LOCUS       NM_012471              12143 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 5 (TRPC5), mRNA.
ACCESSION   NM_012471
VERSION     NM_012471.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12143)
  AUTHORS   Ptakova,A. and Vlachova,V.
  TITLE     Thermosensing ability of TRPC5: current knowledge and unsettled
            questions
  JOURNAL   J Physiol Sci 74 (1), 50 (2024)
   PUBMED   39363236
  REMARK    GeneRIF: Thermosensing ability of TRPC5: current knowledge and
            unsettled questions.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12143)
  AUTHORS   Sakaguchi,R., Takahashi,N., Yoshida,T., Ogawa,N., Ueda,Y.,
            Hamano,S., Yamaguchi,K., Sawamura,S., Yamamoto,S., Hara,Y.,
            Kawamoto,T., Suzuki,R., Nakao,A., Mori,M.X., Furukawa,T.,
            Shimizu,S., Inoue,R. and Mori,Y.
  TITLE     Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein
            assembly potentiates the positive feedback interaction between Ca2+
            and NO signals
  JOURNAL   J Biol Chem 300 (9), 107705 (2024)
   PUBMED   39178948
  REMARK    GeneRIF: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS
            protein assembly potentiates the positive feedback interaction
            between Ca[2+] and NO signals.
REFERENCE   3  (bases 1 to 12143)
  AUTHORS   Li,Y., Cacciottolo,T.M., Yin,N., He,Y., Liu,H., Liu,H., Yang,Y.,
            Henning,E., Keogh,J.M., Lawler,K., Mendes de Oliveira,E.,
            Gardner,E.J., Kentistou,K.A., Laouris,P., Bounds,R., Ong,K.K.,
            Perry,J.R.B., Barroso,I., Tu,L., Bean,J.C., Yu,M., Conde,K.M.,
            Wang,M., Ginnard,O., Fang,X., Tong,L., Han,J., Darwich,T.,
            Williams,K.W., Yang,Y., Wang,C., Joss,S., Firth,H.V., Xu,Y. and
            Farooqi,I.S.
  TITLE     Loss of transient receptor potential channel 5 causes obesity and
            postpartum depression
  JOURNAL   Cell 187 (16), 4176-4192 (2024)
   PUBMED   38959890
REFERENCE   4  (bases 1 to 12143)
  AUTHORS   Huang,B., Zhang,Y., Sun,P., Yuan,Y. and Wang,C.
  TITLE     MiR-138-5p Inhibits Thyroid Cancer Cell Growth and Stemness by
            Targeting TRPC5/Wnt/beta-Catenin Pathway
  JOURNAL   Mol Biotechnol 66 (3), 544-553 (2024)
   PUBMED   37278959
  REMARK    GeneRIF: MiR-138-5p Inhibits Thyroid Cancer Cell Growth and
            Stemness by Targeting TRPC5/Wnt/beta-Catenin Pathway.
REFERENCE   5  (bases 1 to 12143)
  AUTHORS   Ptakova,A., Mitro,M., Zimova,L. and Vlachova,V.
  TITLE     Cellular context determines primary characteristics of human TRPC5
            as a cold-activated channel
  JOURNAL   J Cell Physiol 237 (9), 3614-3626 (2022)
   PUBMED   35762104
  REMARK    GeneRIF: Cellular context determines primary characteristics of
            human TRPC5 as a cold-activated channel.
REFERENCE   6  (bases 1 to 12143)
  AUTHORS   Hofmann,T., Schaefer,M., Schultz,G. and Gudermann,T.
  TITLE     Subunit composition of mammalian transient receptor potential
            channels in living cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (11), 7461-7466 (2002)
   PUBMED   12032305
REFERENCE   7  (bases 1 to 12143)
  AUTHORS   Tang,J., Lin,Y., Zhang,Z., Tikunova,S., Birnbaumer,L. and Zhu,M.X.
  TITLE     Identification of common binding sites for calmodulin and inositol
            1,4,5-trisphosphate receptors on the carboxyl termini of trp
            channels
  JOURNAL   J Biol Chem 276 (24), 21303-21310 (2001)
   PUBMED   11290752
REFERENCE   8  (bases 1 to 12143)
  AUTHORS   Strubing,C., Krapivinsky,G., Krapivinsky,L. and Clapham,D.E.
