LOCUS       NM_014112               9964 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens transcriptional repressor GATA binding 1 (TRPS1),
            transcript variant 1, mRNA.
ACCESSION   NM_014112
VERSION     NM_014112.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9964)
  AUTHORS   He,X., Huang,H., Liu,Y., Li,H. and Ren,H.
  TITLE     Analysis of the function, mechanism and clinical application
            prospect of TRPS1, a new marker for breast cancer
  JOURNAL   Gene 932, 148880 (2025)
   PUBMED   39181273
  REMARK    GeneRIF: Analysis of the function, mechanism and clinical
            application prospect of TRPS1, a new marker for breast cancer.
            Review article
REFERENCE   2  (bases 1 to 9964)
  AUTHORS   Zhang,Y., Hu,Y., Lei,L., Jiang,L., Fu,C., Chen,M., Wu,S., Duan,X.,
            Chen,J. and Zeng,Q.
  TITLE     UVB-induced TRPS1 regulates MITF transcription activity to promote
            skin pigmentation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167445 (2024)
   PUBMED   39074626
  REMARK    GeneRIF: UVB-induced TRPS1 regulates MITF transcription activity to
            promote skin pigmentation.
REFERENCE   3  (bases 1 to 9964)
  AUTHORS   Cai,J., Zhang,W., Lu,Y., Liu,W., Zhou,H., Liu,M., Bi,X., Liu,J.,
            Chen,J., Yin,Y., Deng,Y., Luo,Z., Yang,Y., Chen,Q., Chen,X., Xu,Z.,
            Zhang,Y., Wu,C., Long,Q., Huang,C., Yan,C., Liu,Y., Guo,L., Li,W.,
            Yuan,P., Jiao,Y., Song,W., Wang,X., Huang,Z., Ying,J. and Zhao,H.
  TITLE     Single-cell exome sequencing reveals polyclonal seeding and TRPS1
            mutations in colon cancer metastasis
  JOURNAL   Signal Transduct Target Ther 9 (1), 247 (2024)
   PUBMED   39307879
  REMARK    GeneRIF: Single-cell exome sequencing reveals polyclonal seeding
            and TRPS1 mutations in colon cancer metastasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9964)
  AUTHORS   Herlin,L.K., Herlin,M.K., Blechingberg,J., Ronholt,K.,
            Graversen,L., Schmidt,S.A.J., Jorgensen,M.W., Hellfritzsch,M.B.,
            Hald,J.D., Beck-Nielsen,S.S., Gjorup,H., Andersen,B.N.,
            Gregersen,P.A. and Sommerlund,M.
  TITLE     Clinical presentation and genetics of tricho-rhino-phalangeal
            syndrome (TRPS) type 1: A single-center case series of 15 patients
            and seven novel TRPS1 variants
  JOURNAL   Eur J Med Genet 69, 104937 (2024)
   PUBMED   38574886
  REMARK    GeneRIF: Clinical presentation and genetics of
            tricho-rhino-phalangeal syndrome (TRPS) type 1: A single-center
            case series of 15 patients and seven novel TRPS1 variants.
REFERENCE   5  (bases 1 to 9964)
  AUTHORS   Scott,T.G., Sathyan,K.M., Gioeli,D. and Guertin,M.J.
  TITLE     TRPS1 modulates chromatin accessibility to regulate estrogen
            receptor alpha (ER) binding and ER target gene expression in
            luminal breast cancer cells
  JOURNAL   PLoS Genet 20 (2), e1011159 (2024)
   PUBMED   38377146
  REMARK    GeneRIF: TRPS1 modulates chromatin accessibility to regulate
            estrogen receptor alpha (ER) binding and ER target gene expression
            in luminal breast cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9964)
  AUTHORS   Momeni,P., Glockner,G., Schmidt,O., von Holtum,D., Albrecht,B.,
            Gillessen-Kaesbach,G., Hennekam,R., Meinecke,P., Zabel,B.,
            Rosenthal,A., Horsthemke,B. and Ludecke,H.J.
