LOCUS       NM_019841               2890 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            V member 5 (TRPV5), mRNA.
ACCESSION   NM_019841
VERSION     NM_019841.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2890)
  AUTHORS   Mahtani,T., Sheth,H., Smith,L.K., Benedict,L., Brecier,A.,
            Ghasemlou,N. and Treanor,B.
  TITLE     The ion channel TRPV5 regulates B-cell signaling and activation
  JOURNAL   Front Immunol 15, 1386719 (2024)
   PUBMED   38694510
  REMARK    GeneRIF: The ion channel TRPV5 regulates B-cell signaling and
            activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2890)
  AUTHORS   Luo,Z.H., Ma,J.X., Zhang,W., Tian,A.X., Gong,S.W., Li,Y., Lai,Y.X.
            and Ma,X.L.
  TITLE     Alterations in the microenvironment and the effects produced of
            TRPV5 in osteoporosis
  JOURNAL   J Transl Med 21 (1), 327 (2023)
   PUBMED   37198647
  REMARK    GeneRIF: Alterations in the microenvironment and the effects
            produced of TRPV5 in osteoporosis.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2890)
  AUTHORS   Ali,F.T., El-Azeem,E.M.A., Hekal,H.F.A., El-Gizawy,M.M.,
            Sayed,M.S., Mandoh,A.Y. and Soliman,A.F.
  TITLE     Association of TRPV5, CASR, and CALCR genetic variants with kidney
            stone disease susceptibility in Egyptians through main effects and
            gene-gene interactions
  JOURNAL   Urolithiasis 50 (6), 701-710 (2022)
   PUBMED   36088585
  REMARK    GeneRIF: Association of TRPV5, CASR, and CALCR genetic variants
            with kidney stone disease susceptibility in Egyptians through main
            effects and gene-gene interactions.
REFERENCE   4  (bases 1 to 2890)
  AUTHORS   Mitra,P., Pal,D.K. and Das,M.
  TITLE     Association of TRPV5 gene polymorphism with calcium urolithiasis: a
            case-control study from West Bengal, India
  JOURNAL   World J Urol 38 (5), 1311-1322 (2020)
   PUBMED   31428848
  REMARK    GeneRIF: Association of TRPV5 gene polymorphism with calcium
            urolithiasis: a case-control study from West Bengal, India.
REFERENCE   5  (bases 1 to 2890)
  AUTHORS   van der Wijst,J., van Goor,M.K., Schreuder,M.F. and Hoenderop,J.G.
  TITLE     TRPV5 in renal tubular calcium handling and its potential relevance
            for nephrolithiasis
  JOURNAL   Kidney Int 96 (6), 1283-1291 (2019)
   PUBMED   31471161
  REMARK    GeneRIF: TRPV5 in renal tubular calcium handling and its potential
            relevance for nephrolithiasis.
            Review article
REFERENCE   6  (bases 1 to 2890)
  AUTHORS   Vassilev,P.M., Peng,J.B., Hediger,M.A. and Brown,E.M.
  TITLE     Single-channel activities of the human epithelial Ca2+ transport
            proteins CaT1 and CaT2
  JOURNAL   J Membr Biol 184 (2), 113-120 (2001)
   PUBMED   11719848
REFERENCE   7  (bases 1 to 2890)
  AUTHORS   Vennekens,R., Droogmans,G. and Nilius,B.
  TITLE     Functional properties of the epithelial Ca2+ channel, ECaC
  JOURNAL   Gen Physiol Biophys 20 (3), 239-253 (2001)
   PUBMED   11765215
  REMARK    GeneRIF: Functional properties of the epithelial Ca2+ channel,
            ECaC.
            Review article
REFERENCE   8  (bases 1 to 2890)
  AUTHORS   Peng,J.B., Brown,E.M. and Hediger,M.A.
  TITLE     Structural conservation of the genes encoding CaT1, CaT2, and
            related cation channels
  JOURNAL   Genomics 76 (1-3), 99-109 (2001)
   PUBMED   11549322
REFERENCE   9  (bases 1 to 2890)
  AUTHORS   Muller,D., Hoenderop,J.G., Merkx,G.F., van Os,C.H. and Bindels,R.J.
