LOCUS       NM_016113               2779 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            V member 2 (TRPV2), mRNA.
ACCESSION   NM_016113 NM_015930
VERSION     NM_016113.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2779)
  AUTHORS   Fricke,T.C. and Leffler,A.
  TITLE     TRPV2: a universal regulator in cellular physiology with a yet
            poorly defined thermosensitivity
  JOURNAL   J Physiol Sci 74 (1), 42 (2024)
   PUBMED   39285320
  REMARK    GeneRIF: TRPV2: a universal regulator in cellular physiology with a
            yet poorly defined thermosensitivity.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2779)
  AUTHORS   Yang,S., Du,Y., Li,Y., Tang,Q., Zhang,Y. and Zhao,X.
  TITLE     Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel
            tune microglial beta-amyloid peptide phagocytosis
  JOURNAL   J Neuroinflammation 21 (1), 218 (2024)
   PUBMED   39227967
  REMARK    GeneRIF: Tyrosine phosphorylation and palmitoylation of TRPV2 ion
            channel tune microglial beta-amyloid peptide phagocytosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2779)
  AUTHORS   Kong,L., Cheng,C., Cheruiyot,A., Yuan,J., Yang,Y., Hwang,S.,
            Foust,D., Tsao,N., Wilkerson,E., Mosammaparast,N., Major,M.B.,
            Piston,D.W., Li,S. and You,Z.
  TITLE     TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic
            DNA to protect stressed replication forks
  JOURNAL   Nat Commun 15 (1), 4609 (2024)
   PUBMED   38816425
  REMARK    GeneRIF: TCAF1 promotes TRPV2-mediated Ca[2+] release in response
            to cytosolic DNA to protect stressed replication forks.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2779)
  AUTHORS   Dunne,O.M., Martin,S.L., Sergeant,G.P., McAuley,D.F., O'Kane,C.M.,
            Button,B., McGarvey,L.P. and Lundy,F.T.
  TITLE     TRPV2 modulates mechanically Induced ATP Release from Human
            bronchial epithelial cells
  JOURNAL   Respir Res 25 (1), 188 (2024)
   PUBMED   38678280
  REMARK    GeneRIF: TRPV2 modulates mechanically Induced ATP Release from
            Human bronchial epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2779)
  AUTHORS   Li,C., Zhao,M., Liu,X., Li,Y., Xu,B., Zhou,L., Sun,X., Sun,W.,
            Kang,N., Ji,Z., Li,T., An,H., Wang,F., Wu,C., Ye,J.Y., Zhang,J.R.,
            Wang,Q., Zhao,X., Li,Z. and Liu,W.
  TITLE     Ion channel TRPV2 is critical in enhancing B cell activation and
            function
  JOURNAL   J Exp Med 221 (3) (2024)
   PUBMED   38353705
  REMARK    GeneRIF: Ion channel TRPV2 is critical in enhancing B cell
            activation and function.
REFERENCE   6  (bases 1 to 2779)
  AUTHORS   Benham,C.D., Gunthorpe,M.J. and Davis,J.B.
  TITLE     TRPV channels as temperature sensors
  JOURNAL   Cell Calcium 33 (5-6), 479-487 (2003)
   PUBMED   12765693
  REMARK    Review article
REFERENCE   7  (bases 1 to 2779)
  AUTHORS   Voets,T., Prenen,J., Vriens,J., Watanabe,H., Janssens,A.,
            Wissenbach,U., Bodding,M., Droogmans,G. and Nilius,B.
  TITLE     Molecular determinants of permeation through the cation channel
            TRPV4
  JOURNAL   J Biol Chem 277 (37), 33704-33710 (2002)
   PUBMED   12093812
REFERENCE   8  (bases 1 to 2779)
  AUTHORS   Smith,G.D., Gunthorpe,M.J., Kelsell,R.E., Hayes,P.D., Reilly,P.,
            Facer,P., Wright,J.E., Jerman,J.C., Walhin,J.P., Ooi,L.,
            Egerton,J., Charles,K.J., Smart,D., Randall,A.D., Anand,P. and
            Davis,J.B.