  TITLE     Mutations in a new gene, encoding a zinc-finger protein, cause
            tricho-rhino-phalangeal syndrome type I
  JOURNAL   Nat Genet 24 (1), 71-74 (2000)
   PUBMED   10615131
REFERENCE   7  (bases 1 to 9964)
  AUTHORS   Ludecke,H.J., Schmidt,O., Nardmann,J., von Holtum,D., Meinecke,P.,
            Muenke,M. and Horsthemke,B.
  TITLE     Genes and chromosomal breakpoints in the Langer-Giedion syndrome
            region on human chromosome 8
  JOURNAL   Hum Genet 105 (6), 619-628 (1999)
   PUBMED   10647898
REFERENCE   8  (bases 1 to 9964)
  AUTHORS   Hou,J., Parrish,J., Ludecke,H.J., Sapru,M., Wang,Y., Chen,W.,
            Hill,A., Siegel-Bartelt,J., Northrup,H., Elder,F.F. et al.
  TITLE     A 4-megabase YAC contig that spans the Langer-Giedion syndrome
            region on human chromosome 8q24.1: use in refining the location of
            the trichorhinophalangeal syndrome and multiple exostoses genes
            (TRPS1 and EXT1)
  JOURNAL   Genomics 29 (1), 87-97 (1995)
   PUBMED   8530105
REFERENCE   9  (bases 1 to 9964)
  AUTHORS   Tuysuz,B., Gunes,N. and Alkaya,D.U.
  TITLE     Trichorhinophalangeal Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28426188
REFERENCE   10 (bases 1 to 9964)
  AUTHORS   Hamers,A., Jongbloet,P., Peeters,G., Fryns,J.P. and Geraedts,J.
  TITLE     Severe mental retardation in a patient with tricho-rhino-phalangeal
            syndrome type I and 8q deletion
  JOURNAL   Eur J Pediatr 149 (9), 618-620 (1990)
   PUBMED   2373110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF178030.3, AF183810.1,
            KF454923.1 and KC877306.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_014112.4.
            
            Summary: This gene encodes a transcription factor that represses
            GATA-regulated genes and binds to a dynein light chain protein.
            Binding of the encoded protein to the dynein light chain protein
            affects binding to GATA consensus sequences and suppresses its
            transcriptional activity. Defects in this gene are a cause of
            tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF183810.1, SRR14038193.777115.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395715.8/ ENSP00000379065.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AF178030.3         290250-290507       c
            259-701             AF183810.1         306-748
            702-935             AF178030.3         241247-241480       c
            936-7197            AF183810.1         983-7244
            7198-7198           KF454923.1         233-233             c
            7199-7199           AF183810.1         7246-7246
            7200-7430           KF454923.1         1-231               c
            7431-9249           AF178030.3         30744-32562         c
            9250-9349           KC877306.1         1-100               c
            9350-9964           AF178030.3         30029-30643         c
FEATURES             Location/Qualifiers
     source          1..9964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.3"
     gene            1..9964
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="transcriptional repressor GATA binding 1"
