LOCUS       NM_001252024            5787 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            M member 1 (TRPM1), transcript variant 3, mRNA.
ACCESSION   NM_001252024
VERSION     NM_001252024.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5787)
  AUTHORS   Cohen-Gulkar,M., David,A., Messika-Gold,N., Eshel,M., Ovadia,S.,
            Zuk-Bar,N., Idelson,M., Cohen-Tayar,Y., Reubinoff,B., Ziv,T.,
            Shamay,M., Elkon,R. and Ashery-Padan,R.
  TITLE     The LHX2-OTX2 transcriptional regulatory module controls retinal
            pigmented epithelium differentiation and underlies genetic risk for
            age-related macular degeneration
  JOURNAL   PLoS Biol 21 (1), e3001924 (2023)
   PUBMED   36649236
  REMARK    GeneRIF: The LHX2-OTX2 transcriptional regulatory module controls
            retinal pigmented epithelium differentiation and underlies genetic
            risk for age-related macular degeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5787)
  AUTHORS   Hsieh,C.C., Su,Y.C., Jiang,K.Y., Ito,T., Li,T.W., Kaku-Ito,Y.,
            Cheng,S.T., Chen,L.T., Hwang,D.Y. and Shen,C.H.
  TITLE     TRPM1 promotes tumor progression in acral melanoma by activating
            the Ca2+/CaMKIIdelta/AKT pathway
  JOURNAL   J Adv Res 43, 45-57 (2023)
   PUBMED   36585114
  REMARK    GeneRIF: TRPM1 promotes tumor progression in acral melanoma by
            activating the Ca[2+]/CaMKIIdelta/AKT pathway.
REFERENCE   3  (bases 1 to 5787)
  AUTHORS   Iosifidis,C., Liu,J., Gale,T., Ellingford,J.M., Campbell,C.,
            Ingram,S., Chandler,K., Parry,N.R.A., Black,G.C. and
            Sergouniotis,P.I.
  TITLE     Clinical and genetic findings in TRPM1-related congenital
            stationary night blindness
  JOURNAL   Acta Ophthalmol 100 (6), e1332-e1339 (2022)
   PUBMED   35633130
  REMARK    GeneRIF: Clinical and genetic findings in TRPM1-related congenital
            stationary night blindness.
REFERENCE   4  (bases 1 to 5787)
  AUTHORS   Delle Fave,M., Cordonnier,M., Vallee,L., Condroyer,C., Zeitz,C. and
            Balikova,I.
  TITLE     Congenital stationary night blindness in a patient with mild
            learning disability due to a compound heterozygous microdeletion of
            15q13 and a missense mutation in TRPM1
  JOURNAL   Ophthalmic Genet 42 (3), 296-299 (2021)
   PUBMED   33691579
  REMARK    GeneRIF: Congenital stationary night blindness in a patient with
            mild learning disability due to a compound heterozygous
            microdeletion of 15q13 and a missense mutation in TRPM1.
REFERENCE   5  (bases 1 to 5787)
  AUTHORS   Oancea,E. and Wicks,N.L.
  TITLE     TRPM1: new trends for an old TRP
  JOURNAL   Adv Exp Med Biol 704, 135-145 (2011)
   PUBMED   21290293
  REMARK    GeneRIF: summarize and discuss our present knowledge of TRPM1: its
            discovery, expression, regulation, and proposed functions in skin
            and eye
            Review article
REFERENCE   6  (bases 1 to 5787)
  AUTHORS   Xu,X.Z., Moebius,F., Gill,D.L. and Montell,C.
  TITLE     Regulation of melastatin, a TRP-related protein, through
            interaction with a cytoplasmic isoform
  JOURNAL   Proc Natl Acad Sci U S A 98 (19), 10692-10697 (2001)
   PUBMED   11535825
REFERENCE   7  (bases 1 to 5787)
  AUTHORS   Fang,D. and Setaluri,V.