  TITLE     Gene structure and chromosomal mapping of human epithelial calcium
            channel
  JOURNAL   Biochem Biophys Res Commun 275 (1), 47-52 (2000)
   PUBMED   10944439
REFERENCE   10 (bases 1 to 2890)
  AUTHORS   Muller,D., Hoenderop,J.G., Meij,I.C., van den Heuvel,L.P.,
            Knoers,N.V., den Hollander,A.I., Eggert,P., Garcia-Nieto,V.,
            Claverie-Martin,F. and Bindels,R.J.
  TITLE     Molecular cloning, tissue distribution, and chromosomal mapping of
            the human epithelial Ca2+ channel (ECAC1)
  JOURNAL   Genomics 67 (1), 48-53 (2000)
   PUBMED   10945469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245427.3, BC034740.1 and
            AF304464.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_019841.6.
            
            Summary: This gene is a member of the transient receptor family and
            the TrpV subfamily. The calcium-selective channel encoded by this
            gene has 6 transmembrane-spanning domains, multiple potential
            phosphorylation sites, an N-linked glycosylation site, and 5 ANK
            repeats. This protein forms homotetramers or heterotetramers and is
            activated by a low internal calcium level. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF304464.1, AJ487965.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265310.6/ ENSP00000265310.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC245427.3         224824-224846       c
            24-1409             BC034740.1         1-1386
            1410-1973           AF304464.1         1472-2035
            1974-1974           AC245427.3         203683-203683       c
            1975-2770           AF304464.1         2037-2832
            2771-2820           AF304464.1         2834-2883
            2821-2821           AC245427.3         199270-199270       c
            2822-2890           AF304464.1         2885-2953
FEATURES             Location/Qualifiers
     source          1..2890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2890
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /note="transient receptor potential cation channel
                     subfamily V member 5"
                     /db_xref="GeneID:56302"
                     /db_xref="HGNC:HGNC:3145"
                     /db_xref="MIM:606679"
     exon            1..415
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..2477
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /note="epithelial calcium channel 1; calcium transporter
                     2; osm-9-like TRP channel 3; calcium transport protein 2"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 5"
                     /protein_id="NP_062815.3"
                     /db_xref="CCDS:CCDS5875.1"
                     /db_xref="GeneID:56302"
                     /db_xref="HGNC:HGNC:3145"
                     /db_xref="MIM:606679"
                     /translation="MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRI
                     LESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAA
                     PELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRHSPRNLI
                     YFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL
                     LLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSI
                     LYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAA
                     LYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVS
                     IVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGE
                     VVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF
                     YIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFTIIA
                     TLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFG
                     LGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLA
                     LPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSEGDGEEVYHF"
     exon            416..513
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..636
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..774
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            775..873
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1049
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1196