                     /db_xref="GeneID:7227"
                     /db_xref="HGNC:HGNC:12340"
                     /db_xref="MIM:604386"
     exon            1..431
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            432..589
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..4437
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger transcription factor Trps1; zinc finger protein
                     GC79; trichorhinophalangeal syndrome I;
                     tricho-rhino-phalangeal syndrome type I protein"
                     /codon_start=1
                     /product="zinc finger transcription factor Trps1 isoform
                     1"
                     /protein_id="NP_054831.2"
                     /db_xref="CCDS:CCDS6318.2"
                     /db_xref="GeneID:7227"
                     /db_xref="HGNC:HGNC:12340"
                     /db_xref="MIM:604386"
                     /translation="MPYEVNAGYDFTNMVRKKNPPLRNVASEGEGQILEPIGTESKVS
                     GKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKSAVLSEKAGFNYE
                     SPSKGGNFPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDS
                     LETKEDQKMSPKATEETGQAQSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLL
                     VNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSK
                     ILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGR
                     KTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPNKIKASLPSSEVAKPSEKNS
                     NKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCK
                     FCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETM
                     TKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQL
                     HNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSR
                     VKHQCHQCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCT
                     KCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQDITTANGE
                     EDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESS
                     SDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIY
                     GLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCLT
                     TKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQ
                     AEQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQ
                     QPVLVSQTLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPA
                     KHPNYSPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPG
                     LPNPCQNYVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNV
                     KNEGPLNVVKTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQ
                     HLCTDKYDFTTHIQRGLHRNNAQVEKNGKPKE"
     exon            590..1518
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..2648
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..3252
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3375
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..9964
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6781..6786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="hexamer: AATAAA"
     polyA_site      6816
