LOCUS       NM_198057               2269 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TSC22 domain family member 3 (TSC22D3), transcript
            variant 1, mRNA.
ACCESSION   NM_198057
VERSION     NM_198057.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Dankers,W., Northcott,M., Bennett,T., D'Cruz,A., Sherlock,R.,
            Gearing,L.J., Hertzog,P., Russ,B., Miceli,I., Scheer,S.,
            Fujishiro,M., Hayakawa,K., Ikeda,K., Morand,E.F. and Jones,S.A.
  TITLE     Type 1 interferon suppresses expression and glucocorticoid
            induction of glucocorticoid-induced leucine zipper (GILZ)
  JOURNAL   Front Immunol 13, 1034880 (2022)
   PUBMED   36505447
  REMARK    GeneRIF: Type 1 interferon suppresses expression and glucocorticoid
            induction of glucocorticoid-induced leucine zipper (GILZ).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Mozaffari,M.S. and Abdelsayed,R.
  TITLE     Expression Profiles of GILZ and Annexin A1 in Human Oral
            Candidiasis and Lichen Planus
  JOURNAL   Cells 11 (9), 1470 (2022)
   PUBMED   35563776
  REMARK    GeneRIF: Expression Profiles of GILZ and Annexin A1 in Human Oral
            Candidiasis and Lichen Planus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Flamini,S., Sergeev,P., Viana de Barros,Z., Mello,T., Biagioli,M.,
            Paglialunga,M., Fiorucci,C., Prikazchikova,T., Pagano,S.,
            Gagliardi,A., Riccardi,C., Zatsepin,T., Migliorati,G.,
            Bereshchenko,O. and Bruscoli,S.
  TITLE     Glucocorticoid-induced leucine zipper regulates liver fibrosis by
            suppressing CCL2-mediated leukocyte recruitment
  JOURNAL   Cell Death Dis 12 (5), 421 (2021)
   PUBMED   33927191
  REMARK    GeneRIF: Glucocorticoid-induced leucine zipper regulates liver
            fibrosis by suppressing CCL2-mediated leukocyte recruitment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Cheng,Q., Fan,H., Ngo,D., Beaulieu,E., Leung,P., Lo,C.Y.,
            Burgess,R., van der Zwan,Y.G., White,S.J., Khachigian,L.M.,
            Hickey,M.J. and Morand,E.F.
  TITLE     GILZ overexpression inhibits endothelial cell adhesive function
            through regulation of NF-kappaB and MAPK activity
  JOURNAL   J Immunol 191 (1), 424-433 (2013)
   PUBMED   23729444
  REMARK    GeneRIF: Exogenous GILZ exerts inhibitory effects on endothelial
            cell adhesive function via a novel pathway involving modulation of
            NF-kappaB p65 DNA binding and MAPK activity.
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Sugawara,F., Yamada,Y., Kuroe,A., Someya,Y., Kubota,A., Ihara,Y.,
            Takahashi,K. and Seino,Y.
  TITLE     Human TSC-22 gene: no association with type 2 diabetes
  JOURNAL   Intern Med 40 (10), 993-997 (2001)
   PUBMED   11688842
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Mittelstadt,P.R. and Ashwell,J.D.
  TITLE     Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ
  JOURNAL   J Biol Chem 276 (31), 29603-29610 (2001)
   PUBMED   11397794
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Ayroldi,E., Migliorati,G., Bruscoli,S., Marchetti,C., Zollo,O.,
            Cannarile,L., D'Adamio,F. and Riccardi,C.
  TITLE     Modulation of T-cell activation by the glucocorticoid-induced
            leucine zipper factor via inhibition of nuclear factor kappaB
  JOURNAL   Blood 98 (3), 743-753 (2001)
   PUBMED   11468175
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Cannarile,L., Zollo,O., D'Adamio,F., Ayroldi,E., Marchetti,C.,
            Tabilio,A., Bruscoli,S. and Riccardi,C.
