LOCUS       NM_003307               5419 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            M member 2 (TRPM2), transcript variant 1, mRNA.
ACCESSION   NM_003307
VERSION     NM_003307.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5419)
  AUTHORS   Ma,C., Luo,Y., Zhang,C., Cheng,C., Hua,N., Liu,X., Wu,J., Qin,L.,
            Yu,P., Luo,J., Yang,F., Jiang,L.H., Zhang,G. and Yang,W.
  TITLE     Evolutionary trajectory of TRPM2 channel activation by adenosine
            diphosphate ribose and calcium
  JOURNAL   Sci Bull (Beijing) 69 (18), 2892-2905 (2024)
   PUBMED   38734586
  REMARK    GeneRIF: Evolutionary trajectory of TRPM2 channel activation by
            adenosine diphosphate ribose and calcium.
REFERENCE   2  (bases 1 to 5419)
  AUTHORS   Chen,Z., Vallega,K.A., Boda,V.K., Quan,Z., Wang,D., Fan,S.,
            Wang,Q., Ramalingam,S.S., Li,W. and Sun,S.Y.
  TITLE     Targeting Transient Receptor Potential Melastatin-2 (TRPM2)
            Enhances Therapeutic Efficacy of Third Generation EGFR Inhibitors
            against EGFR Mutant Lung Cancer
  JOURNAL   Adv Sci (Weinh) 11 (35), e2310126 (2024)
   PUBMED   39044361
  REMARK    GeneRIF: Targeting Transient Receptor Potential Melastatin-2
            (TRPM2) Enhances Therapeutic Efficacy of Third Generation EGFR
            Inhibitors against EGFR Mutant Lung Cancer.
REFERENCE   3  (bases 1 to 5419)
  AUTHORS   Gu,Y., Liu,M., Ma,L. and Quinn,R.J.
  TITLE     Identification of Ligands for Ion Channels: TRPM2
  JOURNAL   Chembiochem 25 (5), e202300790 (2024)
   PUBMED   38242853
  REMARK    GeneRIF: Identification of Ligands for Ion Channels: TRPM2.
REFERENCE   4  (bases 1 to 5419)
  AUTHORS   Cheng,K., Jia,Q., Batbatan,C., Guo,Z. and Cheng,F.
  TITLE     TRPM2-L Participates in the Interleukin-6 Pathway to Enhance Tumor
            Growth in Prostate Cancer by Hypoxia-Inducible Factor-1alpha
  JOURNAL   J Interferon Cytokine Res 43 (11), 495-511 (2023)
   PUBMED   37906101
  REMARK    GeneRIF: TRPM2-L Participates in the Interleukin-6 Pathway to
            Enhance Tumor Growth in Prostate Cancer by Hypoxia-Inducible
            Factor-1alpha.
REFERENCE   5  (bases 1 to 5419)
  AUTHORS   Zhang,M., Wang,Y., Xu,S., Huang,S., Wu,M., Chen,G. and Wang,Y.
  TITLE     Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk Classifier
            for Survival Evaluation in Epithelial Ovarian Cancer and TRPM2: A
            Potential Therapeutic Target of Ovarian Cancer
  JOURNAL   Int J Mol Sci 24 (18), 14010 (2023)
   PUBMED   37762313
  REMARK    GeneRIF: Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk
            Classifier for Survival Evaluation in Epithelial Ovarian Cancer and
            TRPM2: A Potential Therapeutic Target of Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5419)
  AUTHORS   Sano,Y., Inamura,K., Miyake,A., Mochizuki,S., Yokoi,H.,
            Matsushime,H. and Furuichi,K.
  TITLE     Immunocyte Ca2+ influx system mediated by LTRPC2
  JOURNAL   Science 293 (5533), 1327-1330 (2001)
   PUBMED   11509734
REFERENCE   7  (bases 1 to 5419)
  AUTHORS   Tang,J., Lin,Y., Zhang,Z., Tikunova,S., Birnbaumer,L. and Zhu,M.X.
