LOCUS       NM_001282903            9950 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens transcriptional repressor GATA binding 1 (TRPS1),
            transcript variant 3, mRNA.
ACCESSION   NM_001282903 XM_005251047
VERSION     NM_001282903.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9950)
  AUTHORS   He,X., Huang,H., Liu,Y., Li,H. and Ren,H.
  TITLE     Analysis of the function, mechanism and clinical application
            prospect of TRPS1, a new marker for breast cancer
  JOURNAL   Gene 932, 148880 (2025)
   PUBMED   39181273
  REMARK    GeneRIF: Analysis of the function, mechanism and clinical
            application prospect of TRPS1, a new marker for breast cancer.
            Review article
REFERENCE   2  (bases 1 to 9950)
  AUTHORS   Zhang,Y., Hu,Y., Lei,L., Jiang,L., Fu,C., Chen,M., Wu,S., Duan,X.,
            Chen,J. and Zeng,Q.
  TITLE     UVB-induced TRPS1 regulates MITF transcription activity to promote
            skin pigmentation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167445 (2024)
   PUBMED   39074626
  REMARK    GeneRIF: UVB-induced TRPS1 regulates MITF transcription activity to
            promote skin pigmentation.
REFERENCE   3  (bases 1 to 9950)
  AUTHORS   Cai,J., Zhang,W., Lu,Y., Liu,W., Zhou,H., Liu,M., Bi,X., Liu,J.,
            Chen,J., Yin,Y., Deng,Y., Luo,Z., Yang,Y., Chen,Q., Chen,X., Xu,Z.,
            Zhang,Y., Wu,C., Long,Q., Huang,C., Yan,C., Liu,Y., Guo,L., Li,W.,
            Yuan,P., Jiao,Y., Song,W., Wang,X., Huang,Z., Ying,J. and Zhao,H.
  TITLE     Single-cell exome sequencing reveals polyclonal seeding and TRPS1
            mutations in colon cancer metastasis
  JOURNAL   Signal Transduct Target Ther 9 (1), 247 (2024)
   PUBMED   39307879
  REMARK    GeneRIF: Single-cell exome sequencing reveals polyclonal seeding
            and TRPS1 mutations in colon cancer metastasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9950)
  AUTHORS   Herlin,L.K., Herlin,M.K., Blechingberg,J., Ronholt,K.,
            Graversen,L., Schmidt,S.A.J., Jorgensen,M.W., Hellfritzsch,M.B.,
            Hald,J.D., Beck-Nielsen,S.S., Gjorup,H., Andersen,B.N.,
            Gregersen,P.A. and Sommerlund,M.
  TITLE     Clinical presentation and genetics of tricho-rhino-phalangeal
            syndrome (TRPS) type 1: A single-center case series of 15 patients
            and seven novel TRPS1 variants
  JOURNAL   Eur J Med Genet 69, 104937 (2024)
   PUBMED   38574886
  REMARK    GeneRIF: Clinical presentation and genetics of
            tricho-rhino-phalangeal syndrome (TRPS) type 1: A single-center
            case series of 15 patients and seven novel TRPS1 variants.
REFERENCE   5  (bases 1 to 9950)
  AUTHORS   Scott,T.G., Sathyan,K.M., Gioeli,D. and Guertin,M.J.
  TITLE     TRPS1 modulates chromatin accessibility to regulate estrogen
            receptor alpha (ER) binding and ER target gene expression in
            luminal breast cancer cells
  JOURNAL   PLoS Genet 20 (2), e1011159 (2024)
   PUBMED   38377146
  REMARK    GeneRIF: TRPS1 modulates chromatin accessibility to regulate
            estrogen receptor alpha (ER) binding and ER target gene expression
            in luminal breast cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9950)
  AUTHORS   Momeni,P., Glockner,G., Schmidt,O., von Holtum,D., Albrecht,B.,
            Gillessen-Kaesbach,G., Hennekam,R., Meinecke,P., Zabel,B.,
            Rosenthal,A., Horsthemke,B. and Ludecke,H.J.
