LOCUS       NM_014555               5689 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            M member 5 (TRPM5), mRNA.
ACCESSION   NM_014555
VERSION     NM_014555.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5689)
  AUTHORS   Koc,G., Soyocak,A., Duzgun Ergun,D., Pastaci Ozsobaci,N.,
            Andac-Ozturk,S. and Ergun,S.
  TITLE     Association of TRPM5 Asn235Ser Polymorphism and Trace
            Elements/Minerals in Chronic Gastritis Patients: a Case-Control
            Study
  JOURNAL   Biol Trace Elem Res 200 (2), 535-542 (2022)
   PUBMED   34767145
  REMARK    GeneRIF: Association of TRPM5 Asn235Ser Polymorphism and Trace
            Elements/Minerals in Chronic Gastritis Patients: a Case-Control
            Study.
REFERENCE   2  (bases 1 to 5689)
  AUTHORS   Li,X., Lai,L., Su,J., Chen,S., Lin,S., Wang,B., Gao,J., Zhang,L.,
            Yao,K. and Duan,S.
  TITLE     Novel association between a transient receptor potential cation
            channel subfamily M member 5 expression quantitative trait locus
            rs35197079 and decreased susceptibility of gestational diabetes
            mellitus in a Chinese population
  JOURNAL   J Diabetes Investig 12 (11), 2062-2070 (2021)
   PUBMED   33979016
  REMARK    GeneRIF: Novel association between a transient receptor potential
            cation channel subfamily M member 5 expression quantitative trait
            locus rs35197079 and decreased susceptibility of gestational
            diabetes mellitus in a Chinese population.
REFERENCE   3  (bases 1 to 5689)
  AUTHORS   Mardaryev,A., van Lessen,M., Alam,M., Jimenez Acosta,F., Biro,T.
            and Paus,R.
  TITLE     Hair Follicle Chemosensation: TRPM5 Signaling Is Required for
            Anagen Maintenance
  JOURNAL   J Invest Dermatol 141 (9), 2300-2303 (2021)
   PUBMED   33773986
  REMARK    GeneRIF: Hair Follicle Chemosensation: TRPM5 Signaling Is Required
            for Anagen Maintenance.
REFERENCE   4  (bases 1 to 5689)
  AUTHORS   Sakaguchi,T., Okumura,R., Ono,C., Okuzaki,D., Kawai,T., Okochi,Y.,
            Tanimura,N., Murakami,M., Kayama,H., Umemoto,E., Kioka,H.,
            Ohtani,T., Sakata,Y., Miyake,K., Okamura,Y., Baba,Y. and Takeda,K.
  TITLE     TRPM5 Negatively Regulates Calcium-Dependent Responses in
            Lipopolysaccharide-Stimulated B Lymphocytes
  JOURNAL   Cell Rep 31 (10), 107755 (2020)
   PUBMED   32521253
  REMARK    GeneRIF: TRPM5 Negatively Regulates Calcium-Dependent Responses in
            Lipopolysaccharide-Stimulated B Lymphocytes.
REFERENCE   5  (bases 1 to 5689)
  AUTHORS   Liu,D., Zhang,Z. and Liman,E.R.
  TITLE     Extracellular acid block and acid-enhanced inactivation of the
            Ca2+-activated cation channel TRPM5 involve residues in the S3-S4
            and S5-S6 extracellular domains
  JOURNAL   J Biol Chem 280 (21), 20691-20699 (2005)
   PUBMED   15731110
  REMARK    GeneRIF: data show that extracellular acidification acts through
            specific residues on transient receptor potential cation channel,
            subfamily M(TRPM5) to block conduction through two distinct but
            related mechanisms
REFERENCE   6  (bases 1 to 5689)
  AUTHORS   Liu,D. and Liman,E.R.
  TITLE     Intracellular Ca2+ and the phospholipid PIP2 regulate the taste
            transduction ion channel TRPM5
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15160-15165 (2003)
   PUBMED   14657398
  REMARK    GeneRIF: regulation of TRPM5 by Ca2+ mediates sensory activation in
            the taste system
REFERENCE   7  (bases 1 to 5689)
  AUTHORS   Prawitt,D., Monteilh-Zoller,M.K., Brixel,L., Spangenberg,C.,
            Zabel,B., Fleig,A. and Penner,R.