  TITLE     TRPC1 and TRPC5 form a novel cation channel in mammalian brain
  JOURNAL   Neuron 29 (3), 645-655 (2001)
   PUBMED   11301024
REFERENCE   9  (bases 1 to 12143)
  AUTHORS   Tang,Y., Tang,J., Chen,Z., Trost,C., Flockerzi,V., Li,M., Ramesh,V.
            and Zhu,M.X.
  TITLE     Association of mammalian trp4 and phospholipase C isozymes with a
            PDZ domain-containing protein, NHERF
  JOURNAL   J Biol Chem 275 (48), 37559-37564 (2000)
   PUBMED   10980202
REFERENCE   10 (bases 1 to 12143)
  AUTHORS   Sossey-Alaoui,K., Lyon,J.A., Jones,L., Abidi,F.E., Hartung,A.J.,
            Hane,B., Schwartz,C.E., Stevenson,R.E. and Srivastava,A.K.
  TITLE     Molecular cloning and characterization of TRPC5 (HTRP5), the human
            homologue of a mouse brain receptor-activated capacitative Ca2+
            entry channel
  JOURNAL   Genomics 60 (3), 330-340 (1999)
   PUBMED   10493832
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031388.1, AF054568.1 and
            AL049563.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_012471.2.
            
            Summary: This gene belongs to the transient receptor family. It
            encodes one of the seven mammalian TRPC (transient receptor
            potential channel) proteins. The encoded protein is a multi-pass
            membrane protein and is thought to form a receptor-activated
            non-selective calcium permeant cation channel. The protein is
            active alone or as a heteromultimeric assembly with TRPC1, TRPC3,
            and TRPC4. It also interacts with multiple proteins including
            calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor
            (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger
            protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing
            protein 1 (SESTD1). [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF054568.1, BC137274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262839.3/ ENSP00000262839.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-884               AL031388.1         60115-60998         c
            885-4595            AF054568.1         884-4594
            4596-5840           AL049563.4         51257-52501         c
            5841-12143          AL049563.4         44954-51256         c
FEATURES             Location/Qualifiers
     source          1..12143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..12143
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /note="transient receptor potential cation channel
                     subfamily C member 5"
                     /db_xref="GeneID:7224"
                     /db_xref="HGNC:HGNC:12337"
                     /db_xref="MIM:300334"
     exon            1..898
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1297
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             920..3841
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /note="transient receptor potential channel 5; TRP-5;
                     hTRP5; transient receptor protein 5; protein phosphatase
                     1, regulatory subunit 159"
                     /codon_start=1
                     /product="short transient receptor potential channel 5"
                     /protein_id="NP_036603.1"
                     /db_xref="CCDS:CCDS14561.1"
                     /db_xref="GeneID:7224"
                     /db_xref="HGNC:HGNC:12337"
                     /db_xref="MIM:300334"