  TITLE     Identification of common binding sites for calmodulin and inositol
            1,4,5-trisphosphate receptors on the carboxyl termini of trp
            channels
  JOURNAL   J Biol Chem 276 (24), 21303-21310 (2001)
   PUBMED   11290752
REFERENCE   8  (bases 1 to 5419)
  AUTHORS   Perraud,A.L., Fleig,A., Dunn,C.A., Bagley,L.A., Launay,P.,
            Schmitz,C., Stokes,A.J., Zhu,Q., Bessman,M.J., Penner,R.,
            Kinet,J.P. and Scharenberg,A.M.
  TITLE     ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed
            by Nudix motif homology
  JOURNAL   Nature 411 (6837), 595-599 (2001)
   PUBMED   11385575
REFERENCE   9  (bases 1 to 5419)
  AUTHORS   Nagamine,K., Kudoh,J., Minoshima,S., Kawasaki,K., Asakawa,S.,
            Ito,F. and Shimizu,N.
  TITLE     Molecular cloning of a novel putative Ca2+ channel protein (TRPC7)
            highly expressed in brain
  JOURNAL   Genomics 54 (1), 124-131 (1998)
   PUBMED   9806837
REFERENCE   10 (bases 1 to 5419)
  AUTHORS   Kudoh,J., Nagamine,K., Asakawa,S., Abe,I., Kawasaki,K., Maeda,H.,
            Tsujimoto,S., Minoshima,S., Ito,F. and Shimizu,N.
  TITLE     Localization of 16 exons to a 450-kb region involved in the
            autoimmune polyglandular disease type I (APECED) on human
            chromosome 21q22.3
  JOURNAL   DNA Res 4 (1), 45-52 (1997)
   PUBMED   9179495
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001063.1, AP001064.1 and
            AP001065.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 18, 2020 this sequence version replaced NM_003307.3.
            
            Summary: The protein encoded by this gene forms a tetrameric cation
            channel that is permeable to calcium, sodium, and potassium and is
            regulated by free intracellular ADP-ribose. The encoded protein is
            activated by oxidative stress and confers susceptibility to cell
            death. Alternative splicing results in multiple transcript variants
            encoding distinct protein isoforms. Additional transcript variants
            of this gene have been described, but their full-length nature is
            not known. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001535.1, AJ878416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397928.6/ ENSP00000381023.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AP001063.1         12992-13236
            246-334             AP001063.1         14019-14107
            335-503             AP001063.1         23485-23653
            504-684             AP001063.1         26125-26305
            685-851             AP001063.1         28548-28714
            852-1032            AP001063.1         35204-35384
            1033-1094           AP001063.1         37083-37144
            1095-1295           AP001063.1         38368-38568
            1296-1398           AP001064.1         1036-1138
            1399-1520           AP001064.1         9222-9343
            1521-1874           AP001064.1         9590-9943
            1875-2012           AP001065.1         1139-1276
            2013-2142           AP001065.1         3472-3601
            2143-2288           AP001065.1         5021-5166
            2289-2401           AP001065.1         5984-6096
            2402-2618           AP001065.1         7406-7622
            2619-2737           AP001065.1         10867-10985
            2738-2870           AP001065.1         11630-11762
            2871-3042           AP001065.1         12319-12490
            3043-3226           AP001065.1         19616-19799
            3227-3408           AP001065.1         23652-23833
            3409-3541           AP001065.1         24148-24280
            3542-3629           AP001065.1         29370-29457
            3630-3717           AP001065.1         30577-30664
            3718-3875           AP001065.1         31395-31552
            3876-3952           AP001065.1         32385-32461
            3953-4054           AP001065.1         32735-32836
            4055-4141           AP001065.1         40856-40942
            4142-4247           AP001065.1         42787-42892
            4248-4349           AP001065.1         44792-44893