  TITLE     Expression and Up-regulation of alternatively spliced transcripts
            of melastatin, a melanoma metastasis-related gene, in human
            melanoma cells
  JOURNAL   Biochem Biophys Res Commun 279 (1), 53-61 (2000)
   PUBMED   11112417
REFERENCE   8  (bases 1 to 5787)
  AUTHORS   Hunter,J.J., Shao,J., Smutko,J.S., Dussault,B.J., Nagle,D.L.,
            Woolf,E.A., Holmgren,L.M., Moore,K.J. and Shyjan,A.W.
  TITLE     Chromosomal localization and genomic characterization of the mouse
            melastatin gene (Mlsn1)
  JOURNAL   Genomics 54 (1), 116-123 (1998)
   PUBMED   9806836
REFERENCE   9  (bases 1 to 5787)
  AUTHORS   Duncan,L.M., Deeds,J., Hunter,J., Shao,J., Holmgren,L.M.,
            Woolf,E.A., Tepper,R.I. and Shyjan,A.W.
  TITLE     Down-regulation of the novel gene melastatin correlates with
            potential for melanoma metastasis
  JOURNAL   Cancer Res 58 (7), 1515-1520 (1998)
   PUBMED   9537257
REFERENCE   10 (bases 1 to 5787)
  AUTHORS   van Bon,B.W.M., Mefford,H.C., de Vries,B.B.A. and Schaaf,C.P.
  TITLE     15q13.3 Recurrent Deletion
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21290787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC058286.1, HM135790.1,
            AC009562.9 and BU743036.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001252024.1.
            
            Summary: This gene encodes a member of the transient receptor
            potential melastatin subfamily of transient receptor potential ion
            channels. The encoded protein is a calcium permeable cation channel
            that is expressed in melanocytes and may play a role in melanin
            synthesis. Specific mutations in this gene are the cause autosomal
            recessive complete congenital stationary night blindness-1C. The
            expression of this protein is inversely correlated with melanoma
            aggressiveness and as such it is used as a prognostic marker for
            melanoma metastasis. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate exon in the 5' coding region. These differences cause
            translation initiation at an alternate start codon, compared to
            variant 1. The encoded isoform (3) has a distinct N-terminus and is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM135790.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256552.11/ ENSP00000256552.7
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BC058286.1         6-9
            5-219               HM135790.1         1-215
            220-220             AC009562.9         132993-132993
            221-5518            HM135790.1         217-5514
            5519-5787           BU743036.1         23-291              c
FEATURES             Location/Qualifiers
     source          1..5787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     gene            1..5787
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /note="transient receptor potential cation channel
                     subfamily M member 1"
                     /db_xref="GeneID:4308"
                     /db_xref="HGNC:HGNC:7146"
                     /db_xref="MIM:603576"
     exon            1..69
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..155
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..5030
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transient receptor potential melastatin family;
                     melastatin-1; long transient receptor potential channel 1;
                     TRPM1-203 APA Isoform, Intron 3; TRPM1-203 APA Isoform,
                     Intron 10"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 1 isoform 3"
                     /protein_id="NP_001238953.1"
                     /db_xref="CCDS:CCDS58346.1"
                     /db_xref="GeneID:4308"
                     /db_xref="HGNC:HGNC:7146"
