LOCUS       NM_001304826             659 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TSSK6 activating cochaperone (TSACC), transcript
            variant 11, mRNA.
ACCESSION   NM_001304826
VERSION     NM_001304826.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 659)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 659)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 659)
  AUTHORS   Jha,K.N., Wong,L., Zerfas,P.M., De Silva,R.S., Fan,Y.X.,
            Spiridonov,N.A. and Johnson,G.R.
  TITLE     Identification of a novel HSP70-binding cochaperone critical to
            HSP90-mediated activation of small serine/threonine kinase
  JOURNAL   J Biol Chem 285 (45), 35180-35187 (2010)
   PUBMED   20829357
REFERENCE   4  (bases 1 to 659)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   5  (bases 1 to 659)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589685.17, HY044099.1 and AY048673.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001304826.1.
            
            Transcript Variant: This variant (11) differs in the 5' UTR and
            uses two alternate splice junctions at the 5' end compared to
            variant 1. The resulting isoform (c) is longer at the N-terminus
            compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY048673.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AL589685.17        64046-64111
            67-168              HY044099.1         2-103
            169-659             AY048673.1         1-491
FEATURES             Location/Qualifiers
     source          1..659
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..659
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="TSSK6 activating cochaperone"
                     /db_xref="GeneID:128229"
                     /db_xref="HGNC:HGNC:30636"
                     /db_xref="MIM:619679"
     exon            1..245
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..646
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="isoform c is encoded by transcript variant 11;
                     SSTK-interacting protein (SSTK-IP); TSSK6-activating
                     co-chaperone protein; TSSK6 activating co-chaperone"
                     /codon_start=1
                     /product="TSSK6-activating co-chaperone protein isoform c"
                     /protein_id="NP_001291755.1"
                     /db_xref="GeneID:128229"
                     /db_xref="HGNC:HGNC:30636"
                     /db_xref="MIM:619679"
                     /translation="MGERPAGLAQGTTPVGVQMERHTSHPNRKVPAKEEANAVPLCRA
                     KPSPSYINLQASSPPATFLNIQTTKLPSVDHKPKECLGLLECMYANLQLQTQLAQQQM
                     AVLEHLQASVTQLAPGRGSNNSSLPALSPNPLLNHLPQFSK"
     exon            246..302
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     exon            303..431
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     exon            432..659
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      642..647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="hexamer: AATGAA"
     polyA_site      659
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="major polyA site"
ORIGIN      
        1 agttggccag cacaccacta cgcatgtgtg tcaactctag ggttgggtgc tggggttgcg
       61 gctttcggtt aacaccgcag gtgaggtcgt taaactgtgt attgcgactc ggctcctatc
      121 ggaccgtgaa ggctaagaaa ggcttcacag ttcccactct tttggtctag ccttagcaac
      181 aggtggacta gagaggcggg actccagcca gcacatgggg gaaagacctg ccggcttggc
      241 gcagggcacc acacctgttg gtgttcagat ggagcggcac actagtcatc ctaacagaaa
      301 agttccagcc aaagaggaag ctaatgctgt gcctctctgt agagcaaaac cctcccccag
      361 ctatattaat cttcaagcaa gttccccacc agccactttt ctgaacatcc agacaacaaa
      421 gctgccctcg gttgatcaca agcccaagga atgcctagga ctcctggaat gtatgtatgc
      481 aaacctccag cttcagaccc agctcgccca acaacagatg gctgttttgg aacatttaca
      541 ggcatctgtg acacaactgg ctcctgggag gggaagcaat aactcttctc tcccagcctt
      601 atctcctaat ccattgttaa atcacctgcc ccaattcagt aaatgaattg tggaacaaa
//
