LOCUS       NM_145068               5927 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            V member 3 (TRPV3), transcript variant 2, mRNA.
ACCESSION   NM_145068
VERSION     NM_145068.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5927)
  AUTHORS   Martin,L.S., Josset-Lamaugarny,A., El Jammal,T., Ducreux,S.,
            Chevalier,F.P. and Fromy,B.
  TITLE     Aging is associated with impaired triggering of TRPV3-mediated
            cutaneous vasodilation: a crucial process for local heat exposure
  JOURNAL   Geroscience 46 (4), 3567-3580 (2024)
   PUBMED   37855862
  REMARK    GeneRIF: Aging is associated with impaired triggering of
            TRPV3-mediated cutaneous vasodilation: a crucial process for local
            heat exposure.
REFERENCE   2  (bases 1 to 5927)
  AUTHORS   Wei,Z., Gao,M., Liu,Y., Zeng,R., Liu,J., Sun,S., Li,S., Hu,L.,
            Xiang,R., Mo,R., Song,Z., Chen,Z., Bao,D., Hua,D., Zouboulis,C.C.,
            Feng,Y., Li,J. and Yang,Y.
  TITLE     TRPV3 promotes sebocyte inflammation via transcriptional modulating
            TLR2 in acne
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167195 (2024)
   PUBMED   38648901
  REMARK    GeneRIF: TRPV3 promotes sebocyte inflammation via transcriptional
            modulating TLR2 in acne.
REFERENCE   3  (bases 1 to 5927)
  AUTHORS   Nadezhdin,K.D., Neuberger,A., Khosrof,L.S., Talyzina,I.A., Khau,J.,
            Yelshanskaya,M.V. and Sobolevsky,A.I.
  TITLE     TRPV3 activation by different agonists accompanied by lipid
            dissociation from the vanilloid site
  JOURNAL   Sci Adv 10 (18), eadn2453 (2024)
   PUBMED   38691614
REFERENCE   4  (bases 1 to 5927)
  AUTHORS   Lansky,S., Betancourt,J.M., Zhang,J., Jiang,Y., Kim,E.D.,
            Paknejad,N., Nimigean,C.M., Yuan,P. and Scheuring,S.
  TITLE     A pentameric TRPV3 channel with a dilated pore
  JOURNAL   Nature 621 (7977), 206-214 (2023)
   PUBMED   37648856
REFERENCE   5  (bases 1 to 5927)
  AUTHORS   Kim,J., Won,J., Chung,D.K. and Lee,H.H.
  TITLE     FRET analysis of the temperature-induced structural changes in
            human TRPV3
  JOURNAL   Sci Rep 13 (1), 10108 (2023)
   PUBMED   37344508
  REMARK    GeneRIF: FRET analysis of the temperature-induced structural
            changes in human TRPV3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5927)
  AUTHORS   Facer,P., Casula,M.A., Smith,G.D., Benham,C.D., Chessell,I.P.,
            Bountra,C., Sinisi,M., Birch,R. and Anand,P.
  TITLE     Differential expression of the capsaicin receptor TRPV1 and related
            novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and
            changes in traumatic and diabetic neuropathy
  JOURNAL   BMC Neurol 7, 11 (2007)
   PUBMED   17521436
  REMARK    GeneRIF: accumulation of TRPV1 and TRPV3 in peripheral nerves after
            injury, in spared axons, matches our previously reported changes in
            avulsed DRG.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5927)
  AUTHORS   Clapham,D.E., Julius,D., Montell,C. and Schultz,G.
  TITLE     International Union of Pharmacology. XLIX. Nomenclature and
            structure-function relationships of transient receptor potential
            channels
  JOURNAL   Pharmacol Rev 57 (4), 427-450 (2005)
   PUBMED   16382100
  REMARK    Review article
REFERENCE   8  (bases 1 to 5927)
  AUTHORS   Smith,G.D., Gunthorpe,M.J., Kelsell,R.E., Hayes,P.D., Reilly,P.,
            Facer,P., Wright,J.E., Jerman,J.C., Walhin,J.P., Ooi,L.,
            Egerton,J., Charles,K.J., Smart,D., Randall,A.D., Anand,P. and
            Davis,J.B.