                     /translation="MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGD
                     YATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLY
                     AIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKL
                     LVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPIL
                     TAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHS
                     EELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTC
                     MTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTD
                     LHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATI
                     SLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQI
                     SLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFS
                     TLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMM
                     NNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFC
                     PKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTE
                     ENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVS
                     FNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHM
                     SEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQ
                     SSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTR
                     L"
     exon            1298..1819
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2156
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2296
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2619
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2815
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..3019
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3061
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3151
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..12143
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12115..12120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /note="hexamer: AATAAA"
     polyA_site      12143
                     /gene="TRPC5"
                     /gene_synonym="PPP1R159; TRP5"
                     /note="major polyA site"
ORIGIN      
        1 accccacatc acaaccacga cgggttgtcc gcagctcgca gccaccccaa agggaggaat
       61 aaagaacagg agcagaggga agccgggcgc agaaagaagg gaaaaggaag agctcagggt
      121 tggacatttt tggagacagg ggtggggagg ataaagggag cgtgcctcct tgattttccc
      181 ctccccaccc ctctttgctt ttctctcccc ttctctgtat agcatattcc agaaacggca
      241 gcagaagggg acagaaacct ctagtgtaga aaagggtttt ggaggggtag ccagcgctcc
      301 cgccagccgc tacctaacag ctggagcttg agtgtgcgtg taagagtgtg aatgcggctc
      361 tctctctttt tttctctctc tctcccctct ctctccatcc cttccttcct ccctccttct
      421 ccctctcctt cacactacag tgtcagctac ccctgtcagt ttccccgtgt cagtttcttc
      481 cctagctctt attgtgtgtg actggctgcg tgaagggagt gggtgcgctt gaaggggctc
      541 aggttgggtt agagagctgg gagaacaggg tagggacatt ggtagagcaa agagtttcag
      601 ggcactggcg aaggtgaaag gtgaggaggg ccgatctgtt acaggcaagt ttggcaataa
      661 ctgagcatcc aaaggggaag ccaaggtagg agccagtact tgcgctcgtc tttacacccc
      721 gcccctttcc ctgtgctcat ccgcccaccc acccatcagc ctagaggccc cgggctgtcc
      781 cagtcggctg ctgtttcgcg ccgcaaaaga ggagtccggc aaggcgccgc accacgcatc
      841 ctggccggtg gacatccaga cgacacagat tttatccgaa aaaaccactt ggctcaggat
      901 ttctgcattg ctatgaacca tggcccaact gtactacaaa aaggtcaact actcaccgta
      961 cagagaccgc atccccctgc aaattgtgag ggctgagaca gagctctctg cagaggagaa
     1021 ggccttcctc aatgctgtgg agaaggggga ctatgccact gtgaagcagg cccttcagga