                     /db_xref="MIM:603576"
                     /translation="MGQKSWIEKTFCKRECIFVIPSMKDSNRCCCGQFTNQHIPPLPS
                     ATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGGGYSNKAMYIRVSYDTK
                     PDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTG
                     GVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQTMSNPL
                     SKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLVGLVV
                     EGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQLLV
                     TIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVS
                     APDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPPMATTKGGR
                     GKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIENGVN
                     MQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGA
                     YRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDD
                     PAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESD
                     LVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAA
                     KHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQT
                     SKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFY
                     TISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIK
                     VWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNK
                     YLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYW
                     MIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANIL
                     LVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRL
                     SGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERI
                     RVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRS
                     DLIQARSRASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEDTSLSTSPGTGVR
                     KKTCSFRIKEEKDVKTHLVPECQNSLHLSLGTSTSATPDGSHLAVDDLKNAEESKLGP
                     DIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNTQLTVETTNIEGTISYP
                     LEETKITRYFPDETINACKTMKSRSFVYSRGRKLVGGVNQDVEYSSITDQQLTTEWQC
                     QVQKITRSHSTDIPYIVSEAAVQAEHKEQFADMQDEHHVAEAIPRIPRLSLTITDRNG
                     MENLLSVKPDQTLGFPSLRSKSLHGHPRNVKSIQGKLDRSGHASSVSSLVIVSGMTAE
                     EKKVKKEKASTETEC"
     exon            156..235
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..431
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..645
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..770
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..942
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1117
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1241
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1314
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1415
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1589
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1724
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1775
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1916
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1946
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2239
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2468
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2591
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2723
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2852
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3104
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3279
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3300
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3445
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3648
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3781