  TITLE     TRPV3 is a temperature-sensitive vanilloid receptor-like protein
  JOURNAL   Nature 418 (6894), 186-190 (2002)
   PUBMED   12077606
  REMARK    GeneRIF: temperature-sensitive (but capsaicin-insensitive)
            vanilloid receptor-like protein; may represent an additional
            vanilloid receptor subunit involved in the formation of heteromeric
            vanilloid receptor channels
REFERENCE   9  (bases 1 to 5927)
  AUTHORS   Xu,H., Ramsey,I.S., Kotecha,S.A., Moran,M.M., Chong,J.A.,
            Lawson,D., Ge,P., Lilly,J., Silos-Santiago,I., Xie,Y.,
            DiStefano,P.S., Curtis,R. and Clapham,D.E.
  TITLE     TRPV3 is a calcium-permeable temperature-sensitive cation channel
  JOURNAL   Nature 418 (6894), 181-186 (2002)
   PUBMED   12077604
  REMARK    GeneRIF: member of the vanilloid channel family that is expressed
            in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal
            cord and brain; a calcium-permeable temperature-sensitive cation
            channel
REFERENCE   10 (bases 1 to 5927)
  AUTHORS   Peier,A.M., Reeve,A.J., Andersson,D.A., Moqrich,A., Earley,T.J.,
            Hergarden,A.C., Story,G.M., Colley,S., Hogenesch,J.B., McIntyre,P.,
            Bevan,S. and Patapoutian,A.
  TITLE     A heat-sensitive TRP channel expressed in keratinocytes
  JOURNAL   Science 296 (5575), 2046-2049 (2002)
   PUBMED   12016205
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027796.9, AF514998.1,
            AC025125.15 and BX537539.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_145068.3.
            
            Summary: This gene product belongs to a family of nonselective
            cation channels that function in a variety of processes, including
            temperature sensation and vasoregulation. The thermosensitive
            members of this family are expressed in subsets of sensory neurons
            that terminate in the skin, and are activated at distinct
            physiological temperatures. This channel is activated at
            temperatures between 22 and 40 degrees C. This gene lies in close
            proximity to another family member gene on chromosome 17, and the
            two encoded proteins are thought to associate with each other to
            form heteromeric channels. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            resulting protein (isoform 2) is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.943936.1,
                                           SRR14038192.727198.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000576742.6/ ENSP00000461518.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC027796.9         105089-105163
            76-3237             AF514998.1         1-3162
            3238-5887           AC025125.15        35759-38408
            5888-5927           BX537539.1         5009-5048
FEATURES             Location/Qualifiers
     source          1..5927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..5927
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /note="transient receptor potential cation channel
                     subfamily V member 3"
                     /db_xref="GeneID:162514"
                     /db_xref="HGNC:HGNC:18084"
                     /db_xref="MIM:607066"
     exon            1..137
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            138..258
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2512