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="major polyA site"
     regulatory      9939..9944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="hexamer: AATAAA"
     polyA_site      9964
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="major polyA site"
ORIGIN      
        1 gtaatgcgcg gagactgagg tcctgacaag cgataacatt tctgataaag acccgatctt
       61 actgcaatct ctagcgtcct cttttttggt gctgctggtt tctccagacc tcgcgtcctc
      121 tcgattgctc tctcgccttc ctatttcttt tttttttttt taaacaaaaa acaacacccc
      181 ctcccctctc ccacccggca ccgggcacat ccttgctcta tttcctttct ctttctctct
      241 ctctctctct ctctctcttt tttaataagg gtgggggagg gaaagggggg ggaggcagga
      301 aagacctttt tctctccccc ccgcaataat ccaagatcaa ctctgcaaac aacagaagac
      361 ggttcatggc tttggccgcc gcgccaccat ctttcgggct gccgagggtg ttcttgacga
      421 ttaatcaaca gatgtacaga tcagctctca aaatgtcttc tgtgtcttct gagcgtcttc
      481 taagacaatt gcattagcct cctgctagtt gactaataga attaataatt gtaaaaagca
      541 ctctaaagcc acatgcctta tgaagtcaat gctgggtatg attttacaaa tatggtccgg
      601 aaaaagaacc cccctctgag aaacgttgca agtgaaggcg agggccagat cctggagcct
      661 ataggtacag aaagcaaggt atctggaaag aacaaagaat tttctgcaga tcagatgtca
      721 gaaaatacgg atcagagtga tgctgcagaa ctaaatcata aggaggaaca tagcttgcat
      781 gttcaagatc catcttctag cagtaagaag gacttgaaaa gcgcagttct gagtgagaag
      841 gctggcttca attatgaaag ccccagtaag ggaggaaact ttccctcctt tccgcatgat
      901 gaggtgacag acagaaatat gttggctttc tcatctccag ctgctggggg agtctgtgag
      961 cccttgaagt ctccgcaaag agcagaggca gatgaccctc aagatatggc ctgcaccccc
     1021 tcaggggact cactggagac aaaggaagat cagaagatgt caccaaaggc tacagaggaa
     1081 acagggcaag cacagagtgg tcaagccaat tgtcaaggtt tgagcccagt ttcagtggcc
     1141 tcaaaaaacc cacaagtgcc ttcagatggg ggtgtaagac tgaataaatc caaaactgac
     1201 ttactggtga atgacaaccc agacccggca cctctgtctc cagagcttca ggactttaaa
     1261 tgcaatatct gtggatatgg ttactacggc aacgacccca cagatctgat taagcacttc
     1321 cgaaagtatc acttaggact gcataaccgc accaggcaag atgctgagct ggacagcaaa
     1381 atcttggccc ttcataacat ggtgcagttc agccattcca aagacttcca gaaggtcaac
     1441 cgttctgtgt tttctggtgt gctgcaggac atcaattctt caaggcctgt tttactaaat
     1501 gggacctatg atgtgcaggt gacttcaggt ggaacattca ttggcattgg acggaaaaca
     1561 ccagattgcc aagggaacac caagtatttc cgctgtaaat tctgcaattt cacttatatg
     1621 ggcaactcat ccaccgaatt agaacaacat tttcttcaga ctcacccaaa caaaataaaa
     1681 gcttctctcc cctcctctga ggttgcaaaa ccttcagaga aaaactctaa caagtccatc
     1741 cctgcacttc aatccagtga ttctggagac ttgggaaaat ggcaggacaa gataacagtc
     1801 aaagcaggag atgacactcc tgttgggtac tcagtgccca taaagcccct cgattcctct
     1861 agacaaaatg gtacagaggc caccagttac tactggtgta aattttgtag tttcagctgt
     1921 gagtcatcta gctcacttaa actgctagaa cattatggca agcagcacgg agcagtgcag
     1981 tcaggcggcc ttaatccaga gttaaatgat aagctttcca ggggctctgt cattaatcag
     2041 aatgatctag ccaaaagttc agaaggagag acaatgacca agacagacaa gagctcgagt
     2101 ggggctaaaa agaaggactt ctccagcaag ggagccgagg ataatatggt aacgagctat
     2161 aattgtcagt tctgtgactt ccgatattcc aaaagccatg gccctgatgt aattgtagtg
     2221 gggccacttc tccgtcatta tcaacagctc cataacattc acaagtgtac cattaaacac
     2281 tgtccattct gtcccagagg actttgcagc ccagaaaagc accttggaga aattacttat
