LOCUS       NM_024080               5646 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            M member 8 (TRPM8), transcript variant 1, mRNA.
ACCESSION   NM_024080
VERSION     NM_024080.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5646)
  AUTHORS   Behrendt,M.
  TITLE     Implications of TRPM3 and TRPM8 for sensory neuron sensitisation
  JOURNAL   Biol Chem 405 (9-10), 583-599 (2024)
   PUBMED   39417661
  REMARK    GeneRIF: Implications of TRPM3 and TRPM8 for sensory neuron
            sensitisation.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5646)
  AUTHORS   Chen,L., Xu,N., Gou,D., Song,J., Zhou,M., Zhang,Y., Zhang,H.,
            Zhu,L., Huang,W., Zhu,Y., Gao,C., Gu,D., Xu,Y. and Zhou,H.
  TITLE     TRPM8 overexpression suppresses hepatocellular carcinoma
            progression and improves survival by modulating the RTP3/STAT3
            pathway
  JOURNAL   Cancer Med 13 (19), e70109 (2024)
   PUBMED   39385506
  REMARK    GeneRIF: TRPM8 overexpression suppresses hepatocellular carcinoma
            progression and improves survival by modulating the RTP3/STAT3
            pathway.
REFERENCE   3  (bases 1 to 5646)
  AUTHORS   Iftinca,M. and Altier,C.
  TITLE     The cool things to know about TRPM8!
  JOURNAL   Channels (Austin) 14 (1), 413-420 (2020)
   PUBMED   33147416
  REMARK    Review article
REFERENCE   4  (bases 1 to 5646)
  AUTHORS   Liu,Y., Mikrani,R., He,Y., Faran Ashraf Baig,M.M., Abbas,M.,
            Naveed,M., Tang,M., Zhang,Q., Li,C. and Zhou,X.
  TITLE     TRPM8 channels: A review of distribution and clinical role
  JOURNAL   Eur J Pharmacol 882, 173312 (2020)
   PUBMED   32610057
  REMARK    GeneRIF: TRPM8 channels: A review of distribution and clinical
            role.
            Review article
REFERENCE   5  (bases 1 to 5646)
  AUTHORS   Gonzalez-Muniz,R., Bonache,M.A., Martin-Escura,C. and
            Gomez-Monterrey,I.
  TITLE     Recent Progress in TRPM8 Modulation: An Update
  JOURNAL   Int J Mol Sci 20 (11), 2618 (2019)
   PUBMED   31141957
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5646)
  AUTHORS   Almaraz,L., Manenschijn,J.A., de la Pena,E. and Viana,F.
  TITLE     TRPM8.
  JOURNAL   Handb Exp Pharmacol 222, 547-579 (2014)
   PUBMED   24756721
REFERENCE   7  (bases 1 to 5646)
  AUTHORS   Bautista,D.M., Siemens,J., Glazer,J.M., Tsuruda,P.R., Basbaum,A.I.,
            Stucky,C.L., Jordt,S.E. and Julius,D.
  TITLE     The menthol receptor TRPM8 is the principal detector of
            environmental cold
  JOURNAL   Nature 448 (7150), 204-208 (2007)
   PUBMED   17538622
REFERENCE   8  (bases 1 to 5646)
  AUTHORS   Voets,T., Owsianik,G. and Nilius,B.
  TITLE     TRPM8.
  JOURNAL   Handb Exp Pharmacol (179), 329-344 (2007)
   PUBMED   17217067
  REMARK    GeneRIF: TRPM8 is now best known as a cold- and menthol-activated
            channel implicated in thermosensation--{REVIEW}
            Review article
REFERENCE   9  (bases 1 to 5646)
  AUTHORS   Voets,T., Droogmans,G., Wissenbach,U., Janssens,A., Flockerzi,V.
            and Nilius,B.
  TITLE     The principle of temperature-dependent gating in cold- and
            heat-sensitive TRP channels
  JOURNAL   Nature 430 (7001), 748-754 (2004)
   PUBMED   15306801
  REMARK    GeneRIF: temperature sensing is tightly linked to voltage-dependent
            gating in the cold-sensitive channel TRPM8 and the heat-sensitive
            channel TRPV1
REFERENCE   10 (bases 1 to 5646)
  AUTHORS   Tsavaler,L., Shapero,M.H., Morkowski,S. and Laus,R.