  TITLE     TRPM5 is a transient Ca2+-activated cation channel responding to
            rapid changes in [Ca2+]i
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15166-15171 (2003)
   PUBMED   14634208
  REMARK    GeneRIF: TRPM5 is a transient Ca2+-activated cation channel
            responding to rapid changes in [Ca2+]i
REFERENCE   8  (bases 1 to 5689)
  AUTHORS   Perez,C.A., Huang,L., Rong,M., Kozak,J.A., Preuss,A.K., Zhang,H.,
            Max,M. and Margolskee,R.F.
  TITLE     A transient receptor potential channel expressed in taste receptor
            cells
  JOURNAL   Nat Neurosci 5 (11), 1169-1176 (2002)
   PUBMED   12368808
REFERENCE   9  (bases 1 to 5689)
  AUTHORS   Paulsen,M., El-Maarri,O., Engemann,S., Strodicke,M., Franck,O.,
            Davies,K., Reinhardt,R., Reik,W. and Walter,J.
  TITLE     Sequence conservation and variability of imprinting in the
            Beckwith-Wiedemann syndrome gene cluster in human and mouse
  JOURNAL   Hum Mol Genet 9 (12), 1829-1841 (2000)
   PUBMED   10915772
REFERENCE   10 (bases 1 to 5689)
  AUTHORS   Prawitt,D., Enklaar,T., Klemm,G., Gartner,B., Spangenberg,C.,
            Winterpacht,A., Higgins,M., Pelletier,J. and Zabel,B.
  TITLE     Identification and characterization of MTR1, a novel gene with
            homology to melastatin (MLSN1) and the trp gene family located in
            the BWS-WT2 critical region on chromosome 11p15.5 and showing
            allele-specific expression
  JOURNAL   Hum Mol Genet 9 (2), 203-216 (2000)
   PUBMED   10607831
  REMARK    GeneRIF: TRPM5 gene is imprinted, with preferential expression from
            the paternal allele.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124057.12.
            
            On Jul 15, 2021 this sequence version replaced NM_014555.3.
            
            Summary: This gene encodes a member of the transient receptor
            potential (TRP) protein family, which is a diverse group of
            proteins with structural features typical of ion channels. This
            protein plays an important role in taste transduction, and has
            characteristics of a calcium-activated, non-selective cation
            channel that carries Na+, K+, and Cs+ ions equally well, but not
            Ca(2+) ions. It is activated by lower concentrations of
            intracellular Ca(2+), and inhibited by higher concentrations. It is
            also a highly temperature-sensitive, heat activated channel showing
            a steep increase of inward currents at temperatures between 15 and
            35 degrees Celsius. This gene is located within the
            Beckwith-Wiedemann syndrome critical region-1 on chromosome
            11p15.5, and has been shown to be imprinted, with exclusive
            expression from the paternal allele. [provided by RefSeq, Oct
            2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF177473.1, BC093787.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            imprinted gene                   :: PMID: 10607831
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000696290.1/
                                                ENSP00000512529.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC124057.12        95577-95660
            85-205              AC124057.12        104993-105113
            206-1363            AC124057.12        106746-107903
            1364-1592           AC124057.12        112338-112566
            1593-1755           AC124057.12        116586-116748
            1756-1886           AC124057.12        117041-117171
            1887-2067           AC124057.12        117770-117950
            2068-2234           AC124057.12        118893-119059
            2235-2418           AC124057.12        119686-119869
            2419-2483           AC124057.12        121500-121564
            2484-2675           AC124057.12        121733-121924
            2676-2778           AC124057.12        122262-122364
            2779-2897           AC124057.12        124067-124185
            2898-3248           AC124057.12        124620-124970
            3249-3389           AC124057.12        125044-125184