     2341 ccgtttgctt gtagaaaaag taattgttcc cactgtgcac tcttgcttct gcacttgtct
     2401 cctggggcgg ctggaagctc gcgagtcaaa catcagtgcc atcagtgttc attcaccacc
     2461 cctgacgtag atgtactcct ctttcactat gaaagtgtgc atgagtccca agcatcggat
     2521 gtcaaacaag aagcaaatca cctgcaagga tcggatgggc agcagtctgt caaggaaagc
     2581 aaagaacact catgtaccaa atgtgatttt attacccaag tggaagaaga gatttcccga
     2641 cactacagga gagcacacag ctgctacaaa tgccgtcagt gcagttttac agctgccgat
     2701 actcagtcac tactggagca cttcaacact gttcactgcc aggaacagga catcactaca
     2761 gccaacggcg aagaggacgg tcatgccata tccaccatca aagaggagcc caaaattgac
     2821 ttcagggtct acaatctgct aactccagac tctaaaatgg gagagccagt ttctgagagt
     2881 gtggtgaaga gagagaagct ggaagagaag gacgggctca aagagaaagt ttggaccgag
     2941 agttccagtg atgaccttcg caatgtgact tggagagggg cagacatcct gcgggggagt
     3001 ccgtcataca cccaagcaag cctggggctg ctgacgcctg tgtctggcac ccaagagcag
     3061 acaaagactc taagggatag tcccaatgtg gaggccgccc atctggcgcg acctatttat
     3121 ggcttggctg tggaaaccaa gggattcctg cagggggcgc cagctggcgg agagaagtct
     3181 ggggccctcc cccagcagta tcctgcatcg ggagaaaaca agtccaagga tgaatcccag
     3241 tccctgttac ggaggcgtag aggctccggt gttttttgtg ccaattgcct gaccacaaag
     3301 acctctctct ggcgaaagaa tgcaaatggc ggatatgtat gcaacgcgtg tggcctctac
     3361 cagaagcttc actcgactcc caggccttta aacatcatta aacaaaacaa cggtgagcag
     3421 attattagga ggagaacaag aaagcgcctt aacccagagg cacttcaggc tgagcagctc
     3481 aacaaacagc agaggggcag caatgaggag caagtcaatg gaagcccgtt agagaggagg
     3541 tcagaagatc atctaactga aagtcaccag agagaaattc cactccccag cctaagtaaa
     3601 tacgaagccc agggttcatt gactaaaagc cattctgctc agcagccagt cctggtcagc
     3661 caaactctgg atattcacaa aaggatgcaa cctttgcaca ttcagataaa aagtcctcag
     3721 gaaagtactg gagatccagg aaatagttca tccgtatctg aagggaaagg aagttctgag
     3781 agaggcagtc ctatagaaaa gtacatgaga cctgcgaaac acccaaatta ttcaccacca
     3841 ggcagcccta ttgaaaagta ccagtaccca ctttttggac ttccctttgt acataatgac
     3901 ttccagagtg aagctgattg gctgcggttc tggagtaaat ataagctctc cgttcctggg
     3961 aatccgcact acttgagtca cgtgcctggc ctaccaaatc cttgccaaaa ctatgtgcct
     4021 tatcccacct tcaatctgcc tcctcatttt tcagctgttg gatcagacaa tgacattcct
     4081 ctagatttgg cgatcaagca ttccagacct gggccaactg caaacggtgc ctccaaggag
     4141 aaaacgaagg caccaccaaa tgtaaaaaat gaaggtccct tgaatgtagt aaaaacagag
     4201 aaagttgata gaagtactca agatgaactt tcaacaaaat gtgtgcactg tggcattgtc
     4261 tttctggatg aagtgatgta tgctttgcat atgagttgcc atggtgacag tggacctttc
     4321 cagtgcagca tatgccagca tctttgcacg gacaaatatg acttcacaac acatatccag
     4381 aggggcctgc ataggaacaa tgcacaagtg gaaaaaaatg gaaaacctaa agagtaaaac
     4441 cttagcactt agcacaatta aatagaaata ggttttcttg atgggaattc aatagcttgt
     4501 aatgtcttat gaagacctat taaaaaaata cttcatagag cctgccttat ccaacatgaa
     4561 attcccttct tttgttattc tttcttttga tgagtaggtt accaagatta aaaagtgaga
     4621 taaatggtca atgagaaaga atggaagatg gtaaacaatc actttttaaa acctgttaag
     4681 tcaaaaccat cttggctaat atgtactggg gaaataatcc ataagagata tcaccagact
     4741 agaattaata tatttataaa gaaagagacc aaaactgtct agaatttgaa agggtttaca
     4801 tattattata ctaaagcagt actggactgg ccattggacc atttgttcca aaacccataa