  TITLE     Cloning, chromosomal assignment and tissue distribution of human
            GILZ, a glucocorticoid hormone-induced gene
  JOURNAL   Cell Death Differ 8 (2), 201-203 (2001)
   PUBMED   11313722
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Vogel,P., Magert,H.J., Cieslak,A., Adermann,K. and Forssmann,W.G.
  TITLE     hDIP--a potential transcriptional regulator related to murine
            TSC-22 and Drosophila shortsighted (shs)--is expressed in a large
            number of human tissues
  JOURNAL   Biochim Biophys Acta 1309 (3), 200-204 (1996)
   PUBMED   8982256
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM047061.1, AK092669.1 and
            CR933650.1.
            
            On Jun 2, 2019 this sequence version replaced NM_198057.2.
            
            Summary: This gene encodes the anti-inflammatory protein
            glucocorticoid (GC)-induced leucine zipper. Expression of this gene
            stimulated by glucocorticoids and interleukin 10 and it appears to
            play a key role in the anti-inflammatory and immunosuppressive
            effects of this steroid. This protein has also been shown to
            inhibit pro-inflammatory molecules including nuclear factor
            &#954;B. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.147417.1,
                                           SRR1803614.201881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372383.9/ ENSP00000361458.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BM047061.1         2-29
            29-2260             AK092669.1         1-2232
            2261-2269           CR933650.1         1947-1955
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..2269
                     /gene="TSC22D3"
                     /gene_synonym="DIP; DSIPI; GILZ; TSC-22R"
                     /note="TSC22 domain family member 3"
                     /db_xref="GeneID:1831"
                     /db_xref="HGNC:HGNC:3051"
                     /db_xref="MIM:300506"
     exon            1..688
                     /gene="TSC22D3"
                     /gene_synonym="DIP; DSIPI; GILZ; TSC-22R"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..971
                     /gene="TSC22D3"
                     /gene_synonym="DIP; DSIPI; GILZ; TSC-22R"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TSC-22 related protein; DSIP-immunoreactive leucine zipper
                     protein; glucocorticoid-induced leucine zipper protein;
                     TSC22 domain family protein 3; TSC-22-like protein; delta
                     sleep-inducing peptide immunoreactor; DSIP-immunoreactive
                     peptide"
                     /codon_start=1
                     /product="TSC22 domain family protein 3 isoform 1"
                     /protein_id="NP_932174.1"
                     /db_xref="CCDS:CCDS14530.1"
                     /db_xref="GeneID:1831"
                     /db_xref="HGNC:HGNC:3051"
                     /db_xref="MIM:300506"
                     /translation="MAQSKLDCRSPVGLDCCNCCLDLAHRSGLQRGSSGENNNPGSPT
                     VSNFRQLQEKLVFENLNTDKLNSIMRQDSLEPVLRDPCYLINEGICNRNIDQTMLSIL
                     LFFHSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLEREN
                     TLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV"
     exon            689..740
                     /gene="TSC22D3"
                     /gene_synonym="DIP; DSIPI; GILZ; TSC-22R"