            4350-4466           AP001065.1         46514-46630
            4467-5419           AP001065.1         47417-48369
FEATURES             Location/Qualifiers
     source          1..5419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..5419
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /note="transient receptor potential cation channel
                     subfamily M member 2"
                     /db_xref="GeneID:7226"
                     /db_xref="HGNC:HGNC:12339"
                     /db_xref="MIM:603749"
     exon            1..245
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..4592
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /EC_number="3.6.1.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transient receptor potential channel 7; long transient
                     receptor potential channel 2; estrogen-responsive
                     element-associated gene 1 protein; transient receptor
                     potential melastatin 2"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 2 isoform 1"
                     /protein_id="NP_003298.2"
                     /db_xref="CCDS:CCDS13710.1"
                     /db_xref="GeneID:7226"
                     /db_xref="HGNC:HGNC:12339"
                     /db_xref="MIM:603749"
                     /translation="MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSW
                     RLQCPFGNNDKQESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEA
                     TKPHTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQ
                     HWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQV
                     GEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTC
                     LDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGP
                     GTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFE
                     TFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHE
                     NWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGV
                     QLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLR
                     ELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRD
                     LLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEY
                     EHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLT
                     KVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVV
                     FHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGL
                     MKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRLMHIF
                     TISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVY
                     HSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLC
                     LYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLS
                     HLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQ
                     KIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTAQALHWIVRTLRASGFS
                     SEADVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNEKV
                     PWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQ
                     AGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVK
                     LPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTD
                     NAWIETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQK
                     AAAEFGAHY"
     exon            246..334
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            335..503
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            504..684
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            685..851
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1032
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1094
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1295
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1398
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1520
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1874
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2012
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2142
