LOCUS       NM_080704               4164 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            V member 1 (TRPV1), transcript variant 1, mRNA.
ACCESSION   NM_080704 XM_005256783
VERSION     NM_080704.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Mohanta,S., Saha,S., Das,N.K., Swain,N., Kumar,S. and Goswami,C.
  TITLE     Tubulin interaction at tubulin-binding sequence 1 (TBS1) is
            required for proper surface expression and TRPV1 channel activity
  JOURNAL   Life Sci 357, 123070 (2024)
   PUBMED   39332490
  REMARK    GeneRIF: Tubulin interaction at tubulin-binding sequence 1 (TBS1)
            is required for proper surface expression and TRPV1 channel
            activity.
REFERENCE   2  (bases 1 to 4164)
  AUTHORS   Gualdani,R., Barbeau,S., Yuan,J.H., Jacobs,D.S., Gailly,P.,
            Dib-Hajj,S.D. and Waxman,S.G.
  TITLE     TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin
            sensitization, and capsaicin desensitization
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2406186121 (2024)
   PUBMED   39226353
  REMARK    GeneRIF: TRPV1 corneal neuralgia mutation: Enhanced pH response,
            bradykinin sensitization, and capsaicin desensitization.
REFERENCE   3  (bases 1 to 4164)
  AUTHORS   Bai,W., Xiao,G., Xie,G., Chen,Z., Xu,X., Zeng,J. and Xie,J.
  TITLE     METTL3/IGF2BP1 influences the development of non-small-cell lung
            cancer by mediating m6A methylation modification of TRPV1
  JOURNAL   Thorac Cancer 15 (26), 1871-1881 (2024)
   PUBMED   39090761
  REMARK    GeneRIF: METTL3/IGF2BP1 influences the development of
            non-small-cell lung cancer by mediating m6A methylation
            modification of TRPV1.
REFERENCE   4  (bases 1 to 4164)
  AUTHORS   Gianni,M., Antinucci,M., Bertoncini,S., Taglioli,L., Giuliani,C.,
            Luiselli,D., Risso,D., Marini,E., Morini,G. and Tofanelli,S.
  TITLE     Association between Variants of the TRPV1 Gene and Body Composition
            in Sub-Saharan Africans
  JOURNAL   Genes (Basel) 15 (6), 752 (2024)
   PUBMED   38927688
  REMARK    GeneRIF: Association between Variants of the TRPV1 Gene and Body
            Composition in Sub-Saharan Africans.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4164)
  AUTHORS   Kim,M.S. and Simons,C.T.
  TITLE     The role of TRPA1 and TRPV1 in the perception of astringency
  JOURNAL   Chem Senses 49 (2024)
   PUBMED   39223911
  REMARK    GeneRIF: The role of TRPA1 and TRPV1 in the perception of
            astringency.
REFERENCE   6  (bases 1 to 4164)
  AUTHORS   Olah,Z., Szabo,T., Karai,L., Hough,C., Fields,R.D., Caudle,R.M.,
            Blumberg,P.M. and Iadarola,M.J.
  TITLE     Ligand-induced dynamic membrane changes and cell deletion conferred
            by vanilloid receptor 1
  JOURNAL   J Biol Chem 276 (14), 11021-11030 (2001)
   PUBMED   11124944
REFERENCE   7  (bases 1 to 4164)
  AUTHORS   Hayes,P., Meadows,H.J., Gunthorpe,M.J., Harries,M.H.,
            Duckworth,M.D., Cairns,W., Harrison,D.C., Clarke,C.E.,
            Ellington,K., Prinjha,R.K., Barton,A.J.L., Medhurst,A.D.,
            Smith,G.D., Topp,S., Murdock,P., Sanger,G.J., Terrett,J.,
            Jenkins,O., Benham,C.D., Randall,A.D., Gloger,I.S. and Davis,J.B.
