LOCUS       NM_020389               3570 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 7 (TRPC7), transcript variant 1, mRNA.
ACCESSION   NM_020389
VERSION     NM_020389.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3570)
  AUTHORS   Hsu,W.L., Tsai,M.H., Wu,C.Y., Liang,J.L., Lu,J.H., Kahle,J.S.,
            Yu,H.S., Yen,C.J., Yen,C.T., Hsieh,Y.C., Huang,Y.Y., Lin,L.C.,
            Tsai,T.F., Chen,C.H. and Yoshioka,T.
  TITLE     Nociceptive transient receptor potential canonical 7 (TRPC7)
            mediates aging-associated tumorigenesis induced by ultraviolet B
  JOURNAL   Aging Cell 19 (1), e13075 (2020)
   PUBMED   31755176
  REMARK    GeneRIF: Nociceptive transient receptor potential canonical 7
            (TRPC7) mediates aging-associated tumorigenesis induced by
            ultraviolet B.
REFERENCE   2  (bases 1 to 3570)
  AUTHORS   Itsuki,K., Imai,Y., Hase,H., Okamura,Y., Inoue,R. and Mori,M.X.
  TITLE     PLC-mediated PI(4,5)P2 hydrolysis regulates activation and
            inactivation of TRPC6/7 channels
  JOURNAL   J Gen Physiol 143 (2), 183-201 (2014)
   PUBMED   24470487
  REMARK    GeneRIF: A fundamental role for PI(4,5)P2 was identified in the
            regulation of TRPC7 and TRPC6.
REFERENCE   3  (bases 1 to 3570)
  AUTHORS   Yuasa,K., Matsuda,T. and Tsuji,A.
  TITLE     Functional regulation of transient receptor potential canonical 7
            by cGMP-dependent protein kinase Ialpha
  JOURNAL   Cell Signal 23 (7), 1179-1187 (2011)
   PUBMED   21402151
  REMARK    GeneRIF: Phosphorylation of transient receptor potential cation
            channel subfamily C member 7 significantly suppressed
            carbachol-induced calcium influx and CREB phosphorylation.
REFERENCE   4  (bases 1 to 3570)
  AUTHORS   Miyagi,K., Kiyonaka,S., Yamada,K., Miki,T., Mori,E., Kato,K.,
            Numata,T., Sawaguchi,Y., Numaga,T., Kimura,T., Kanai,Y., Kawano,M.,
            Wakamori,M., Nomura,H., Koni,I., Yamagishi,M. and Mori,Y.
  TITLE     A pathogenic C terminus-truncated polycystin-2 mutant enhances
            receptor-activated Ca2+ entry via association with TRPC3 and TRPC7
  JOURNAL   J Biol Chem 284 (49), 34400-34412 (2009)
   PUBMED   19812035
  REMARK    GeneRIF: heteromeric cation channels comprised of the TRPP2 mutant
            and the TRPC3 or TRPC7 protein induce enhanced receptor-activated
            Ca(2+) influx that may lead to dysregulated cell growth in ADPKD
REFERENCE   5  (bases 1 to 3570)
  AUTHORS   Graubert,T.A., Payton,M.A., Shao,J., Walgren,R.A., Monahan,R.S.,
            Frater,J.L., Walshauser,M.A., Martin,M.G., Kasai,Y. and Walter,M.J.
  TITLE     Integrated genomic analysis implicates haploinsufficiency of
            multiple chromosome 5q31.2 genes in de novo myelodysplastic
            syndromes pathogenesis
  JOURNAL   PLoS One 4 (2), e4583 (2009)
   PUBMED   19240791
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3570)
  AUTHORS   Lievremont,J.P., Numaga,T., Vazquez,G., Lemonnier,L., Hara,Y.,
            Mori,E., Trebak,M., Moss,S.E., Bird,G.S., Mori,Y. and Putney,J.W.
            Jr.