  TITLE     Trp-p8, a novel prostate-specific gene, is up-regulated in prostate
            cancer and other malignancies and shares high homology with
            transient receptor potential calcium channel proteins
  JOURNAL   Cancer Res 61 (9), 3760-3769 (2001)
   PUBMED   11325849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005538.3, AY090109.1, BC001135.2 and BC033137.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024080.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KC692993.1, AY090109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153427, SAMEA2155984
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324695.9/ ENSP00000323926.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC005538.3         91130-91154
            26-237              AY090109.1         1-212
            238-256             BC001135.2         91-109
            257-3382            AY090109.1         232-3357
            3383-4562           BC033137.1         964-2143
            4563-5646           AC005538.3         192195-193278
FEATURES             Location/Qualifiers
     source          1..5646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..5646
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /note="transient receptor potential cation channel
                     subfamily M member 8"
                     /db_xref="GeneID:79054"
                     /db_xref="HGNC:HGNC:17961"
                     /db_xref="MIM:606678"
     exon            1..60
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            61..182
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3380
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transient receptor potential subfamily M member 8;
                     transient receptor potential p8; TRPM8 cationic channel"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 8 isoform 1"
                     /protein_id="NP_076985.4"
                     /db_xref="CCDS:CCDS33407.1"
                     /db_xref="GeneID:79054"
                     /db_xref="HGNC:HGNC:17961"
                     /db_xref="MIM:606678"
                     /translation="MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNF
                     IQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDA
                     FGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPR
                     MRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWG
                     MVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAK
                     LRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQ
                     IADVIASLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLT
                     VIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTND
                     RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRN
                     LQIAKNSYNDALLTFVWKLVANFRRGFRKEDRNGRDEMDIELHDVSPITRHPLQALFI
                     WAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETR
                     AVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQW
                     YGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSW
                     NVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLW
                     NVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPK
                     IIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ
                     VPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLV
                     NLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFK
                     CCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRHRFRQLDTK
                     LNDLKGLLKEIANKIK"
     exon            183..256
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            257..413
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            414..591
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            592..764
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            765..939
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1007
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1205
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1308