  TITLE     Cloning and functional expression of a human orthologue of rat
            vanilloid receptor-1
  JOURNAL   Pain 88 (2), 205-215 (2000)
   PUBMED   11050376
REFERENCE   8  (bases 1 to 4164)
  AUTHORS   Mezey,E., Toth,Z.E., Cortright,D.N., Arzubi,M.K., Krause,J.E.,
            Elde,R., Guo,A., Blumberg,P.M. and Szallasi,A.
  TITLE     Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and
            VR1-like immunoreactivity, in the central nervous system of the rat
            and human
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3655-3660 (2000)
   PUBMED   10725386
REFERENCE   9  (bases 1 to 4164)
  AUTHORS   Caterina,M.J., Rosen,T.A., Tominaga,M., Brake,A.J. and Julius,D.
  TITLE     A capsaicin-receptor homologue with a high threshold for noxious
            heat
  JOURNAL   Nature 398 (6726), 436-441 (1999)
   PUBMED   10201375
REFERENCE   10 (bases 1 to 4164)
  AUTHORS   Caterina,M.J., Schumacher,M.A., Tominaga,M., Rosen,T.A.,
            Levine,J.D. and Julius,D.
  TITLE     The capsaicin receptor: a heat-activated ion channel in the pain
            pathway
  JOURNAL   Nature 389 (6653), 816-824 (1997)
   PUBMED   9349813
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027796.9, AF196175.1,
            AJ272063.2 and AL136801.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_080704.3.
            
            Summary: Capsaicin, the main pungent ingredient in hot chili
            peppers, elicits a sensation of burning pain by selectively
            activating sensory neurons that convey information about noxious
            stimuli to the central nervous system. The protein encoded by this
            gene is a receptor for capsaicin and is a non-selective cation
            channel that is structurally related to members of the TRP family
            of ion channels. This receptor is also activated by increases in
            temperature in the noxious range, suggesting that it functions as a
            transducer of painful thermal stimuli in vivo. Four transcript
            variants encoding the same protein, but with different 5' UTR
            sequence, have been described for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) contains a different segment
            in the 5' UTR, compared to variant 3. Variants 1-4 all encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136801.1, SRR14038193.837262.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000572705.2/ ENSP00000459962.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC027796.9         53491-53593
            104-242             AC027796.9         54337-54475
            243-1680            AF196175.1         181-1618
            1681-2622           AJ272063.2         1564-2505
            2623-3503           AC027796.9         95914-96794
            3504-4164           AL136801.1         3499-4159
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..4164
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /note="transient receptor potential cation channel
                     subfamily V member 1"
                     /db_xref="GeneID:7442"
                     /db_xref="HGNC:HGNC:12716"
                     /db_xref="MIM:602076"
     exon            1..103
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            104..242
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..559
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..2795
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /note="capsaicin receptor; vanilloid receptor subtype 1;
                     transient receptor potential vanilloid 1b; transient
                     receptor potential vanilloid 1a; OTRPC1; osm-9-like TRP
                     channel 1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 1"
                     /protein_id="NP_542435.2"
                     /db_xref="CCDS:CCDS45576.1"
