LOCUS       NM_030935               2318 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TSC22 domain family member 4 (TSC22D4), transcript
            variant 1, mRNA.
ACCESSION   NM_030935
VERSION     NM_030935.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2318)
  AUTHORS   Goto,N., Suzuki,H., Zheng,L., Okano,Y., Okita,Y., Watanabe,Y.,
            Kato,Y. and Kato,M.
  TITLE     Promotion of squamous cell carcinoma tumorigenesis by
            oncogene-mediated THG-1/TSC22D4 phosphorylation
  JOURNAL   Cancer Sci 114 (10), 3972-3983 (2023)
   PUBMED   37607779
  REMARK    GeneRIF: Promotion of squamous cell carcinoma tumorigenesis by
            oncogene-mediated THG-1/TSC22D4 phosphorylation.
REFERENCE   2  (bases 1 to 2318)
  AUTHORS   Sakurai,M., Weber,P., Wolff,G., Wieder,A., Szendroedi,J., Herzig,S.
            and Ekim Ustunel,B.
  TITLE     TSC22D4 promotes TGFbeta1-induced activation of hepatic stellate
            cells
  JOURNAL   Biochem Biophys Res Commun 618, 46-53 (2022)
   PUBMED   35714570
  REMARK    GeneRIF: TSC22D4 promotes TGFbeta1-induced activation of hepatic
            stellate cells.
REFERENCE   3  (bases 1 to 2318)
  AUTHORS   Wolff,G., Sakurai,M., Mhamane,A., Troullinaki,M., Maida,A.,
            Deligiannis,I.K., Yin,K., Weber,P., Morgenstern,J., Wieder,A.,
            Kwon,Y., Sekar,R., Zeigerer,A., Roden,M., Bluher,M., Volk,N.,
            Poth,T., Hackert,T., Wiedmann,L., De Angelis Rigotti,F.,
            Rodriguez-Vita,J., Fischer,A., Mukthavaram,R., Limphong,P.,
            Tachikawa,K., Karmali,P., Payne,J., Chivukula,P., Ekim-Ustunel,B.,
            Martinez-Jimenez,C.P., Szendrodi,J., Nawroth,P. and Herzig,S.
  TITLE     Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD
            by impairing mitochondrial function
  JOURNAL   Mol Metab 60, 101487 (2022)
   PUBMED   35378329
  REMARK    GeneRIF: Hepatocyte-specific activity of TSC22D4 triggers
            progressive NAFLD by impairing mitochondrial function.
REFERENCE   4  (bases 1 to 2318)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2318)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2318)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   7  (bases 1 to 2318)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 2318)
  AUTHORS   Petersen,H.H., Hilpert,J., Militz,D., Zandler,V., Jacobsen,C.,
            Roebroek,A.J. and Willnow,T.E.
  TITLE     Functional interaction of megalin with the megalinbinding protein
            (MegBP), a novel tetratrico peptide repeat-containing adaptor
            molecule
  JOURNAL   J Cell Sci 116 (Pt 3), 453-461 (2003)
   PUBMED   12508107
REFERENCE   9  (bases 1 to 2318)
  AUTHORS   Fiorenza,M.T., Mukhopadhyay,M. and Westphal,H.
  TITLE     Expression screening for Lhx3 downstream genes identifies Thg-1pit
            as a novel mouse gene involved in pituitary development
  JOURNAL   Gene 278 (1-2), 125-130 (2001)
   PUBMED   11707329
REFERENCE   10 (bases 1 to 2318)
  AUTHORS   Kester,H.A., Blanchetot,C., den Hertog,J., van der Saag,P.T. and
            van der Burg,B.
  TITLE     Transforming growth factor-beta-stimulated clone-22 is a member of
            a family of leucine zipper proteins that can homo- and
            heterodimerize and has transcriptional repressor activity
  JOURNAL   J Biol Chem 274 (39), 27439-27447 (1999)
   PUBMED   10488076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC001486.2, AC092849.4, AK296580.1, BC010406.2 and AA991748.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030935.4.