     4861 attgttgcct aaatttataa tgatcatgaa accctaggca gaggaggaga aattgaaggt
     4921 ccagggcaat gaaagaaaaa tggcgccctc tcaatttagt cttctctcat tggccatgtt
     4981 tcagattttg acctagaaat gcgagctgtg gttaggcttg gttagagtgc agcaagcaac
     5041 atgacagatg gtggcacgct gtttttaccc agccctgcct gtacatacac atgcacaccc
     5101 tctctgatat ttttgtcctt tagatgttca aatactcagt agtccttttg tttgcggttt
     5161 agattcattt tgtccacaca tgtacccatt ttaaaaaaca atgtcctcga tgcttctgta
     5221 gtgatttcat tttagccagg tatttctttc ttgtgtgtga tgaaccagta tggatttgct
     5281 tttctaagcc tcctgttggt tactaatctc acttggcaca ttataactaa aggaatcccc
     5341 tcaattcaaa agcatagatg gatacaaatg tcagaccgtg ggtttaattt gtttagaaca
     5401 catggcattt cttcacaagg taacctgctg tatttattta ttttcttttg gttaaatata
     5461 atttccaaac tttgtggtca ggcagcgtct aaggttacgt taccacagac tgacagttgg
     5521 tatatgtacc agccaatccc ttcattaaat gtatacagat ttagttaagt agcattaaat
     5581 aggattctta gaagtatgtc ctcatagaac ttttaatact taaggctttg taaaaactat
     5641 ccatgaaggg aaagctcctc agcataactg ctcagggaaa tagggctaaa taactgaaca
     5701 ttaaataatt ggttaaaggt gctgttagtc gagcctcaat gcttgctaca aggatgtatg
     5761 tacaaggact gactttaata atttgcatta tattgtccca accagtagtt tattttttgc
     5821 cacggagatg tagaagatat tacaagctac tggatgcact gtcagattaa cttatttcat
     5881 taaagaagtt gggagaacaa ataggaaaaa aaaaacttat ttttctagta aatattaatg
     5941 tattacattt caaataatgg tgcctgacat attgaataat tattttctac agtgtacgta
     6001 tgcaacaaag atattccatc atgcattaga gtcagttctg gctctgccta gctgtttaca
     6061 tttgcaaatg tagcaaacaa ggtaatgaag caactatttc tattgcagta gatatccttt
     6121 tgtgtgtgtg tgtgtgcatt aaagttgtaa acggtaacat gaaacaaatg aaagttcttg
     6181 ctataatggt atggaaaaca agaaggaaat gaaaatattt ttatgcctac ttaggaaaaa
     6241 aagggtagca cttattcatt ccaagtactt tttttttttt aatttttaag ctcttaactc
     6301 acattgttat gcttaagatg ataaacatat atcctctttt tattgctttg tctatgtttc
     6361 atatgaaaca tttcagaaat tattttgata agtgttgctg gaatctgcaa cgctgatttt
     6421 tttttgcatt ctgtagtcgc atttgcactc catttttaca ttaattcgca gttgctttgt
     6481 atcattgttt tgtttgggtt ttgtttcttt ttcacagtgc cgggtcttcg tttcttaaag
     6541 ttggatggca ggtagagttc aaccagttcg tgactgttgt agcgaatgaa gttaaaaaaa
     6601 tgtctttctg atgttgtgtt gtcattttca tttttgcatt tttttgtttg catattaaaa
     6661 aaagagaaaa gagaaagcaa gagacagaaa tcaggactaa gtcctctgct tcagtttcat
     6721 tgttaacggg ccttattctg atctcacctg tcgcgtagct ctaatattca cataaactga
     6781 aataaagaag tggaatgagg agctttgaca ttcaaattat gtgatgtaat ttatcttcct
     6841 taggaatttt gatggatgca tctcaaaatg tatagccaga cttgagaggt gacaattaaa
     6901 gatctaaaaa agagaggaga ttcccccaaa caacaatatt taattttctt agtaaaaaga
     6961 ataacagaat gcatcgtggc aatccttaag caacattatc tatgtggact gcttaaatca
     7021 gcaaaacacc agaagtttgg ttaacttggg caatatgaca agtattactt tttgggcaaa
     7081 actactcatt aagcaatttc tctagtgtgt cggacacaaa taggttcttt atttttggca
     7141 tgtatgcctt tttattttca ttcaattttt tttttttctc agacagacat agtagtaacg
     7201 actagcattg gaaaatacat atcactattc ttggaatatt tatggtcagt ctacttttta
     7261 gtagaatatt tttggatagc gttgacacga tagatcttat tccatacttc tttattattg
     7321 ataattttat tttcattttt tgctttcatt attatacata ttttggtgga gaagaggttg
     7381 ggcttttttg aaagagacaa aaatttatta taacactaaa cactcctttt ttgacatatt
