LOCUS       NM_001354806            7642 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 4 (TRPC4), transcript variant 7, mRNA.
ACCESSION   NM_001354806
VERSION     NM_001354806.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7642)
  AUTHORS   Chen,X., Yan,Y., Liu,Z., Yang,S., Li,W., Wang,Z., Wang,M., Guo,J.,
            Li,Z., Zhu,W., Yang,J., Yin,J., Dai,Q., Li,Y., Wang,C., Zhao,L.,
            Yang,X., Guo,X., Leng,L., Xu,J., Obukhov,A.G., Cao,R. and Zhong,W.
  TITLE     In vitro and in vivo inhibition of the host TRPC4 channel
            attenuates Zika virus infection
  JOURNAL   EMBO Mol Med 16 (8), 1817-1839 (2024)
   PUBMED   39009885
  REMARK    GeneRIF: In vitro and in vivo inhibition of the host TRPC4 channel
            attenuates Zika virus infection.
REFERENCE   2  (bases 1 to 7642)
  AUTHORS   Chen,Z., Zhao,Y., Tian,Y., Cao,R. and Shang,D.
  TITLE     Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4,
            and Its Expression Correlated with Prognosis, Tumor
            Microenvironment, and Treatment Sensitivity
  JOURNAL   Biomolecules 13 (2), 282 (2023)
   PUBMED   36830651
  REMARK    GeneRIF: Pan-Cancer Analysis of the TRP Family, Especially TRPV4
            and TRPC4, and Its Expression Correlated with Prognosis, Tumor
            Microenvironment, and Treatment Sensitivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7642)
  AUTHORS   Gotz,V., Qiao,S., Beck,A. and Boehm,U.
  TITLE     Transient receptor potential (TRP) channel function in the
            reproductive axis
  JOURNAL   Cell Calcium 67, 138-147 (2017)
   PUBMED   28522036
  REMARK    Review article
REFERENCE   4  (bases 1 to 7642)
  AUTHORS   Dietrich,A., Steinritz,D. and Gudermann,T.
  TITLE     Transient receptor potential (TRP) channels as molecular targets in
            lung toxicology and associated diseases
  JOURNAL   Cell Calcium 67, 123-137 (2017)
   PUBMED   28499580
  REMARK    Review article
REFERENCE   5  (bases 1 to 7642)
  AUTHORS   Zeng,B., Yuan,C., Yang,X., Atkin,S.L. and Xu,S.Z.
  TITLE     TRPC channels and their splice variants are essential for promoting
            human ovarian cancer cell proliferation and tumorigenesis
  JOURNAL   Curr Cancer Drug Targets 13 (1), 103-116 (2013)
   PUBMED   22920441
REFERENCE   6  (bases 1 to 7642)
  AUTHORS   von Spiczak,S., Muhle,H., Helbig,I., de Kovel,C.G., Hampe,J.,
            Gaus,V., Koeleman,B.P., Lindhout,D., Schreiber,S., Sander,T. and
            Stephani,U.
  TITLE     Association study of TRPC4 as a candidate gene for generalized
            epilepsy with photosensitivity
  JOURNAL   Neuromolecular Med 12 (3), 292-299 (2010)
   PUBMED   20574736
  REMARK    GeneRIF: Results showed a trend toward association of TRPC4
            variants and photoparoxysmal response/idiopathic generalized
            epilepsies.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7642)
  AUTHORS   Schaefer,M., Plant,T.D., Stresow,N., Albrecht,N. and Schultz,G.
  TITLE     Functional differences between TRPC4 splice variants
  JOURNAL   J Biol Chem 277 (5), 3752-3759 (2002)
   PUBMED   11713258
REFERENCE   8  (bases 1 to 7642)
  AUTHORS   Mery,L., Magnino,F., Schmidt,K., Krause,K.H. and Dufour,J.F.
  TITLE     Alternative splice variants of hTrp4 differentially interact with
            the C-terminal portion of the inositol 1,4,5-trisphosphate
            receptors
  JOURNAL   FEBS Lett 487 (3), 377-383 (2001)
   PUBMED   11163362
REFERENCE   9  (bases 1 to 7642)
  AUTHORS   McKay,R.R., Szymeczek-Seay,C.L., Lievremont,J.P., Bird,G.S.,
            Zitt,C., Jungling,E., Luckhoff,A. and Putney,J.W. Jr.