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2288
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2401
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2618
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2737
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2870
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3042
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3226
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3408
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3541
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3629
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3717
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3875
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..3952
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4054
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4141
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4247
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4248..4349
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4350..4466
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            4467..5419
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5399..5404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /note="hexamer: ATTAAA"
     polyA_site      5419
                     /gene="TRPM2"
                     /gene_synonym="EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H;
                     NUDT9L1; TRPC7"
                     /note="major polyA site"
ORIGIN      
        1 agaaccccag tgtagcgagc tggagagagg actgtcctga gggcagcagg cctggttgca
       61 gctggcgtgg gggtctcaga atggagccct cagccctgag gaaagctggc tcggagcagg
      121 aggagggctt tgaggggctg cccagaaggg tcactgacct ggggatggtc tccaatctcc
      181 ggcgcagcaa cagcagcctc ttcaagagct ggaggctaca gtgccccttc ggcaacaatg
      241 acaagcaaga aagcctcagt tcgtggattc ctgaaaacat caagaagaaa gaatgcgtgt
      301 attttgtgga aagttccaaa ctgtctgatg ctgggaaggt ggtgtgtcag tgtggctaca
      361 cgcatgagca gcacttggag gaggctacca agccccacac cttccagggc acacagtggg
      421 acccaaagaa acatgtccag gagatgccaa ccgatgcctt tggcgacatc gtcttcacgg
      481 gcctgagcca gaaggtgaaa aagtacgtcc gagtctccca ggacacgccc tccagcgtga
      541 tctaccacct catgacccag cactgggggc tggacgtccc caatctcttg atctcggtga
      601 ccgggggggc caagaacttc aacatgaagc cgcggctgaa gagcattttc cgcagaggcc
      661 tggtcaaggt ggctcagacc acaggggcct ggatcatcac aggggggtcc cacaccggcg
      721 tcatgaagca ggtaggcgag gcggtgcggg acttcagcct gagcagcagc tacaaggaag
      781 gcgagctcat caccatcgga gtcgccacct ggggcactgt ccaccgccgc gagggcctga
      841 tccatcccac gggcagcttc cccgccgagt acatactgga tgaggatggc caagggaacc
      901 tgacctgcct agacagcaac cactctcact tcatcctcgt ggacgacggg acccacggcc
      961 agtacggggt ggagattcct ctgaggacca ggctggagaa gttcatatcg gagcagacca
     1021 aggaaagagg aggtgtggcc atcaagatcc ccatcgtgtg cgtggtgctg gagggcggcc
     1081 cgggcacgtt gcacaccatc gacaacgcca ccaccaacgg caccccctgt gtggttgtgg
     1141 agggctcggg ccgcgtggcc gacgtcattg cccaggtggc caacctgcct gtctcggaca
     1201 tcactatctc cctgatccag cagaaactga gcgtgttctt ccaggagatg tttgagacct
     1261 tcacggaaag caggattgtc gagtggacca aaaagatcca agatatcgtc cggaggcggc
     1321 agctgctgac tgtcttccgg gaaggcaagg atggtcagca ggacgtggat gtggccatct
     1381 tgcaggcctt gctgaaagcc tcacggagcc aagaccactt tggccacgag aactgggacc
     1441 accagctgaa actggcagtg gcatggaatc gcgtggacat tgcccgcagt gagatcttca
     1501 tggatgagtg gcagtggaag ccttcagatc tgcaccccac gatgacagct gcactcatct
     1561 ccaacaagcc tgagtttgtg aagctcttcc tggagaacgg ggtgcagctg aaggagtttg
     1621 tcacctggga caccttgctc tacctgtacg agaacctgga cccctcctgc ctgttccaca
     1681 gcaagctgca gaaggtgctg gtggaggatc ccgagcgccc ggcttgcgcg cccgcggcgc
     1741 cccgcctgca gatgcaccac gtggcccagg tgctgcggga gctgctgggg gacttcacgc
     1801 agccgcttta tccccggccc cggcacaacg accggctgcg gctcctgctg cccgttcccc
     1861 acgtcaagct caacgtgcag ggagtgagcc tccggtccct ctacaagcgt tcctcaggcc
     1921 atgtgacctt caccatggac cccatccgtg accttctcat ttgggccatt gtccagaacc
     1981 gtcgggagct ggcaggaatc atctgggctc agagccagga ctgcatcgca gcggccttgg
     2041 cctgcagcaa gatcctgaag gaactgtcca aggaggagga ggacacggac agctcggagg