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     vanilloid receptor-related osmotically activated channel
                     protein; VRL-3; vanilloid receptor-like 3"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 3 isoform 2"
                     /protein_id="NP_659505.1"
                     /db_xref="CCDS:CCDS11029.1"
                     /db_xref="GeneID:162514"
                     /db_xref="HGNC:HGNC:18084"
                     /db_xref="MIM:607066"
                     /translation="MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFF
                     LEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNS
                     PSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMH
                     KLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTA
                     LNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPE
                     IVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELE
                     TTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDL
                     TNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFF
                     YNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLL
                     RPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYT
                     RGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGS
                     FSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVE
                     NVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWT
                     EWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV"
     exon            259..363
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            364..450
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..605
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..782
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            783..923
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1204
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1381
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1540
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1642
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1716
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1882
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1949
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2224
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2337
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2417
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..5927
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5903..5908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /note="hexamer: AATAAA"
     polyA_site      5927
                     /gene="TRPV3"
                     /gene_synonym="FNEPPK2; OLMS; OLMS1; VRL3"
                     /note="major polyA site"
ORIGIN      
        1 gcctcattcc agccatccct ctgcctgcaa tgagagcttc ccgccgcctc agccacagtc
       61 ccacccgggg gccttgggcc ccagacatgc ggtgatctca gggcaagggt tgccacgacc
      121 acccagaacc tcaccagcca tgaaagccca ccccaaggag atggtgcctc tcatgggcaa
      181 gagagttgct gcccccagtg ggaaccctgc catcctgcca gagaagaggc cggcggagat
      241 cacccccaca aagaagagtg cacacttctt cctggagata gaagggtttg aacccaaccc
      301 cacagttgcc aagacctctc ctcctgtctt ctccaagccc atggattcca acatccggca
      361 gtgcatctct ggtaactgtg atgacatgga ctccccccag tctcctcagg atgatgtgac
      421 agagacccca tccaatccca acagccccag tgcacagctg gccaaggaag agcagaggag