  TITLE     Cloning and expression of the human transient receptor potential 4
            (TRP4) gene: localization and functional expression of human TRP4
            and TRP3
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 735-746 (2000)
   PUBMED   11042129
REFERENCE   10 (bases 1 to 7642)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356495.15, AL354802.15 and
            AL138679.11.
            
            On Aug 6, 2019 this sequence version replaced NM_001354806.1.
            
            Summary: This gene encodes a member of the canonical subfamily of
            transient receptor potential cation channels. The encoded protein
            forms a non-selective calcium-permeable cation channel that is
            activated by Gq-coupled receptors and tyrosine kinases, and plays a
            role in multiple processes including endothelial permeability,
            vasodilation, neurotransmitter release and cell proliferation.
            Single nucleotide polymorphisms in this gene may be associated with
            generalized epilepsy with photosensitivity. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2316412.1,
                                           SRR14372080.3255443.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AL356495.15        14744-14921         c
            179-583             AL354802.15        99189-99593         c
            584-1102            AL354802.15        62170-62688         c
            1103-1242           AL138679.11        94386-94525         c
            1243-1556           AL138679.11        83574-83887         c
            1557-1752           AL138679.11        75246-75441         c
            1753-1947           AL138679.11        71423-71617         c
            1948-1989           AL138679.11        59416-59457         c
            1990-2079           AL138679.11        59198-59287         c
            2080-7642           AL138679.11        52221-57783         c
FEATURES             Location/Qualifiers
     source          1..7642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..7642
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="transient receptor potential cation channel
                     subfamily C member 4"
                     /db_xref="GeneID:7223"
                     /db_xref="HGNC:HGNC:12336"
                     /db_xref="MIM:603651"
     exon            1..178
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            179..583
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            584..1102
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1242
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1129..2802
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="isoform eta is encoded by transcript variant 7;
                     short transient receptor potential channel 4; trp-related
                     protein 4"
                     /codon_start=1
                     /product="short transient receptor potential channel 4
                     isoform eta"
                     /protein_id="NP_001341735.1"
                     /db_xref="GeneID:7223"
                     /db_xref="HGNC:HGNC:12336"
                     /db_xref="MIM:603651"
                     /translation="MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNP
                     RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI
                     YCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN
                     LYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFA
                     RTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRA
                     ADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLL
                     RGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIAS
                     ERHNISNGSALVVQEPPREKQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEE
                     VARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVC
                     PFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL"
     exon            1243..1556
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1752
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1947
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..1989
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2079
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..7642
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3029..3034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      3047
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="major polyA site"
     regulatory      5783..5788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      5802
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      5813..5818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      5833
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="major polyA site"
     regulatory      5995..6000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      6016
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      7387..7392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATATA"
     polyA_site      7405
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      7618..7623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      7642
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
ORIGIN      
        1 agttcggtgc cagctgcgtg ggctccagct tcgatcgttt tccttggaat gctccaaaac
       61 tcagcagcga ctaagggaat tccattggaa tttgccgggc gtgctctcac cccgcacggc
      121 acccgcgccg tcagtcctcg gatcccatca cttcagcccg aagattgcaa ctttgcagag
      181 acgaagaaat agcatggcat gaaacatggc tcagttctat tacaaaagaa atgttaatgc
      241 tccctataga gaccgcatcc ctctaaggat agtaagagca gaatcagaac tctcgccatc
      301 agaaaaagcc tacttgaatg ctgtggaaaa gggagattat gccagtgtca agaaatccct
      361 agaggaagct gaaatttatt ttaaaatcaa tattaattgc attgatcctc tcggaagaac
      421 tgctctcctc attgcaattg aaaatgagaa cttggagctc atcgaactac tcttaagctt
      481 taatgtctat gttggagatg ctctattaca tgctatcaga aaagaagtcg tcggagctgt
      541 tgagctgtta ttgaaccaca aaaaacctag tggagaaaaa caggtgcctc ctatactcct
      601 tgataagcag ttctctgaat tcactccaga cattacacca atcattttgg cagcccatac
      661 aaataattat gagataataa aactcttggt tcagaaagga gtctcagtgc ctcgacccca
      721 cgaggtccgc tgtaactgtg tggaatgcgt gtccagttca gatgtggaca gcctccgtca
      781 ctcacgctcc agactcaaca tctacaaggc cttggccagt ccctctctca ttgcactgtc
      841 aagcgaagat ccttttctca cagcctttca gttaagttgg gaacttcagg aactgagcaa
      901 ggtggaaaat gaattcaagt cggagtatga agagctgtca cggcagtgca aacaatttgc
      961 taaggaccta ctggatcaga cgagaagttc cagagaactg gaaatcattc ttaattaccg
     1021 agatgacaat agtctcatag aagaacaaag tggaaatgat cttgcaagac taaaattggc
     1081 cattaagtac cgtcaaaaag aggcttcata tggggagaaa ttaaacagat gtgggatggc
     1141 ggacttcagg actacatcca tgattggtgg aatctaatgg actttgtaat gaactcctta
     1201 tatttagcaa caatctcctt gaaaattgtt gcatttgtaa agtacagtgc ccttaatcca
     1261 cgagaatcat gggacatgtg gcatcccact ctggtggcag aggctttatt tgctattgca
     1321 aacatcttca gttctctgcg tctgatctca ctgtttactg caaattctca cctgggacct
     1381 ctgcaaatat ctctgggaag aatgctcctg gacattttga agtttctatt catatactgc
     1441 cttgtgttgc tagcatttgc aaatggccta aatcaattgt acttctatta tgaagaaacg
     1501 aaagggttaa cctgcaaagg cataagatgt gaaaagcaga ataatgcatt ttcaacgtta
     1561 tttgagacac tgcagtccct gttttggtca atatttgggc tcatcaattt atatgtgacc
     1621 aatgtcaaag cacagcatga atttactgag tttgttggtg ccaccatgtt tgggacatac
     1681 aatgtcatct ctctggttgt tctactcaac atgttaatag ctatgatgaa taattcttac
