
     1621 tggaggttaa caagctgaag aatatattaa agtctgaaga atctgagaac cggcaaatga
     1681 tggaacaact tcgaaaagcc aatgaagatg ctgaaaactg ggaaaataaa gcccgtcaat
     1741 cagaggcaga taacaatacc ctcaaactgg aacttatcac tgctgaggca gagggtaaca
     1801 gattaaaaga aaaagtagat tccctcaaca gagaggttga gcaacactta aatgcagaaa
     1861 ggtcttacaa gtcccagatt tctaccttac ataaatctgt tgtaaaaatg gaagaggagc
     1921 ttcagaaggt tcagtttgaa aaagtgtccg ctcttgcaga tttgtcttct actagggaac
     1981 tctgtattaa acttgactca agcaaagaac ttcttaatcg acagctggtt gctaaagatc
     2041 aagaaataga aatgagggag aatgagttag attctgctca ttctgaaatt gaactcctga
     2101 ggagtcagat ggcaaatgag agaatctcca tgcagaatct agaagctttg ctggtggcca
     2161 atcgagacaa agaatatcag tctcagatag cacttcaaga aaaagaatct gaaattcagc
     2221 ttcttaaaga acacctttgt ttggcagaaa ataaaatggc catccagagt agagatgtgg
     2281 cccagttcag aaatgttgtc acacaattgg aagctgattt agacattacc aaaagacaac
     2341 taggaacaga gcgctttgaa agggagaggg ccgtacaaga acttcgccgc caaaattatt
     2401 caagtaatgc ttatcatatg agttctacaa tgaagccaaa tacaaaatgt cattcaccag
     2461 aacgtgctca ccatcgatct cctgaccgag gcctagatcg atcattagaa gagaatcttt
     2521 gctacagaga tttctgacac ctgaaatgat tcttcacatc cctgagaaag gtcaaagtta
     2581 caaactgatt tttttttttt tgctacatga gtgcatttat cttttaaatg cttggcaatg
     2641 ttaaatgtat ttattaactt tgtgtctctg aatctctgtt ctaatgtgcc atgttgcagt
     2701 gatctgagat gacttataaa aacaaaaatg tatatggctc tttctatcca tgcagtgata
     2761 gtgagtgtaa aatctgctta cttcactatt gaacactatt ctgttcacta tctggagtaa
     2821 ataaagaagc ttattaaaac agggaaaagt gtttttacaa aactgctttc ctttcctttc
     2881 ttggtatctc aaataattgg ttggttaatt ttttttcttt gtgatttgtg ttttcatggc
     2941 tggaaaatct gtgccaaaat gggtacaact tactgatact ggtctgggat ctgatattcc
     3001 attttggaac caaccttaca tgaattccat gccataatct gatattgaag cagcagaaag
     3061 taggagtgtt gtcagggttt taaaacctat agtattgtac cactcaaaga ctaagtaaca
     3121 tacatattct acaattgtgt ttactactac tgcttttaga aaggtaggtg atggtatatc
     3181 tgtcaagaat gtaagatttt attaaaaatc tttattttta ataagttttc tttcaagtac
     3241 tgcaatcaac ttaattgcga ttttatttta ttgtctgtgg cagctgtctg taatctggag
     3301 taataagata agtgatgttt ccttcctccc ccaatttcct aaatctctta ccttatctat
     3361 ccataggctt tgatgtaatg ttcatattag agcctgaatg ctactgtatt ttactgatat
     3421 aaactatttg tattcttgcc attttaataa aaaaaggctt gtcattaata gta
//
