LOCUS       NM_001354799            7968 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 4 (TRPC4), transcript variant 8, mRNA.
ACCESSION   NM_001354799 XM_017020724
VERSION     NM_001354799.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7968)
  AUTHORS   Chen,X., Yan,Y., Liu,Z., Yang,S., Li,W., Wang,Z., Wang,M., Guo,J.,
            Li,Z., Zhu,W., Yang,J., Yin,J., Dai,Q., Li,Y., Wang,C., Zhao,L.,
            Yang,X., Guo,X., Leng,L., Xu,J., Obukhov,A.G., Cao,R. and Zhong,W.
  TITLE     In vitro and in vivo inhibition of the host TRPC4 channel
            attenuates Zika virus infection
  JOURNAL   EMBO Mol Med 16 (8), 1817-1839 (2024)
   PUBMED   39009885
  REMARK    GeneRIF: In vitro and in vivo inhibition of the host TRPC4 channel
            attenuates Zika virus infection.
REFERENCE   2  (bases 1 to 7968)
  AUTHORS   Chen,Z., Zhao,Y., Tian,Y., Cao,R. and Shang,D.
  TITLE     Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4,
            and Its Expression Correlated with Prognosis, Tumor
            Microenvironment, and Treatment Sensitivity
  JOURNAL   Biomolecules 13 (2), 282 (2023)
   PUBMED   36830651
  REMARK    GeneRIF: Pan-Cancer Analysis of the TRP Family, Especially TRPV4
            and TRPC4, and Its Expression Correlated with Prognosis, Tumor
            Microenvironment, and Treatment Sensitivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7968)
  AUTHORS   Gotz,V., Qiao,S., Beck,A. and Boehm,U.
  TITLE     Transient receptor potential (TRP) channel function in the
            reproductive axis
  JOURNAL   Cell Calcium 67, 138-147 (2017)
   PUBMED   28522036
  REMARK    Review article
REFERENCE   4  (bases 1 to 7968)
  AUTHORS   Dietrich,A., Steinritz,D. and Gudermann,T.
  TITLE     Transient receptor potential (TRP) channels as molecular targets in
            lung toxicology and associated diseases
  JOURNAL   Cell Calcium 67, 123-137 (2017)
   PUBMED   28499580
  REMARK    Review article
REFERENCE   5  (bases 1 to 7968)
  AUTHORS   Zeng,B., Yuan,C., Yang,X., Atkin,S.L. and Xu,S.Z.
  TITLE     TRPC channels and their splice variants are essential for promoting
            human ovarian cancer cell proliferation and tumorigenesis
  JOURNAL   Curr Cancer Drug Targets 13 (1), 103-116 (2013)
   PUBMED   22920441
REFERENCE   6  (bases 1 to 7968)
  AUTHORS   von Spiczak,S., Muhle,H., Helbig,I., de Kovel,C.G., Hampe,J.,
            Gaus,V., Koeleman,B.P., Lindhout,D., Schreiber,S., Sander,T. and
            Stephani,U.
  TITLE     Association study of TRPC4 as a candidate gene for generalized
            epilepsy with photosensitivity
  JOURNAL   Neuromolecular Med 12 (3), 292-299 (2010)
   PUBMED   20574736
  REMARK    GeneRIF: Results showed a trend toward association of TRPC4
            variants and photoparoxysmal response/idiopathic generalized
            epilepsies.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7968)
  AUTHORS   Schaefer,M., Plant,T.D., Stresow,N., Albrecht,N. and Schultz,G.
  TITLE     Functional differences between TRPC4 splice variants
  JOURNAL   J Biol Chem 277 (5), 3752-3759 (2002)
   PUBMED   11713258
REFERENCE   8  (bases 1 to 7968)
  AUTHORS   Mery,L., Magnino,F., Schmidt,K., Krause,K.H. and Dufour,J.F.
  TITLE     Alternative splice variants of hTrp4 differentially interact with
            the C-terminal portion of the inositol 1,4,5-trisphosphate
            receptors
  JOURNAL   FEBS Lett 487 (3), 377-383 (2001)
   PUBMED   11163362
REFERENCE   9  (bases 1 to 7968)
  AUTHORS   McKay,R.R., Szymeczek-Seay,C.L., Lievremont,J.P., Bird,G.S.,
            Zitt,C., Jungling,E., Luckhoff,A. and Putney,J.W. Jr.
