LOCUS       NM_001304821             854 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TSSK6 activating cochaperone (TSACC), transcript
            variant 1, mRNA.
ACCESSION   NM_001304821
VERSION     NM_001304821.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 854)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 854)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 854)
  AUTHORS   Jha,K.N., Wong,L., Zerfas,P.M., De Silva,R.S., Fan,Y.X.,
            Spiridonov,N.A. and Johnson,G.R.
  TITLE     Identification of a novel HSP70-binding cochaperone critical to
            HSP90-mediated activation of small serine/threonine kinase
  JOURNAL   J Biol Chem 285 (45), 35180-35187 (2010)
   PUBMED   20829357
REFERENCE   4  (bases 1 to 854)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   5  (bases 1 to 854)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589685.17, HY044099.1, HY230397.1 and BC014605.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001304821.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, 4, 5, and 6 all encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.99923.1,
                                           SRR5189667.327867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AL589685.17        64046-64111
            67-266              HY044099.1         2-201
            267-662             HY230397.1         1-396               c
            663-854             BC014605.1         565-756
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..854
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="TSSK6 activating cochaperone"
                     /db_xref="GeneID:128229"
                     /db_xref="HGNC:HGNC:30636"
                     /db_xref="MIM:619679"
     exon            1..339
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     exon            340..497
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             464..841
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="isoform a is encoded by transcript variant 1;
                     SSTK-interacting protein (SSTK-IP); TSSK6-activating
                     co-chaperone protein; TSSK6 activating co-chaperone"
                     /codon_start=1
                     /product="TSSK6-activating co-chaperone protein isoform a"
                     /protein_id="NP_001291750.1"
                     /db_xref="CCDS:CCDS1141.1"
                     /db_xref="GeneID:128229"
                     /db_xref="HGNC:HGNC:30636"
                     /db_xref="MIM:619679"
                     /translation="MERHTSHPNRKVPAKEEANAVPLCRAKPSPSYINLQASSPPATF
                     LNIQTTKLPSVDHKPKECLGLLECMYANLQLQTQLAQQQMAVLEHLQASVTQLAPGRG
                     SNNSSLPALSPNPLLNHLPQFSK"
     exon            498..626
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     exon            627..854
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      837..842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="hexamer: AATGAA"
     polyA_site      854
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="major polyA site"
ORIGIN      
        1 agttggccag cacaccacta cgcatgtgtg tcaactctag ggttgggtgc tggggttgcg
       61 gctttcggtt aacaccgcag gtgaggtcgt taaactgtgt attgcgactc ggctcctatc
      121 ggaccgtgaa ggctaagaaa ggcttcacag ttcccactct tttggtctag ccttagcaac
      181 aggtggacta gagaggcggg actccagcca gcacatgggg gaaagacctg ccggcttggc
      241 gcagggtgaa gtgggagttg tagtcttacc gggccggact gcgcagcctt tttccgggca
      301 cactgggagt tgtggtttat cgcctctgga ctaatggcta ttggaacagg ctgagatctg
      361 ctggagacaa cttaggaaat tatcatagtg aaaatactaa catggattgt tgatcatctg
      421 atgctatgat tctttcccag gcaccacacc tgttggtgtt cagatggagc ggcacactag
      481 tcatcctaac agaaaagttc cagccaaaga ggaagctaat gctgtgcctc tctgtagagc
      541 aaaaccctcc cccagctata ttaatcttca agcaagttcc ccaccagcca cttttctgaa
      601 catccagaca acaaagctgc cctcggttga tcacaagccc aaggaatgcc taggactcct
      661 ggaatgtatg tatgcaaacc tccagcttca gacccagctc gcccaacaac agatggctgt
      721 tttggaacat ttacaggcat ctgtgacaca actggctcct gggaggggaa gcaataactc
      781 ttctctccca gccttatctc ctaatccatt gttaaatcac ctgccccaat tcagtaaatg
      841 aattgtggaa caaa
//
