LOCUS       NM_006292               1534 bp    mRNA    linear   PRI 11-AUG-2024
DEFINITION  Homo sapiens tumor susceptibility 101 (TSG101), mRNA.
ACCESSION   NM_006292
VERSION     NM_006292.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Murciano-Calles,J., Rodriguez-Martinez,A., Palencia,A.,
            Andujar-Sanchez,M., Iglesias-Bexiga,M., Corbi-Verge,C., Buzon,P.,
            Ruiz-Sanz,J., Martinez,J.C., Perez-Sanchez,H., Camara-Artigas,A.
            and Luque,I.
  TITLE     Phage display identification of high-affinity ligands for human
            TSG101-UEV: A structural and thermodynamic study of PTAP
            recognition
  JOURNAL   Int J Biol Macromol 274 (Pt 1), 133233 (2024)
   PUBMED   38901510
  REMARK    GeneRIF: Phage display identification of high-affinity ligands for
            human TSG101-UEV: A structural and thermodynamic study of PTAP
            recognition.
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Zieminski,R., Stupak,A., Kwiatek,M., Geca,T., Warowicka,A.,
            Hejne,K., Kwasniewska,A., Gozdzicka-Jozefiak,A. and Kwasniewski,W.
  TITLE     Analysis of the Expression of LSF Transcription Factor in the
            Regulation of Transcription and TSG101 during the Neoplastic
            Transformation of Endometrial Cells
  JOURNAL   Cells 13 (7), 580 (2024)
   PUBMED   38607019
  REMARK    GeneRIF: Analysis of the Expression of LSF Transcription Factor in
            the Regulation of Transcription and TSG101 during the Neoplastic
            Transformation of Endometrial Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Maeda,Y., Monde,K., Terasawa,H., Tanaka,Y. and Sawa,T.
  TITLE     Interaction of TSG101 with the PTAP Motif in Distinct Locations of
            Gag Determines the Incorporation of HTLV-1 Env into the Retroviral
            Virion
  JOURNAL   Int J Mol Sci 24 (22), 16520 (2023)
   PUBMED   38003710
  REMARK    GeneRIF: Interaction of TSG101 with the PTAP Motif in Distinct
            Locations of Gag Determines the Incorporation of HTLV-1 Env into
            the Retroviral Virion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   5  (bases 1 to 1534)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1534)
  AUTHORS   Xie,W., Li,L. and Cohen,S.N.
  TITLE     Cell cycle-dependent subcellular localization of the TSG101 protein
            and mitotic and nuclear abnormalities associated with TSG101
            deficiency
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1595-1600 (1998)
   PUBMED   9465061
REFERENCE   7  (bases 1 to 1534)
  AUTHORS   Gayther,S.A., Barski,P., Batley,S.J., Li,L., de Foy,K.A.,
            Cohen,S.N., Ponder,B.A. and Caldas,C.
  TITLE     Aberrant splicing of the TSG101 and FHIT genes occurs frequently in
            multiple malignancies and in normal tissues and mimics alterations
            previously described in tumours
  JOURNAL   Oncogene 15 (17), 2119-2126 (1997)
   PUBMED   9366528
REFERENCE   8  (bases 1 to 1534)
  AUTHORS   Lee,M.P. and Feinberg,A.P.
  TITLE     Aberrant splicing but not mutations of TSG101 in human breast
            cancer
  JOURNAL   Cancer Res 57 (15), 3131-3134 (1997)
   PUBMED   9242438
REFERENCE   9  (bases 1 to 1534)
  AUTHORS   Steiner,P., Barnes,D.M., Harris,W.H. and Weinberg,R.A.
  TITLE     Absence of rearrangements in the tumour susceptibility gene TSG101
            in human breast cancer
  JOURNAL   Nat Genet 16 (4), 332-333 (1997)
   PUBMED   9241265
REFERENCE   10 (bases 1 to 1534)
  AUTHORS   Koonin,E.V. and Abagyan,R.A.
  TITLE     TSG101 may be the prototype of a class of dominant negative
            ubiquitin regulators
  JOURNAL   Nat Genet 16 (4), 330-331 (1997)
   PUBMED   9241264
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP347883.1, U82130.1 and
            CB528488.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006292.3.
            
            Summary: The protein encoded by this gene belongs to a group of
            apparently inactive homologs of ubiquitin-conjugating enzymes. The
            gene product contains a coiled-coil domain that interacts with
            stathmin, a cytosolic phosphoprotein implicated in tumorigenesis.