  TITLE     Cloning and expression of the human transient receptor potential 4
            (TRP4) gene: localization and functional expression of human TRP4
            and TRP3
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 735-746 (2000)
   PUBMED   11042129
REFERENCE   10 (bases 1 to 7968)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356495.15, AL354802.15 and
            AL138679.11.
            
            On Aug 7, 2019 this sequence version replaced NM_001354799.1.
            
            Summary: This gene encodes a member of the canonical subfamily of
            transient receptor potential cation channels. The encoded protein
            forms a non-selective calcium-permeable cation channel that is
            activated by Gq-coupled receptors and tyrosine kinases, and plays a
            role in multiple processes including endothelial permeability,
            vasodilation, neurotransmitter release and cell proliferation.
            Single nucleotide polymorphisms in this gene may be associated with
            generalized epilepsy with photosensitivity. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.598601.1,
                                           SRR1803615.242707.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AL356495.15        14744-14921         c
            179-583             AL354802.15        99189-99593         c
            584-1102            AL354802.15        62170-62688         c
            1103-1428           AL354802.15        8243-8568           c
            1429-1568           AL138679.11        94386-94525         c
            1569-1882           AL138679.11        83574-83887         c
            1883-2078           AL138679.11        75246-75441         c
            2079-2273           AL138679.11        71423-71617         c
            2274-2315           AL138679.11        59416-59457         c
            2316-2405           AL138679.11        59198-59287         c
            2406-7968           AL138679.11        52221-57783         c
FEATURES             Location/Qualifiers
     source          1..7968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..7968
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="transient receptor potential cation channel
                     subfamily C member 4"
                     /db_xref="GeneID:7223"
                     /db_xref="HGNC:HGNC:12336"
                     /db_xref="MIM:603651"
     exon            1..178
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            179..583
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            584..1102
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1428
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1568
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1455..3128
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="isoform eta is encoded by transcript variant 8;
                     short transient receptor potential channel 4; trp-related
                     protein 4"
                     /codon_start=1
                     /product="short transient receptor potential channel 4
                     isoform eta"
                     /protein_id="NP_001341728.1"
                     /db_xref="GeneID:7223"
                     /db_xref="HGNC:HGNC:12336"
                     /db_xref="MIM:603651"
                     /translation="MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNP
                     RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI
                     YCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN
                     LYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFA
                     RTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRA
                     ADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLL
                     RGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIAS
                     ERHNISNGSALVVQEPPREKQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEE
                     VARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVC
                     PFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL"
     exon            1569..1882
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2078
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2273
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2315
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2405
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..7968
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3355..3360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      3373
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="major polyA site"
     regulatory      6109..6114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      6128
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      6139..6144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      6159
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="major polyA site"
     regulatory      6321..6326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      6342
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      7713..7718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATATA"
     polyA_site      7731
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      7944..7949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      7968
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
ORIGIN      
        1 agttcggtgc cagctgcgtg ggctccagct tcgatcgttt tccttggaat gctccaaaac
       61 tcagcagcga ctaagggaat tccattggaa tttgccgggc gtgctctcac cccgcacggc
      121 acccgcgccg tcagtcctcg gatcccatca cttcagcccg aagattgcaa ctttgcagag
      181 acgaagaaat agcatggcat gaaacatggc tcagttctat tacaaaagaa atgttaatgc
      241 tccctataga gaccgcatcc ctctaaggat agtaagagca gaatcagaac tctcgccatc
      301 agaaaaagcc tacttgaatg ctgtggaaaa gggagattat gccagtgtca agaaatccct
      361 agaggaagct gaaatttatt ttaaaatcaa tattaattgc attgatcctc tcggaagaac
      421 tgctctcctc attgcaattg aaaatgagaa cttggagctc atcgaactac tcttaagctt
      481 taatgtctat gttggagatg ctctattaca tgctatcaga aaagaagtcg tcggagctgt
      541 tgagctgtta ttgaaccaca aaaaacctag tggagaaaaa caggtgcctc ctatactcct
      601 tgataagcag ttctctgaat tcactccaga cattacacca atcattttgg cagcccatac
      661 aaataattat gagataataa aactcttggt tcagaaagga gtctcagtgc ctcgacccca
      721 cgaggtccgc tgtaactgtg tggaatgcgt gtccagttca gatgtggaca gcctccgtca
      781 ctcacgctcc agactcaaca tctacaaggc cttggccagt ccctctctca ttgcactgtc
      841 aagcgaagat ccttttctca cagcctttca gttaagttgg gaacttcagg aactgagcaa
      901 ggtggaaaat gaattcaagt cggagtatga agagctgtca cggcagtgca aacaatttgc
      961 taaggaccta ctggatcaga cgagaagttc cagagaactg gaaatcattc ttaattaccg
     1021 agatgacaat agtctcatag aagaacaaag tggaaatgat cttgcaagac taaaattggc
     1081 cattaagtac cgtcaaaaag agtttgttgc ccagcccaat tgtcaacagc tgctggcatc
     1141 tcgctggtac gatgagtttc caggctggag gagaagacac tgggcagtga agatggtgac
     1201 atgtttcata ataggacttc tttttcctgt cttctctgtg tgctacctga tagctcccaa
     1261 aagcccactt ggactgttca tcaggaagcc atttatcaag tttatctgcc acacagcctc
     1321 ctatttgact tttttgttcc tgctgctgct tgcctctcag cacatcgaca ggtcagactt
     1381 gaacaggcaa ggtccaccac caaccatcgt cgagtggatg atattaccgc ttcatatggg
     1441 gagaaattaa acagatgtgg gatggcggac ttcaggacta catccatgat tggtggaatc
     1501 taatggactt tgtaatgaac tccttatatt tagcaacaat ctccttgaaa attgttgcat
     1561 ttgtaaagta cagtgccctt aatccacgag aatcatggga catgtggcat cccactctgg
     1621 tggcagaggc tttatttgct attgcaaaca tcttcagttc tctgcgtctg atctcactgt
     1681 ttactgcaaa ttctcacctg ggacctctgc aaatatctct gggaagaatg ctcctggaca
     1741 ttttgaagtt tctattcata tactgccttg tgttgctagc atttgcaaat ggcctaaatc
     1801 aattgtactt ctattatgaa gaaacgaaag ggttaacctg caaaggcata agatgtgaaa