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1427
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1718
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1814
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1944
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2090
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2203
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2420
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2512
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2654
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2826
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3004
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3195
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3295
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3329
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3422
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..5646
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5624..5629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /note="hexamer: AATAAA"
     polyA_site      5646
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /note="major polyA site"
ORIGIN      
        1 agagaccagc aggatccttg ggtgaaagaa aatcctgctt gacaaaaacc gtcacttagg
       61 aaaagatgtc ctttcgggca gccaggctca gcatgaggaa cagaaggaat gacactctgg
      121 acagcacccg gaccctgtac tccagcgcgt ctcggagcac agacttgtct tacagtgaaa
      181 gcgacttggt gaattttatt caagcaaatt ttaagaaacg agaatgtgtc ttctttacca
      241 aagattccaa ggccacggag aatgtgtgca agtgtggcta tgcccagagc cagcacatgg
      301 aaggcaccca gatcaaccaa agtgagaaat ggaactacaa gaaacacacc aaggaatttc
      361 ctaccgacgc ctttggggat attcagtttg agacactggg gaagaaaggg aagtatatac
      421 gtctgtcctg cgacacggac gcggaaatcc tttacgagct gctgacccag cactggcacc
      481 tgaaaacacc caacctggtc atttctgtga ccgggggcgc caagaacttc gccctgaagc
      541 cgcgcatgcg caagatcttc agccggctca tctacatcgc gcagtccaaa ggtgcttgga
      601 ttctcacggg aggcacccat tatggcctga tgaagtacat cggggaggtg gtgagagata
      661 acaccatcag caggagttca gaggagaata ttgtggccat tggcatagca gcttggggca
      721 tggtctccaa ccgggacacc ctcatcagga attgcgatgc tgagggctat tttttagccc
      781 agtaccttat ggatgacttc acaagagatc cactgtatat cctggacaac aaccacacac
      841 atttgctgct cgtggacaat ggctgtcatg gacatcccac tgtcgaagca aagctccgga
      901 atcagctaga gaagtatatc tctgagcgca ctattcaaga ttccaactat ggtggcaaga
      961 tccccattgt gtgttttgcc caaggaggtg gaaaagagac tttgaaagcc atcaatacct
     1021 ccatcaaaaa taaaattcct tgtgtggtgg tggaaggctc gggccagatc gctgatgtga
     1081 tcgctagcct ggtggaggtg gaggatgccc tgacatcttc tgccgtcaag gagaagctgg
     1141 tgcgcttttt accccgcacg gtgtcccggc tgcctgagga ggagactgag agttggatca
     1201 aatggctcaa agaaattctc gaatgttctc acctattaac agttattaaa atggaagaag
     1261 ctggggatga aattgtgagc aatgccatct cctacgctct atacaaagcc ttcagcacca
     1321 gtgagcaaga caaggataac tggaatgggc agctgaagct tctgctggag tggaaccagc
     1381 tggacttagc caatgatgag attttcacca atgaccgccg atgggagtct gctgaccttc
     1441 aagaagtcat gtttacggct ctcataaagg acagacccaa gtttgtccgc ctctttctgg
     1501 agaatggctt gaacctacgg aagtttctca cccatgatgt cctcactgaa ctcttctcca
     1561 accacttcag cacgcttgtg taccggaatc tgcagatcgc caagaattcc tataatgatg
     1621 ccctcctcac gtttgtctgg aaactggttg cgaacttccg aagaggcttc cggaaggaag
     1681 acagaaatgg ccgggacgag atggacatag aactccacga cgtgtctcct attactcggc
     1741 accccctgca agctctcttc atctgggcca ttcttcagaa taagaaggaa ctctccaaag
     1801 tcatttggga gcagaccagg ggctgcactc tggcagccct gggagccagc aagcttctga
     1861 agactctggc caaagtgaag aacgacatca atgctgctgg ggagtccgag gagctggcta
     1921 atgagtacga gacccgggct gttgagctgt tcactgagtg ttacagcagc gatgaagact
     1981 tggcagaaca gctgctggtc tattcctgtg aagcttgggg tggaagcaac tgtctggagc
     2041 tggcggtgga ggccacagac cagcatttca tcgcccagcc tggggtccag aattttcttt
     2101 ctaagcaatg gtatggagag atttcccgag acaccaagaa ctggaagatt atcctgtgtc
     2161 tgtttattat acccttggtg ggctgtggct ttgtatcatt taggaagaaa cctgtcgaca
     2221 agcacaagaa gctgctttgg tactatgtgg cgttcttcac ctcccccttc gtggtcttct
     2281 cctggaatgt ggtcttctac atcgccttcc tcctgctgtt tgcctacgtg ctgctcatgg
