LOCUS       NM_001033678             968 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tRNA phosphotransferase 1 (TRPT1), transcript variant
            1, mRNA.
ACCESSION   NM_001033678
VERSION     NM_001033678.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 968)
  AUTHORS   Yang,X., Wang,J., Li,S., Li,X., Gong,J., Yan,Z., Zhou,H., Wu,C. and
            Liu,X.
  TITLE     Structural and biochemical insights into the molecular mechanism of
            TRPT1 for nucleic acid ADP-ribosylation
  JOURNAL   Nucleic Acids Res 51 (14), 7649-7665 (2023)
   PUBMED   37334830
  REMARK    GeneRIF: Structural and biochemical insights into the molecular
            mechanism of TRPT1 for nucleic acid ADP-ribosylation.
REFERENCE   2  (bases 1 to 968)
  AUTHORS   Weixler,L., Feijs,K.L.H. and Zaja,R.
  TITLE     ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and
            multiple PARPs
  JOURNAL   Nucleic Acids Res 50 (16), 9426-9441 (2022)
   PUBMED   36018800
  REMARK    GeneRIF: ADP-ribosylation of RNA in mammalian cells is mediated by
            TRPT1 and multiple PARPs.
REFERENCE   3  (bases 1 to 968)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 968)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 968)
  AUTHORS   Mick,E., McGough,J., Loo,S., Doyle,A.E., Wozniak,J., Wilens,T.E.,
            Smalley,S., McCracken,J., Biederman,J. and Faraone,S.V.
  TITLE     Genome-wide association study of the child behavior checklist
            dysregulation profile
  JOURNAL   J Am Acad Child Adolesc Psychiatry 50 (8), 807-17 (2011)
   PUBMED   21784300
REFERENCE   6  (bases 1 to 968)
  AUTHORS   Hu,Q.D., Lu,H., Huo,K., Ying,K., Li,J., Xie,Y., Mao,Y. and Li,Y.Y.
  TITLE     A human homolog of the yeast gene encoding tRNA
            2'-phosphotransferase: cloning, characterization and
            complementation analysis
  JOURNAL   Cell Mol Life Sci 60 (8), 1725-1732 (2003)
   PUBMED   14504659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006334.1 and AP005668.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001033678.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY211494.1, SRR18074968.4178733.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317459.11/ ENSP00000314073.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AP006334.1         24776-24912         c
            138-221             AP006334.1         24512-24595         c
            222-303             AP006334.1         24225-24306         c
            304-473             AP006334.1         23527-23696         c
            474-563             AP006334.1         23354-23443         c
            564-648             AP005668.2         39871-39955         c
            649-705             AP005668.2         39613-39669         c
            706-816             AP005668.2         39428-39538         c
            817-968             AP005668.2         39144-39295         c
FEATURES             Location/Qualifiers
     source          1..968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..968
                     /gene="TRPT1"
                     /note="tRNA phosphotransferase 1"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
     exon            1..137
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..221
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..908
                     /gene="TRPT1"
                     /EC_number="2.7.1.160"
                     /note="isoform 1 is encoded by transcript variant 1; tRNA
                     2'-phosphotransferase 1; tRNA splicing 2'
                     phosphotransferase 1"
                     /codon_start=1
                     /product="tRNA 2'-phosphotransferase 1 isoform 1"
                     /protein_id="NP_001028850.2"
                     /db_xref="CCDS:CCDS31595.1"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
                     /translation="MNFSGGGRQEAAGSRGRRAPRPREQDRDVQLSKALSYALRHGAL
                     KLGLPMGADGFVPLGTLLQLPQFRGFSAEDVQRVVDTNRKQRFALQLGDPSTGLLIRA
                     NQGHSLQVPKLELMPLETPQALPPMLVHGTFWKHWPSILLKGLSCQGRTHIHLAPGLP
                     GDPGIISGMRSHCEIAVFIDGPLALADGIPFFRSANGVILTPGNTDGFLLPKYFKEAL
                     QLRPTRKPLSLAGDEETECQSSPKHSSRERRRIQQ"
     exon            222..303
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..473
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..648
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..705
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..816
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..968
                     /gene="TRPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      904..909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPT1"
                     /note="hexamer: AATAAA"
     regulatory      919..924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPT1"
                     /note="hexamer: TATAAA"
     regulatory      926..931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPT1"
                     /note="hexamer: AAGAAA"
     polyA_site      931
                     /gene="TRPT1"
                     /note="major polyA site"
     polyA_site      940
                     /gene="TRPT1"
                     /note="major polyA site"
     regulatory      946..951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPT1"
                     /note="hexamer: AAGAAA"
     polyA_site      951
                     /gene="TRPT1"
                     /note="major polyA site"
     polyA_site      968
                     /gene="TRPT1"
                     /note="major polyA site"
ORIGIN      
        1 gtccccgccg ccccgacgct tccgcccggt ccgtcggcac gtcggccctg cctcccggac
       61 caccctgcgg ggcgcaccag cgatctgggg tgcggggctc ggcctccctg cgctcctggc
      121 tgaccgtgtg accttgggtc ttaaccatga acttctctgg aggagggagg caggaagcag
      181 cagggtccag gggtagaagg gctcccagac cccgagaaca ggaccgagac gtgcagctgt
      241 ccaaggctct gtcctatgcc ctgcgccatg gggccttgaa gctggggctt cccatgggag
      301 ctgatggctt cgtgcccctg ggcaccctcc tgcagttgcc ccagttccgc ggcttctctg
      361 ctgaagatgt gcagcgcgtg gtggacacca ataggaagca gcggttcgcc ctgcagctgg
      421 gggatcccag cactggcctt ctcatccggg ccaaccaggg ccattccctg caggtaccta
      481 agttggagct gatgcccctg gagacaccgc aggccctgcc cccgatgcta gtccatggta
      541 cattctggaa gcactggcca tccatcctac tcaaaggcct gtcctgccag ggaaggacgc
      601 acattcacct ggccccagga ctgcctggag accccggtat catcagtggc atgcggtccc
      661 attgtgaaat agctgtgttc atcgatggac ccctggctct ggcagatgga atacccttct
      721 tccgctctgc caatggggtg attctgactc cagggaatac tgatggcttc ctccttccca
      781 agtacttcaa ggaggccctg cagctacgcc ctacccgaaa gcccctttcc ttggctggtg
      841 atgaagagac agagtgtcag agtagcccca agcacagctc cagagaaagg aggaggatcc
      901 aacaataaaa tattaattta taaaaaagaa attttaaaaa gtaacaagaa agaactcgtt
      961 tgaaacca
//