     1861 agcagaataa tgcattttca acgttatttg agacactgca gtccctgttt tggtcaatat
     1921 ttgggctcat caatttatat gtgaccaatg tcaaagcaca gcatgaattt actgagtttg
     1981 ttggtgccac catgtttggg acatacaatg tcatctctct ggttgttcta ctcaacatgt
     2041 taatagctat gatgaataat tcttaccaac tgattgctga ccatgcagat atagaatgga
     2101 aatttgcacg aacaaagctt tggatgagtt attttgaaga aggaggtact ctgcctactc
     2161 ccttcaatgt catcccgagc cccaagtctc tctggtacct gatcaaatgg atctggacac
     2221 acttgtgcaa gaaaaagatg agaagaaagc cagaaagttt tggaacaata gggaggcgag
     2281 ctgctgataa cttgagaaga catcaccaat accaagaagt tatgaggaac ctggtgaagc
     2341 gatacgttgc tgcaatgatt agagatgcta aaactgaaga aggcctgacc gaagagaact
     2401 ttaaggaact aaagcaagac atttctagtt tccgctttga agtcctggga ttactaagag
     2461 gaagcaaact ttccacaata caatctgcga atgcctcgaa ggagtcttca aattcggcag
     2521 actcagatga aaagagtgat agcgaaggta atagcaagga caagaaaaag aatttcagcc
     2581 tttttgattt aaccaccctg attcatccga gatcagcagc aattgcctct gaaagacata
     2641 acataagcaa tggctctgcc ctggtggttc aggagccgcc cagggagaag cagagaaaag
     2701 tgaattttgt gaccgatatc aaaaactttg ggttatttca tagacgatca aaacaaaatg
     2761 ctgctgagca aaatgcaaac caaatcttct ctgtttcaga agaagttgct cgtcaacagg
     2821 ctgcaggacc acttgagaga aatattcaac tggaatctcg aggattagct tcacggggtg
     2881 acctgagcat tcccggtctc agtgaacaat gtgtgttagt agaccataga gaaaggaata
     2941 cggacacact ggggttacag gtaggaaaga gagtgtgtcc attcaagtca gagaaggtgg
     3001 tggtggagga cacggttcct ataataccaa aggagaaaca tgcaaaagaa gaggactcta
     3061 gtatagacta tgatctaaac ctcccagaca cagtcaccca cgaagattac gtgaccacaa
     3121 gattgtgata cttgaaggag gaagcgttta ccatacacat acgtattttc cgtagtgctc
     3181 tgggtggggg aaaatgttta aattgtatta gcaaatgcta acttacactt tatagcgttt
     3241 atcagctgtg gcatattacc tgtaacatgt ttaaataagg caaaggcaat caaaaacctt
     3301 tttgttttgt agcctgcttt tgctttcaca atttgtctta caattgtttt tgttaataaa
     3361 taaatgcacc ttgtattctt gtactgttgc aataacccac agaaacattt tagctatctt
     3421 tttcaattaa aacaaatgca atttatttca tgtggtagtt gactcctaaa atagatattt
     3481 ttatattcaa aaaccaatgt ggctgaaata ttatagcttt tcataatttt ttagggtctt
     3541 tagagagggt tactcaccaa ggacttttca cctagtccta cagtttggct ttaaaacaca
     3601 aatattacca aattatttct taacgacatg taaataatta ttgtacacaa agcaaacaag
     3661 tcttcttctc atggagtcat atctaaactc cctcaaattc agaaaaactt tgtagtgttt
     3721 taggttgttc cagggtttcc tttcagtaag taaaagaagt gtttgtctta atacattttg
     3781 atgactgatg atttttaacg acattttgtc aggaaaaaaa ctcgcccctc cagttttttt
     3841 aattacctat ttcagattca actgcttatc agtataaata tgagtcttta tgaataactg
     3901 aatttcaaaa atatggcaag atttctgtta taaaaaaata ataaaccata atattgtaag
     3961 tatcttaaac aagcaagatg attacatact aataatatcc aaatgaaaat gaatttattc
     4021 taacaatcta aatctaagta aagttgaatt ccagtatttt caatcaacgc aatattgtaa
     4081 tcaattcaaa agaagtacaa aaaaactagc agtctcctct tttcaccagt aatctttata
     4141 tatttcttta aaattaaatc actcaaaaat cattattaat tttatcagca gatatagata
     4201 tatagttttg cctataggaa aaacattctt atttcttgtt tttctttcta ttgtttgcaa
     4261 ggtaatttag cttataacaa ttcactgaac tattacaagg aaagtgttcg caacttacat
     4321 aaaattgata ctagaaactt aaagcttaaa ttttacattg cttgtgtcta tttaagccac
     4381 tacgggaagt ttcttcacca cataaaatta gcatttattt caaatcaata gaaaaatgct
     4441 aagttcattt tatttcaaaa attactctgc gaacctcaga aattgcatgt gatttatcat
     4501 tggccccaaa ctgaataatg ttatggcact cagtttctca ttaccaaaca tcaaaaataa
     4561 ggaataacag caataacaat gccagcctct gttctattcc tatacacctg ttaacattta
     4621 tgtactgctc tttacagccc tctgaagtag ctcctgtttt tatccccatt tcacatatga
     4681 tgaaactgag accagcacta actggctaag gtaatacagc tcatgatgga gctgtgatgt
     4741 gtccatcaga gccattccct tcaccactgc attgtaactg cctttcagaa cataaaaaga
     4801 gcaagttata aaacatgcat atacaggggt tacaattgcc acttctgaag tcctatacct
     4861 tgagagagaa tgagtttggt atgcttcata agagtccctt cttctaaagc aagagaagtg
