LOCUS       NM_001304817             595 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens TSSK6 activating cochaperone (TSACC), transcript
            variant 3, mRNA.
ACCESSION   NM_001304817
VERSION     NM_001304817.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 595)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 595)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 595)
  AUTHORS   Jha,K.N., Wong,L., Zerfas,P.M., De Silva,R.S., Fan,Y.X.,
            Spiridonov,N.A. and Johnson,G.R.
  TITLE     Identification of a novel HSP70-binding cochaperone critical to
            HSP90-mediated activation of small serine/threonine kinase
  JOURNAL   J Biol Chem 285 (45), 35180-35187 (2010)
   PUBMED   20829357
REFERENCE   4  (bases 1 to 595)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   5  (bases 1 to 595)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB446801.1, AK311950.1 and BC014605.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001304817.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI463044.1, BP369155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368254.6/ ENSP00000357237.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB446801.1         87-102
            17-529              AK311950.1         1-513
            530-595             BC014605.1         691-756
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..595
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="TSSK6 activating cochaperone"
                     /db_xref="GeneID:128229"
                     /db_xref="HGNC:HGNC:30636"
                     /db_xref="MIM:619679"
     exon            1..80
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     exon            81..238
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..582
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="isoform a is encoded by transcript variant 3;
                     SSTK-interacting protein (SSTK-IP); TSSK6-activating
                     co-chaperone protein; TSSK6 activating co-chaperone"
                     /codon_start=1
                     /product="TSSK6-activating co-chaperone protein isoform a"
                     /protein_id="NP_001291746.1"
                     /db_xref="CCDS:CCDS1141.1"
                     /db_xref="GeneID:128229"
                     /db_xref="HGNC:HGNC:30636"
                     /db_xref="MIM:619679"
                     /translation="MERHTSHPNRKVPAKEEANAVPLCRAKPSPSYINLQASSPPATF
                     LNIQTTKLPSVDHKPKECLGLLECMYANLQLQTQLAQQQMAVLEHLQASVTQLAPGRG
                     SNNSSLPALSPNPLLNHLPQFSK"
     exon            239..367
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     exon            368..595
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      578..583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="hexamer: AATGAA"
     polyA_site      595
                     /gene="TSACC"
                     /gene_synonym="C1orf182; SIP; SSTK-IP"
                     /note="major polyA site"
ORIGIN      
        1 agttggccag cacaccacta cgcatgtgtg tcaactctag ggttgggtgc tggggttgcg
       61 gctttcggtt aacaccgcag attggaacag gctgagatct gctggagaca acttaggaaa
      121 ttatcatagt gaaaatacta acatggattg ttgatcatct gatgctatga ttctttccca
      181 ggcaccacac ctgttggtgt tcagatggag cggcacacta gtcatcctaa cagaaaagtt
      241 ccagccaaag aggaagctaa tgctgtgcct ctctgtagag caaaaccctc ccccagctat
      301 attaatcttc aagcaagttc cccaccagcc acttttctga acatccagac aacaaagctg
      361 ccctcggttg atcacaagcc caaggaatgc ctaggactcc tggaatgtat gtatgcaaac
      421 ctccagcttc agacccagct cgcccaacaa cagatggctg ttttggaaca tttacaggca
      481 tctgtgacac aactggctcc tgggagggga agcaataact cttctctccc agccttatct
      541 cctaatccat tgttaaatca cctgccccaa ttcagtaaat gaattgtgga acaaa
//