      481 gaaaaagagg cggctgaaga agcgcatctt tgcagccgtg tctgagggct gcgtggagga
      541 gttggtagag ttgctggtgg agctgcagga gctttgcagg cggcgccatg atgaggatgt
      601 gcctgacttc ctcatgcaca agctgacggc ctccgacacg gggaagacct gcctgatgaa
      661 ggccttgtta aacatcaacc ccaacaccaa ggagatagtg cggatcctgc ttgcctttgc
      721 tgaagagaac gacatcctgg gcaggttcat caacgccgag tacacagagg aggcctatga
      781 agggcagacg gcgctgaaca tcgccatcga gcggcggcag ggggacatcg cagccctgct
      841 catcgccgcc ggcgccgacg tcaacgcgca cgccaagggg gccttcttca accccaagta
      901 ccaacacgaa ggcttctact tcggtgagac gcccctggcc ctggcagcat gcaccaacca
      961 gcccgagatt gtgcagctgc tgatggagca cgagcagacg gacatcacct cgcgggactc
     1021 acgaggcaac aacatccttc acgccctggt gaccgtggcc gaggacttca agacgcagaa
     1081 tgactttgtg aagcgcatgt acgacatgat cctactgcgg agtggcaact gggagctgga
     1141 gaccactcgc aacaacgatg gcctcacgcc gctgcagctg gccgccaaga tgggcaaggc
     1201 ggagatcctg aagtacatcc tcagtcgtga gatcaaggag aagcggctcc ggagcctgtc
     1261 caggaagttc accgactggg cgtacggacc cgtgtcatcc tccctctacg acctcaccaa
     1321 cgtggacacc accacggaca actcagtgct ggaaatcact gtctacaaca ccaacatcga
     1381 caaccggcat gagatgctga ccctggagcc gctgcacacg ctgctgcata tgaagtggaa
     1441 gaagtttgcc aagcacatgt tctttctgtc cttctgcttt tatttcttct acaacatcac
     1501 cctgaccctc gtctcgtact accgcccccg ggaggaggag gccatcccgc accccttggc
     1561 cctgacgcac aagatggggt ggctgcagct cctagggagg atgtttgtgc tcatctgggc
     1621 catgtgcatc tctgtgaaag agggcattgc catcttcctg ctgagaccct cggatctgca
     1681 gtccatcctc tcggatgcct ggttccactt tgtctttttt atccaagctg tgcttgtgat
     1741 actgtctgtc ttcttgtact tgtttgccta caaagagtac ctcgcctgcc tcgtgctggc
     1801 catggccctg ggctgggcga acatgctcta ctatacgcgg ggtttccagt ccatgggcat
     1861 gtacagcgtc atgatccaga aggtcatttt gcatgatgtt ctgaagttct tgtttgtata
     1921 tatcgtgttt ttgcttggat ttggagtagc cttggcctcg ctgatcgaga agtgtcccaa
     1981 agacaacaag gactgcagct cctacggcag cttcagcgac gcagtgctgg aactcttcaa
     2041 gctcaccata ggcctgggtg acctgaacat ccagcagaac tccaagtatc ccattctctt
     2101 tctgttcctg ctcatcacct atgtcatcct cacctttgtt ctcctcctca acatgctcat
     2161 tgctctgatg ggcgagactg tggagaacgt ctccaaggag agcgaacgca tctggcgcct
     2221 gcagagagcc aggaccatct tggagtttga gaaaatgtta ccagaatggc tgaggagcag
     2281 attccggatg ggagagctgt gcaaagtggc cgaggatgat ttccgactgt gtttgcggat
     2341 caatgaggtg aagtggactg aatggaagac gcacgtctcc ttccttaacg aagacccggg
     2401 gcctgtaaga cgaacagatt tcaacaaaat ccaagattct tccaggaaca acagcaaaac
     2461 cactctcaat gcatttgaag aagtcgagga attcccggaa acctcggtgt agaagcggaa
     2521 cccagagctg gtgtgcgcgt gcgctgtctg gcgctgcagg cggagtcacc gactctgtgc
     2581 agagaggctt tgagggatgg tggagtccgg ctctgctggc ctagaagcag agtgcaccct
     2641 cgtgctcagt gctcagtggg tgtctgaact gaggggcagt tgtcaatttg tctgagtggg
     2701 aaacatcctg gattttgtta cttggcaaac agctggtgta aacctacagc cagcagcagt
     2761 ctggagcctg ggagcctcct gaagtcccgg gtgaagcctc tggttttacc aattgcaggt
     2821 cggcttggct gggagagatg gatggcggga aaggggcagc agtcttgagg agcagggaga
     2881 ggagtctttc ctcctgccag cttcccccgt cagccccaac cccagcccac acattgtacc
     2941 atctcttctg ctgtgactgg gttgcctgaa tttgtgggag acccgtgatc ccatcccaga
     3001 gtgtgcgggg gacggaggta agctggatat cctgggggag gaggggaatg cgctctggaa
     3061 acacccttcc ggaacccttc ggggaaaagg agaccatcct tggagtgaac gtcccctgac
     3121 accccaaggt tcaaactgtc tcaagctgag agatgttttt agtagcagaa ttaacacagg