            
            Summary: TSC22D4 is a member of the TSC22 domain family of leucine
            zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester
            et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed
            11707329]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001486.2, BC010406.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300181.7/ ENSP00000300181.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               BC001486.2         66-288
            224-224             AC092849.4         12489-12489
            225-1484            BC001486.2         290-1549
            1485-1724           AK296580.1         998-1237
            1725-2315           BC010406.2         1704-2294
            2316-2318           AA991748.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..2318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2318
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /note="TSC22 domain family member 4"
                     /db_xref="GeneID:81628"
                     /db_xref="HGNC:HGNC:21696"
                     /db_xref="MIM:611914"
     exon            1..421
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            422..1452
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             691..1878
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /note="isoform a is encoded by transcript variant 1; TSC22
                     domain family protein 4; tsc-22-like protein THG-1;
                     TSC22-related-inducible leucine zipper protein 2; sperm
                     acrosome developmental regulator"
                     /codon_start=1
                     /product="TSC22 domain family protein 4 isoform a"
                     /protein_id="NP_112197.1"
                     /db_xref="CCDS:CCDS5695.1"
                     /db_xref="GeneID:81628"
                     /db_xref="HGNC:HGNC:21696"
                     /db_xref="MIM:611914"
                     /translation="MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLP
                     NGEPSPDPGGKGTPRNGSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEP
                     HSFGGLLEGIRGASGGAGGRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPG
                     PQARSFTGGLGQLVVPSKAKAEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRV
                     EAEAGGSGARTPPLSRRKAVDMRLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLV
                     HKSPDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLM
                     FAVREEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNG
                     PSV"
     exon            1453..1619
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1668
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..2318
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2294..2299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /note="hexamer: ATTAAA"
     polyA_site      2318
                     /gene="TSC22D4"
                     /gene_synonym="SPACDR; THG-1; THG1; TILZ2"
                     /note="major polyA site"
ORIGIN      
        1 gttgtcaaca gcccagaaag agaaagacgg agaggcagag acccagggga gccgaggagc
       61 ggagacacgg acccagcagg gtcacgcggg aggagactcg ggacacccac tcgctggctg
      121 ccaccgggag cagagggggg ctcggccgcc ccctcccaca tcagtctcca gacccttggg
      181 gcttcagagg ccgctcctag gctcctcgga ggaggcgcgg gtttcttctt ttccggagag
      241 caaactttcc tcggagatgc ctggcaggat gagccgcggc ccccggagag gacgggacag
      301 cctctgatcg ccgcctgcgt gccccgccac tgcccatggc caggaggccc cagggaacgg
      361 acagcccgac ctcttaggcg ccgggaccct caggctcaga tcagtggccg aggccccaga
      421 gtttgcaaac tcagctctgg agttcagcag caacagcagc aggaaaaacc tgcccctgct
      481 cccccctccc gccacctccc ctctcctctt ctcccctcac ccagcaggca cccccggttc
      541 ccgccaggcc ctcctgccat gtcggaccca gacgtcccca ggggctcgga tgtccccgcc
      601 atgtggcccc cttgttccag gggtgcctga gccccttcaa ggagccccaa cccaccccca
      661 accttggccc agccctgagc cccagggacc atgagcgggg gcaagaagaa gagtagtttc
      721 caaatcacca gcgtcaccac ggactatgag ggccctggga gcccaggggc ttcggatccc
      781 cctaccccac agcccccaac cgggcccccg ccccgcctgc ccaatgggga gcccagcccc
      841 gatccggggg gcaagggcac cccccggaat ggctccccac cacctggggc cccttcctcc
      901 cgtttccggg tggtgaagct gccccacggc ctgggagagc cttatcgccg cggtcgctgg
      961 acgtgtgtgg atgtttatga gcgagacctg gagccccaca gcttcggcgg actcctggag
     1021 ggaattcgag gggcctcagg gggcgccggg ggcagatctt tggattccag gttggagctg
     1081 gccagcctcg gcctgggcgc ccccacccca ccgtcaggcc tgtctcaggg ccccacctcc
     1141 tggctccgtc caccccccac ctctcctgga cctcaggccc gctccttcac tgggggactg
     1201 ggccagctgg tggtgcccag caaagccaag gcagagaaac ccccactgtc ggcctcctca
     1261 ccccagcagc gccccccaga gcctgagacc ggtgagagtg cgggcacatc ccgggctgcc
     1321 acgcccctgc cctctctgag ggtggaagcg gaggctgggg gctcaggggc caggacccct
     1381 ccactgtccc ggaggaaagc tgtagacatg cggctgcgga tggagttggg tgctccagaa
     1441 gagatggggc aggtgccccc acttgactct cgccccagct ccccagccct ctacttcacc
     1501 cacgatgcca gcctggttca caaatctcca gaccccttcg gagcagtagc agctcagaag
     1561 ttcagcctgg cccactccat gttggccatc agtggtcacc tagacagcga cgatgatagt
     1621 ggctccggaa gcctggttgg cattgacaac aaaatcgagc aagccatgga cttggtgaag
     1681 tcccacctca tgtttgcggt ccgggaggag gtggaggtgc tgaaggagca gatccgggaa
     1741 ttggcggagc ggaacgctgc gctggagcag gagaatgggc tgctgcgcgc cctggccagc
     1801 ccggagcagc tggctcagct gccctcctcg ggggtcccac ggcttgggcc ccctgcgccc
     1861 aatgggccct ccgtctgagc ctcccttccc ttacaatgtg cctttggggc tgcccggcct
     1921 tgcgtcagcc gcctgccccc tcttcctatg cagctttaat gtccccgtgt ccccggggtg
     1981 ggagttcaag gctcagtaat ggcctggtcc cccggcccct gccccatctc ctcatcatcc
     2041 ccagccttga tggaggaggg agggcttcag gacggggcgt cagagggagc cccctctggg
     2101 agggaaccaa cccccaccct ccctcctggg accccccagc agtagacggc ttgggggagt
     2161 cggaggctcc ccggcagaca ccccaccccc atcttgttcc cttgaggtgc ctcctctcct
     2221 ctgcccaggg gagggagtgt ggacagtatc tggaagttct gggattcagg ttgttattaa
     2281 aataataata ataattaaaa actctgaaga aacttgaa
//