     4921 tgcaaaatat aaaatgtgct gtatttgatt ctttagacta aattacatta aagttagtag
     4981 attttaaaaa catatttatt atgtgatctc agaactcaat ttgaaatact agattttaat
     5041 tttcagaaaa gccaggagca ctaagcccct gttcactcct aaacctggtt tttgggaatt
     5101 taggaatggg ccagatagat ttggagaaac acaagcctaa atgaatgcat ttactgtttc
     5161 aagaacacct ttatctcaag tatattagga ctcagagcaa atcctggggc tactgaaata
     5221 ctcatttttt tctaaatcat acctacagta gtagagaaat tgtaggccta ttgttaatat
     5281 ttgggatatt ttctattaat ttctttttgc ctctcttgtg cgttgttgtt ttattttgtt
     5341 ttttcccaaa gtaaggacac tatacataac cattttacat actttaccag aatttaattt
     5401 caaattctct ctgttccgtc aagcaacacc aataacagta caagcaacaa aacctttttt
     5461 cccccagtag cttatttata tcaggggtta aggtgctgac attttatagg gggacatgat
     5521 ggtaatagag gaatgtattt ggagcaagta agaccctcct tttcagtgcc ctagaaagga
     5581 tgattctaac aacccccaga tgttgctgac agatgtgttt atgagtatga acaaagtgct
     5641 ggatattatt agtacccgat gttactaata tcactagaat tgaatgctat tctaaatacg
     5701 tagtgacatt atgtagcatt aatgaagatg aggagtaggg ataaaataag aaaagtcaaa
     5761 caacagcagg atagcaagca aagaaatact gtttctttga ggtttgtaag tgcgtacttc
     5821 agggtgttcg tttctattca tatttctatc cacagaaatt tctaaatgct acagagaact
     5881 ttgaaattac cttcatttac ataaataatg tttctcattt ttcgtactct cttaatctta
     5941 aaaaatctgt ttttcttaaa ttttgtgtct gagttaggtg aaggagtgtg ttgaaaattc
     6001 agtttaatag actagcaggt aagtttaaaa cactttgttt atcacaattg tattttggaa
     6061 gtcccattta taagaaagta tgctataaag atgtacctca ttattcgtaa taaaggtttt
     6121 ccttaaaatt tctgtgcaaa taaatctata ttaacttcag taaggaaatt ggctatattt
     6181 tttaaaatgg ggtgaattat tttataaaat catgagtaat ttttcaaagt gctaaacatc
     6241 ctcaaaatgt atctgtttca tgaattgaat atttgtatat caaattttct taaattagtt
     6301 actctattta ctggatggca attaaactaa tgcaaaaaca tactcacttt cttgccttga
     6361 cgtagacagc aacttgaaat actttagtga tgaaacaaat tgatgaaaag tcaaggatag
     6421 tagactcacc atgctgttct caaagaagca aagtcaattt tctagcaaag gtggaggaaa
     6481 cataagtaac aatagcataa gaatatattc ttctaacatt caataatcct taataactct
     6541 gggatttagc tgagtaaatg actatccagt ctcacagctc tttattgaag agaggccacc
     6601 aagttttgaa atctgtccat tcttagtcct catgcattgt atttttagct gtcttctatg
     6661 gtgtatacag ctgccttcca tgctcagtgt ccttaaaact caacctagta agaaccatcc
     6721 attgtggccc tgtaaatatg cttacaatat atttttcttt ctctgtatta tctgaaattc
     6781 tgacttaaaa ctaaccatag aatttagaaa tttaatatta ctggcattcc tcttaacttc
     6841 aaaaccatta ttctgatttt acaatgtctg aaaagacatt ttatttatac agtgttatca
     6901 catgcctttt ttaatttgaa ttttagaatc atgttaaata agttcactgt agataactgg
     6961 ggaaagtaaa gcccagggaa tttatggaaa ttatctaaat ttacccatgt gtttggtggt
     7021 caagttgggg cttaaacaaa aacctcctca tctagatatt tggatgaggc atcacattat
     7081 aaatgccttg accactgact ttttatttgg ggaacatttt gtcttctttg cccttgtaga
     7141 aaatatagtt gtccaaacat tcaagttaaa attcagaatt aataccatat tatcttttgt
     7201 ttttctacaa agttgtgtta agagaatttt taaaaagctg gtttcttact gttttcagaa
     7261 aatacactgt tcattttcac tggaagtgta gattttatga taacctgtat gcatactggt
     7321 aataataaaa tgtattaaat tatatcaaag cttctcaact gaaaaacatt agagatggac
     7381 aatgtacagt tgaactaaga ttgggacaat gggaccaagc ctggatacag tcacaccgtt
     7441 actaggctga cagtgaagac gtctctgcaa gtcaaattca ccagtagcaa aaccgttaat
     7501 ttcctctaga gctgcactgt tcagtaacgt agctcctata ctcatacggc tattaatcac
     7561 ttgtaagtgt gacaagtctg aattaagatg tgctgtaagt gtgaaacaca caccagattt
     7621 ctaggacagt atgaaaataa tgtaaactag ctcataaata ttttatgttg gctacatatt
     7681 gaactgatag tatttatgaa gtattgattt aaaatatact aagtaaatga gtttgatgtt
     7741 tctttttcct tttacaatgt ggctactaga aaactgaaaa atacgtatgt ggcttgcatt
     7801 tgtgccttgc aatacatttc tattggacag tgctgctcag gaacatttgt atttgtttca
     7861 gtcagctcat gtatctccat catctgaatt gcaaaggtag aaaattctat ctttaattac
     7921 tcaaaaaagt tttgtgtagc tctattaaag tttgcagtct ctccttga
//