            3390-3513           AC124057.12        125253-125376
            3514-3659           AC124057.12        125885-126030
            3660-3772           AC124057.12        126503-126615
            3773-3865           AC124057.12        126865-126957
            3866-4124           AC124057.12        127079-127337
            4125-4243           AC124057.12        127838-127956
            4244-4376           AC124057.12        128324-128456
            4377-4551           AC124057.12        128565-128739
            4552-4705           AC124057.12        132179-132332
            4706-4887           AC124057.12        132791-132972
            4888-5020           AC124057.12        133298-133430
            5021-5093           AC124057.12        134000-134072
            5094-5160           AC124057.12        134498-134564
            5161-5689           AC124057.12        135048-135576
FEATURES             Location/Qualifiers
     source          1..5689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..5689
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /note="transient receptor potential cation channel
                     subfamily M member 5"
                     /db_xref="GeneID:29850"
                     /db_xref="HGNC:HGNC:14323"
                     /db_xref="MIM:604600"
     exon            1..84
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..205
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..1363
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1592
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1755
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1886
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1770..5267
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /note="MLSN1 and TRP-related; MLSN1- and TRP-related gene
                     1 protein; long transient receptor potential channel 5"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 5"
                     /protein_id="NP_055370.1"
                     /db_xref="CCDS:CCDS31340.1"
                     /db_xref="GeneID:29850"
                     /db_xref="HGNC:HGNC:14323"
                     /db_xref="MIM:604600"
                     /translation="MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVP
                     SGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAW
                     ILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPV
                     HYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGT
                     GSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPK
                     VAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKAL
                     VKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNK
                     PEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQ
                     AREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEKGPAKRPTGQKWLL
                     DLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAE
                     AARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFF
                     AHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDLQD
                     LDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVV
                     MYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKK
                     FTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIH
                     KQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPY
                     LQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMN
                     LLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKK
                     EAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFI
                     AKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQLVAADH
                     RGGLDGWEQPGAGQPPSDT"
     exon            1887..2067
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2234
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2418
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2483
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2675
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2778
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2897