  TITLE     The role of canonical transient receptor potential 7 in B-cell
            receptor-activated channels
  JOURNAL   J Biol Chem 280 (42), 35346-35351 (2005)
   PUBMED   16123040
  REMARK    GeneRIF: in B-lymphocytes, TRPC7 appears to participate in the
            formation of ion channels that could be activated by phospholipase
            C-linked receptors
REFERENCE   7  (bases 1 to 3570)
  AUTHORS   Zagranichnaya,T.K., Wu,X. and Villereal,M.L.
  TITLE     Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native
            store-operated channels in HEK-293 cells
  JOURNAL   J Biol Chem 280 (33), 29559-29569 (2005)
   PUBMED   15972814
  REMARK    GeneRIF: endogenous TRPC1, TRPC3, and TRPC7 participate in forming
            heteromeric store-operated channels, whereas TRPC3 and TRPC7 can
            also participate in forming heteromeric receptor-operated channels.
REFERENCE   8  (bases 1 to 3570)
  AUTHORS   Lussier,M.P., Cayouette,S., Lepage,P.K., Bernier,C.L.,
            Francoeur,N., St-Hilaire,M., Pinard,M. and Boulay,G.
  TITLE     MxA, a member of the dynamin superfamily, interacts with the
            ankyrin-like repeat domain of TRPC
  JOURNAL   J Biol Chem 280 (19), 19393-19400 (2005)
   PUBMED   15757897
REFERENCE   9  (bases 1 to 3570)
  AUTHORS   Lievremont,J.P., Bird,G.S. and Putney,J.W. Jr.
  TITLE     Canonical transient receptor potential TRPC7 can function as both a
            receptor- and store-operated channel in HEK-293 cells
  JOURNAL   Am J Physiol Cell Physiol 287 (6), C1709-C1716 (2004)
   PUBMED   15342342
  REMARK    GeneRIF: can be activated by both receptor- and store-operated
            modes in the same cell.
REFERENCE   10 (bases 1 to 3570)
  AUTHORS   Riccio,A., Mattei,C., Kelsell,R.E., Medhurst,A.D., Calver,A.R.,
            Randall,A.D., Davis,J.B., Benham,C.D. and Pangalos,M.N.
  TITLE     Cloning and functional expression of human short TRP7, a candidate
            protein for store-operated Ca2+ influx
  JOURNAL   J Biol Chem 277 (14), 12302-12309 (2002)
   PUBMED   11805119
  REMARK    GeneRIF: Cloning and functional expression of human short TRP7, a
            candidate protein for store-operated Ca2+ influx
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008661.6.
            
            On Nov 22, 2019 this sequence version replaced NM_020389.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968968, SAMEA1970526
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000513104.6/ ENSP00000426070.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AC008661.6         179079-179371       c
            294-1071            AC008661.6         170434-171211       c
            1072-1254           AC008661.6         129423-129605       c
            1255-1419           AC008661.6         88499-88663         c
            1420-1636           AC008661.6         80046-80262         c
            1637-1870           AC008661.6         65475-65708         c
            1871-2135           AC008661.6         61297-61561         c
            2136-2331           AC008661.6         45180-45375         c
            2332-2553           AC008661.6         39860-40081         c
            2554-2634           AC008661.6         39100-39180         c
            2635-2710           AC008661.6         30026-30101         c
            2711-3570           AC008661.6         26571-27430         c
FEATURES             Location/Qualifiers
     source          1..3570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..3570
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /note="transient receptor potential cation channel
                     subfamily C member 7"
                     /db_xref="GeneID:57113"