            The protein may play a role in cell growth and differentiation and
            act as a negative growth regulator. In vitro steady-state
            expression of this tumor susceptibility gene appears to be
            important for maintenance of genomic stability and cell cycle
            regulation. Mutations and alternative splicing in this gene occur
            in high frequency in breast cancer and suggest that defects occur
            during breast cancer tumorigenesis and/or progression. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002487.1, AK130787.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251968.4/ ENSP00000251968.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BP347883.1         15-53
            40-1528             U82130.1           4-1492
            1529-1534           CB528488.1         15-20               c
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1534
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /note="tumor susceptibility 101"
                     /db_xref="GeneID:7251"
                     /db_xref="HGNC:HGNC:15971"
                     /db_xref="MIM:601387"
     exon            1..168
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1299
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /note="tumor susceptibility protein; ESCRT-I complex
                     subunit TSG101; tumor susceptibility gene 10; tumor
                     susceptibility gene 101"
                     /codon_start=1
                     /product="tumor susceptibility gene 101 protein"
                     /protein_id="NP_006283.1"
                     /db_xref="CCDS:CCDS7842.1"
                     /db_xref="GeneID:7251"
                     /db_xref="HGNC:HGNC:15971"
                     /db_xref="MIM:601387"
                     /translation="MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVF
                     NDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKH
                     VDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPN
                     TSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRD
                     GTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTR
                     LDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAE
                     ENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY"
     exon            169..253
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     exon            254..319
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     exon            320..483
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     exon            484..607
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     exon            608..674
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     exon            675..766
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     exon            767..969
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1209
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1534
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1516..1521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /note="hexamer: AATAAA"
     polyA_site      1534
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /note="major polyA site"
ORIGIN      
        1 gtagtggtgc cgacttcctg ttgtttgagg ccgggttggg ggtgtgcgat tgtgtgggac
       61 ggtctggggc agcccagcag cggctgaccc tctgcctgcg gggaagggag tcgccaggcg
      121 gccgtcatgg cggtgtcgga gagccagctc aagaaaatgg tgtccaagta caaatacaga
      181 gacctaactg tacgtgaaac tgtcaatgtt attactctat acaaagatct caaacctgtt
      241 ttggattcat atgtttttaa cgatggcagt tccagggaac taatgaacct cactggaaca
      301 atccctgtgc cttatagagg taatacatac aatattccaa tatgcctatg gctactggac
      361 acatacccat ataatccccc tatctgtttt gttaagccta ctagttcaat gactattaaa
      421 acaggaaagc atgttgatgc aaatgggaag atatatcttc cttatctaca tgaatggaaa
      481 cacccacagt cagacttgtt ggggcttatt caggtcatga ttgtggtatt tggagatgaa
      541 cctccagtct tctctcgtcc tatttcggca tcctatccgc cataccaggc aacggggcca
      601 ccaaatactt cctacatgcc aggcatgcca ggtggaatct ctccataccc atccggatac
      661 cctcccaatc ccagtggtta cccaggctgt ccttacccac ctggtggtcc atatcctgcc
      721 acaacaagtt ctcagtaccc ttctcagcct cctgtgacca ctgttggtcc cagtagggat
      781 ggcacaatca gcgaggacac catccgagcc tctctcatct ctgcggtcag tgacaaactg
      841 agatggcgga tgaaggagga aatggatcgt gcccaggcag agctcaatgc cttgaaacga
      901 acagaagaag acctgaaaaa gggtcaccag aaactggaag agatggttac ccgtttagat
      961 caagaagtag ccgaggttga taaaaacata gaacttttga aaaagaagga tgaagaactc
     1021 agttctgctc tggaaaaaat ggaaaatcag tctgaaaaca atgatatcga tgaagttatc
     1081 attcccacag ctcccttata caaacagatc ctgaatctgt atgcagaaga aaacgctatt
     1141 gaagacacta tcttttactt gggagaagcc ttgagaaggg gcgtgataga cctggatgtc
     1201 ttcctgaagc atgtacgtct tctgtcccgt aaacagttcc agctgagggc actaatgcaa
     1261 aaagcaagaa agactgccgg tctcagtgac ctctactgac ttctctgata ccagctggag
     1321 gttgagctct tcttaaagta ttcttctctt ccttttatca gtaggtgccc agaataagtt
     1381 attgcagttt atcattcaag tgtaaaatat tttgaatcaa taatatattt tctgttttct
     1441 tttggtaaag actggctttt attaatgcac tttctatcct ctgtaaactt tttgtgctga
     1501 atgttgggac tgctaaataa aatttgttgc ataa
//