     7441 aaagccttta ttccatctct caagatatat tataaaattt atttttttaa tttaagattt
     7501 ctgaattatt ttatcttaaa ttgtgatttt aaacgagcta ttatggtacg gaactttttt
     7561 taatgaggaa tttcatgatg atttaggaat tttctctctt ggaaaaggct tcccctgtga
     7621 tgaaaatgat gtgccagcta aaattgtgtg ccatttaaaa actgaaaata ttttaaaatt
     7681 atttgtctat attctaaatt gagctttgga tcaaacttta ggccaggacc agctcatgcg
     7741 ttctcattct tccttttctc actctttctc tcatcactca cctctgtatt cattctgttg
     7801 tttgggatag aaaaatcata aagagccaac ccatctcaga acgttgtgga ttgagagaga
     7861 cactacatga ctccaagtat atgagaaaag gacagagctc taattgataa ctctgtagtt
     7921 caaaaggaaa agagtatgcc caattctctc tacatgacat attgagattt tttttaatca
     7981 acttttaaga tagtgatgtt ctgttctaaa ctgttctgtt ttagtgaagg tagattttta
     8041 taaaacaagc atggggattc ttttctaagg taatattaat gagaagggaa aaaagtatct
     8101 ttaacagctc tttgttgaag cctgtggtag cacattatgt ttataattgc acatgtgcac
     8161 ataatctatt atgatccaat gcaaatacag ctccaaaaat attaaatgta tatatatttt
     8221 aaaatgcctg aggaaataca tttttcttaa taaactgaag agtctcagta tggctattaa
     8281 aataattatt agcctcctgt tgtgtggctg caaaacatca caaagtgacc ggtcttgaga
     8341 cctgtgaact gctgccctgt ttagtaaata aaattaatgc atttctagag ggggaatatc
     8401 tgccatccag tggtggaaat gtggagtaaa gaagctggtg gtctgcttct gtgctgtatg
     8461 ccagcctttt gccttaagtt gagaggaggt caactttagc tactgtcttt ggtttgagag
     8521 ccatggcaaa aaaaaaaaaa gaaaaaaaga tcaagtcgtc tttggtgagc cagtaaggtg
     8581 aaagcttgct gactgtccaa ggcacaagag aaaattgagg aattgaaatg caacctgagt
     8641 atcaaactaa atattctaat caaaggtagg tactgttagg tggaattcta tcagcaggca
     8701 actgcaaatg agaagaagat agaaggacgc ccgtcgggac tttggagggc attgttattt
     8761 tcccaaagaa agacggccaa gggcagaggc atggattctt tgcagagcac ttccttttgg
     8821 tttttcagta ctgtttcata gacagtgggc tcacatgttc ctgatagtgc tgcagttgct
     8881 tagaaagcat cccagttaat tgcagtaatt agaacttctg gaatatgcta gggcagaagt
     8941 atgtcaagta tgtcacatga agaaaatgtg aaattcaaga gtaatccaca cgtgagaaac
     9001 tagacaatgt acattcatgt gttctcttga aaggaaaggg agagctgtaa gcttcactct
     9061 gtcctacacc ggagaaaagc aggaataact ttaccgtgga aataatgttt agcttttatc
     9121 agagaaaatt gtccttctag agcatagagt cccaaaactc aattctggtt ttcccctgtt
     9181 tttttttttt ttttttttcc caacatataa actgcagcat atcacttttt ctttttgtgc
     9241 ctcaggttcc tcagctgtaa aattgaaaaa tatatgtatt aataatatta ttaataataa
     9301 taatggtaat gtagtacttg tttgtaaagc actttgagat ccttggttga aaggcaccat
     9361 aggagtgcca agtattatta tgtggccaag ggggttattt aaactgtcag ttcccaaagg
     9421 ccaggaaagg ttggggtcat ttttcttaaa gacgagctgt aaatatcaac taggcagcca
     9481 atagtgttga ctatgaagat gcaaaactat tactaggctg ataaaatcat agtttcttaa
     9541 tggctaccaa taaggcaaat atcacaataa taaacgccaa attccttagg gcggactatt
     9601 tgacaaccac atggaaaact ttgggggagg catgaggggg gaacatctca aaatgccaat
     9661 gtaaaattta acttacagca atattcacca gcagaaaatg tctttcatat ggaatgattt
     9721 catgttgcta agaaaaagaa ttcaatttgt agtcctgatt tgaatactag aatgttggct
     9781 ataatagttc tgttcttaca acacatgaaa ttttttcgtt ttattttatt ttgttttcat
     9841 agtgcatgtt catttctact cacaaacatg ttcttggtgt atttcttatg caaacaatct
     9901 tcaggcagca aagatgtctg ttacatctaa acttgaataa taaagtttta ccaccagtta
     9961 caca
//
