LOCUS       NM_001397612            4224 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            M member 8 (TRPM8), transcript variant 8, mRNA.
ACCESSION   NM_001397612
VERSION     NM_001397612.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4224)
  AUTHORS   Behrendt,M.
  TITLE     Implications of TRPM3 and TRPM8 for sensory neuron sensitisation
  JOURNAL   Biol Chem 405 (9-10), 583-599 (2024)
   PUBMED   39417661
  REMARK    GeneRIF: Implications of TRPM3 and TRPM8 for sensory neuron
            sensitisation.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4224)
  AUTHORS   Chen,L., Xu,N., Gou,D., Song,J., Zhou,M., Zhang,Y., Zhang,H.,
            Zhu,L., Huang,W., Zhu,Y., Gao,C., Gu,D., Xu,Y. and Zhou,H.
  TITLE     TRPM8 overexpression suppresses hepatocellular carcinoma
            progression and improves survival by modulating the RTP3/STAT3
            pathway
  JOURNAL   Cancer Med 13 (19), e70109 (2024)
   PUBMED   39385506
  REMARK    GeneRIF: TRPM8 overexpression suppresses hepatocellular carcinoma
            progression and improves survival by modulating the RTP3/STAT3
            pathway.
REFERENCE   3  (bases 1 to 4224)
  AUTHORS   Iftinca,M. and Altier,C.
  TITLE     The cool things to know about TRPM8!
  JOURNAL   Channels (Austin) 14 (1), 413-420 (2020)
   PUBMED   33147416
  REMARK    Review article
REFERENCE   4  (bases 1 to 4224)
  AUTHORS   Liu,Y., Mikrani,R., He,Y., Faran Ashraf Baig,M.M., Abbas,M.,
            Naveed,M., Tang,M., Zhang,Q., Li,C. and Zhou,X.
  TITLE     TRPM8 channels: A review of distribution and clinical role
  JOURNAL   Eur J Pharmacol 882, 173312 (2020)
   PUBMED   32610057
  REMARK    GeneRIF: TRPM8 channels: A review of distribution and clinical
            role.
            Review article
REFERENCE   5  (bases 1 to 4224)
  AUTHORS   Gonzalez-Muniz,R., Bonache,M.A., Martin-Escura,C. and
            Gomez-Monterrey,I.
  TITLE     Recent Progress in TRPM8 Modulation: An Update
  JOURNAL   Int J Mol Sci 20 (11), 2618 (2019)
   PUBMED   31141957
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4224)
  AUTHORS   Almaraz,L., Manenschijn,J.A., de la Pena,E. and Viana,F.
  TITLE     TRPM8.
  JOURNAL   Handb Exp Pharmacol 222, 547-579 (2014)
   PUBMED   24756721
REFERENCE   7  (bases 1 to 4224)
  AUTHORS   Bautista,D.M., Siemens,J., Glazer,J.M., Tsuruda,P.R., Basbaum,A.I.,
            Stucky,C.L., Jordt,S.E. and Julius,D.
  TITLE     The menthol receptor TRPM8 is the principal detector of
            environmental cold
  JOURNAL   Nature 448 (7150), 204-208 (2007)
   PUBMED   17538622
REFERENCE   8  (bases 1 to 4224)
  AUTHORS   Voets,T., Owsianik,G. and Nilius,B.
  TITLE     TRPM8.
  JOURNAL   Handb Exp Pharmacol (179), 329-344 (2007)
   PUBMED   17217067
  REMARK    GeneRIF: TRPM8 is now best known as a cold- and menthol-activated
            channel implicated in thermosensation--{REVIEW}
            Review article
REFERENCE   9  (bases 1 to 4224)
  AUTHORS   Voets,T., Droogmans,G., Wissenbach,U., Janssens,A., Flockerzi,V.
            and Nilius,B.
  TITLE     The principle of temperature-dependent gating in cold- and
            heat-sensitive TRP channels
  JOURNAL   Nature 430 (7001), 748-754 (2004)
   PUBMED   15306801
  REMARK    GeneRIF: temperature sensing is tightly linked to voltage-dependent
            gating in the cold-sensitive channel TRPM8 and the heat-sensitive
            channel TRPV1
REFERENCE   10 (bases 1 to 4224)
  AUTHORS   Tsavaler,L., Shapero,M.H., Morkowski,S. and Laus,R.