     1741 caactgattg ctgaccatgc agatatagaa tggaaatttg cacgaacaaa gctttggatg
     1801 agttattttg aagaaggagg tactctgcct actcccttca atgtcatccc gagccccaag
     1861 tctctctggt acctgatcaa atggatctgg acacacttgt gcaagaaaaa gatgagaaga
     1921 aagccagaaa gttttggaac aatagggagg cgagctgctg ataacttgag aagacatcac
     1981 caataccaag aagttatgag gaacctggtg aagcgatacg ttgctgcaat gattagagat
     2041 gctaaaactg aagaaggcct gaccgaagag aactttaagg aactaaagca agacatttct
     2101 agtttccgct ttgaagtcct gggattacta agaggaagca aactttccac aatacaatct
     2161 gcgaatgcct cgaaggagtc ttcaaattcg gcagactcag atgaaaagag tgatagcgaa
     2221 ggtaatagca aggacaagaa aaagaatttc agcctttttg atttaaccac cctgattcat
     2281 ccgagatcag cagcaattgc ctctgaaaga cataacataa gcaatggctc tgccctggtg
     2341 gttcaggagc cgcccaggga gaagcagaga aaagtgaatt ttgtgaccga tatcaaaaac
     2401 tttgggttat ttcatagacg atcaaaacaa aatgctgctg agcaaaatgc aaaccaaatc
     2461 ttctctgttt cagaagaagt tgctcgtcaa caggctgcag gaccacttga gagaaatatt
     2521 caactggaat ctcgaggatt agcttcacgg ggtgacctga gcattcccgg tctcagtgaa
     2581 caatgtgtgt tagtagacca tagagaaagg aatacggaca cactggggtt acaggtagga
     2641 aagagagtgt gtccattcaa gtcagagaag gtggtggtgg aggacacggt tcctataata
     2701 ccaaaggaga aacatgcaaa agaagaggac tctagtatag actatgatct aaacctccca
     2761 gacacagtca cccacgaaga ttacgtgacc acaagattgt gatacttgaa ggaggaagcg
     2821 tttaccatac acatacgtat tttccgtagt gctctgggtg ggggaaaatg tttaaattgt
     2881 attagcaaat gctaacttac actttatagc gtttatcagc tgtggcatat tacctgtaac
     2941 atgtttaaat aaggcaaagg caatcaaaaa cctttttgtt ttgtagcctg cttttgcttt
     3001 cacaatttgt cttacaattg tttttgttaa taaataaatg caccttgtat tcttgtactg
     3061 ttgcaataac ccacagaaac attttagcta tctttttcaa ttaaaacaaa tgcaatttat
     3121 ttcatgtggt agttgactcc taaaatagat atttttatat tcaaaaacca atgtggctga
     3181 aatattatag cttttcataa ttttttaggg tctttagaga gggttactca ccaaggactt
     3241 ttcacctagt cctacagttt ggctttaaaa cacaaatatt accaaattat ttcttaacga
     3301 catgtaaata attattgtac acaaagcaaa caagtcttct tctcatggag tcatatctaa
     3361 actccctcaa attcagaaaa actttgtagt gttttaggtt gttccagggt ttcctttcag
     3421 taagtaaaag aagtgtttgt cttaatacat tttgatgact gatgattttt aacgacattt
     3481 tgtcaggaaa aaaactcgcc cctccagttt ttttaattac ctatttcaga ttcaactgct
     3541 tatcagtata aatatgagtc tttatgaata actgaatttc aaaaatatgg caagatttct
     3601 gttataaaaa aataataaac cataatattg taagtatctt aaacaagcaa gatgattaca
     3661 tactaataat atccaaatga aaatgaattt attctaacaa tctaaatcta agtaaagttg
     3721 aattccagta ttttcaatca acgcaatatt gtaatcaatt caaaagaagt acaaaaaaac
     3781 tagcagtctc ctcttttcac cagtaatctt tatatatttc tttaaaatta aatcactcaa
     3841 aaatcattat taattttatc agcagatata gatatatagt tttgcctata ggaaaaacat
     3901 tcttatttct tgtttttctt tctattgttt gcaaggtaat ttagcttata acaattcact
     3961 gaactattac aaggaaagtg ttcgcaactt acataaaatt gatactagaa acttaaagct
     4021 taaattttac attgcttgtg tctatttaag ccactacggg aagtttcttc accacataaa
     4081 attagcattt atttcaaatc aatagaaaaa tgctaagttc attttatttc aaaaattact
     4141 ctgcgaacct cagaaattgc atgtgattta tcattggccc caaactgaat aatgttatgg
     4201 cactcagttt ctcattacca aacatcaaaa ataaggaata acagcaataa caatgccagc
     4261 ctctgttcta ttcctataca cctgttaaca tttatgtact gctctttaca gccctctgaa
     4321 gtagctcctg tttttatccc catttcacat atgatgaaac tgagaccagc actaactggc
     4381 taaggtaata cagctcatga tggagctgtg atgtgtccat cagagccatt cccttcacca
     4441 ctgcattgta actgcctttc agaacataaa aagagcaagt tataaaacat gcatatacag
     4501 gggttacaat tgccacttct gaagtcctat accttgagag agaatgagtt tggtatgctt
     4561 cataagagtc ccttcttcta aagcaagaga agtgtgcaaa atataaaatg tgctgtattt
     4621 gattctttag actaaattac attaaagtta gtagatttta aaaacatatt tattatgtga