     3181 gttttaactt gcaatacgga aaagacattt cagttgagaa tgaaaattac tacaatgaag
     3241 tttgtgattt taaaagtgga gacagactgg gggctttggg gctggatgta agtattatat
     3301 atttggcctc agggtgccca gagcaagaca aaaagctttt cttcacacac acaaaagtct
     3361 gcatgagaca ctccgggcaa gtcctgctgg gccgccgcga tctgggtgaa aggtcctggc
     3421 tcttttcctc gtcctgacct cacagtagcg cgtgcctgtg tgctgggatc gtggctttcg
     3481 ctgaagcaga aatagcagct gctcgatcga tatcatcttg gaactcagca gttagtcgca
     3541 tacctcagta tgtctcagtg ggggaattta acaaaatgcc tcaactgctt tggtacgaag
     3601 tatttttttt ttaattttaa ctgtgaattt tgaagctgaa ggggaagctt gtgagagaaa
     3661 agcatttgcc aagactttga gcttattttt aggtcctcgt cctctgatgt tctctttctg
     3721 aaatgacacg gagtcagtct ggggggcaga ggtgaagtgg agacggaagg attttccagg
     3781 tgactggggc cgaaaccacc agaaaatcca ctctgccgcc gttatctggt gaaaggattc
     3841 atgtaaaaat gttcgaggtg gaattataaa aatagtaacc ataaatgtta atcttaaatg
     3901 gcagaaatag aaatttggcc ttcagataac atggcgatag ataagttcat ctggcttgag
     3961 gcaaactgaa gagtcggggc ctagcagtgc actctgggcc agtttctctg ccctgggcca
     4021 ctctgtgtgc cagactagct ggacagatag agactttgtg cccctgatgg ggccgattgg
     4081 ggagaggtgg gctggggtgt gtgaggcttc acaatccaca gcagcccctg ccctcccagc
     4141 tgacccaggg agtaatcgcg tgctctaagc cacagtggtc ggggctgggc atgggcctct
     4201 ggagaagaga agatttgagg agaactgtcc tagaggcagg aggagcagat gtgtttcaga
     4261 atgggcagaa ttaggaaatt gagaaagatt ttggctcaac agaatccagc aactgctcca
     4321 gatgttggag atgtttaagc agaagctggt tgcgcactta atgaggaatg ttgttgaaaa
     4381 tggtcattgg aagaagttta aggtcccttt tagcctggag attgtacaaa tcagcattcc
     4441 acatctggag ttagctaccc gcattaagcc tgaacagaca tcttggtctg aaaggaagtg
     4501 gtttggattc atgatgccaa gctccacact atggagctgg gaattccaga attgctttga
     4561 ctcagatatt aatggagaaa gtcatatcca ttaatggata aagccgtatc tgttatggat
     4621 aaagccgtat ccagagttgc tttgactcgg atgttaatgg ataaagccaa ttattgattt
     4681 ctatttgcct aacctgccag cttttgtcca agtggggaat ggagagccat agggatgttt
     4741 gtcatctcac atgttttggt gatctgctgt ctgtgggtct ggatggaatt tgttggcaag
     4801 accattttct gtattggata ttcttcccaa cagtgtccac cccaaaaggc tttcagccaa
     4861 aacgtctgag cctaggtagg tttaccaagg gaagccataa gtcaagaagc atcagagtga
     4921 aaaggagcac ttccttcatt ttacgcccag aggctaatgc tccgagagga atgtgtactt
     4981 gggcaaagtc atgcaggaag gtcatatcag agctgtggag gctggagtgt cctgattctt
     5041 ggaccacaga tgtctccctg agccattatt tatttatttt taaaaagcac agttattcca
     5101 tcattttgag tctttgtatt tcgcttatat tggggggcag gactattttc tcaggtgtct
     5161 catttggcag tcaacattgt cccctatgtt ccctatgact agttgaaaat tcaagtgtgc
     5221 ccacaggggt gcacaaaacc acacccatgc acacacacac cctcagcccc cacacacacc
     5281 ccgttgaacc cgtgggtcta tcaggacatc ctaaaactcc gtgattgaca tttcagtaat
     5341 ttcaggggaa ggtgttttcc agggatgggg tctcccaggt tcagatagtg cctttggctg
     5401 caaatgctcc tttagctaaa cttttcctca ggaagaattc attattctag acattatgtg
     5461 atatatctgt taggaataaa aggtgcttaa ccttcctccc tgggatgtgg gagaaggtgc
     5521 tggaggttgt actgtgaagt cttcaggctc ttagaaggct ccagcctgag agagcccttt
     5581 attattgaca ttcctgtcct tcctcaaggc ctggtgacct gtgacctttc gctctgggca
     5641 gggcccaggt agatgggccg tcatccgggc ctgtaagccg tacttgattt ctgcattgat
     5701 ttacatattt tttactgtga tcttggttcc aaacacagaa tcgtcacccc attctccctt
     5761 gaatgtgccg gatccttgta aattctcatt tacctacttg ttcttagtgt gtatgtgtgt
     5821 gcgaaactct atgttcaaga aagaaatcat acaaagagta agaacatgtt tgtgccattg
     5881 aagaaatggt tttttgattt ctaataaata tttgttttgc ctcgtta
//