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..5787
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5768..5773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /note="hexamer: AATAAA"
     polyA_site      5787
                     /gene="TRPM1"
                     /gene_synonym="CSNB1C; LTRPC1; MLSN1"
                     /note="major polyA site"
ORIGIN      
        1 ccctgccctg gccaaggagg aggctgaaag agcctgagct gtgccctctc cattccactg
       61 ctgtggcagg ttctagaaga tttctgagga ctcagcagta acttgcagtg ctggactgag
      121 gctatttcct tatatcaact ttttgaaaac tcatgggtca gaaatcttgg atagagaaaa
      181 ccttttgcaa acgggaatgt atctttgtaa ttcctagcat gaaagactct aacaggtgtt
      241 gctgtggcca gttcaccaac cagcatatcc cccctctgcc aagtgcaaca cccagcaaaa
      301 atgaagagga aagcaaacag gtggagactc agcctgagaa atggtctgtt gccaagcaca
      361 cccagagcta cccaacagat tcctatggag ttcttgaatt ccagggtggc ggatattcca
      421 ataaagccat gtatatccgt gtatcctatg acaccaagcc agactcactg ctccatctca
      481 tggtgaaaga ttggcagctg gaactcccca agctcttaat atctgtgcat ggaggcctcc
      541 agaactttga gatgcagccc aagctgaaac aagtctttgg gaaaggcctg atcaaggctg
      601 ctatgaccac cggggcctgg atcttcaccg ggggtgtcag cacaggtgtt atcagccacg
      661 taggggatgc cttgaaagac cactcctcca agtccagagg ccgggtttgt gctataggaa
      721 ttgctccatg gggcatcgtg gagaataagg aagacctggt tggaaaggat gtaacaagag
      781 tgtaccagac catgtccaac cctctaagta agctctctgt gctcaacaac tcccacaccc
      841 acttcatcct ggctgacaat ggcaccctgg gcaagtatgg cgccgaggtg aagctgcgaa
      901 ggctgctgga aaagcacatc tccctgcaga agatcaacac aagactgggg cagggcgtgc
      961 ccctcgtggg tctcgtggtg gaggggggcc ctaacgtggt gtccatcgtc ttggaatacc
     1021 tgcaagaaga gcctcccatc cctgtggtga tttgtgatgg cagcggacgt gcctcggaca
     1081 tcctgtcctt tgcgcacaag tactgtgaag aaggcggaat aataaatgag tccctcaggg
     1141 agcagcttct agttaccatt cagaaaacat ttaattataa taaggcacaa tcacatcagc
     1201 tgtttgcaat tataatggag tgcatgaaga agaaagaact cgtcactgtg ttcagaatgg
     1261 gttctgaggg ccagcaggac atcgagatgg caattttaac tgccctgctg aaaggaacaa
     1321 acgtatctgc tccagatcag ctgagcttgg cactggcttg gaaccgcgtg gacatagcac
     1381 gaagccagat ctttgtcttt gggccccact ggccgcccct gggaagcctg gcacccccga
     1441 cggacagcaa agccacggag aaggagaaga agccacccat ggccaccacc aagggaggaa
     1501 gaggaaaagg gaaaggcaag aagaaaggga aagtgaaaga ggaagtggag gaagaaactg
     1561 acccccggaa gatagagctg ctgaactggg tgaatgcttt ggagcaagcg atgctagatg
     1621 ctttagtctt agatcgtgtc gactttgtga agctcctgat tgaaaacgga gtgaacatgc
     1681 aacactttct gaccattccg aggctggagg agctttataa cacaagactg ggtccaccaa
     1741 acacacttca tctgctggtg agggatgtga aaaagagcaa ccttccgcct gattaccaca
     1801 tcagcctcat agacatcggg ctcgtgctgg agtacctcat gggaggagcc taccgctgca
     1861 actacactcg gaaaaacttt cggacccttt acaacaactt gtttggacca aagaggccta
     1921 aagctcttaa acttctggga atggaagatg atgagcctcc agctaaaggg aagaaaaaga
     1981 aaaagaagaa aaaggaggaa gagatcgaca ttgatgtgga cgaccctgcc gtgagtcggt
     2041 tccagtatcc cttccacgag ctgatggtgt gggcagtgct gatgaaacgc cagaaaatgg
     2101 cagtgttcct ctggcagcga ggggaagaga gcatggccaa ggccctggtg gcctgcaagc
     2161 tctacaaggc catggcccac gagtcctccg agagtgatct ggtggatgac atctcccagg
     2221 acttggataa caattccaaa gacttcggcc agcttgcttt ggagttatta gaccagtcct
     2281 ataagcatga cgagcagatc gctatgaaac tcctgaccta cgagctgaaa aactggagca
     2341 actcgacctg cctcaaactg gccgtggcag ccaaacaccg ggacttcatt gctcacacct
     2401 gcagccagat gctgctgacc gatatgtgga tgggaagact gcggatgcgg aagaaccccg
     2461 gcctgaaggt tatcatgggg attcttctac cccccaccat cttgtttttg gaatttcgca
     2521 catatgatga tttctcgtat caaacatcca aggaaaatga ggatggcaaa gaaaaagaag
     2581 aggaaaatac ggatgcaaat gcagatgctg gctcaagaaa gggggatgag gagaacgagc
     2641 acaaaaaaca gagaagtatt cccatcggaa caaagatctg tgaattctat aacgcgccca
     2701 ttgtcaagtt ctggttttac acaatatcat acttgggcta cctgctgctg tttaactacg