     2341 atttccattc ggtgccacac ccccccgagc tggtcctgta ctcgctggtc tttgtcctct
     2401 tctgtgatga agtgagacag tggtacgtaa atggggtgaa ttattttact gacctgtgga
     2461 atgtgatgga cacgctgggg cttttttact tcatagcagg aattgtattt cggctccact
     2521 cttctaataa aagctctttg tattctggac gagtcatttt ctgtctggac tacattattt
     2581 tcactctaag attgatccac atttttactg taagcagaaa cttaggaccc aagattataa
     2641 tgctgcagag gatgctgatc gatgtgttct tcttcctgtt cctctttgcg gtgtggatgg
     2701 tggcctttgg cgtggccagg caagggatcc ttaggcagaa tgagcagcgc tggaggtgga
     2761 tattccgttc ggtcatctac gagccctacc tggccatgtt cggccaggtg cccagtgacg
     2821 tggatggtac cacgtatgac tttgcccact gcaccttcac tgggaatgag tccaagccac
     2881 tgtgtgtgga gctggatgag cacaacctgc cccggttccc cgagtggatc accatccccc
     2941 tggtgtgcat ctacatgtta tccaccaaca tcctgctggt caacctgctg gtcgccatgt
     3001 ttggctacac ggtgggcacc gtccaggaga acaatgacca ggtctggaag ttccagaggt
     3061 acttcctggt gcaggagtac tgcagccgcc tcaatatccc cttccccttc atcgtcttcg
     3121 cttacttcta catggtggtg aagaagtgct tcaagtgttg ctgcaaggag aaaaacatgg
     3181 agtcttctgt ctgctgtttc aaaaatgaag acaatgagac tctggcatgg gagggtgtca
     3241 tgaaggaaaa ctaccttgtc aagatcaaca caaaagccaa cgacacctca gaggaaatga
     3301 ggcatcgatt tagacaactg gatacaaagc ttaatgatct caagggtctt ctgaaagaga
     3361 ttgctaataa aatcaaataa aactgtatga actctaatgg agaaaaatct aattatagca
     3421 agatcatatt aaggaatgct gatgaacaat tttgctatcg actactaaat gagagatttt
     3481 cagacccctg ggtacatggt ggatgatttt aaatcaccct agtgtgctga gaccttgaga
     3541 ataaagtgtg tgattggttt catacttgaa gacggatata aaggaagaat atttccttta
     3601 tgtgtttctc cagaatggtg cctgtttctc tctgtgtctc aatgcctggg actggaggtt
     3661 gatagtttaa gtgtgttctt accgcctcct ttttccttta atcttatttt tgatgaacac
     3721 atatatagga gaacatctat cctatgaata agaacctggt catgctttac tcctgtattg
     3781 ttattttgtt catttccaat tgattctcta cttttccctt ttttgtatta tgtgactaat
     3841 tagttggcat attgttaaaa gtctctcaaa ttaggccaga ttctaaaaca tgctgcagca
     3901 agaggacccc gctctcttca ggaaaagtgt tttcatttct caggatgctt cttacctgtc
     3961 agaggaggtg acaaggcagt ctcttgctct cttggactca ccaggctcct attgaaggaa
     4021 ccacccccat tcctaaatat gtgaaaagtc gcccaaaatg caaccttgaa aggcactact
     4081 gactttgttc ttattggata ctcctcttat tatttttcca ttaaaaataa tagctggcta
     4141 ttatagaaaa tttagaccat acagagatgt agaaagaaca taaattgtcc ccattacctt
     4201 aaggtaatca ctgctaacaa tttctggatg gtttttcaag tctatttttt ttctatgtat
     4261 gtctcaattc tctttcaaaa ttttacagaa tgttatcata ctacatatat actttttatg
     4321 taagcttttt cacttagtat tttatcaaat atgtttttat tatattcata gccttcttaa
     4381 acattatatc aataattgca taataggcaa cctctagcga ttaccataat tttgctcatt
     4441 gaaggctatc tccagttgat cattgggatg agcatctttg tgcatgaatc ctattgctgt
     4501 atttgggaaa attttccaag gttagattcc aataaatatc tatttattat taaatattaa
     4561 aatatctatt tattattaaa accatttata aggctttttc ataaatgtat agcaaatagg
     4621 aattattaac ttgagcataa gatatgagat acatgaacct gaactattaa aataaaatat
     4681 tatatttaac ccttagttta agaagaagtc aatatgctta tttaaatatt atggatggtg
     4741 ggcagatcac ttgaggtcag gagttcgaga ccagcctggc caacatggca aaaccacatc
     4801 tctactaaaa ataaaaaaat tagctgggtg tggtggtgca ctcctgtaat cccagctact
     4861 cagaaggctg aggtacaaga attgctggaa cctgggaggc ggaggttgca gtgaaccaag
     4921 attgcaccac tgcactccag ccggggtgac agagtgagac tccgactgaa aataaataaa
     4981 taaataaata aataaataaa taaatattat ggatggtgaa gggaatggta tagaattgga
     5041 gagattatct tactgaacac ctgtagtccc agctttctct ggaagtggtc gtatttgagc
     5101 aggatgtgca caaggcaatt gaaatgccca taattagttt ctcagctttg aatacactat
     5161 aaactcactg gctgaaggag gaaattttag aaggaagcta ctaaaagatc taatttgaaa
     5221 aactacaaaa gcattaacta aaaaagttta ttttcctttt gtctgggcag tagtgaaaat
     5281 aactactcac aacattcact atgtttgcaa ggaattaaca caaataaaag atgccttttt
     5341 acttaaacac caagacagaa aacttgccca atactgagaa gcaacttgca ttagagaggg
     5401 aactgttaaa tgttttcaac ccagttcatc tggtggatgt ttttgcaggt tactctgaga
     5461 attttgctta tgaaaaatca ttatttttag tgtagttcac aataatgtat tgaacatact
     5521 tctaatcaaa ggtgctatgt ccttgtgtat ggtactaaat gtgtcctgtg tacttttgca
     5581 caactgagaa tcctgcagct tggtttaatg agtgtgttca tgaaataaat aatggaggaa
     5641 ttgtca
//
