LOCUS       NM_031472                884 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tRNA phosphotransferase 1 (TRPT1), transcript variant
            2, mRNA.
ACCESSION   NM_031472
VERSION     NM_031472.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 884)
  AUTHORS   Yang,X., Wang,J., Li,S., Li,X., Gong,J., Yan,Z., Zhou,H., Wu,C. and
            Liu,X.
  TITLE     Structural and biochemical insights into the molecular mechanism of
            TRPT1 for nucleic acid ADP-ribosylation
  JOURNAL   Nucleic Acids Res 51 (14), 7649-7665 (2023)
   PUBMED   37334830
  REMARK    GeneRIF: Structural and biochemical insights into the molecular
            mechanism of TRPT1 for nucleic acid ADP-ribosylation.
REFERENCE   2  (bases 1 to 884)
  AUTHORS   Weixler,L., Feijs,K.L.H. and Zaja,R.
  TITLE     ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and
            multiple PARPs
  JOURNAL   Nucleic Acids Res 50 (16), 9426-9441 (2022)
   PUBMED   36018800
  REMARK    GeneRIF: ADP-ribosylation of RNA in mammalian cells is mediated by
            TRPT1 and multiple PARPs.
REFERENCE   3  (bases 1 to 884)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 884)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 884)
  AUTHORS   Mick,E., McGough,J., Loo,S., Doyle,A.E., Wozniak,J., Wilens,T.E.,
            Smalley,S., McCracken,J., Biederman,J. and Faraone,S.V.
  TITLE     Genome-wide association study of the child behavior checklist
            dysregulation profile
  JOURNAL   J Am Acad Child Adolesc Psychiatry 50 (8), 807-17 (2011)
   PUBMED   21784300
REFERENCE   6  (bases 1 to 884)
  AUTHORS   Hu,Q.D., Lu,H., Huo,K., Ying,K., Li,J., Xie,Y., Mao,Y. and Li,Y.Y.
  TITLE     A human homolog of the yeast gene encoding tRNA
            2'-phosphotransferase: cloning, characterization and
            complementation analysis
  JOURNAL   Cell Mol Life Sci 60 (8), 1725-1732 (2003)
   PUBMED   14504659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006334.1 and AP005668.2.
            
            On May 31, 2019 this sequence version replaced NM_031472.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138527.455898.1, BC005133.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AP006334.1         24776-24912         c
            138-219             AP006334.1         24225-24306         c
            220-389             AP006334.1         23527-23696         c
            390-479             AP006334.1         23354-23443         c
            480-564             AP005668.2         39871-39955         c
            565-621             AP005668.2         39613-39669         c
            622-732             AP005668.2         39428-39538         c
            733-884             AP005668.2         39144-39295         c
FEATURES             Location/Qualifiers
     source          1..884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..884
                     /gene="TRPT1"
                     /note="tRNA phosphotransferase 1"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
     exon            1..137
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..219
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..824
                     /gene="TRPT1"
                     /EC_number="2.7.1.160"
                     /note="isoform 2 is encoded by transcript variant 2; tRNA
                     2'-phosphotransferase 1; tRNA splicing 2'
                     phosphotransferase 1"
                     /codon_start=1
                     /product="tRNA 2'-phosphotransferase 1 isoform 2"
                     /protein_id="NP_113660.1"
                     /db_xref="CCDS:CCDS44639.1"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
                     /translation="MGADGFVPLGTLLQLPQFRGFSAEDVQRVVDTNRKQRFALQLGD
                     PSTGLLIRANQGHSLQVPKLELMPLETPQALPPMLVHGTFWKHWPSILLKGLSCQGRT
                     HIHLAPGLPGDPGIISGMRSHCEIAVFIDGPLALADGIPFFRSANGVILTPGNTDGFL
                     LPKYFKEALQLRPTRKPLSLAGDEETECQSSPKHSSRERRRIQQ"
     exon            220..389
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..564
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..621
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..732
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..884
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      820..825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPT1"
                     /note="hexamer: AATAAA"
     regulatory      835..840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPT1"
                     /note="hexamer: TATAAA"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPT1"
                     /note="hexamer: AAGAAA"
     polyA_site      847
                     /gene="TRPT1"
                     /note="major polyA site"
     polyA_site      856
                     /gene="TRPT1"
                     /note="major polyA site"
     regulatory      862..867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPT1"
                     /note="hexamer: AAGAAA"
     polyA_site      867
                     /gene="TRPT1"
                     /note="major polyA site"
     polyA_site      884
                     /gene="TRPT1"
                     /note="major polyA site"
ORIGIN      
        1 gtccccgccg ccccgacgct tccgcccggt ccgtcggcac gtcggccctg cctcccggac
       61 caccctgcgg ggcgcaccag cgatctgggg tgcggggctc ggcctccctg cgctcctggc
      121 tgaccgtgtg accttgggac cgagacgtgc agctgtccaa ggctctgtcc tatgccctgc
      181 gccatggggc cttgaagctg gggcttccca tgggagctga tggcttcgtg cccctgggca
      241 ccctcctgca gttgccccag ttccgcggct tctctgctga agatgtgcag cgcgtggtgg
      301 acaccaatag gaagcagcgg ttcgccctgc agctggggga tcccagcact ggccttctca
      361 tccgggccaa ccagggccat tccctgcagg tacctaagtt ggagctgatg cccctggaga
      421 caccgcaggc cctgcccccg atgctagtcc atggtacatt ctggaagcac tggccatcca
      481 tcctactcaa aggcctgtcc tgccagggaa ggacgcacat tcacctggcc ccaggactgc
      541 ctggagaccc cggtatcatc agtggcatgc ggtcccattg tgaaatagct gtgttcatcg
      601 atggacccct ggctctggca gatggaatac ccttcttccg ctctgccaat ggggtgattc
      661 tgactccagg gaatactgat ggcttcctcc ttcccaagta cttcaaggag gccctgcagc
      721 tacgccctac ccgaaagccc ctttccttgg ctggtgatga agagacagag tgtcagagta
      781 gccccaagca cagctccaga gaaaggagga ggatccaaca ataaaatatt aatttataaa
      841 aaagaaattt taaaaagtaa caagaaagaa ctcgtttgaa acca
//