  TITLE     TRPV3 is a temperature-sensitive vanilloid receptor-like protein
  JOURNAL   Nature 418 (6894), 186-190 (2002)
   PUBMED   12077606
REFERENCE   9  (bases 1 to 2779)
  AUTHORS   Tominaga,M. and Julius,D.
  TITLE     Capsaicin receptor in the pain pathway
  JOURNAL   Jpn J Pharmacol 83 (1), 20-24 (2000)
   PUBMED   10887936
  REMARK    Review article
REFERENCE   10 (bases 1 to 2779)
  AUTHORS   Caterina,M.J., Rosen,T.A., Tominaga,M., Brake,A.J. and Julius,D.
  TITLE     A capsaicin-receptor homologue with a high threshold for noxious
            heat
  JOURNAL   Nature 398 (6726), 436-441 (1999)
   PUBMED   10201375
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289705.1 and BC018926.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016113.4.
            
            Summary: This gene encodes an ion channel that is activated by high
            temperatures above 52 degrees Celsius. The protein may be involved
            in transduction of high-temperature heat responses in sensory
            ganglia. It is thought that in other tissues the channel may be
            activated by stimuli other than heat. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018926.2, AK289705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338560.12/ ENSP00000342222.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK289705.1         30-32
            4-2779              BC018926.2         1-2776
FEATURES             Location/Qualifiers
     source          1..2779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..2779
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /note="transient receptor potential cation channel
                     subfamily V member 2"
                     /db_xref="GeneID:51393"
                     /db_xref="HGNC:HGNC:18082"
                     /db_xref="MIM:606676"
     exon            1..263
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..570
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..2665
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /note="vanilloid receptor-like protein 1; OTRPC2;
                     osm-9-like TRP channel 2"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 2"
                     /protein_id="NP_057197.2"
                     /db_xref="CCDS:CCDS32576.1"
                     /db_xref="GeneID:51393"
                     /db_xref="HGNC:HGNC:18082"
                     /db_xref="MIM:606676"
                     /translation="MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQ
                     GEDRKFAPQIRVNLNYRKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTS
                     KYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDY
                     YRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAAC
                     TKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQA
                     GARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYG
                     PVRVSLYDLASVDSCEENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFF
                     LNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAEVGNSMLLTGHILILLGGIYLLVGQ
                     LWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWL
                     NLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAP
                     TGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLL
                     LLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRKKQ
                     RAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLA
                     SPPKEDEDGASEENYVPVQLLQSN"
     exon            571..704
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..995
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1294
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1465
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1621
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1720
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1791
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1957
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2024