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1409
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1496
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1573
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1739
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1806
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2075
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2182
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2890
                     /gene="TRPV5"
                     /gene_synonym="CAT2; ECAC1; OTRPC3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccctca gcgcacctgc atgcacacac accacctcac aaccacacac tgcatgcaca
       61 cacatacacc acagccacac actgtgcata cacgcacacc ccacaaccca catactgcat
      121 gcacacacac acacctacaa gctgcatgct gcatacacaa gtcatacagg agataaactc
      181 agagtcccag ccccaaatag accccatctc ttgctcagtt gctgtcatcc tagacctgtt
      241 tctttcgcca catttctata atctgccagt gtctgcaagg agaagacatg gggggttttc
      301 tacctaaggc agaagggccc gggagccaac tccagaaact tctgccctcc tttctggtca
      361 gagaacaaga ctgggaccag cacctggaca agcttcatat gctgcagcag aagaggattc
      421 tagagtctcc actgcttcga gcatccaagg aaaatgacct gtctgttctt aggcaacttc
      481 tactggactg cacctgtgac gttcgacaaa gaggagccct gggggagacg gcgctgcaca
      541 tagcagccct ctatgacaac ttggaggcgg ccttggtgct gatggaggct gccccagagc
      601 tggtctttga gcccaccaca tgtgaggctt ttgcaggtca gactgcactg cacatcgctg
      661 ttgtgaacca gaatgtgaac ctggtgcgtg ccctgctcac ccgcagggcc agtgtctctg
      721 ccagagccac aggcactgcc ttccgccata gtccccgcaa cctcatctac tttggggagc
      781 accctttgtc ctttgctgcc tgtgtgaaca gcgaggagat cgtgcggctg ctcattgagc
      841 atggagctga catcagggcc caggactccc tgggaaacac agtattacac atcctcatcc
      901 tccagcccaa caaaaccttt gcctgccaga tgtacaacct gctgctgtcc tatgatggac
      961 atggggacca cctgcagccc ctggaccttg tgcccaatca ccagggtctc acccccttca
     1021 agctggctgg agtggagggt aacactgtga tgttccagca cctgatgcag aagcggaggc
     1081 acatccagtg gacgtatgga cccctgacct ccattctcta cgacctcacg gagatcgact
     1141 cctggggaga ggagctgtcc ttcctggagc ttgtggtctc ctctgataaa cgagaggctc
     1201 gccaaattct ggaacagacc ccagtgaagg agctggtgag cttcaagtgg aacaagtatg
     1261 gccggccgta cttctgcatc ctggctgcct tgtacctgct ctacatgatc tgctttacta
     1321 cgtgctgcgt ctaccgcccc cttaagtttc gtggtggcaa ccgcactcat tctcgagaca
     1381 tcaccatcct ccagcaaaaa ctactacagg aggcctatga gacacgtgaa gatatcatca
     1441 ggctggtggg ggagctggtg agcatcgttg gggctgtgat catcctgctc ctagagattc
     1501 cagacatctt cagggttggt gcctctcgct attttggaaa gacgattctt ggggggccat
     1561 tccatgtcat catcatcacc tatgcctccc tggtgctggt gaccatggtg atgcggctca
     1621 ccaacaccaa tggggaggtg gtgcccatgt cctttgccct ggtgctgggc tggtgcagtg
     1681 tcatgtattt cactcgagga ttccagatgc tgggtccctt caccatcatg atccagaaga
     1741 tgatttttgg agacctaatg cgtttctgct ggctgatggc tgtggtcatc ttgggatttg
     1801 cctccgcgtt ctatatcatt ttccagacag aggacccaac cagtctgggg caattctatg
     1861 actaccccat ggcactgttc accacctttg agctttttct cactgttatt gatgcacctg
     1921 ccaactacga cgtggacttg cccttcatgt tcagcattgt caacttcgcc ttcaccatca
     1981 ttgccacact gctcatgctc aacttgttca tcgccatgat gggcgacacc cactggaggg
     2041 tggcccagga gagggatgag ctctggaggg cccaggtcgt ggccaccaca gtgatgctgg
     2101 agcggaagct gcctcgctgc ctgtggcctc gctccgggat ctgtgggtgc gaattcgggc
     2161 tgggggaccg ctggttcctg cgggttgaga accacaatga tcagaatcct ctgcgagtgc
     2221 ttcgctatgt ggaagtgttc aagaactcag acaaggagga tgaccaggag catccatctg
     2281 agaaacagcc ctctggggct gagagtggga ctctagccag agcctctttg gctcttccaa
     2341 cttcctccct gtcccggacc gcgtcccaga gcagcagtca ccgaggctgg gagatccttc
     2401 gtcaaaacac cctggggcac ttgaatcttg gactgaacct tagtgagggg gatggagagg
     2461 aggtctacca tttttgatta acatcgctat cactcttgac cttactcccg gttggcctgg
     2521 gggcggggac agagacggag acctctgcct atgcaagtgt ctaacttctg tgcctgttaa
     2581 tcatgggagg gtgagacaga acaatcccta aagggtcatg cctcacactt cacatcagaa
     2641 tttctggcaa tgggcaatgg tcatcgattg tctcacgtat tttctgggct cttgcaagtc
     2701 acccatctca ggaaaaagga ggttggcaac taaagacatg aggcagggat gctagattaa
     2761 tgtcaggacc atttctcttc tgccccacgc agcccctaga aagtagtaag ctgtgaggct
     2821 tttctggctc cccagggctt acgtgggaag agccaggcat ggcatagagg ttgtggccct
     2881 tctttttttc
//