     4681 tctcagaact caatttgaaa tactagattt taattttcag aaaagccagg agcactaagc
     4741 ccctgttcac tcctaaacct ggtttttggg aatttaggaa tgggccagat agatttggag
     4801 aaacacaagc ctaaatgaat gcatttactg tttcaagaac acctttatct caagtatatt
     4861 aggactcaga gcaaatcctg gggctactga aatactcatt tttttctaaa tcatacctac
     4921 agtagtagag aaattgtagg cctattgtta atatttggga tattttctat taatttcttt
     4981 ttgcctctct tgtgcgttgt tgttttattt tgttttttcc caaagtaagg acactataca
     5041 taaccatttt acatacttta ccagaattta atttcaaatt ctctctgttc cgtcaagcaa
     5101 caccaataac agtacaagca acaaaacctt ttttccccca gtagcttatt tatatcaggg
     5161 gttaaggtgc tgacatttta tagggggaca tgatggtaat agaggaatgt atttggagca
     5221 agtaagaccc tccttttcag tgccctagaa aggatgattc taacaacccc cagatgttgc
     5281 tgacagatgt gtttatgagt atgaacaaag tgctggatat tattagtacc cgatgttact
     5341 aatatcacta gaattgaatg ctattctaaa tacgtagtga cattatgtag cattaatgaa
     5401 gatgaggagt agggataaaa taagaaaagt caaacaacag caggatagca agcaaagaaa
     5461 tactgtttct ttgaggtttg taagtgcgta cttcagggtg ttcgtttcta ttcatatttc
     5521 tatccacaga aatttctaaa tgctacagag aactttgaaa ttaccttcat ttacataaat
     5581 aatgtttctc atttttcgta ctctcttaat cttaaaaaat ctgtttttct taaattttgt
     5641 gtctgagtta ggtgaaggag tgtgttgaaa attcagttta atagactagc aggtaagttt
     5701 aaaacacttt gtttatcaca attgtatttt ggaagtccca tttataagaa agtatgctat
     5761 aaagatgtac ctcattattc gtaataaagg ttttccttaa aatttctgtg caaataaatc
     5821 tatattaact tcagtaagga aattggctat attttttaaa atggggtgaa ttattttata
     5881 aaatcatgag taatttttca aagtgctaaa catcctcaaa atgtatctgt ttcatgaatt
     5941 gaatatttgt atatcaaatt ttcttaaatt agttactcta tttactggat ggcaattaaa
     6001 ctaatgcaaa aacatactca ctttcttgcc ttgacgtaga cagcaacttg aaatacttta
     6061 gtgatgaaac aaattgatga aaagtcaagg atagtagact caccatgctg ttctcaaaga
     6121 agcaaagtca attttctagc aaaggtggag gaaacataag taacaatagc ataagaatat
     6181 attcttctaa cattcaataa tccttaataa ctctgggatt tagctgagta aatgactatc
     6241 cagtctcaca gctctttatt gaagagaggc caccaagttt tgaaatctgt ccattcttag
     6301 tcctcatgca ttgtattttt agctgtcttc tatggtgtat acagctgcct tccatgctca
     6361 gtgtccttaa aactcaacct agtaagaacc atccattgtg gccctgtaaa tatgcttaca
     6421 atatattttt ctttctctgt attatctgaa attctgactt aaaactaacc atagaattta
     6481 gaaatttaat attactggca ttcctcttaa cttcaaaacc attattctga ttttacaatg
     6541 tctgaaaaga cattttattt atacagtgtt atcacatgcc ttttttaatt tgaattttag
     6601 aatcatgtta aataagttca ctgtagataa ctggggaaag taaagcccag ggaatttatg
     6661 gaaattatct aaatttaccc atgtgtttgg tggtcaagtt ggggcttaaa caaaaacctc
     6721 ctcatctaga tatttggatg aggcatcaca ttataaatgc cttgaccact gactttttat
     6781 ttggggaaca ttttgtcttc tttgcccttg tagaaaatat agttgtccaa acattcaagt
     6841 taaaattcag aattaatacc atattatctt ttgtttttct acaaagttgt gttaagagaa
     6901 tttttaaaaa gctggtttct tactgttttc agaaaataca ctgttcattt tcactggaag
     6961 tgtagatttt atgataacct gtatgcatac tggtaataat aaaatgtatt aaattatatc
     7021 aaagcttctc aactgaaaaa cattagagat ggacaatgta cagttgaact aagattggga
     7081 caatgggacc aagcctggat acagtcacac cgttactagg ctgacagtga agacgtctct
     7141 gcaagtcaaa ttcaccagta gcaaaaccgt taatttcctc tagagctgca ctgttcagta
     7201 acgtagctcc tatactcata cggctattaa tcacttgtaa gtgtgacaag tctgaattaa
     7261 gatgtgctgt aagtgtgaaa cacacaccag atttctagga cagtatgaaa ataatgtaaa
     7321 ctagctcata aatattttat gttggctaca tattgaactg atagtattta tgaagtattg
     7381 atttaaaata tactaagtaa atgagtttga tgtttctttt tccttttaca atgtggctac
     7441 tagaaaactg aaaaatacgt atgtggcttg catttgtgcc ttgcaataca tttctattgg
     7501 acagtgctgc tcaggaacat ttgtatttgt ttcagtcagc tcatgtatct ccatcatctg
     7561 aattgcaaag gtagaaaatt ctatctttaa ttactcaaaa aagttttgtg tagctctatt
     7621 aaagtttgca gtctctcctt ga
//