     1081 ggctgagatc tactataatg ttaacatcaa ctgcatggac cccttgggcc ggagtgccct
     1141 gctcattgcc attgagaacg agaacctgga gatcatggag ctactgctga accacagcgt
     1201 gtatgtgggt gatgcattgc tctatgccat acgcaaggaa gtggtgggcg ctgtggagct
     1261 tctgctcagc tacaggcggc ccagcggaga gaagcaggtc cccactctga tgatggacac
     1321 gcagttctct gaattcacac cggacatcac tcccatcatg ctggctgccc acaccaacaa
     1381 ctacgaaatc atcaaattgc ttgtccaaaa acgggtcact atcccacggc cccaccagat
     1441 ccgctgcaac tgtgtggagt gtgtgtctag ttcagaggta gacagcctgc gccactctcg
     1501 ctcccgactg aacatctata aggctctggc aagcccctca ctcattgcct tatcaagtga
     1561 ggaccccatc ctaactgcct tccgtctggg ctgggagctc aaggagctca gcaaggtgga
     1621 gaatgagttc aaggccgagt atgaggagct ctctcagcag tgcaagctct ttgccaaaga
     1681 cctgctggac caagctcgga gctccaggga actggagatc atcctcaacc atcgagatga
     1741 ccacagtgaa gagcttgacc ctcagaagta ccatgacctg gccaagttga aggtggcaat
     1801 caaataccac cagaaagagt ttgttgctca gcccaactgc caacagttgc ttgccaccct
     1861 gtggtatgat ggcttccctg gatggcggcg gaaacactgg gtagtcaagc ttctaacctg
     1921 catgaccatt gggttcctgt ttcccatgct gtctatagcc tacctgatct cacccaggag
     1981 caaccttggg ctgttcatca agaaaccctt tatcaagttt atctgccaca cagcatccta
     2041 tttgaccttc ctctttatgc ttctcctggc ttctcagcac attgtcagga cagaccttca
     2101 tgtacagggg cctcccccaa ctgtcgtgga atggatgata ttgccttggg ttctaggttt
     2161 catttggggt gagattaagg aaatgtggga tggtggattt actgaataca tccatgactg
     2221 gtggaacctg atggattttg caatgaactc cctctacctg gcaactattt ccctgaagat
     2281 tgtggcctat gtcaagtata atggttctcg tccaagggag gaatgggaaa tgtggcaccc
     2341 gactctgatt gcggaagcac tcttcgcaat atccaacatt ttaagttcgt tgcgtctcat
     2401 atccctgttc acagccaact cccacttagg acctctgcag atctctttgg gacgcatgct
     2461 gcttgatatc ctcaaattcc tctttatcta ctgcctggta ctactagctt ttgccaatgg
     2521 actgaaccag ctttacttct attatgaaac cagagctatc gatgagccta acaactgcaa
     2581 ggggatccga tgtgagaaac agaacaatgc cttctccacg ctctttgaga ctcttcagtc
     2641 actcttctgg tctgtatttg gccttttaaa tctatatgtc accaatgtga aagccagaca
     2701 cgaattcacc gagtttgtag gagctaccat gtttggaaca tacaatgtca tctccctggt
     2761 agtgctgctg aacatgctga ttgctatgat gaacaactcc tatcagctta ttgccgatca
     2821 tgctgatatc gagtggaagt ttgcaaggac gaagctctgg atgagttact ttgatgaagg
     2881 tggcaccttg ccacctcctt tcaacatcat ccccagcccc aagtcatttc tataccttgg
     2941 taactggttc aacaacacct tctgccccaa aagagaccct gacggtagac ggagaaggcg
     3001 caacttgaga agtttcacag aacgcaatgc tgacagcctg atacaaaatc aacattatca
     3061 ggaagttatc aggaatttag tcaaaagata tgtggctgct atgataagaa attccaaaac
     3121 acatgaggga cttacagaag aaaattttaa ggaattaaag caagacatct ccagctttcg
     3181 gtatgaagtg cttgacctct tgggaaatag aaaacatcca aggagctttt ccactagcag
     3241 cactgaactg tctcagagag acgataataa tgatggcagt ggtggggctc gggccaaatc
     3301 caagagtgtc tcttttaatt taggctgcaa gaaaaagact tgccatgggc cacctctcat
     3361 cagaaccatg ccaaggtcca gtggtgccca aggaaagtca aaagctgagt catcaagcaa
     3421 acgctccttc atgggtcctt ctctcaagaa actgggtctc ctattctcca aatttaatgg
     3481 tcatatgtct gaacccagtt cagagccaat gtacacaatt tctgatggaa ttgttcagca
     3541 gcactgtatg tggcaggaca tcagatattc tcagatggag aaagggaaag cagaggcctg
     3601 ttctcaaagt gaaattaacc tcagtgaggt agaattaggt gaagtccagg gcgctgctca
     3661 gagcagtgaa tgccctctag cctgttccag ctctcttcac tgtgcatcca gcatctgctc
     3721 ctcaaattct aaacttttag actcctcaga ggatgtattt gaaacttggg gagaggcttg
     3781 tgacttgctc atgcacaaat ggggtgatgg acaggaagaa caagttacaa ctcgcctcta