  TITLE     Mutations in a new gene, encoding a zinc-finger protein, cause
            tricho-rhino-phalangeal syndrome type I
  JOURNAL   Nat Genet 24 (1), 71-74 (2000)
   PUBMED   10615131
REFERENCE   7  (bases 1 to 9950)
  AUTHORS   Ludecke,H.J., Schmidt,O., Nardmann,J., von Holtum,D., Meinecke,P.,
            Muenke,M. and Horsthemke,B.
  TITLE     Genes and chromosomal breakpoints in the Langer-Giedion syndrome
            region on human chromosome 8
  JOURNAL   Hum Genet 105 (6), 619-628 (1999)
   PUBMED   10647898
REFERENCE   8  (bases 1 to 9950)
  AUTHORS   Hou,J., Parrish,J., Ludecke,H.J., Sapru,M., Wang,Y., Chen,W.,
            Hill,A., Siegel-Bartelt,J., Northrup,H., Elder,F.F. et al.
  TITLE     A 4-megabase YAC contig that spans the Langer-Giedion syndrome
            region on human chromosome 8q24.1: use in refining the location of
            the trichorhinophalangeal syndrome and multiple exostoses genes
            (TRPS1 and EXT1)
  JOURNAL   Genomics 29 (1), 87-97 (1995)
   PUBMED   8530105
REFERENCE   9  (bases 1 to 9950)
  AUTHORS   Tuysuz,B., Gunes,N. and Alkaya,D.U.
  TITLE     Trichorhinophalangeal Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28426188
REFERENCE   10 (bases 1 to 9950)
  AUTHORS   Hamers,A., Jongbloet,P., Peeters,G., Fryns,J.P. and Geraedts,J.
  TITLE     Severe mental retardation in a patient with tricho-rhino-phalangeal
            syndrome type I and 8q deletion
  JOURNAL   Eur J Pediatr 149 (9), 618-620 (1990)
   PUBMED   2373110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF178030.3, BC125020.1,
            KF454923.1 and KC877306.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001282903.2.
            
            Summary: This gene encodes a transcription factor that represses
            GATA-regulated genes and binds to a dynein light chain protein.
            Binding of the encoded protein to the dynein light chain protein
            affects binding to GATA consensus sequences and suppresses its
            transcriptional activity. Defects in this gene are a cause of
            tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) uses an alternate splice in
            the coding region which results in the use of an alternate start
            codon, compared to variant 1. The encoded isoform (3) is shorter
            and has a distinct N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.3013256.1, BC125020.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AF178030.3         290250-290507       c
            259-474             BC125020.1         155-370
            475-544             AF178030.3         245178-245247       c
            545-1494            BC125020.1         442-1391
            1495-1495           AF178030.3         240673-240673       c
            1496-1611           BC125020.1         1393-1508
            1612-1612           AF178030.3         226427-226427       c
            1613-3136           BC125020.1         1510-3033
            3137-3137           AF178030.3         208634-208634       c
            3138-4813           BC125020.1         3035-4710
            4814-7023           AF178030.3         32956-35165         c
            7024-7416           KF454923.1         1-393               c
            7417-9235           AF178030.3         30744-32562         c