                     /db_xref="GeneID:7442"
                     /db_xref="HGNC:HGNC:12716"
                     /db_xref="MIM:602076"
                     /translation="MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAK
                     SRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSV
                     AASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLL
                     KAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALV
                     TLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTA
                     DISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKG
                     MTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCE
                     KNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFT
                     MAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFV
                     DSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYA
                     VMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPP
                     DSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIAL
                     MGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYR
                     WCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLR
                     EASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK"
     exon            560..726
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..879
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1020
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1319
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1499
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1658
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1751
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1822
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1988
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2055
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2378
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2506
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2622
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..4164
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4141..4146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /note="hexamer: AATAAA"
     polyA_site      4164
                     /gene="TRPV1"
                     /gene_synonym="VR1"
                     /note="major polyA site"
ORIGIN      
        1 ggctcaggca ggcctggccc agagtcacgc tggcaaccac gagtttggga agcagtcgta
       61 ttctctctct ctctctctct ctctctctca gtatccatga cagtgtgatg gagagtctct
      121 gccgtgccat ctgggatgca aaccgtccct gtgttcccca cgtccaggcc gtagatgctc
      181 cccgccggtc agtcacttag tcgtcagatc gcccgtcctg gtatcacagt gcttctgttc
      241 aggttgcaca ctgggccaca gaggatccag caaggatgaa gaaatggagc agcacagact
      301 tgggggcagc tgcggaccca ctccaaaagg acacctgccc agaccccctg gatggagacc
      361 ctaactccag gccacctcca gccaagcccc agctctccac ggccaagagc cgcacccggc
      421 tctttgggaa gggtgactcg gaggaggctt tcccggtgga ttgccctcac gaggaaggtg
      481 agctggactc ctgcccgacc atcacagtca gccctgttat caccatccag aggccaggag
      541 acggccccac cggtgccagg ctgctgtccc aggactctgt cgccgccagc accgagaaga
      601 ccctcaggct ctatgatcgc aggagtatct ttgaagccgt tgctcagaat aactgccagg
      661 atctggagag cctgctgctc ttcctgcaga agagcaagaa gcacctcaca gacaacgagt
      721 tcaaagaccc tgagacaggg aagacctgtc tgctgaaagc catgctcaac ctgcacgacg
      781 gacagaacac caccatcccc ctgctcctgg agatcgcgcg gcaaacggac agcctgaagg
      841 agcttgtcaa cgccagctac acggacagct actacaaggg ccagacagca ctgcacatcg
      901 ccatcgagag acgcaacatg gccctggtga ccctcctggt ggagaacgga gcagacgtcc
      961 aggctgcggc ccatggggac ttctttaaga aaaccaaagg gcggcctgga ttctacttcg
     1021 gtgaactgcc cctgtccctg gccgcgtgca ccaaccagct gggcatcgtg aagttcctgc
     1081 tgcagaactc ctggcagacg gccgacatca gcgccaggga ctcggtgggc aacacggtgc