     3841 agtcaagccc taatcatctg ttctggaact caacagaaat ctgtaatttc cttgctctca
     3901 gaggtgacac agaatatgat tccctcactg cccctgcccc ccagaaagga gagtgaaact
     3961 cttatttgca ccatctttta tagccacatt ctccattttt gttcttgttt tattattact
     4021 ttcattatta tttgcctttt taatacctat acacactaag tccatcttac aaccgactga
     4081 aggggtgttg cacctaatca tcagaggtgc agttgggtgc ttaacctttt tgctttgctt
     4141 ttctcaccca tgcttccttg aagccccagg tgccactttg ctggtcttgt tgccgcacag
     4201 attcctgacc atcctcagaa tctcatgcca ttttcccgca gagctgaggg atgtggtcag
     4261 cagtccccac cagctatcag ataaggcaaa ctaccctgcc catctttgtt gccattcagt
     4321 gctacgcgct gcccatgctg ggtcaatgaa cagcatcaaa gggaggctga agagatttca
     4381 aagaattgtc agcttgtggt ttctgggtat aagtggcttg tttcgttctt aaatactaca
     4441 acttcttatt gtgggggcta ttgagttttc ttgtttctta aagatgtgtt agtttcctaa
     4501 tgtgtgccaa tgaaatattt accccatagt atatgtcata tctaataagt taggcgaatt
     4561 atttttctgt ttgtgtgttt cagttaactt actacatttg aaaatttgat agtatcaaaa
     4621 ttagtattta gaatttgtgc tattttttaa aaacatctac tacactctaa ccaatagtca
     4681 ctacatctca tacattggca agataaatag ttgtcatatt tgttgggtcc tattctactg
     4741 ttgatagttt taattatcat tgctatcaaa taatttctaa gataaaagcc tgaatttgaa
     4801 atatttttat cagaaaaatg gcatattgct gaagtgtcaa aatatgagaa aagagcatct
     4861 tcattttaat taactgcttt ataaaaatgg caactttagg tatagataac ctaattcagg
     4921 ttgcagtttt aatattcatt gggggcagtg gaattgcatg tgtaaattat gttagatata
     4981 tatcataaca accctagtgg attcatggaa ttataaacgt gatccaaatt ctactgtctt
     5041 ccaagaaagc tacatttata catccaaaca aattcttttc cacagcttaa gagtacctca
     5101 tcagaataca gtggttcaag ttaaaaaata aagtccataa tgcatatggt catcattcta
     5161 gacctgataa ccactgagaa cctgctgagc aaggacggct tttaccaaca ttagcacaaa
     5221 ggtttcctca gtttagactc taacatatga cctgaaacaa ctctaggtct gagtcctaga
     5281 gattacataa atagtgtgta gcccagaaaa gtaaaatagg tgtcacgctg ttttttttaa
     5341 tgtcaacacc aataggaatc catttagatt aatgtatgta atttctgata aaagtaagag
     5401 aaatgaggaa ctttcgaact gcaaatatgc ctccaaacta gcttttgata agtgtggttt
     5461 ctgttatttg aatggattcc catctttgtc tctagcctgg agaagagcaa aatggagggg
     5521 gaggggccag aaataggagg aggttttgaa gaataaagcc tcatatccag gaaaaagtga
     5581 tcaagtgaaa aagctgcatc aagacccatt tggcaagagg ttgtccgaaa ataattcctt
     5641 gatcatatct gaagtggtta tttactcaaa tcaatttctc ccctgcttcg ctaagactgt
     5701 cataaaatgg ccttgacatt taatcacagg ttactttcca gaaaggtttc taaagttaca
     5761 gattcagctt ttcaaattgt caaattcact ttgaataata atagaacctg ggctacattc
     5821 ctaactcata ttaacagcac caaaagaaat agcatataac cccattttat aaaaagaaaa
     5881 acatgttttt ctcagaaatg tatatcactt ctgaaaactt ataagttttc tagcagtgac
     5941 cttatcaact tgtcagaaaa caggctagcc agacatggaa ctgtattcca aaagtcttct
     6001 gtcacttacg ttctaaagag ataatatgtg taaatcaatc tctactattg aaagaaccag
     6061 tgtcatatgt cacgggagta cattcctttt cagatcttct cagggttatc gttgtgactt
     6121 gggcttaaga ctttactagc tatagtgaag cctcatttag gatgggggtt aaagctgaac
     6181 agctattgcc ctaacttcca tgttggtgac accaacattt ttattaactc taattcagta
     6241 caaagtagga aaggaaaaag attttgttca cttccttact ctcttgatca agtatcataa
     6301 aaggtatttc aagtgaaaat gcttaggtat atcctctgac cccagaggag ttataagcca
     6361 acttgagagt aaatttataa acataaaaag aactaaaaga gaactttata aaggatctac
     6421 tctattccaa cctcatattt tacaaataga aaataaagag gcccagagaa ggacaatgac
     6481 ttgctcaagg tcacagagct ggtcaataaa ctcaagtctt ctagattata gaagacattt
     6541 attagtaagc atatatgtta tatatagatg tgaagtggcc actacagaca cccttttgtt