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3248
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3389
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3513
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3659
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3772
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3865
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..4124
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4243
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4376
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4551
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4552..4705
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4887
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4888..5020
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5021..5093
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5094..5160
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5161..5689
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5689
                     /gene="TRPM5"
                     /gene_synonym="LTRPC5; MTR1"
                     /note="major polyA site"
ORIGIN      
        1 acccacctgc ttggccccca cttctgatgc ccgcctgctc tgcctggccc ggaggaggac
       61 cccagctgcg ccagggagga aggggccggc tgtggtggct catgcctgta atccagtgct
      121 gtgggaggcc gaggtgggag gattgctcaa gtccaagtgt ttgaggccag tctgggcagc
      181 atagtgagac cacatctcta caaaaatctg ctgtctgatc gccaagcacc ctctgcgggg
      241 agcagggtag ggggacgtct tcctgcagct gtggaagctc caggacagga cagcagggga
      301 gagggcgtgg gccttgcctc atggcggcat tgctatgggc aggtcatttg gcctcgctgg
      361 cccctacggc ctctacctct gttcacatct tgtgatgggg tcaaggttgc cctcccagag
      421 tagaaggaca ggcaaaaggt gatgctgcaa ggatggtgcc gagacagcag tggcacgctg
      481 caggcgctgc ccgggccagg gaacttaatg gagtggggac ggacgtgcgg ctccactggt
      541 tcccggactc ctggtctcca ctgctgggca ctcaggatct gcccggaggc cttggacaca
      601 ggcaccactg gcagagcttg cccatggccc tgctgcccca ctgcatggct tcgggctgcc
      661 ccccgagggg tcagacctga cgcccccacc atcagctttc ctgtctgagg ggctccgggc
      721 tgcttccctc ccacctgggg ctagactgtg tgtggttcag agggagatgc tgggttgggg
      781 gcgcccacca cactggcatg gggaccctgg gccagcgggc cctactctgg gtggtggttt
      841 ctcccctcta agacaaagaa gaagtgggtt gcaaatcttt ctgtaaataa aatgccacat
      901 ggcacccaag gatgtgcctg gggggaggct gcctgtggtg caggtgggga gccagcctgc
      961 agctccttct ctctcagcag aggcccgagg accccggtca gggacggctc acgctctcct
     1021 ggacactggg gtcagcttct gagcctgtgg gcccagcctc gcatggcagg gcttggcagg
     1081 agagagctga gcctctgcag tcagccattg gggttgctgg agatccaaag gggatctgct
     1141 gtcccaggga tagaggcccc gtgggggcag gggctgggcc ctgttggagt cctgctctac
     1201 tggcgtggcc tctcctccaa aggaagttcc aacgtaaagc ctgcccgggg ccaactgtag
     1261 caaagaagac agaggccgct ggaggaaacc cgctgtagag ggcaggcaga ggctgctctg
     1321 tcggcagctg ggatgtccct catgacagca cgcatggacg cagggtggat ttcagctgca
     1381 tcggtcccgg gccaccccgc cagacatcgc caaaggaggc aacgacagca atctaagtgg
     1441 cctagaagcc acgtccacac agggtctcct ctcccagtca aatcggacat gcccccaggg
     1501 ccttggtgcc aatcacacct gaggacggcc agcccttggt gtctgggtgg ctttggagac
     1561 agcaggcctg tgggctcggc cgtgtggagc aggtgcaccc agggtctcca catccctgtc
     1621 ctgggagcgg gtgggctgtg tggccagggg actgcaaggc ctctgctgag tctttcggag
     1681 tttccaggtc atccccacaa aaggcctctg gagaaatgtc tgcaggtgtg gccaacctga
     1741 ggtgccctga gtgggctcta gaggccacca tgcaggatgt ccaaggcccc cgtcccggaa
     1801 gccccgggga tgctgaagac cggcgggagc tgggcttgca caggggcgag gtcaactttg
     1861 gagggtctgg gaagaagcga ggcaagtttg tacgggtgcc gagcggagtg gccccgtctg
     1921 tgctctttga cctgctgctt gctgagtggc acctgccggc ccccaacctg gtggtgtccc
     1981 tggtgggtga ggagcagcct ttcgccatga agtcctggct gcgggatgtg ctgcgcaagg
     2041 ggctggtgaa ggcggctcag agcacaggag cctggatcct gaccagtgcc ctccgcgtgg
     2101 gcctggccag gcatgtcggg caggccgtgc gcgaccactc gctggccagc acgtccacca
     2161 aggtccgtgt ggttgctgtc ggcatggcct cgctgggccg cgtcctgcac cgccgcattc
     2221 tggaggaggc ccaggaggat tttcctgtcc actaccctga ggatgacggc ggcagccagg
     2281 gccccctctg ttcactggac agcaacctct cccacttcat cctggtggag ccaggccccc
     2341 cggggaaggg cgatgggctg acggagctgc ggctgaggct ggagaagcac atctcggagc