            9236-9335           KC877306.1         1-100               c
            9336-9950           AF178030.3         30029-30643         c
FEATURES             Location/Qualifiers
     source          1..9950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.3"
     gene            1..9950
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="transcriptional repressor GATA binding 1"
                     /db_xref="GeneID:7227"
                     /db_xref="HGNC:HGNC:12340"
                     /db_xref="MIM:604386"
     exon            1..431
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            432..575
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             560..4423
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="isoform 3 is encoded by transcript variant 3; zinc
                     finger transcription factor Trps1; zinc finger protein
                     GC79; trichorhinophalangeal syndrome I;
                     tricho-rhino-phalangeal syndrome type I protein"
                     /codon_start=1
                     /product="zinc finger transcription factor Trps1 isoform
                     3"
                     /protein_id="NP_001269832.1"
                     /db_xref="GeneID:7227"
                     /db_xref="HGNC:HGNC:12340"
                     /db_xref="MIM:604386"
                     /translation="MKSMLDMVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFS
                     ADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKSAVLSEKAGFNYESPSKGGN
                     FPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQ
                     KMSPKATEETGQAQSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDP
                     APLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNM
                     VQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQG
                     NTKYFRCKFCNFTYMGNSSTELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPAL
                     QSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCE
                     SSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSS
                     SGAKKKDFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCT
                     IKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCHQ
                     CSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQ
                     VEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQDITTANGEEDGHAIS
                     TIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNV
                     TWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETK
                     GFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCLTTKTSLWR
                     KNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQ
                     QRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQ
                     TLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNYSP
                     PGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQN
                     YVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLN
                     VVKTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKY
                     DFTTHIQRGLHRNNAQVEKNGKPKE"
     exon            576..1504
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..2634