  TITLE     Trp-p8, a novel prostate-specific gene, is up-regulated in prostate
            cancer and other malignancies and shares high homology with
            transient receptor potential calcium channel proteins
  JOURNAL   Cancer Res 61 (9), 3760-3769 (2001)
   PUBMED   11325849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005538.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1968189
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-927               AC005538.3         106787-107713
            928-1084            AC005538.3         111109-111265
            1085-1262           AC005538.3         112754-112931
            1263-1435           AC005538.3         116332-116504
            1436-1610           AC005538.3         119612-119786
            1611-1678           AC005538.3         120844-120911
            1679-1876           AC005538.3         123705-123902
            1877-1979           AC005538.3         127673-127775
            1980-2098           AC005538.3         128888-129006
            2099-2389           AC005538.3         134532-134822
            2390-2485           AC005538.3         137038-137133
            2486-2615           AC005538.3         138384-138513
            2616-2761           AC005538.3         140366-140511
            2762-2874           AC005538.3         143451-143563
            2875-3091           AC005538.3         143966-144182
            3092-3183           AC005538.3         153944-154035
            3184-3325           AC005538.3         155530-155671
            3326-3497           AC005538.3         156809-156980
            3498-3675           AC005538.3         159444-159621
            3676-4224           AC005538.3         170082-170630
FEATURES             Location/Qualifiers
     source          1..4224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..4224
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /note="transient receptor potential cation channel
                     subfamily M member 8"
                     /db_xref="GeneID:79054"
                     /db_xref="HGNC:HGNC:17961"
                     /db_xref="MIM:606678"
     exon            1..927
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1084
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             968..4042
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /note="isoform 6 is encoded by transcript variant 8;
                     transient receptor potential subfamily M member 8;
                     transient receptor potential p8; TRPM8 cationic channel"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 8 isoform 6"
                     /protein_id="NP_001384541.1"
                     /db_xref="GeneID:79054"
                     /db_xref="HGNC:HGNC:17961"
                     /db_xref="MIM:606678"
                     /translation="MEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRLS
                     CDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWI
                     LTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFL
                     AQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNY
                     GGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSA
                     VKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYA
                     LYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKD
                     RPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKL
                     VANFRRGFRKEDRNGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTR
                     GCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQL
                     LVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFI
                     IPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMD
                     FHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRL
                     HSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFA
                     VWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTG
                     NESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENND
                     QVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCEWFIH
                     VYLGSEAAINFREGCLVCISTGRNYSQIFHCSHLYICKDQASGQPMNYSREM"
     exon            1085..1262
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1435
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1610
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1678
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1876
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1979
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2098
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2389
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2485
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2615
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2761
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2874
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3091
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3183
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3325
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3497
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3498..3675
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..4224
                     /gene="TRPM8"