                     /inference="alignment:Splign:2.1.0"
     exon            741..2269
                     /gene="TSC22D3"
                     /gene_synonym="DIP; DSIPI; GILZ; TSC-22R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2238..2243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSC22D3"
                     /gene_synonym="DIP; DSIPI; GILZ; TSC-22R"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="TSC22D3"
                     /gene_synonym="DIP; DSIPI; GILZ; TSC-22R"
                     /note="major polyA site"
ORIGIN      
        1 ctccacaggt ccgccccaat ccccgctcac acttgggaaa cttgggactg cgctggggcc
       61 gcgtgtggca cctcaggggg gcggcccccg gcctcaagag gagggggagg agaaggagga
      121 agaggaggaa gtgagcccga aggatccgct cggagctgtt tgtccagctg tttctattcg
      181 cacccggagc agtacagcca gaagggggcc gagccgaagg tggctggctt taggcgctaa
      241 tttccaactc ttttcctcac agcttgtctt ttccaggcac cctggagtcc cctcaggcca
      301 gctcggtggg cgcgcacctg ccagccgccc ctgacctcgc aggccaggcg acctccgagc
      361 ctgagaagat ggcccagtcc aagctcgatt gccgctcacc tgtcggcctc gactgctgca
      421 actgctgcct ggacctggcc catcggagtg ggctccagcg aggcagcagc ggggagaaca
      481 acaacccggg cagccctaca gtgagcaact ttcggcagct gcaggaaaag ctggtctttg
      541 agaacctcaa taccgacaag ctcaacagca taatgcggca ggattcgcta gagccggtgc
      601 tgcgggaccc ctgctacctg atcaacgagg gcatctgcaa ccgcaacatc gaccagacca
      661 tgctctccat cctgctcttc ttccacagtg cctccggagc cagcgtggtg gccatagaca
      721 acaagatcga acaggccatg gatctggtga agaatcatct gatgtatgct gtgagagagg
      781 aggtggagat cctgaaggag cagatccgag agctggtgga gaagaactcc cagctagagc
      841 gtgagaacac cctgttgaag accctggcaa gcccagagca gctggagaag ttccagtcct
      901 gtctgagccc tgaagagcca gctcccgaat ccccacaagt gcccgaggcc cctggtggtt
      961 ctgcggtgta agtggctctg tcctcagggt gggcagagcc actaaacttg ttttacctag
     1021 ttctttccag tttgtttttg gctccccaag catcatctca cgaggagaac tttacaccta
     1081 gcacagctgg tgccaagaga tgtcctaagg acatggccac ctgggtccac tccagcgaca
     1141 gacccctgac aagagcaggt ctctggaggc tgagttgcat ggggcctagt aacaccaagc
     1201 cagtgagcct ctaatgctac tgcgccctgg gggctcccag ggcctgggca acttagctgc
     1261 aactggcaaa ggagaagggt agtttgaggt gtgacaccag tttgctccag aaagtttaag
     1321 gggtctgttt ctcatctcca tggacatctt caacagcttc acctgacaac gactgttcct
     1381 atgaagaagc cacttgtgtt ttaagcagag gcaacctctc tcttctcctc tgtttcgtga
     1441 aggcagggga cacagatggg agagattgag ccaagtcagc cttctgttgg ttaatatggt
     1501 ataatgcatg gctttgtgca cagcccagtg tgggattaca gctttgggat gaccgcttac
     1561 aaagttctgt ttggttagta ttggcatagt ttttctatat agccataaat gcgtatatat
     1621 acccataggg ctagatctgt atcttagtgt agcgatgtat acatatacac atccacctac
     1681 atgttgaagg gcctaaccag ccttgggagt attgactggt cccttacctc ttatggctaa
     1741 gtctttgact gtgttcattt accaagttga cccagtttgt cttttaggtt aagtaagact
     1801 cgagagtaaa ggcaaggagg ggggccagcc tctgaatgcg gccacggatg ccttgctgct
     1861 gcaacccttt ccccagctgt ccactgaaac gtgaagtcct gttttgaatg ccaaacccac
     1921 cattcactgg tgctgactac atagaatggg gttgagagaa gatcagtttg ggcttcacag
     1981 tgtcatttga aaacgttttt tgttttgttt tgtaattatt gtggaaaact ttcaagtgaa
     2041 cagaaggatg gtgtcctact gtggatgagg gatgaacaag gggatggctt tgatccaatg
     2101 gagcctggga ggtgtgccca gaaagcttgt ctgtagcggg ttttgtgaga gtgaacactt
     2161 tccacttttt gacaccttat cctgatgtat ggttccagga tttggatttt gattttccaa
     2221 atgtagcttg aaatttcaat aaactttgct ctgtttttct aaaaataaa
//