     2101 agatgctggc gctggcggag gagtatgagc acagagccat cggggtcttc accgagtgct
     2161 accggaagga cgaagagaga gcccagaaac tgctcacccg cgtgtccgag gcctggggga
     2221 agaccacctg cctgcagctc gccctggagg ccaaggacat gaagtttgtg tctcacgggg
     2281 gcatccaggc cttcctgacc aaggtgtggt ggggccagct ctccgtggac aatgggctgt
     2341 ggcgtgtgac cctgtgcatg ctggccttcc cgctgctcct caccggcctc atctccttca
     2401 gggagaagag gctgcaggat gtgggcaccc ccgcggcccg cgcccgtgcc ttcttcaccg
     2461 cacccgtggt ggtcttccac ctgaacatcc tctcctactt cgccttcctc tgcctgttcg
     2521 cctacgtgct catggtggac ttccagcctg tgccctcctg gtgcgagtgt gccatctacc
     2581 tctggctctt ctccttggtg tgcgaggaga tgcggcagct cttctatgac cctgacgagt
     2641 gcgggctgat gaagaaggca gccttgtact tcagtgactt ctggaataag ctggacgtcg
     2701 gcgcaatctt gctcttcgtg gcagggctga cctgcaggct catcccggcg acgctgtacc
     2761 ccgggcgcgt catcctctct ctggacttca tcctgttctg cctccggctc atgcacattt
     2821 ttaccatcag taagacgctg gggcccaaga tcatcattgt gaagcggatg atgaaggacg
     2881 tcttcttctt cctcttcctg ctggctgtgt gggtggtgtc cttcggggtg gccaagcagg
     2941 ccatcctcat ccacaacgag cgccgggtgg actggctgtt ccgaggggcc gtctaccact
     3001 cctacctcac catcttcggg cagatcccgg gctacatcga cggtgtgaac ttcaacccgg
     3061 agcactgcag ccccaatggc accgacccct acaagcctaa gtgccccgag agcgacgcga
     3121 cgcagcagag gccggccttc cctgagtggc tgacggtcct cctactctgc ctctacctgc
     3181 tcttcaccaa catcctgctg ctcaacctcc tcatcgccat gttcaactac accttccagc
     3241 aggtgcagga gcacacggac cagatttgga agttccagcg ccatgacctg atcgaggagt
     3301 accacggccg ccccgccgcg ccgcccccct tcatcctcct cagccacctg cagctcttca
     3361 tcaagagggt ggtcctgaag actccggcca agaggcacaa gcagctcaag aacaagctgg
     3421 agaagaacga ggaggcggcc ctgctatcct gggagatcta cctgaaggag aactacctcc
     3481 agaaccgaca gttccagcaa aagcagcggc ccgagcagaa gatcgaggac atcagcaata
     3541 aggttgacgc catggtggac ctgctggacc tggacccact gaagaggtcg ggctccatgg
     3601 agcagaggtt ggcctccctg gaggagcagg tggcccagac agcccaagcc ctgcactgga
     3661 tcgtgaggac gctgcgggcc agcggcttca gctcggaggc ggacgtcccc actctggcct
     3721 cccagaaggc cgcggaggag ccggatgctg agccgggagg caggaagaag acggaggagc
     3781 cgggcgacag ctaccacgtg aatgcccggc acctcctcta ccccaactgc cctgtcacgc
     3841 gcttccccgt gcccaacgag aaggtgccct gggagacgga gttcctgatc tatgacccac
     3901 ccttttacac ggcagagagg aaggacgcgg ccgccatgga ccccatggga gacaccctgg
     3961 agccactgtc cacgatccag tacaacgtgg tggatggcct gagggaccgc cggagcttcc
     4021 acgggccgta cacagtgcag gccgggttgc ccctgaaccc catgggccgc acaggactgc
     4081 gtgggcgcgg gagcctcagc tgcttcggac ccaaccacac gctgtacccc atggtcacgc
     4141 ggtggaggcg gaacgaggat ggagccatct gcaggaagag cataaagaag atgctggaag
     4201 tgctggtggt gaagctccct ctctccgagc actgggccct gcctgggggc tcccgggagc
     4261 caggggagat gctacctcgg aagctgaagc ggatcctccg gcaggagcac tggccgtctt
     4321 ttgaaaactt gctgaagtgc ggcatggagg tgtacaaagg ctacatggat gacccgagga
     4381 acacggacaa tgcctggatc gagacggtgg ccgtcagcgt ccacttccag gaccagaatg
     4441 acgtggagct gaacaggctg aactctaacc tgcacgcctg cgactcgggg gcctccatcc
     4501 gatggcaggt ggtggacagg cgcatcccac tctatgcgaa ccacaagacc ctcctccaga
     4561 aggcagccgc tgagttcggg gctcactact gactgtgccc tcaggctggg cggctccagt
     4621 ccatagacgt tccccccaga aaccagggct tctctctcct gagcctggcc aggactcagg
     4681 ctgttcctgg gccctgcaca tgatggggtt tggtggaccc agtgcccctc acggctgccg
     4741 caagtctgct gcagatgacc tcatgaactg gaaggggtca aggtgacccg ggaggagagc
     4801 tcaagacagg gcacaggcta ctcagagctg aggggcccct gggacccttg gccatcaggc
     4861 gaggggctgg gcctgtgcag ctgggccctt ggccagagtc cactcccttc ctggctgtgt
     4921 caccccgagc agctcatcca ccatggaggt cattggcctg aggcaagttc cccggagagt
     4981 cggggtcccc tgtggccccc tcaggcctat gtctgtgagg aaggggccct gccactctcc
     5041 ccaagagggc ctccatgttt cgaggtgcct caacatggag ccttgcctgg cctgggctag
     5101 gggcactgtc tgaactcctg actgtcagga taaactccgt gggggtacag gagcccagac
     5161 aaagcccagg cctgtcaaga gacgcagagg gcccctgcca gggttggccc cagggaccct
     5221 gggacgaggc tgcagaagct ctccctccct actccctggg agccacgtgc tggccatgtg
     5281 gccagggacg gcatgagcag gaggcgggga cgtgggggcc ttctggtttg gtgtcaacag
     5341 ctcacaggag cgtgaaccat gagggccctc aggaggggaa cgtggtaaaa cccaagacat
     5401 taaatctgcc atctcaggc
//