     6601 catttgccaa aaatgctgtg aactccaaaa cttcagactt acatatttaa atgtgaagtt
     6661 aaaaatgtac tgcaaagtca aacacaaata atacaaaaat catttactac ttatctaaaa
     6721 tatccatatc atgttccacc tacattacag ttggcttatc acttccggac accttggatt
     6781 catttatttg atctcataaa atctccctaa taataaaggt aaaaattaca aagaaaatat
     6841 ttgaattata ttagaaagtg accattgttg aaatatctcc acttccagct ttatgtccag
     6901 tgaaatacag aggaaagact aaatttaaaa tcattttcgg aaaatgccaa actttacaga
     6961 gatataaatg cttcaagtta cgcttctgtc tactgacatg gagatattaa aaaattccct
     7021 gttctgcctc catcattttt cattccactg tgacctaact taggctattt cagctaagtc
     7081 gtaaatacct gtctgcaatt tgattaaatc atttttaaaa aacgaacgcc tccacttttc
     7141 aaatgactta ataccttttc caaaaagaac tttatagttc ttatggcagt gcaaacctca
     7201 tctgaaaacc tcagtgggaa ctttagagat aaatatgagg ccaaacctta gcctgaaaat
     7261 acaaatgacc attggcattc atgttacatc atgggtgaat ctcgtgtggt gttttgacta
     7321 atagttttag tgccccagac cttggtttgt taaatcatca ggtaaaaagt acttgaagat
     7381 aggcagcaaa tcctttgttt aaaagtacct tagaaaaatt gaggctgggc atggtggccc
     7441 actcctgtaa tcccagcact ttgggaggcc aaaatgggtg gttcacttga gtccaggagt
     7501 ttgagatcag cctggccaac atggtgaaac ccatctctac taaaaataca aaaattagct
     7561 gggcatggtg gtacacgcct gtagtccaac tacttgagag gctgaggcat gagaatcact
     7621 tgaacctggg aggcagaggt tgcagtgcac tgagatcaca ccactgcact caagcctggg
     7681 cggcagagcg agactgtctc aaaaataaat aaataaaggt acctaagaaa aattgagtat
     7741 attttcttgg taatcaagtt ttcaaaagat tgctcatata gacatagtca atgcaaattg
     7801 atccaagtgt tcagatcatt taaataacct cttcatacct acttcacagc cctaccttca
     7861 atccctgcag ctttgcctca aaactaagga tattttagat tgtttctttg gcttacttta
     7921 tctagataat tgctccaaat atccaccttg ttggtgtagg actcggcagt gggatctgag
     7981 taccccaaat gaatgtgagc tttacttcag cagagagaaa cattgttacc attatatttc
     8041 caatgaacct tccagtaact ttttttccaa cagatgtggg ttttggcttg ctttgccttt
     8101 tgagggatgt ctgtaaaagt gagaacgtgt ctgtgtatat acatagacac acataacaaa
     8161 acttaacagc atttgatggt tctgcccttg gccctttatc cctttaggta attactagat
     8221 cattttgaag agagggaagc aagaataact tttcaatgag acatttcctg agctgtgagg
     8281 aattgccaaa atgaactgcc atgacagcat cttctgtagc acttttatat tgagagctat
     8341 caagatttga ggttcctggt tttgtttaaa aaaaaaaaaa gcatttaggt cagaataact
     8401 tacctggaag acttaaatat acacattttt ggcaaaataa agtcagtctg catacttcag
     8461 atttactgta tacctgagat ttggtgcata cttgaggtgt taatattcat tcatatgctg
     8521 gtacgtggcc taggattttc atcttttgtg tggtgatcca gaggaggtgt tagtgggtgc
     8581 tttgtgagag ctttactttt agaaaatgta atgtttaaga aacagagtta actgctggaa
     8641 tgatagaggc agcaagccag tgtgctctag catctttagg ctcagtattt gtgttatccc
     8701 caacttgagt ggatttgtat cttgtacttg attactggat ctgagttgtg ttcattcttt
     8761 ttctaaagat ataccatcaa tgtttgtggt acctgagaga catatacata ttaagaatta
     8821 taatatttaa acataaaact aagtggaatg cccttatgcc aaaaagctag ttttcttata
     8881 tgatgtgaaa agatgtgaaa gctctagagg cttcctgtta ctacacaaat aaatgacaaa
     8941 caatttctgt aggaacataa acagcccaca acttttgatc attgaaatca actgtcatac
     9001 atccctgaaa gtagcatgta tctgtcctac cctcctcccc ctcaaagaac tttctttata
     9061 actccagtga cttgatagaa ccaaaaaaga ctaactgaag taggttagaa tgacttgcaa
     9121 cgtgaaggtc attttcacca tttttcagca tatttgccct ttgactttag caggttttgg
     9181 ggcaacctaa catcccagga gcttacatac atacacacaa aaggcactgt ccttagtggc
     9241 acttgaatga atatgtggca gtgtgccttt tatttaagcc taaggtagcc agccatttga
     9301 aagtacaatt aagctgggat tggccatttt gtatcttttc ccagaagttc aatatatccc