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..3238
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3361
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..9950
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6767..6772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="hexamer: AATAAA"
     polyA_site      6802
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="major polyA site"
     regulatory      9925..9930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="hexamer: AATAAA"
     polyA_site      9950
                     /gene="TRPS1"
                     /gene_synonym="GC79; LGCR"
                     /note="major polyA site"
ORIGIN      
        1 gtaatgcgcg gagactgagg tcctgacaag cgataacatt tctgataaag acccgatctt
       61 actgcaatct ctagcgtcct cttttttggt gctgctggtt tctccagacc tcgcgtcctc
      121 tcgattgctc tctcgccttc ctatttcttt tttttttttt taaacaaaaa acaacacccc
      181 ctcccctctc ccacccggca ccgggcacat ccttgctcta tttcctttct ctttctctct
      241 ctctctctct ctctctcttt tttaataagg gtgggggagg gaaagggggg ggaggcagga
      301 aagacctttt tctctccccc ccgcaataat ccaagatcaa ctctgcaaac aacagaagac
      361 ggttcatggc tttggccgcc gcgccaccat ctttcgggct gccgagggtg ttcttgacga
      421 ttaatcaaca gatgtacaga tcagctctca aaatgtcttc tgtgtcttct gagcgtcttc
      481 taagacaatt gcattagcct cctgctagtt gactaataga attaataatt gtaaaaagca
      541 ctctaaagcc acatgcctta tgaagtcaat gctggatatg gtccggaaaa agaacccccc
      601 tctgagaaac gttgcaagtg aaggcgaggg ccagatcctg gagcctatag gtacagaaag
      661 caaggtatct ggaaagaaca aagaattttc tgcagatcag atgtcagaaa atacggatca
      721 gagtgatgct gcagaactaa atcataagga ggaacatagc ttgcatgttc aagatccatc
      781 ttctagcagt aagaaggact tgaaaagcgc agttctgagt gagaaggctg gcttcaatta
      841 tgaaagcccc agtaagggag gaaactttcc ctcctttccg catgatgagg tgacagacag
      901 aaatatgttg gctttctcat ctccagctgc tgggggagtc tgtgagccct tgaagtctcc
      961 gcaaagagca gaggcagatg accctcaaga tatggcctgc accccctcag gggactcact
     1021 ggagacaaag gaagatcaga agatgtcacc aaaggctaca gaggaaacag ggcaagcaca
     1081 gagtggtcaa gccaattgtc aaggtttgag cccagtttca gtggcctcaa aaaacccaca
     1141 agtgccttca gatgggggtg taagactgaa taaatccaaa actgacttac tggtgaatga
     1201 caacccagac ccggcacctc tgtctccaga gcttcaggac tttaaatgca atatctgtgg
     1261 atatggttac tacggcaacg accccacaga tctgattaag cacttccgaa agtatcactt
     1321 aggactgcat aaccgcacca ggcaagatgc tgagctggac agcaaaatct tggcccttca
     1381 taacatggtg cagttcagcc attccaaaga cttccagaag gtcaaccgtt ctgtgttttc
     1441 tggtgtgctg caggacatca attcttcaag gcctgtttta ctaaatggga cctatgatgt
     1501 gcaggtgact tcaggtggaa cattcattgg cattggacgg aaaacaccag attgccaagg
     1561 gaacaccaag tatttccgct gtaaattctg caatttcact tatatgggca actcatccac
     1621 cgaattagaa caacattttc ttcagactca cccaaacaaa ataaaagctt ctctcccctc
     1681 ctctgaggtt gcaaaacctt cagagaaaaa ctctaacaag tccatccctg cacttcaatc
     1741 cagtgattct ggagacttgg gaaaatggca ggacaagata acagtcaaag caggagatga
     1801 cactcctgtt gggtactcag tgcccataaa gcccctcgat tcctctagac aaaatggtac
     1861 agaggccacc agttactact ggtgtaaatt ttgtagtttc agctgtgagt catctagctc
     1921 acttaaactg ctagaacatt atggcaagca gcacggagca gtgcagtcag gcggccttaa
     1981 tccagagtta aatgataagc tttccagggg ctctgtcatt aatcagaatg atctagccaa
     2041 aagttcagaa ggagagacaa tgaccaagac agacaagagc tcgagtgggg ctaaaaagaa