                     /db_xref="HGNC:HGNC:20754"
     exon            1..293
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..2880
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /EC_number="3.6.1.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative capacitative calcium channel; likley ortholog of
                     mouse transient receptor potential cation channel,
                     subfamily C, member 7; short transient receptor potential
                     channel 7; transient receptor protein 7"
                     /codon_start=1
                     /product="short transient receptor potential channel 7
                     isoform 1"
                     /protein_id="NP_065122.1"
                     /db_xref="CCDS:CCDS47267.2"
                     /db_xref="GeneID:57113"
                     /db_xref="HGNC:HGNC:20754"
                     /translation="MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEE
                     ERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKEN
                     LARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTR
                     FSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSR
                     MNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVG
                     VLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLT
                     MWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHA
                     VSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGM
                     IWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQ
                     DDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFG
                     PLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLF
                     WSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEED
                     ADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSC
                     ENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVD
                     RENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRV
                     NKGKDI"
     exon            294..1071
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1254
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1419
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1636
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1870
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2135
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2331
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2553
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2634
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2710
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..3570
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3550..3555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /note="hexamer: AATAAA"
     polyA_site      3570
                     /gene="TRPC7"
                     /gene_synonym="TRP7"
                     /note="major polyA site"
ORIGIN      
        1 actctcacac agatgcttct ccgtcatgtt ctctgggaaa tttccccccg attaggaaaa
       61 ggacggtaac acggttctgc ctcggaaggc gagtttttac cactgcaaca caaagaacag
      121 aggagcgcgc tttcacatcg ttgcaactta actcacttga ccagctctat acttcagcac
      181 cacggagagc ggtacatcct tggctaccac ccatggggag ccagcttctg gcgactcaac
      241 accggattcc ggtcatctag aggaggaaca agcctgcgta ttacaccctc aatgttgagg
      301 aacagcacct tcaaaaacat gcagcgccgg cacacaacgc tgagggagaa gggccgtcgc
      361 caggccatcc ggggtcccgc ctacatgttc aacgagaagg gcaccagtct gacgcccgag
      421 gaggagcgct tcctggactc ggctgagtat ggcaacatcc cggtggtccg gaaaatgctg
      481 gaggagtcca agacccttaa cttcaactgt gtggactaca tggggcagaa cgctctgcag
      541 ctggccgtgg gcaacgagca cctagaggtc acggagctgc tgctgaagaa ggagaacctg
