LOCUS       NM_144627                751 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens TSSK6 activating cochaperone (TSACC), transcript
            variant 2, mRNA.
ACCESSION   NM_144627
VERSION     NM_144627.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 751)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 751)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 751)
  AUTHORS   Jha,K.N., Wong,L., Zerfas,P.M., De Silva,R.S., Fan,Y.X.,
            Spiridonov,N.A. and Johnson,G.R.
  TITLE     Identification of a novel HSP70-binding cochaperone critical to
            HSP90-mediated activation of small serine/threonine kinase
  JOURNAL   J Biol Chem 285 (45), 35180-35187 (2010)
   PUBMED   20829357
REFERENCE   4  (bases 1 to 751)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   5  (bases 1 to 751)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589685.17 and BC014605.1.
            
            On Aug 13, 2020 this sequence version replaced NM_144627.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014605.1, BI826537.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL589685.17        62834-62837
            5-751               BC014605.1         10-756
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..751
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="TSSK6 activating cochaperone"
                     /db_xref="GeneID:128229"
                     /db_xref="HGNC:HGNC:30636"
                     /db_xref="MIM:619679"
     exon            1..236
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     exon            237..394
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..738
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="isoform a is encoded by transcript variant 2;
                     SSTK-interacting protein (SSTK-IP); TSSK6-activating
                     co-chaperone protein; TSSK6 activating co-chaperone"
                     /codon_start=1
                     /product="TSSK6-activating co-chaperone protein isoform a"
                     /protein_id="NP_653228.1"
                     /db_xref="CCDS:CCDS1141.1"
                     /db_xref="GeneID:128229"
                     /db_xref="HGNC:HGNC:30636"
                     /db_xref="MIM:619679"
                     /translation="MERHTSHPNRKVPAKEEANAVPLCRAKPSPSYINLQASSPPATF
                     LNIQTTKLPSVDHKPKECLGLLECMYANLQLQTQLAQQQMAVLEHLQASVTQLAPGRG
                     SNNSSLPALSPNPLLNHLPQFSK"
     exon            395..523
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     exon            524..751
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      734..739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="hexamer: AATGAA"
     polyA_site      751
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="major polyA site"
ORIGIN      
        1 aggaggatcg cttgaacctg ggaggcagag gttgcagtga acagagatcg cgccactgca
       61 acccagcctg ggtgacagag cgagactttg tctcaaaata taaaaagaaa aaaaataagg
      121 gatcttccaa aaggaaaagg tgaccagtcg agaaatctgg gaaaacccaa ctggttagtg
      181 ggaaagagta caacgccggg gacacggagg gaacgattac atctaagatc agtgagattg
      241 gaacaggctg agatctgctg gagacaactt aggaaattat catagtgaaa atactaacat
      301 ggattgttga tcatctgatg ctatgattct ttcccaggca ccacacctgt tggtgttcag
      361 atggagcggc acactagtca tcctaacaga aaagttccag ccaaagagga agctaatgct
      421 gtgcctctct gtagagcaaa accctccccc agctatatta atcttcaagc aagttcccca
      481 ccagccactt ttctgaacat ccagacaaca aagctgccct cggttgatca caagcccaag
      541 gaatgcctag gactcctgga atgtatgtat gcaaacctcc agcttcagac ccagctcgcc
      601 caacaacaga tggctgtttt ggaacattta caggcatctg tgacacaact ggctcctggg
      661 aggggaagca ataactcttc tctcccagcc ttatctccta atccattgtt aaatcacctg
      721 ccccaattca gtaaatgaat tgtggaacaa a
//