     2101 ggacttctcc agcaagggag ccgaggataa tatggtaacg agctataatt gtcagttctg
     2161 tgacttccga tattccaaaa gccatggccc tgatgtaatt gtagtggggc cacttctccg
     2221 tcattatcaa cagctccata acattcacaa gtgtaccatt aaacactgtc cattctgtcc
     2281 cagaggactt tgcagcccag aaaagcacct tggagaaatt acttatccgt ttgcttgtag
     2341 aaaaagtaat tgttcccact gtgcactctt gcttctgcac ttgtctcctg gggcggctgg
     2401 aagctcgcga gtcaaacatc agtgccatca gtgttcattc accacccctg acgtagatgt
     2461 actcctcttt cactatgaaa gtgtgcatga gtcccaagca tcggatgtca aacaagaagc
     2521 aaatcacctg caaggatcgg atgggcagca gtctgtcaag gaaagcaaag aacactcatg
     2581 taccaaatgt gattttatta cccaagtgga agaagagatt tcccgacact acaggagagc
     2641 acacagctgc tacaaatgcc gtcagtgcag ttttacagct gccgatactc agtcactact
     2701 ggagcacttc aacactgttc actgccagga acaggacatc actacagcca acggcgaaga
     2761 ggacggtcat gccatatcca ccatcaaaga ggagcccaaa attgacttca gggtctacaa
     2821 tctgctaact ccagactcta aaatgggaga gccagtttct gagagtgtgg tgaagagaga
     2881 gaagctggaa gagaaggacg ggctcaaaga gaaagtttgg accgagagtt ccagtgatga
     2941 ccttcgcaat gtgacttgga gaggggcaga catcctgcgg gggagtccgt catacaccca
     3001 agcaagcctg gggctgctga cgcctgtgtc tggcacccaa gagcagacaa agactctaag
     3061 ggatagtccc aatgtggagg ccgcccatct ggcgcgacct atttatggct tggctgtgga
     3121 aaccaaggga ttcctgcagg gggcgccagc tggcggagag aagtctgggg ccctccccca
     3181 gcagtatcct gcatcgggag aaaacaagtc caaggatgaa tcccagtccc tgttacggag
     3241 gcgtagaggc tccggtgttt tttgtgccaa ttgcctgacc acaaagacct ctctctggcg
     3301 aaagaatgca aatggcggat atgtatgcaa cgcgtgtggc ctctaccaga agcttcactc
     3361 gactcccagg cctttaaaca tcattaaaca aaacaacggt gagcagatta ttaggaggag
     3421 aacaagaaag cgccttaacc cagaggcact tcaggctgag cagctcaaca aacagcagag
     3481 gggcagcaat gaggagcaag tcaatggaag cccgttagag aggaggtcag aagatcatct
     3541 aactgaaagt caccagagag aaattccact ccccagccta agtaaatacg aagcccaggg
     3601 ttcattgact aaaagccatt ctgctcagca gccagtcctg gtcagccaaa ctctggatat
     3661 tcacaaaagg atgcaacctt tgcacattca gataaaaagt cctcaggaaa gtactggaga
     3721 tccaggaaat agttcatccg tatctgaagg gaaaggaagt tctgagagag gcagtcctat
     3781 agaaaagtac atgagacctg cgaaacaccc aaattattca ccaccaggca gccctattga
     3841 aaagtaccag tacccacttt ttggacttcc ctttgtacat aatgacttcc agagtgaagc
     3901 tgattggctg cggttctgga gtaaatataa gctctccgtt cctgggaatc cgcactactt
     3961 gagtcacgtg cctggcctac caaatccttg ccaaaactat gtgccttatc ccaccttcaa
     4021 tctgcctcct catttttcag ctgttggatc agacaatgac attcctctag atttggcgat
     4081 caagcattcc agacctgggc caactgcaaa cggtgcctcc aaggagaaaa cgaaggcacc
     4141 accaaatgta aaaaatgaag gtcccttgaa tgtagtaaaa acagagaaag ttgatagaag
     4201 tactcaagat gaactttcaa caaaatgtgt gcactgtggc attgtctttc tggatgaagt
     4261 gatgtatgct ttgcatatga gttgccatgg tgacagtgga cctttccagt gcagcatatg
     4321 ccagcatctt tgcacggaca aatatgactt cacaacacat atccagaggg gcctgcatag
     4381 gaacaatgca caagtggaaa aaaatggaaa acctaaagag taaaacctta gcacttagca
     4441 caattaaata gaaataggtt ttcttgatgg gaattcaata gcttgtaatg tcttatgaag
     4501 acctattaaa aaaatacttc atagagcctg ccttatccaa catgaaattc ccttcttttg
     4561 ttattctttc ttttgatgag taggttacca agattaaaaa gtgagataaa tggtcaatga
     4621 gaaagaatgg aagatggtaa acaatcactt tttaaaacct gttaagtcaa aaccatcttg