      601 gcacgggtgg gggacgcgct gctgctggcc atcagcaagg gctatgtgcg catcgtggag
      661 gccatcctca accacccggc cttcgcgcag ggccagcgcc tgacgctcag cccgctggaa
      721 caggagctgc gcgacgacga cttctatgcc tacgacgagg acggcacgcg cttctcccac
      781 gacatcacgc ccatcatcct ggcggcgcac tgccaggagt atgagatcgt gcacatcctg
      841 ctgctcaagg gcgcccgcat cgagcggccc cacgactact tctgcaagtg caatgagtgc
      901 accgagaaac agcggaaaga ctccttcagc cactcgcgct cgcgcatgaa cgcctacaaa
      961 ggactggcga gtgctgccta cttgtccctg tccagcgaag accctgtcct caccgccctg
     1021 gagctcagca acgagttagc cagactagcc aacattgaga ctgaatttaa gaacgattac
     1081 aggaagttat ctatgcaatg caaggatttt gtagtgggcg tgctggacct gtgccgagac
     1141 acagaagagg tggaagcaat tttaaacggt gatgtgaact tccaagtctg gtccgaccac
     1201 caccgtccaa gtctgagccg gatcaaactc gccattaaat atgaagtcaa gaagttcgtt
     1261 gctcatccta actgtcagca gcaattgctt accatgtggt atgaaaatct ctcaggctta
     1321 cgtcaacagt ctatcgctgt gaaattcctg gctgtctttg gagtctccat aggcctccct
     1381 tttctcgcca tagcctattg gattgctccg tgcagcaagc taggacgaac cctgaggagc
     1441 cctttcatga agtttgtagc tcatgcagtt tcttttacaa tcttcttggg attattagtt
     1501 gtgaatgcat ctgaccgatt tgaaggtgtt aaaaccctgc caaacgaaac cttcacagac
     1561 tacccaaaac aaatcttcag agtgaaaacc acacagttct cctggacaga aatgctcatt
     1621 atgaagtggg tcttaggaat gatttggtcc gaatgcaagg aaatctggga ggaggggcca
     1681 cgggagtacg tgctgcactt gtggaacctg ctagatttcg ggatgctgtc catcttcgtg
     1741 gcctccttca cagcacgctt catggccttc ctgaaggcca cggaggcaca gctgtacgtg
     1801 gaccagcacg tgcaggacga cacgctgcac aatgtctcgc ttccgccgga agtggcatac
     1861 ttcacctacg ccagggacaa gtggtggcct tcagaccctc agatcatatc ggaagggctc
     1921 tacgcgatag ccgtcgtgct gagcttctct cgcattgcat acattctgcc agccaacgag
     1981 agttttgggc ccctgcagat ctcgctaggg agaactgtga aagatatctt caagttcatg
     2041 gtcattttca tcatggtatt tgtggccttc atgattggga tgttcaacct gtactcttac
     2101 taccgaggtg ccaaatacaa cccagcgttt acaacggttg aagaaagttt taaaactttg
     2161 ttttggtcca tattcggctt atctgaagta atctcagtgg tgctgaaata cgaccacaaa
     2221 ttcatcgaga acattggcta cgttctctac ggcgtttata acgtcaccat ggtggtagtg
     2281 ttgctcaaca tgctaatagc catgataaac aactcctatc aggaaattga ggaggatgca
     2341 gatgtggaat ggaagttcgc ccgagcaaaa ctctggctgt cttactttga tgaaggaaga
     2401 actctacctg ctccttttaa tctagtgcca agtcctaaat cattttatta tctcataatg
     2461 agaatcaaga tgtgcctcat aaaactctgc aaatctaagg ccaaaagctg tgaaaatgac
     2521 cttgaaatgg gcatgctgaa ttccaaattc aagaagactc gctaccaggc tggcatgagg
     2581 aattctgaaa atctgacagc aaataacact ttgagcaagc ccaccagata ccagaaaatc
     2641 atgaaacggc tcataaaaag atacgtcctg aaagcccagg tggacagaga aaatgacgaa
     2701 gtcaatgaag gcgagctgaa ggaaatcaag caagatatct ccagcctgcg ctatgagctt
     2761 cttgaggaaa aatctcaagc tactggtgag ctggcagacc tgattcaaca actcagcgag
     2821 aagtttggaa agaacttaaa caaagaccac ctgagggtga acaagggcaa agacatttag
     2881 cagcccacat cggcgtctgt gacttctacc agcattccaa ggccaggttg gatgccctcg
     2941 cccccatcct tggtggggag gggtccccag cccactcctc taggacacga aggggatctc
     3001 ctggctcagt ctcttgcagc atgactgaca tctccagccc gctggcctgc ctagacccag
     3061 aactgctgtg aatctaggtg gttgggtaag aaaagctacc atgggaggag gggaggaaca
     3121 gccccctgac gagtgtgaga cctttggtcc agccacagtg aaacccatcc ctgtggccag
     3181 agcaggaaaa ggccatcttg ggtgcacacc tgtgccctcc cactgcaggt gggactgcag
     3241 ctctggctgt gtcctgggaa gacaaacacc tcaacccaca aactccttct cactccctcc
     3301 ctgccacccc caacacatcc aaacagaacc aggaggtgac ctgtgatcta ttcttaagtg
     3361 ccagatgaga acacagccta atagcaaaat agttctattt gtttatataa aaaaaaagtt
     3421 taaaaatcct aaattgaaaa ctgtactgta ggtagcactg tttagaaaac aacaacaaaa
     3481 tccaaatgat gtatttttac ctttattaag attatcttgt atttactatt tttacctaaa
     3541 atggaaagaa ataaaattac ctcataataa
//