     2761 tcatcctggt gcggatggat ggctggccgt ccctccagga gtggatcgtc atctcctaca
     2821 tcgtgagcct ggcgttagag aagatacgag agatcctcat gtcagaacca ggcaaactca
     2881 gccagaaaat caaagtttgg cttcaggagt actggaacat cacagatctc gtggccattt
     2941 ccacattcat gattggagca attcttcgcc tacagaacca gccctacatg ggctatggcc
     3001 gggtgatcta ctgtgtggat atcatcttct ggtacatccg tgtcctggac atctttggtg
     3061 tcaacaagta tctggggcca tacgtgatga tgattggaaa gatgatgatc gacatgctgt
     3121 actttgtggt catcatgctg gtcgtgctca tgagtttcgg agtagcccgt caagccattc
     3181 tgcatccaga ggagaagccc tcttggaaac tggcccgaaa catcttctac atgccctact
     3241 ggatgatcta tggagaggtg tttgcagacc agatagacct ctacgccatg gaaattaatc
     3301 ctccttgtgg tgagaaccta tatgatgagg agggcaagcg gcttcctccc tgtatccccg
     3361 gcgcctggct cactccagca ctcatggcgt gctatctact ggtcgccaac atcctgctgg
     3421 tgaacctgct gattgctgtg ttcaacaata ccttctttga agtaaaatca atatccaacc
     3481 aggtgtggaa gttccagcga tatcagctga ttatgacatt tcatgacagg ccagtcctgc
     3541 ccccaccgat gatcatttta agccacatct acatcatcat tatgcgtctc agcggccgct
     3601 gcaggaaaaa gagagaaggg gaccaagagg aacgggatcg tggattgaag ctcttcctta
     3661 gcgacgagga gctaaagagg ctgcatgagt tcgaggagca gtgcgtgcag gagcacttcc
     3721 gggagaagga ggatgagcag cagtcgtcca gcgacgagcg catccgggtc acttctgaaa
     3781 gagttgaaaa tatgtcaatg aggttggaag aaatcaatga aagagaaact tttatgaaaa
     3841 cttccctgca gactgttgac cttcgacttg ctcagctaga agaattatct aacagaatgg
     3901 tgaatgctct tgaaaatctt gcgggaatcg acaggtctga cctgatccag gcacggtccc
     3961 gggcttcttc tgaatgtgag gcaacgtatc ttctccggca aagcagcatc aatagcgctg
     4021 atggctacag cttgtatcga tatcatttta acggagaaga gttattattt gaggatacat
     4081 ctctctccac gtcaccaggg acaggagtca ggaaaaaaac ctgttccttc cgtataaagg
     4141 aagagaagga cgtgaaaacg cacctagtcc cagaatgtca gaacagtctt cacctttcac
     4201 tgggcacaag cacatcagca accccagatg gcagtcacct tgcagtagat gacttaaaga
     4261 acgctgaaga gtcaaaatta ggtccagata ttgggatttc aaaggaagat gatgaaagac
     4321 agacagactc taaaaaagaa gaaactattt ccccaagttt aaataaaaca gatgtgatac
     4381 atggacagga caaatcagat gttcaaaaca ctcagctaac agtggaaacg acaaatatag
     4441 aaggcactat ttcctatccc ctggaagaaa ccaaaattac acgctatttc cccgatgaaa
     4501 cgatcaatgc ttgtaaaaca atgaagtcca gaagcttcgt ctattcccgg ggaagaaagc
     4561 tggtcggtgg ggttaaccag gatgtagagt acagttcaat cacggaccag caattgacga
     4621 cggaatggca atgccaagtt caaaagatca cgcgctctca tagcacagat attccttaca
     4681 ttgtgtcgga agctgcagtg caagctgagc ataaagagca gtttgcagat atgcaagatg
     4741 aacaccatgt cgctgaagca attcctcgaa tccctcgctt gtccctaacc attactgaca
     4801 gaaatgggat ggaaaactta ctgtctgtga agccagatca aactttggga ttcccatctc
     4861 tcaggtcaaa aagtttacat ggacatccta ggaatgtgaa atccattcag ggaaagttag
     4921 acagatctgg acatgccagt agtgtaagca gcttagtaat tgtgtctgga atgacagcag
     4981 aagaaaaaaa ggttaagaaa gagaaagctt ccacagaaac tgaatgctag tctgttttgt
     5041 ttctttaatt ttttttttta acagtcagaa ccactaatgg gtgtcatctt ggccatctaa
     5101 acatcatcaa tttctaaaaa cattttcctt aaaaaatttt ggaaattcag acttgattta
     5161 caatttaatg cactaaaagt agtattttgt tagcatatgt tagtaggctt agttttttca
     5221 gttgcagtag tatcaaatga aagtgatgat actgtaacga agataaattg gctaatcagt
     5281 atacaagatt atacaatctc tttattactg agggccacca aatagcctag gaagtgccct
     5341 cgagcactga agtcaccatt aggtcactta agaagtaagc aactagctgg gcacagtggc
     5401 tcatgcctgt aatcctagca ctttgggagg ccaaggcaga aagatagctt gagtccagga
     5461 gtttgagacc agcctgggca acatagtgat accccatctc ttaaaaaaaa aaaaaaaagt
     5521 aagcaactgt gtaagaaaga gaaactaaag agaaagcaaa catgaaaaaa gggaggggtg
     5581 gaaagaagaa aaataaaatt gtgaggcaca ataagtggga aggagccaca aatatgtttt
     5641 tatggggtct ttgttttctg ttttaatgtt ttattttaaa ctacacaatg ggaaaaaaag
     5701 tacacaatta tatcaaacat catactctaa taatttaggg tgacctagag ttttgttaat
     5761 gtgcaaaaat aaagtatcca atatgca
//