     4681 gctaatatgt actggggaaa taatccataa gagatatcac cagactagaa ttaatatatt
     4741 tataaagaaa gagaccaaaa ctgtctagaa tttgaaaggg tttacatatt attatactaa
     4801 agcagtactg gactggccat tggaccattt gttccaaaac ccataaattg ttgcctaaat
     4861 ttataatgat catgaaaccc taggcagagg aggagaaatt gaaggtccag ggcaatgaaa
     4921 gaaaaatggc gccctctcaa tttagtcttc tctcattggc catgtttcag attttgacct
     4981 agaaatgcga gctgtggtta ggcttggtta gagtgcagca agcaacatga cagatggtgg
     5041 cacgctgttt ttacccagcc ctgcctgtac atacacatgc acaccctctc tgatattttt
     5101 gtcctttaga tgttcaaata ctcagtagtc cttttgtttg cggtttagat tcattttgtc
     5161 cacacatgta cccattttaa aaaacaatgt cctcgatgct tctgtagtga tttcatttta
     5221 gccaggtatt tctttcttgt gtgtgatgaa ccagtatgga tttgcttttc taagcctcct
     5281 gttggttact aatctcactt ggcacattat aactaaagga atcccctcaa ttcaaaagca
     5341 tagatggata caaatgtcag accgtgggtt taatttgttt agaacacatg gcatttcttc
     5401 acaaggtaac ctgctgtatt tatttatttt cttttggtta aatataattt ccaaactttg
     5461 tggtcaggca gcgtctaagg ttacgttacc acagactgac agttggtata tgtaccagcc
     5521 aatcccttca ttaaatgtat acagatttag ttaagtagca ttaaatagga ttcttagaag
     5581 tatgtcctca tagaactttt aatacttaag gctttgtaaa aactatccat gaagggaaag
     5641 ctcctcagca taactgctca gggaaatagg gctaaataac tgaacattaa ataattggtt
     5701 aaaggtgctg ttagtcgagc ctcaatgctt gctacaagga tgtatgtaca aggactgact
     5761 ttaataattt gcattatatt gtcccaacca gtagtttatt ttttgccacg gagatgtaga
     5821 agatattaca agctactgga tgcactgtca gattaactta tttcattaaa gaagttggga
     5881 gaacaaatag gaaaaaaaaa acttattttt ctagtaaata ttaatgtatt acatttcaaa
     5941 taatggtgcc tgacatattg aataattatt ttctacagtg tacgtatgca acaaagatat
     6001 tccatcatgc attagagtca gttctggctc tgcctagctg tttacatttg caaatgtagc
     6061 aaacaaggta atgaagcaac tatttctatt gcagtagata tccttttgtg tgtgtgtgtg
     6121 tgcattaaag ttgtaaacgg taacatgaaa caaatgaaag ttcttgctat aatggtatgg
     6181 aaaacaagaa ggaaatgaaa atatttttat gcctacttag gaaaaaaagg gtagcactta
     6241 ttcattccaa gtactttttt ttttttaatt tttaagctct taactcacat tgttatgctt
     6301 aagatgataa acatatatcc tctttttatt gctttgtcta tgtttcatat gaaacatttc
     6361 agaaattatt ttgataagtg ttgctggaat ctgcaacgct gatttttttt tgcattctgt
     6421 agtcgcattt gcactccatt tttacattaa ttcgcagttg ctttgtatca ttgttttgtt
     6481 tgggttttgt ttctttttca cagtgccggg tcttcgtttc ttaaagttgg atggcaggta
     6541 gagttcaacc agttcgtgac tgttgtagcg aatgaagtta aaaaaatgtc tttctgatgt
     6601 tgtgttgtca ttttcatttt tgcatttttt tgtttgcata ttaaaaaaag agaaaagaga
     6661 aagcaagaga cagaaatcag gactaagtcc tctgcttcag tttcattgtt aacgggcctt
     6721 attctgatct cacctgtcgc gtagctctaa tattcacata aactgaaata aagaagtgga
     6781 atgaggagct ttgacattca aattatgtga tgtaatttat cttccttagg aattttgatg
     6841 gatgcatctc aaaatgtata gccagacttg agaggtgaca attaaagatc taaaaaagag
     6901 aggagattcc cccaaacaac aatatttaat tttcttagta aaaagaataa cagaatgcat
     6961 cgtggcaatc cttaagcaac attatctatg tggactgctt aaatcagcaa aacaccagaa
     7021 gtttggttaa cttgggcaat atgacaagta ttactttttg ggcaaaacta ctcattaagc
     7081 aatttctcta gtgtgtcgga cacaaatagg ttctttattt ttggcatgta tgccttttta
     7141 ttttcattca attttttttt tttctcagac agacatagta gtaacgacta gcattggaaa
     7201 atacatatca ctattcttgg aatatttatg gtcagtctac tttttagtag aatatttttg
     7261 gatagcgttg acacgataga tcttattcca tacttcttta ttattgataa ttttattttc