                     /gene_synonym="LTrpC-6; LTRPC6; trp-p8; TRPP8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgccgcac ttttgcccct gctgctgtgt cctctgaaat gtgctgccag cttaggagcc
       61 accttctggc acactatggg tagtaagctc ctaggtctgg ttttgctcta gtcacttctc
      121 acttccttgg ccatgctggg ttccaggtag aaacagaaag aatgctacct tcacaacagc
      181 agcactgtgc aacagaactt tcttccctgg tggaaatatt ctatgtccgc accatccaat
      241 acggtagcca ctagccacat ctggctattg atcatttgaa atgtggctag gacaacgaag
      301 gaatgttttt aatttattta atttcactta acttaaatat aaaattaaat aaccacgtga
      361 ggtcagtggc taccatattg gacggtgtag ttctacagga ttcagatttg gtccaagggg
      421 gtagaactag ggtcctgatg ttttcctgtc ctcttcattt ctcctgtctg tcatccttat
      481 tcctccttca ggtatctgca ctcctaatgt cttcctggca atttcttttc tccatttata
      541 aaccagttca tacaaattgg tgcttagagg gctaccagcc catagaccag agctgccagg
      601 cagctctctt ggtcaaggtc acctgtgaca cacccctacc cttagcaggg aaaagggccc
      661 aacagtttgt tttcagttat agcaagaaca gatggggcgg ggaattctct cccccatcct
      721 ccaataagct tgggtgggtg gacagatccc aaaggatggt gggacagtgg aagctatgga
      781 gagagaagag gaacatcagg aagtagcctg ggctcaggaa gtgccctaac acttaggaag
      841 agagagggct aagaacattg tgctgaattc tggttgacat atcttggcca cactgagtga
      901 tgccctggga actgttccaa aacagaggga gaatgtgtgc aagtgtggct atgcccagag
      961 ccagcacatg gaaggcaccc agatcaacca aagtgagaaa tggaactaca agaaacacac
     1021 caaggaattt cctaccgacg cctttgggga tattcagttt gagacactgg ggaagaaagg
     1081 gaagtatata cgtctgtcct gcgacacgga cgcggaaatc ctttacgagc tgctgaccca
     1141 gcactggcac ctgaaaacac ccaacctggt catttctgtg accgggggcg ccaagaactt
     1201 cgccctgaag ccgcgcatgc gcaagatctt cagccggctc atctacatcg cgcagtccaa
     1261 aggtgcttgg attctcacgg gaggcaccca ttatggcctg atgaagtaca tcggggaggt
     1321 ggtgagagat aacaccatca gcaggagttc agaggagaat attgtggcca ttggcatagc
     1381 agcttggggc atggtctcca accgggacac cctcatcagg aattgcgatg ctgagggcta
     1441 ttttttagcc cagtacctta tggatgactt cacaagagat ccactgtata tcctggacaa
     1501 caaccacaca catttgctgc tcgtggacaa tggctgtcat ggacatccca ctgtcgaagc
     1561 aaagctccgg aatcagctag agaagtatat ctctgagcgc actattcaag attccaacta
     1621 tggtggcaag atccccattg tgtgttttgc ccaaggaggt ggaaaagaga ctttgaaagc
     1681 catcaatacc tccatcaaaa ataaaattcc ttgtgtggtg gtggaaggct cgggccagat
     1741 cgctgatgtg atcgctagcc tggtggaggt ggaggatgcc ctgacatctt ctgccgtcaa
     1801 ggagaagctg gtgcgctttt taccccgcac ggtgtcccgg ctgcctgagg aggagactga
     1861 gagttggatc aaatggctca aagaaattct cgaatgttct cacctattaa cagttattaa
     1921 aatggaagaa gctggggatg aaattgtgag caatgccatc tcctacgctc tatacaaagc
     1981 cttcagcacc agtgagcaag acaaggataa ctggaatggg cagctgaagc ttctgctgga
     2041 gtggaaccag ctggacttag ccaatgatga gattttcacc aatgaccgcc gatgggagtc
     2101 tgctgacctt caagaagtca tgtttacggc tctcataaag gacagaccca agtttgtccg
     2161 cctctttctg gagaatggct tgaacctacg gaagtttctc acccatgatg tcctcactga
     2221 actcttctcc aaccacttca gcacgcttgt gtaccggaat ctgcagatcg ccaagaattc
     2281 ctataatgat gccctcctca cgtttgtctg gaaactggtt gcgaacttcc gaagaggctt
     2341 ccggaaggaa gacagaaatg gccgggacga gatggacata gaactccacg acgtgtctcc
     2401 tattactcgg caccccctgc aagctctctt catctgggcc attcttcaga ataagaagga
     2461 actctccaaa gtcatttggg agcagaccag gggctgcact ctggcagccc tgggagccag
     2521 caagcttctg aagactctgg ccaaagtgaa gaacgacatc aatgctgctg gggagtccga
     2581 ggagctggct aatgagtacg agacccgggc tgttgagctg ttcactgagt gttacagcag
     2641 cgatgaagac ttggcagaac agctgctggt ctattcctgt gaagcttggg gtggaagcaa
     2701 ctgtctggag ctggcggtgg aggccacaga ccagcatttc atcgcccagc ctggggtcca
     2761 gaattttctt tctaagcaat ggtatggaga gatttcccga gacaccaaga actggaagat
     2821 tatcctgtgt ctgtttatta tacccttggt gggctgtggc tttgtatcat ttaggaagaa
     2881 acctgtcgac aagcacaaga agctgctttg gtactatgtg gcgttcttca cctccccctt
     2941 cgtggtcttc tcctggaatg tggtcttcta catcgccttc ctcctgctgt ttgcctacgt
     3001 gctgctcatg gatttccatt cggtgccaca cccccccgag ctggtcctgt actcgctggt
     3061 ctttgtcctc ttctgtgatg aagtgagaca gtggtacgta aatggggtga attattttac
     3121 tgacctgtgg aatgtgatgg acacgctggg gcttttttac ttcatagcag gaattgtatt
     3181 tcggctccac tcttctaata aaagctcttt gtattctgga cgagtcattt tctgtctgga
     3241 ctacattatt ttcactctaa gattgatcca catttttact gtaagcagaa acttaggacc
     3301 caagattata atgctgcaga ggatgctgat cgatgtgttc ttcttcctgt tcctctttgc
     3361 ggtgtggatg gtggcctttg gcgtggccag gcaagggatc cttaggcaga atgagcagcg
     3421 ctggaggtgg atattccgtt cggtcatcta cgagccctac ctggccatgt tcggccaggt
     3481 gcccagtgac gtggatggta ccacgtatga ctttgcccac tgcaccttca ctgggaatga
     3541 gtccaagcca ctgtgtgtgg agctggatga gcacaacctg ccccggttcc ccgagtggat
     3601 caccatcccc ctggtgtgca tctacatgtt atccaccaac atcctgctgg tcaacctgct
     3661 ggtcgccatg tttggctaca cggtgggcac cgtccaggag aacaatgacc aggtctggaa
     3721 gttccagagg tacttcctgg tgcaggagta ctgcagccgc ctcaatatcc ccttcccctt
     3781 catcgtcttc gcttacttct acatggtggt gaagaagtgc ttcaagtgtt gctgcaagga
     3841 gaaaaacatg gagtcttctg tctgctgtga gtggtttatc catgtgtact tgggatcaga
     3901 agcagcgatt aatttcaggg aaggatgcct ggtgtgtatc tcaacaggaa ggaattattc
     3961 acagatcttt cactgttcac atctgtacat ctgtaaagat caggcctcag gccaaccaat
     4021 gaattactct agagaaatgt agctgaagaa agcactgtag atctgccggg atagcctgct
     4081 ctgtggggaa tgaatgactt ttggacagat cgtgtaataa taatgtaaat agtatgttga
     4141 acgggcagaa ttcatgggat agtgtccaat catgactttg tttttgcttt tcattgttcc
     4201 cgtgaaattt attctctagg aacc
//