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2359
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2484
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2564
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2779
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2758..2763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /note="hexamer: AATATA"
     polyA_site      2779
                     /gene="TRPV2"
                     /gene_synonym="VRL; VRL-1; VRL1"
                     /note="major polyA site"
ORIGIN      
        1 agtctctggt ggctagcctg tcctgacagg ggagagttaa gctcccgttc tccaccgtgc
       61 cggctggcca ggtgggctga gggtgaccga gagaccagaa cctgcttgct ggagcttagt
      121 gctcagagct ggggagggag gttccgccgc tcctctgctg tcagcgccgg cagcccctcc
      181 cggcttcact tcctcccgca gcccctgcta ctgagaagct ccgggatccc agcagccgcc
      241 acgccctggc ctcagcctgc ggggctccag tcaggccaac accgacgcgc agctgggagg
      301 aagacaggac ccttgacatc tccatctgca cagaggtcct ggctggaccg agcagcctcc
      361 tcctcctagg atgacctcac cctccagctc tccagttttc aggttggaga cattagatgg
      421 aggccaagaa gatggctctg aggcggacag aggaaagctg gattttggga gcgggctgcc
      481 tcccatggag tcacagttcc agggcgagga ccggaaattc gcccctcaga taagagtcaa
      541 cctcaactac cgaaagggaa caggtgccag tcagccggat ccaaaccgat ttgaccgaga
      601 tcggctcttc aatgcggtct cccggggtgt ccccgaggat ctggctggac ttccagagta
      661 cctgagcaag accagcaagt acctcaccga ctcggaatac acagagggct ccacaggtaa
      721 gacgtgcctg atgaaggctg tgctgaacct taaggacgga gtcaatgcct gcattctgcc
      781 actgctgcag atcgacaggg actctggcaa tcctcagccc ctggtaaatg cccagtgcac
      841 agatgactat taccgaggcc acagcgctct gcacatcgcc attgagaaga ggagtctgca
      901 gtgtgtgaag ctcctggtgg agaatggggc caatgtgcat gcccgggcct gcggccgctt
      961 cttccagaag ggccaaggga cttgctttta tttcggtgag ctacccctct ctttggccgc
     1021 ttgcaccaag cagtgggatg tggtaagcta cctcctggag aacccacacc agcccgccag
     1081 cctgcaggcc actgactccc agggcaacac agtcctgcat gccctagtga tgatctcgga
     1141 caactcagct gagaacattg cactggtgac cagcatgtat gatgggctcc tccaagctgg
     1201 ggcccgcctc tgccctaccg tgcagcttga ggacatccgc aacctgcagg atctcacgcc
     1261 tctgaagctg gccgccaagg agggcaagat cgagattttc aggcacatcc tgcagcggga
     1321 gttttcagga ctgagccacc tttcccgaaa gttcaccgag tggtgctatg ggcctgtccg
     1381 ggtgtcgctg tatgacctgg cttctgtgga cagctgtgag gagaactcag tgctggagat
     1441 cattgccttt cattgcaaga gcccgcaccg acaccgaatg gtcgttttgg agcccctgaa
     1501 caaactgctg caggcgaaat gggatctgct catccccaag ttcttcttaa acttcctgtg
     1561 taatctgatc tacatgttca tcttcaccgc tgttgcctac catcagccta ccctgaagaa
     1621 gcaggccgcc cctcacctga aagcggaggt tggaaactcc atgctgctga cgggccacat
     1681 ccttatcctg ctagggggga tctacctcct cgtgggccag ctgtggtact tctggcggcg
     1741 ccacgtgttc atctggatct cgttcataga cagctacttt gaaatcctct tcctgttcca
     1801 ggccctgctc acagtggtgt cccaggtgct gtgtttcctg gccatcgagt ggtacctgcc
     1861 cctgcttgtg tctgcgctgg tgctgggctg gctgaacctg ctttactata cacgtggctt
     1921 ccagcacaca ggcatctaca gtgtcatgat ccagaaggtc atcctgcggg acctgctgcg
     1981 cttccttctg atctacttag tcttcctttt cggcttcgct gtagccctgg tgagcctgag
     2041 ccaggaggct tggcgccccg aagctcctac aggccccaat gccacagagt cagtgcagcc
     2101 catggaggga caggaggacg agggcaacgg ggcccagtac aggggtatcc tggaagcctc
     2161 cttggagctc ttcaaattca ccatcggcat gggcgagctg gccttccagg agcagctgca
     2221 cttccgcggc atggtgctgc tgctgctgct ggcctacgtg ctgctcacct acatcctgct
     2281 gctcaacatg ctcatcgccc tcatgagcga gaccgtcaac agtgtcgcca ctgacagctg
     2341 gagcatctgg aagctgcaga aagccatctc tgtcctggag atggagaatg gctattggtg
     2401 gtgcaggaag aagcagcggg caggtgtgat gctgaccgtt ggcactaagc cagatggcag
     2461 ccccgatgag cgctggtgct tcagggtgga ggaggtgaac tgggcttcat gggagcagac
     2521 gctgcctacg ctgtgtgagg acccgtcagg ggcaggtgtc cctcgaactc tcgagaaccc
     2581 tgtcctggct tcccctccca aggaggatga ggatggtgcc tctgaggaaa actatgtgcc
     2641 cgtccagctc ctccagtcca actgatggcc cagatgcagc aggaggccag aggacagagc
     2701 agaggatctt tccaaccaca tctgctggct ctggggtccc agtgaattct ggtggcaaat
     2761 atatattttc actaactaa
//