     7321 attttttgct ttcattatta tacatatttt ggtggagaag aggttgggct tttttgaaag
     7381 agacaaaaat ttattataac actaaacact ccttttttga catattaaag cctttattcc
     7441 atctctcaag atatattata aaatttattt ttttaattta agatttctga attattttat
     7501 cttaaattgt gattttaaac gagctattat ggtacggaac tttttttaat gaggaatttc
     7561 atgatgattt aggaattttc tctcttggaa aaggcttccc ctgtgatgaa aatgatgtgc
     7621 cagctaaaat tgtgtgccat ttaaaaactg aaaatatttt aaaattattt gtctatattc
     7681 taaattgagc tttggatcaa actttaggcc aggaccagct catgcgttct cattcttcct
     7741 tttctcactc tttctctcat cactcacctc tgtattcatt ctgttgtttg ggatagaaaa
     7801 atcataaaga gccaacccat ctcagaacgt tgtggattga gagagacact acatgactcc
     7861 aagtatatga gaaaaggaca gagctctaat tgataactct gtagttcaaa aggaaaagag
     7921 tatgcccaat tctctctaca tgacatattg agattttttt taatcaactt ttaagatagt
     7981 gatgttctgt tctaaactgt tctgttttag tgaaggtaga tttttataaa acaagcatgg
     8041 ggattctttt ctaaggtaat attaatgaga agggaaaaaa gtatctttaa cagctctttg
     8101 ttgaagcctg tggtagcaca ttatgtttat aattgcacat gtgcacataa tctattatga
     8161 tccaatgcaa atacagctcc aaaaatatta aatgtatata tattttaaaa tgcctgagga
     8221 aatacatttt tcttaataaa ctgaagagtc tcagtatggc tattaaaata attattagcc
     8281 tcctgttgtg tggctgcaaa acatcacaaa gtgaccggtc ttgagacctg tgaactgctg
     8341 ccctgtttag taaataaaat taatgcattt ctagaggggg aatatctgcc atccagtggt
     8401 ggaaatgtgg agtaaagaag ctggtggtct gcttctgtgc tgtatgccag ccttttgcct
     8461 taagttgaga ggaggtcaac tttagctact gtctttggtt tgagagccat ggcaaaaaaa
     8521 aaaaaagaaa aaaagatcaa gtcgtctttg gtgagccagt aaggtgaaag cttgctgact
     8581 gtccaaggca caagagaaaa ttgaggaatt gaaatgcaac ctgagtatca aactaaatat
     8641 tctaatcaaa ggtaggtact gttaggtgga attctatcag caggcaactg caaatgagaa
     8701 gaagatagaa ggacgcccgt cgggactttg gagggcattg ttattttccc aaagaaagac
     8761 ggccaagggc agaggcatgg attctttgca gagcacttcc ttttggtttt tcagtactgt
     8821 ttcatagaca gtgggctcac atgttcctga tagtgctgca gttgcttaga aagcatccca
     8881 gttaattgca gtaattagaa cttctggaat atgctagggc agaagtatgt caagtatgtc
     8941 acatgaagaa aatgtgaaat tcaagagtaa tccacacgtg agaaactaga caatgtacat
     9001 tcatgtgttc tcttgaaagg aaagggagag ctgtaagctt cactctgtcc tacaccggag
     9061 aaaagcagga ataactttac cgtggaaata atgtttagct tttatcagag aaaattgtcc
     9121 ttctagagca tagagtccca aaactcaatt ctggttttcc cctgtttttt tttttttttt
     9181 ttttcccaac atataaactg cagcatatca ctttttcttt ttgtgcctca ggttcctcag
     9241 ctgtaaaatt gaaaaatata tgtattaata atattattaa taataataat ggtaatgtag
     9301 tacttgtttg taaagcactt tgagatcctt ggttgaaagg caccatagga gtgccaagta
     9361 ttattatgtg gccaaggggg ttatttaaac tgtcagttcc caaaggccag gaaaggttgg
     9421 ggtcattttt cttaaagacg agctgtaaat atcaactagg cagccaatag tgttgactat
     9481 gaagatgcaa aactattact aggctgataa aatcatagtt tcttaatggc taccaataag
     9541 gcaaatatca caataataaa cgccaaattc cttagggcgg actatttgac aaccacatgg
     9601 aaaactttgg gggaggcatg aggggggaac atctcaaaat gccaatgtaa aatttaactt
     9661 acagcaatat tcaccagcag aaaatgtctt tcatatggaa tgatttcatg ttgctaagaa
     9721 aaagaattca atttgtagtc ctgatttgaa tactagaatg ttggctataa tagttctgtt
     9781 cttacaacac atgaaatttt ttcgttttat tttattttgt tttcatagtg catgttcatt
     9841 tctactcaca aacatgttct tggtgtattt cttatgcaaa caatcttcag gcagcaaaga
     9901 tgtctgttac atctaaactt gaataataaa gttttaccac cagttacaca
//