     2401 agagggcggg ctacgggggc actggcagca tcgagatccc tgtcctctgc ttgctggtca
     2461 atggtgatcc caacaccttg gagaggatct ccagggccgt ggagcaggct gccccgtggc
     2521 tgatcctggt aggctcgggg ggcatcgccg atgtgcttgc tgccctagtg aaccagcccc
     2581 acctcctggt gcccaaggtg gccgagaagc agtttaagga gaagttcccc agcaagcatt
     2641 tctcttggga ggacatcgtg cgctggacca agctgctgca gaacatcacc tcacaccagc
     2701 acctgctcac cgtgtatgac ttcgagcagg agggctccga ggagctggac acggtcatcc
     2761 tgaaggcgct ggtgaaagcc tgcaagagcc acagccagga gcctcaggac tatctggatg
     2821 agctcaagct ggccgtggcc tgggaccgcg tggacatcgc caagagtgag atcttcaatg
     2881 gggacgtgga gtggaagtcc tgtgacctgg aggaggtgat ggtggacgcc ctggtcagca
     2941 acaagcccga gtttgtgcgc ctctttgtgg acaacggcgc agacgtggcc gacttcctga
     3001 cgtatgggcg gctgcaggag ctctaccgct ccgtgtcacg caagagcctg ctcttcgacc
     3061 tgctgcagcg gaagcaggag gaggcccggc tgacgctggc cggcctgggc acccagcagg
     3121 cccgggagcc acccgcgggg ccaccggcct tctccctgca cgaggtctcc cgcgtactca
     3181 aggacttcct gcaggacgcc tgccgaggct tctaccagga cggccggcca ggggaccgca
     3241 ggagggcgga gaagggcccg gccaagcggc ccacgggcca gaagtggctg ctggacctga
     3301 accagaagag cgagaacccc tggcgggacc tgttcctgtg ggccgtgctg cagaaccgcc
     3361 acgagatggc cacctacttc tgggccatgg gccaggaagg tgtggcagcc gcactggccg
     3421 cctgcaaaat cctcaaagag atgtcgcacc tggagacgga ggccgaggcg gcccgagcca
     3481 cgcgcgaggc gaaatacgag cggctggccc ttgacctctt ctccgagtgc tacagcaaca
     3541 gtgaggcccg cgccttcgcc ctgctggtgc gccggaaccg ctgctggagc aagaccacct
     3601 gcctgcacct ggccaccgag gctgacgcca aggccttctt tgcccacgac ggcgttcagg
     3661 ccttcctgac caggatctgg tggggggaca tggccgcagg cacgcccatc ctgcggctgc
     3721 taggagcctt cctctgcccc gccctcgtct ataccaacct catcaccttc agtgaggaag
     3781 ctcccctgag gacaggcctg gaggacctgc aggacctgga cagcctggac acggagaaga
     3841 gcccgctgta tggcctgcag agccgggtgg aggagctggt ggaggcgccg agggctcagg
     3901 gtgaccgagg cccacgtgct gtcttcctgc tcacacgctg gcggaaattc tggggcgctc
     3961 ccgtgactgt gttcctgggg aacgtggtca tgtacttcgc cttcctcttc ctgttcacct
     4021 acgtcctgct ggtggacttc aggccgcccc cccagggccc ctcagggccc gaggtcaccc
     4081 tctacttctg ggtctttacg ctggtgctgg aggaaatccg gcagggcttc ttcacagacg
     4141 aggacacaca cctggtgaag aagttcacac tgtatgtggg ggacaactgg aacaagtgtg
     4201 acatggtggc catcttcctg ttcatcgtgg gtgtcacctg caggatgctg ccgtcggcgt
     4261 ttgaggctgg ccgcacagtc ctcgccatgg acttcatggt gttcacgctg cggctgatcc
     4321 atatctttgc catacacaag cagctgggcc ccaagatcat cgtggtagag cgcatgatga
     4381 aggacgtctt cttcttcctc ttctttctga gcgtgtggct cgtggcctac ggtgtcacca
     4441 cccaggcgct gctgcacccc catgacggcc gcctggagtg gatcttccgc cgggtgctct
     4501 accggcccta cctgcagatc ttcggccaga tcccactgga cgagattgat gaagcccgtg
     4561 tgaactgctc cacccaccca ctgctgctgg aggactcacc atcctgcccc agcctctatg
     4621 ccaactggct ggtcatcctc ctgctggtca ccttcctgtt ggtcaccaat gtgctgctca
     4681 tgaacctgct catcgccatg ttcagctaca cgttccaggt ggtgcagggc aacgcagaca
     4741 tgttctggaa gttccagcgc tacaacctga ttgtggagta ccacgagcgc cccgccctgg
     4801 ccccgccctt catcctgctc agccacctga gcctgacgct ccgccgggtc ttcaagaagg
     4861 aggctgagca caagcgggag cacctggaga gagacctgcc agaccccctg gaccagaagg
     4921 tcgtcacctg ggagacagtc cagaaggaga acttcctgag caagatggag aagcggagga
     4981 gggacagcga gggggaggtg ctgcggaaaa ccgcccacag agtggacttc attgccaagt
     5041 acctcggggg tctgagagag caagaaaagc gcatcaagtg tctggagtca cagatcaact
     5101 actgctcggt gctcgtgtcc tccgtggctg acgtgctggc ccagggtggc ggcccccgga
     5161 gctctcagca ctgtggcgag ggaagccagc tggtggctgc tgaccacaga ggtggtttag
     5221 atggctggga acaacccggg gctggccagc ctccctcgga cacctgagct gcttggcctg
     5281 ccacgtgtgg ggccacctct cctcagctgg ccaccctgca cgttgtgcac tgacctttgc
     5341 cgacctccag cggaaccccc cagggggcac cagcccccca gcagacaatg gccctcctgg
     5401 tgcctcacca cagaccctca cccaaaggaa ccgctccttg tccctcctgg cctccccgga
     5461 ggcacagcag tgtcatgggg ctgtctcccc tgacaggcac aactccccgg gcagaaaacg
     5521 tgccccaccg catccctacc tggaaactga ccagcctgca ctgtggaaaa gctggccctg
     5581 tggcgtgacg ggggagcacc cccatccaga ctgcgaagct gctctggggt ctgcacccac
     5641 ccctgccctg acttgtgttg cctgacaaga gactcatctt tttttgaaa
//