     9361 caaaatactc attgccacca attgccttcc aacctaggaa ccctcttgac agttctccgc
     9421 tcttacacaa ctcttaaagc tgacccttgg aaggaagaaa ggaggctttg gatttttgct
     9481 gggattggga aacttagatg gtgatagtgt agtaaagaga cagttggaaa agcttttgaa
     9541 gtaaggatga gtgaggatat acactttaaa acacggggct aaaccaccaa attgtcagtt
     9601 ttttggatgg ccaaattgag atgaataacc tgaattaaaa atataattta aaatggttaa
     9661 ttaaaacatt agcatcatca tttctccttt aatgaaattc aaaaaatgca acaatatatg
     9721 aaagcagaac taccggtaaa tcatttttca aattttgggt catatttggg ttaaatttca
     9781 gatgttaaca agttctcaac cttgggatca ctgtaaatat aagttcaaca caccacaccc
     9841 ataatgcaat atcacagatg ggctttcata aatatgtaca ctttagccaa ttggaaagat
     9901 cacttccttc aaattttatc taagaaataa agtgggtttg tcaaaacaac atgaaagaga
     9961 aatgaaaggt aaggaagggc actatggcaa aaagccagat tatgtatctg ctgtcatctt
    10021 ttagcctcat aaatttggaa taaacataaa ataggataat gactgatatt ttcataaaca
    10081 taccagaact tatgcaccca aatgaacgtg gtcctttaaa gtagtcacct taaaaagcca
    10141 tacccatatt ctaatgatgc tgccattact ctacccactt tggacttctg cttttgaaat
    10201 gactttcaaa gtccacagta caatctctga atatcctcaa tggtagaaaa tcatgatcct
    10261 ataagattaa atttttagga atttagaaat tgccaaaagt aattttagat ccacacttgg
    10321 taaaacatgt ggtagtcaag atgagtacca ctttctctgg ttaaaaacaa acaaacgaac
    10381 aaacaaaaaa cattttcaag tgctactaca caataggcac tttgataggt gcaattataa
    10441 aataatgaga ttgtctcttg tgggatttgt aagggacctg gaactgttct tgggaatcta
    10501 gtttttttcc cctaattaac tttattgagg aatgatttat gtacaattac ctgcattcat
    10561 ttaaagtgta caaattggtg agttttcaga gttgtatata cccctggaag caccagccaa
    10621 aatcaagtta tagaatatct ccatcacccc ctcaagaatg cttgttctcc tttgtatcct
    10681 ggaatctagt ttcaattatg cttggagcag tggtagcctt acatgaataa gcacatagcc
    10741 tcctgaagag aacactttaa agagcaatat atttagatag agaagcttca ctgatttggg
    10801 aacaaccata atgattaacc ctttgtgttt aaacagtaaa atacattgag ttccaatggc
    10861 ttatgctgta aataaactca gaattgactc ctcaaactta tttgatcctt aagaaatgac
    10921 attgtatagc acagaggctc tggtgactag gctgttatca gggagaggga cagtaaagaa
    10981 aaaccactaa cctccataga gaacagaggg gaggattttg gactcataag aacccacggt
    11041 ggcagaagca atggaaagaa actctaatag gaagatggca gctagctagc tgaatgtgtt
    11101 caggtcattt gaaagtcaca tattcagatt aagtatttcc tgtataagat ctagtcatgg
    11161 tatttaaagt atagcctcat catgttgtgg ccacaccttg taggacctcc ttgtaaaaca
    11221 tattaagcaa tcagtttaaa tatccaaggc aaagtaacct gtagtccaat aaatcagtga
    11281 taactgtgct tagtgtacgt gggcaggaga agcagccaga attctcaagt gtcttaacag
    11341 gataagtggg accaatgaca ccaaaatgaa tattatgtga gcacatgaag agtcctctaa
    11401 acccaaaggg ttaacacatt agtctgtggt ttaatgtaaa aggaaattca attcgataaa
    11461 ttaactttaa aattaagtgt tcaaattact accttaacaa agtaaaagta aagctgtatc
    11521 ttatctcaac agtaaagaca cagaccttcc ccaggacact tcagataagg ataaacacat
    11581 ccttctcaag caaatacatt ttagtttgtt tcttataata ggaatgcaca ccagaggtac
    11641 tattcaacag aacaatagtt aaactcttca caggattcta tttattccat atttctcaaa
    11701 aatggggttg aaattaggga tgggagtttc tttctactca aaacaatgaa tgcagtctgc
    11761 agctacaaac taacatttgg tagcaggaag gagaatacta gagaatacga gctatgtgta
    11821 attcaccttc taagcctagt tggcagcccc aaccacatat caccatatag aaagtgtgtc
    11881 aaatttcagt ttaaaatgat acatcttgag cataatcatg aaaagggaaa attccaaatg
    11941 tgtctgtgta aatgacactg gctttgaaga ctattttcaa agtggaaatc tctttgaata
    12001 actatcactt ttatttaaac actttctgta agtgcacagt gtcaatctta atgtattaaa
    12061 aagaatcttg tacaataaaa taattttgtg tatttttagc ttcagtatca acaaaataaa
    12121 gtatttactt ttttcccctg aaa
//