     1141 tgcacgccct ggtggaggtg gccgacaaca cggccgacaa cacgaagttt gtgacgagca
     1201 tgtacaatga gattctgatg ctgggggcca aactgcaccc gacgctgaag ctggaggagc
     1261 tcaccaacaa gaagggaatg acgccgctgg ctctggcagc tgggaccggg aagatcgggg
     1321 tcttggccta tattctccag cgggagatcc aggagcccga gtgcaggcac ctgtccagga
     1381 agttcaccga gtgggcctac gggcccgtgc actcctcgct gtacgacctg tcctgcatcg
     1441 acacctgcga gaagaactcg gtgctggagg tgatcgccta cagcagcagc gagaccccta
     1501 atcgccacga catgctcttg gtggagccgc tgaaccgact cctgcaggac aagtgggaca
     1561 gattcgtcaa gcgcatcttc tacttcaact tcctggtcta ctgcctgtac atgatcatct
     1621 tcaccatggc tgcctactac aggcccgtgg atggcttgcc tccctttaag atggaaaaaa
     1681 ctggagacta tttccgagtt actggagaga tcctgtctgt gttaggagga gtctacttct
     1741 ttttccgagg gattcagtat ttcctgcaga ggcggccgtc gatgaagacc ctgtttgtgg
     1801 acagctacag tgagatgctt ttctttctgc agtcactgtt catgctggcc accgtggtgc
     1861 tgtacttcag ccacctcaag gagtatgtgg cttccatggt attctccctg gccttgggct
     1921 ggaccaacat gctctactac acccgcggtt tccagcagat gggcatctat gccgtcatga
     1981 tagagaagat gatcctgaga gacctgtgcc gtttcatgtt tgtctacatc gtcttcttgt
     2041 tcgggttttc cacagcggtg gtgacgctga ttgaagacgg gaagaatgac tccctgccgt
     2101 ctgagtccac gtcgcacagg tggcgggggc ctgcctgcag gccccccgat agctcctaca
     2161 acagcctgta ctccacctgc ctggagctgt tcaagttcac catcggcatg ggcgacctgg
     2221 agttcactga gaactatgac ttcaaggctg tcttcatcat cctgctgctg gcctatgtaa
     2281 ttctcaccta catcctcctg ctcaacatgc tcatcgccct catgggtgag actgtcaaca
     2341 agatcgcaca ggagagcaag aacatctgga agctgcagag agccatcacc atcctggaca
     2401 cggagaagag cttccttaag tgcatgagga aggccttccg ctcaggcaag ctgctgcagg
     2461 tggggtacac acctgatggc aaggacgact accggtggtg cttcagggtg gacgaggtga
     2521 actggaccac ctggaacacc aacgtgggca tcatcaacga agacccgggc aactgtgagg
     2581 gcgtcaagcg caccctgagc ttctccctgc ggtcaagcag agtttcaggc agacactgga
     2641 agaactttgc cctggtcccc cttttaagag aggcaagtgc tcgagatagg cagtctgctc
     2701 agcccgagga agtttatctg cgacagtttt cagggtctct gaagccagag gacgctgagg
     2761 tcttcaagag tcctgccgct tccggggaga agtgaggacg tcacgcagac agcactgtca
     2821 acactgggcc ttaggagacc ccgttgccac ggggggctgc tgagggaaca ccagtgctct
     2881 gtcagcagcc tggcctggtc tgtgcctgcc cagcatgttc ccaaatctgt gctggacaag
     2941 ctgtgggaag cgttcttgga agcatgggga gtgatgtaca tccaaccgtc actgtcccca
     3001 agtgaatctc ctaacagact ttcaggtttt tactcacttt actaaacagt ttggatggtc
     3061 agtctctact gggacatgtt aggcccttgt tttctttgat tttattcttt tttttgagac
     3121 agaatttcac tcttctcacc caggctggaa tgcagtggca caattttggc tccctgcaac
     3181 ctccgcctcc tggattccag caattctcct gcctcggctt cccaagtagc tgggattaca
     3241 ggcacgtgcc accatgtctg gctaattttt tgtatttttt taatagatat ggggtttcgc
     3301 catgttggcc aggctggtct cgaactcctg acctcaggtg atccgcccac ctcggcctcc
     3361 caaagtgctg ggattacagg tgtgagcctc cacacctggc tgttttcttt gattttattc
     3421 tttttttttt tttctgtgag acagagtttc actcttgttg cccaggctgg agtgcagtgg
     3481 tgtgatcttg gctcactgca acttctgcct cccgggttca agcgattctt ctgcttcagt
     3541 ctcccaagta gcttggatta caggtgagca ctaccacgcc cggctaattt ttgtattttt
     3601 aatagagacg gggtttcacc atgttggcca ggctggtctc gaactcttga cctcaggtga
     3661 tctgcccgcc ttggcctccc aaagtgctgg gattacaggt gtgagccgct gcgctcggcc
     3721 ttctttgatt ttatattatt aggagcaaaa gtaaatgaag cccaggaaaa cacctttggg
     3781 aacaaactct tcctttgatg gaaaatgcag aggcccttcc tctctgtgcc gtgcttgctc
     3841 ctcttacctg cccgggtggt ttgggggtgt tggtgtttcc tccctggaga agatggggga
     3901 ggctgtccca ctcccagctc tggcagaatc aagctgttgc agcagtgcct tcttcatcct
     3961 tccttacgat caatcacagt ctccagaaga tcagctcaat tgctgtgcag gttaaaacta
     4021 cagaaccaca tcccaaaggt acctggtaag aatgtttgaa agatcttcca tttctaggaa
     4081 ccccagtcct gcttctccgc aatggcacat gcttccactc catccatact ggcatcctca
     4141 aataaacaga tatgtataca tata
//
